STRINGSTRING
KCNK2 KCNK2 TNNI3 TNNI3 CR201_G0044109-2 CR201_G0044109-2 ENSPPYP00000024195 ENSPPYP00000024195 ENSPPYP00000024179 ENSPPYP00000024179 WNK1 WNK1 FLNA FLNA PDZD4 PDZD4 FGF13 FGF13 KCNE5 KCNE5 LOC112130990 LOC112130990 WNK3 WNK3 LRRC26 LRRC26 PHPT1 PHPT1 PTPN3 PTPN3 WNK2 WNK2 LOC100455662 LOC100455662 DPP6 DPP6 CFTR CFTR CAV1 CAV1 GRM3 GRM3 AKAP9 AKAP9 TSPAN13 TSPAN13 ENSPPYP00000019656 ENSPPYP00000019656 STX1A STX1A SGK1 SGK1 STX7 STX7 CRISP1 CRISP1 CRISP3 CRISP3 CRISP2 CRISP2 GPLD1 GPLD1 KCNIP1 KCNIP1 KCNMB1 KCNMB1 ADRB2 ADRB2 RASA1 RASA1 SCLT1 SCLT1 CAMK2D CAMK2D STIM2 STIM2 KCNIP4 KCNIP4 DLG1 DLG1 FGF12 FGF12 KCNMB3 KCNMB3 KCNMB2 KCNMB2 KCNAB1 KCNAB1 AMIGO3 AMIGO3 GRM2 GRM2 STIMATE STIMATE ITPR1 ITPR1 CAV3 CAV3 KCNE4 KCNE4 SUMO1 SUMO1 DPP10 DPP10 KCNS3 KCNS3 FKBP1B FKBP1B CALM1-2 CALM1-2 NRXN1 NRXN1 CR201_G0003257 CR201_G0003257 VAMP8 VAMP8 KCNIP3 KCNIP3 YWHAH YWHAH TMPRSS3 TMPRSS3 KCNE1 KCNE1 KCNE2 KCNE2 KCNS1 KCNS1 SGK2 SGK2 SNTA1 SNTA1 REM1 REM1 LRRC38 LRRC38 BSND BSND CACNG6 CACNG6 CACNG7 CACNG7 CABP5 CABP5 CR201_G0049100 CR201_G0049100 FXYD1 FXYD1 CR201_G0049093 CR201_G0049093 SCN1B SCN1B SLC9A3R1 SLC9A3R1 CACNG1 CACNG1 CACNG4 CACNG4 WNK4 WNK4 CNTD1 CNTD1 STX8 STX8 RANGRF RANGRF KCNAB3 KCNAB3 CR201_G0048088 CR201_G0048088 TRPV1 TRPV1 YWHAE YWHAE CIAO2B CIAO2B PRSS8 PRSS8 PRKCB PRKCB PRSS41 PRSS41 STOML1 STOML1 NEDD4 NEDD4 ARPP19 ARPP19 CHRNA7 CHRNA7 AKT1 AKT1 CALM1 CALM1 NRXN3 NRXN3 VTI1B VTI1B REM2 REM2 FGF14 FGF14 CR201_G0000897 CR201_G0000897 NOS1 NOS1 KCNMB4 KCNMB4 CACNB3 CACNB3 AMIGO2 AMIGO2 PKP2 PKP2 ABCC9 ABCC9 SCN3B SCN3B PDZD3 PDZD3 SCN2B SCN2B SCN4B SCN4B FXYD6 FXYD6 LOC103891919 LOC103891919 KCNE3 KCNE3 STIM1 STIM1 PACSIN3 PACSIN3 LRRC55 LRRC55 NRXN2 NRXN2 CABP4 CABP4 CABP2 CABP2 DRD4 DRD4 KCNIP2 KCNIP2 CR201_G0008310 CR201_G0008310 PRKG1 PRKG1 CR201_G0044958 CR201_G0044958 CR201_G0025573 CR201_G0025573 KCNAB2 KCNAB2 HPCAL4 HPCAL4 PCSK9 PCSK9 AMIGO1 AMIGO1 PIAS3 PIAS3 ENSA ENSA CR201_G0007169 CR201_G0007169 LRRC52 LRRC52 ATP2B4 ATP2B4 SLC30A1 SLC30A1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KCNK2Potassium two pore domain channel subfamily K member 2; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (411 aa)
TNNI3TNNI3 isoform 3. (210 aa)
CR201_G0044109-2RACK1 isoform 22. (230 aa)
ENSPPYP00000024195annotation not available (83 aa)
ENSPPYP0000002417914-3-3 protein epsilon-like isoform X1. (173 aa)
WNK1WNK1 isoform 4. (2694 aa)
FLNAFLNA isoform 7. (2647 aa)
PDZD4PDZD4 isoform 1. (673 aa)
FGF13Fibroblast growth factor 13; Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and stabilization of microtubules (By similarity). Through its action on microtubules, may participate to the refinement of axons by negatively regulating axonal and leading processes branching (By similarity). Plays a crucial role in neuron polarization and migration in the cerebral cortex and the hippocampus (By similarity). May regulate voltage-gated sodium channels transport and function (By similarity). May also play a role in MAPK signaling (By similarity). [...] (245 aa)
KCNE5Potassium voltage-gated channel subfamily E regulatory subunit 5. (142 aa)
LOC112130990Putative FXYD domain-containing ion transport regulator 8 isoform X1. (95 aa)
WNK3WNK3 isoform 2. (1777 aa)
LRRC26Leucine rich repeat containing 26. (338 aa)
PHPT114 kDa phosphohistidine phosphatase; Exhibits phosphohistidine phosphatase activity. Belongs to the janus family. (125 aa)
PTPN3Tyrosine-protein phosphatase non-receptor type; May act at junctions between the membrane and the cytoskeleton. (1024 aa)
WNK2WNK2 isoform 7. (2270 aa)
LOC100455662Calmodulin-alpha-like. (149 aa)
DPP6DPP6 isoform 3; Belongs to the peptidase S9B family. (784 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] (1480 aa)
CAV1Caveolin-1; Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt [...] (178 aa)
GRM3Metabotropic glutamate receptor 3; G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity (By similarity). (879 aa)
AKAP9AKAP9 isoform 1. (3770 aa)
TSPAN13TSPAN13 isoform 1; Belongs to the tetraspanin (TM4SF) family. (204 aa)
ENSPPYP00000019656annotation not available (239 aa)
