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SLC11A2 SLC11A2 USH2A USH2A ITLN1 ITLN1 PDZK1 PDZK1 RHOC RHOC CDC14A CDC14A ESPN ESPN CUBN CUBN MYO3A MYO3A VCL VCL CR201_G0030294 CR201_G0030294 CDH23 CDH23 PCDH15 PCDH15 MORN4 MORN4 PDZD7 PDZD7 ADD3 ADD3 CDHR5 CDHR5 SHANK2 SHANK2 ENSPPYP00000003496 ENSPPYP00000003496 SLC22A12 SLC22A12 USH1C USH1C FCHSD2 FCHSD2 CR201_G0023224 CR201_G0023224 PDZD3 PDZD3 CR201_G0026161 CR201_G0026161 EPS8 EPS8 DNM1L DNM1L ADCY6 ADCY6 LIMA1 LIMA1 SOAT2 SOAT2 MYO1A MYO1A PTPRQ PTPRQ VEZT VEZT SLC15A1 SLC15A1 ACTN1 ACTN1 AMN AMN CR201_G0045973 CR201_G0045973 SLC28A2 SLC28A2 MYO1E MYO1E CR201_G0042177 CR201_G0042177 HOMER2 HOMER2 SLC28A1 SLC28A1 ANKS4B ANKS4B BBS2 BBS2 MYO1C MYO1C MYO15A MYO15A FLII FLII IFT20 IFT20 SLC46A1 SLC46A1 MYO1D MYO1D CA4 CA4 GNA13 GNA13 SLC9A3R1 SLC9A3R1 MYO15B MYO15B DCXR DCXR MYL12B MYL12B LOXHD1 LOXHD1 ATP8B1 ATP8B1 ATP8B3 ATP8B3 SLC7A9 SLC7A9 CEACAM16 CEACAM16 KPTN KPTN MYH14 MYH14 MKKS MKKS TMC2 TMC2 TSPEAR TSPEAR SLC19A1 SLC19A1 SLC5A1 SLC5A1 MYH9 MYH9 PVALB PVALB TRIOBP TRIOBP ELMOD3 ELMOD3 SLC3A1 SLC3A1 PLB1 PLB1 SLC5A6 SLC5A6 MYO7B MYO7B VIL1 VIL1 ACTR3 ACTR3 LRP2 LRP2 MYO3B MYO3B CYBRD1 CYBRD1 PJVK PJVK MYO1B MYO1B ESPNL ESPNL TWF2 TWF2 SLC26A6 SLC26A6 SLC4A7 SLC4A7 PLS1 PLS1 CLRN1 CLRN1 MME MME SI SI SLC2A2 SLC2A2 CR201_G0040852 CR201_G0040852 DRD5 DRD5 CLRN2 CLRN2 SLC34A2 SLC34A2 GRXCR1 GRXCR1 ABCG2 ABCG2 MTTP MTTP ENPEP ENPEP SLC7A11 SLC7A11 SLC9A3 SLC9A3 SLC6A19 SLC6A19 ADGRV1 ADGRV1 SLC22A5 SLC22A5 SLC23A1 SLC23A1 GRXCR2 GRXCR2 SLC34A1 SLC34A1 CDHR2 CDHR2 DCDC2 DCDC2 RIPOR2 RIPOR2 KNCN KNCN CLIC1 CLIC1 ITPR3 ITPR3 CLIC5 CLIC5 EZR EZR RSPH9 RSPH9 GNA12 GNA12 NPC1L1 NPC1L1 AQP1 AQP1 SCIN SCIN CD36 CD36 SLC26A4 SLC26A4 SLC26A3 SLC26A3 DOCK4 DOCK4 CAPZA2 CAPZA2 ATP6V0A4 ATP6V0A4 IDO1 IDO1 TRPA1 TRPA1 PLEC PLEC B4GALT1 B4GALT1 TMC1 TMC1 SLC28A3 SLC28A3 WHRN WHRN RALGDS RALGDS TPRN TPRN CR201_G0049742 CR201_G0049742 ACE2 ACE2 CLTRN CLTRN ATP7A ATP7A FLNA FLNA MPP1 MPP1 ENSPPYP00000023721 ENSPPYP00000023721 ENSPPYP00000023839 ENSPPYP00000023839 EPS8L2 EPS8L2 ACTN3 ACTN3 SLC6A18 SLC6A18
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SLC11A2SLC11A2 isoform 12. (573 aa)
USH2AUSH2A isoform 2. (4749 aa)
ITLN1LOW QUALITY PROTEIN: intelectin-1. (311 aa)
PDZK1Na(+)/H(+) exchange regulatory cofactor NHE-RF3; A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resista [...] (519 aa)
RHOCRho-related GTP-binding protein RhoC; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells (By similarity). (192 aa)
CDC14ACell division cycle 14A. (594 aa)
ESPNESPN isoform 1. (848 aa)
CUBNCUBN isoform 1. (3507 aa)
MYO3AMYO3A isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1575 aa)
VCLVCL isoform 2. (1134 aa)
CR201_G0030294CDH23 isoform 6. (250 aa)
CDH23CDH23 isoform 1. (2498 aa)
PCDH15PCDH15 isoform 18. (1163 aa)
MORN4MORN repeat-containing protein 4; Plays a role in promoting axonal degeneration following neuronal injury by toxic insult or trauma. (146 aa)
PDZD7PDZ domain-containing protein 7; In cochlear developing hair cells, essential in organizing the USH2 complex at stereocilia ankle links. Blocks inhibition of adenylate cyclase activity mediated by ADGRV1. (477 aa)
ADD3ADD3 isoform 3. (706 aa)
CDHR5CDHR5 isoform 1. (768 aa)
SHANK2SHANK2 isoform 6. (1266 aa)
ENSPPYP00000003496annotation not available (383 aa)
SLC22A12SLC22A12 isoform 2. (473 aa)
USH1CUSH1C isoform 9. (403 aa)
FCHSD2FCH and double SH3 domains 2. (764 aa)
CR201_G0023224MYO7A isoform 2. (1350 aa)
PDZD3PDZ domain containing 3. (491 aa)
CR201_G0026161USH1C isoform 8. (559 aa)
EPS8Epidermal growth factor receptor kinase substrate 8; Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can regulate different processes. Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac-specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and acti [...] (824 aa)
DNM1LDNM1L isoform 4; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (686 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1165 aa)
LIMA1LIMA1 isoform 1. (760 aa)
SOAT2O-acyltransferase. (489 aa)
MYO1AMYO1A isoform 4; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (827 aa)
PTPRQPTPRQ isoform 5. (154 aa)
VEZTVezatin; Plays a pivotal role in the establishment of adherens junctions and their maintenance in adult life. Required for morphogenesis of the preimplantation embryo, and for the implantation process. (779 aa)
SLC15A1Solute carrier family 15 member 1. (708 aa)
ACTN1ACTN1 isoform 1. (980 aa)
AMNAMN isoform 2. (446 aa)
CR201_G0045973STRC isoform 2. (1473 aa)
SLC28A2Sodium/nucleoside cotransporter; Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family. (658 aa)
MYO1EMYO1E isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1109 aa)
CR201_G0042177CIB2 isoform 1. (346 aa)
HOMER2HOMER2 isoform 1. (397 aa)
SLC28A1Sodium/nucleoside cotransporter; Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family. (608 aa)
ANKS4BAnkyrin repeat and sterile alpha motif domain containing 4B. (417 aa)
BBS2Bardet-Biedl syndrome 2 protein homolog. (720 aa)
MYO1CMYO1C isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1063 aa)
MYO15AMYO15A isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (3281 aa)
FLIIFLII isoform 1. (1239 aa)
IFT20IFT20 isoform 6. (158 aa)
SLC46A1SLC46A1 isoform 1. (459 aa)
MYO1DMYO1D isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1006 aa)
CA4Carbonic anhydrase 4; Belongs to the alpha-carbonic anhydrase family. (312 aa)
GNA13G protein subunit alpha 13. (377 aa)
SLC9A3R1Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (357 aa)
MYO15BMYO15B isoform 13; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1560 aa)
DCXRDCXR isoform 2. (224 aa)
MYL12BMyosin light chain 12B. (172 aa)
LOXHD1LOXHD1 isoform 1. (1714 aa)
ATP8B1Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1212 aa)
ATP8B3Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1227 aa)
SLC7A9Solute carrier family 7 member 9. (487 aa)
CEACAM16CEACAM16 isoform 1. (482 aa)
KPTNKPTN isoform 1. (435 aa)
MYH14MYH14 isoform 6; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1889 aa)
MKKSMcKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin; Probable molecular chaperone that assists the folding of proteins upon ATP hydrolysis. Plays a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. May play a role in protein processing in limb, cardiac and reproductive system development. May play a role in cytokinesis. (570 aa)
TMC2Transmembrane channel-like protein. (905 aa)
TSPEARTSPEAR isoform 1. (670 aa)
SLC19A1SLC19A1 isoform 5. (514 aa)
SLC5A1SLC5A1 isoform 1; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (663 aa)
MYH9MYH9 isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1959 aa)
PVALBPVALB isoform 1; Belongs to the parvalbumin family. (110 aa)
TRIOBPTRIOBP isoform 1. (2199 aa)
ELMOD3ELMOD3 isoform 14. (381 aa)
SLC3A1SLC3A1 isoform 1. (685 aa)
PLB1PLB1 isoform 2. (1458 aa)
SLC5A6Solute carrier family 5 member 6; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (636 aa)
MYO7BMYO7B isoform 2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2036 aa)
VIL1VIL1 isoform 1. (839 aa)
ACTR3Actin-related protein 3; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promote [...] (418 aa)
LRP2LRP2 isoform 1. (4512 aa)
MYO3BMYO3B isoform 3; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1306 aa)
CYBRD1Cytochrome b reductase 1; Ferric-chelate reductase that reduces Fe(3+) to Fe(2+). Present at the brush border of duodenal enterocytes where it probably reduces dietary Fe(3+) thereby facilitating its transport into the mucosal cells. Uses ascorbate as electron donor. May be involved in extracellular ascorbate recycling in erythrocyte membranes. May also act as a ferrireductase in airway epithelial cells (By similarity). (286 aa)
PJVKDFNB59 isoform 1. (352 aa)
MYO1BMYO1B isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (974 aa)
ESPNLESPNL isoform 1. (1002 aa)
TWF2Twinfilin-2; Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G- actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles. May play a role in regulating the mature length of the middle and short rows of stereocilia (By similarity); Belongs to the actin-binding proteins ADF family. Twinfilin subfamily. (349 aa)
SLC26A6SLC26A6 isoform 1. (737 aa)
SLC4A7Anion exchange protein. (1214 aa)
PLS1PLS1 isoform 1. (631 aa)
CLRN1CLRN1 isoform 2. (232 aa)
MMENeprilysin; Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of atrial natriuretic factor (ANF). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers. Belongs to the peptidase M13 family. (750 aa)
SISI isoform 1. (1776 aa)
SLC2A2Solute carrier family 2 member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (524 aa)
CR201_G0040852MFSD10 isoform 1. (469 aa)
DRD5Dopamine receptor D5; Belongs to the G-protein coupled receptor 1 family. (477 aa)
CLRN2CLRN2 isoform 1. (249 aa)
SLC34A2Sodium-dependent phosphate transport protein 2B; May be involved in actively transporting phosphate into cells via Na(+) cotransport. It may be the main phosphate transport protein in the intestinal brush border membrane. May have a role in the synthesis of surfactant in lungs' alveoli (By similarity). Belongs to the SLC34A transporter family. (690 aa)
GRXCR1GRXCR1 isoform 1. (231 aa)
ABCG2ABCG2 isoform 2. (625 aa)
MTTPMTTP isoform 1. (892 aa)
ENPEPAminopeptidase. (957 aa)
SLC7A11Cystine/glutamate transporter; Sodium-independent, high-affinity exchange of anionic amino acids with high specificity for anionic form of cystine and glutamate. (472 aa)
SLC9A3Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (805 aa)
SLC6A19Sodium-dependent neutral amino acid transporter B(0)AT1; Transporter that mediates resorption of neutral amino acids across the apical membrane of renal and intestinal epithelial cells. This uptake is sodium-dependent and chloride-independent. Requires CLTRN in kidney or ACE2 in intestine for cell surface expression and amino acid transporter activity. (551 aa)
ADGRV1ADGRV1 isoform 3; Belongs to the G-protein coupled receptor 2 family. (6076 aa)
SLC22A5SLC22A5 isoform 1. (557 aa)
SLC23A1SLC23A1 isoform 3. (599 aa)
GRXCR2Glutaredoxin and cysteine rich domain containing 2. (248 aa)
SLC34A1SLC34A1 isoform 3. (616 aa)
CDHR2CDHR2 isoform 1. (778 aa)
DCDC2Doublecortin domain containing 2. (476 aa)
RIPOR2T0162759 isoform 1. (1097 aa)
KNCNKNCN isoform 1. (123 aa)
CLIC1Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (241 aa)
ITPR3ITPR3 isoform 1. (2641 aa)
CLIC5Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (205 aa)
EZREZR isoform 1. (586 aa)
RSPH9RSPH9 isoform 2. (276 aa)
GNA12GNA12 isoform 1. (381 aa)
NPC1L1NPC1L1 isoform 2. (1326 aa)
AQP1Aquaporin-1; Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. (323 aa)
SCINSCIN isoform 3. (715 aa)
CD36CD36 isoform 15; Belongs to the CD36 family. (472 aa)
SLC26A4Pendrin; Sodium-independent transporter of chloride and iodide. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (778 aa)
SLC26A3Chloride anion exchanger; Chloride/bicarbonate exchanger. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (762 aa)
DOCK4DOCK4 isoform 1; Belongs to the DOCK family. (1958 aa)
CAPZA2F-actin-capping protein subunit alpha-2; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity). (286 aa)
ATP6V0A4V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (876 aa)
IDO1IDO1 isoform 1. (403 aa)
TRPA1TRPA1 isoform 1; Belongs to the transient receptor (TC 1.A.4) family. (1119 aa)
PLECPLEC isoform 2. (2298 aa)
B4GALT1Beta-1,4-galactosyltransferase 1. (398 aa)
TMC1Transmembrane channel-like protein. (761 aa)
SLC28A3Sodium/nucleoside cotransporter; Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family. (692 aa)
WHRNWHRN isoform 2. (907 aa)
RALGDSRALGDS isoform 4. (912 aa)
TPRNTPRN isoform 2. (404 aa)
CR201_G0049742SLC34A3 isoform 1. (395 aa)
ACE2Processed angiotensin-converting enzyme 2; Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator (By similarity). Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. By cleavage of angiotensin II, may be an important regulator of heart function (By similarity). By cleavage of angiotensin II, may also have a protective role in acute lung injury (By similarity). Plays an important role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 in [...] (802 aa)
CLTRNTMEM27 isoform 1. (247 aa)
ATP7AATPase copper transporting alpha. (1500 aa)
FLNAFLNA isoform 7. (2647 aa)
MPP155 kDa erythrocyte membrane protein; Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity (By similarity). Belongs to the MAGUK family. (466 aa)
ENSPPYP00000023721annotation not available (169 aa)
ENSPPYP00000023839annotation not available (519 aa)
EPS8L2Epidermal growth factor receptor kinase substrate 8-like protein 2; Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton (By similarity). In the cochlea, is required for stereocilia maintenance in adult hair cells (By similarity). (1531 aa)
ACTN3Actinin alpha 2/3. (388 aa)
SLC6A18Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (635 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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