STX1ASyntaxin-1A; Plays an essential role in hormone and neurotransmitter calcium-dependent exocytosis and endocytosis. Part of the SNARE (Soluble NSF Attachment Receptor) complex composed of SNAP25, STX1A and VAMP2 which mediates the fusion of synaptic vesicles with the presynaptic plasma membrane. STX1A and SNAP25 are localized on the plasma membrane while VAMP2 resides in synaptic vesicles. The pairing of the three SNAREs from the N-terminal SNARE motifs to the C-terminal anchors leads to the formation of the SNARE complex, which brings membranes into close proximity and results in final [...] (259 aa)
SGK1Non-specific serine/threonine protein kinase. (526 aa)
STX7Syntaxin-7; May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes (By similarity). (261 aa)
CRISP1Cysteine rich secretory protein 1; Belongs to the CRISP family. (249 aa)
CRISP3CRISP3 isoform 2; Belongs to the CRISP family. (245 aa)
CRISP2CRISP2 isoform 1; Belongs to the CRISP family. (212 aa)
GPLD1GPLD1 isoform 2. (779 aa)
KCNIP1Potassium voltage-gated channel interacting protein 1. (227 aa)
KCNMB1KCNMB1 isoform 1. (191 aa)
ADRB2Adrenoceptor beta 2. (415 aa)
RASA1RASA1 isoform 1. (1047 aa)
SCLT1SCLT1 isoform 1. (688 aa)
CAMK2DCAMK2D isoform 6. (524 aa)
STIM2STIM2 isoform 1. (694 aa)
KCNIP4KCNIP4 isoform 1. (213 aa)
DLG1DLG1 isoform 5; Belongs to the MAGUK family. (922 aa)
FGF12Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (242 aa)
KCNMB3KCNMB3 isoform 7. (256 aa)
KCNMB2T0034024 isoform 1. (235 aa)
KCNAB1Potassium voltage-gated channel subfamily A member regulatory beta subunit 1. (401 aa)
AMIGO3Adhesion molecule with Ig like domain 3. (504 aa)
GRM2GRM2 isoform 1. (811 aa)
STIMATETMEM110 isoform 2. (372 aa)
ITPR1ITPR1 isoform 3. (2769 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (196 aa)
KCNE4KCNE4 isoform 1. (170 aa)
SUMO1Small ubiquitin-related modifier 1; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post- translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for insta [...] (218 aa)
DPP10DPP10 isoform 7; Belongs to the peptidase S9B family. (776 aa)
KCNS3Potassium voltage-gated channel modifier subfamily S member 3; Belongs to the potassium channel family. (491 aa)
FKBP1BPeptidylprolyl isomerase. (108 aa)
CALM1-2Calmodulin 2. (149 aa)
NRXN1NRXN1 isoform 9. (1145 aa)
CR201_G0003257COMMD1 isoform 4. (146 aa)
VAMP8Vesicle-associated membrane protein 8; SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. VAMP8 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane via its interaction with the STX17-SNAP29 binary t- SNARE complex. Also required for dense-granule secretion in platelets. Plays als [...] (253 aa)
KCNIP3KCNIP3 isoform 1. (256 aa)
YWHAHTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta; Belongs to the 14-3-3 family. (246 aa)
TMPRSS3TMPRSS3 isoform 1; Belongs to the peptidase S1 family. (481 aa)
KCNE1Potassium voltage-gated channel subfamily E member 1; Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. Assembled with KCNQ1/KVLQT1 is proposed to form the slowly activating delayed rectifier cardiac potassium (IKs) channel. The outward current reaches its steady state only after 50 seconds. Assembled with K [...] (132 aa)
KCNE2Potassium voltage-gated channel subfamily E regulatory subunit 2. (123 aa)
KCNS1Potassium voltage-gated channel subfamily S member 1; Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1 and KCNB2; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2. Belongs to the potassium channel family. S (TC 1.A.1.2) subfamily. Kv9.1/KCNS1 sub-subfamily. (526 aa)
SGK2Serum/glucocorticoid-regulated kinase 2. (367 aa)
SNTA1SNTA1 isoform 1. (505 aa)
REM1GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (298 aa)
LRRC38LRRC38 isoform 1. (199 aa)
BSNDUncharacterized protein. (231 aa)
CACNG6Voltage-dependent calcium channel gamma-6 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (159 aa)
CACNG7Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (275 aa)
CABP5CABP5 isoform 1. (93 aa)
CR201_G0049100FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (166 aa)
FXYD1FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (92 aa)
CR201_G0049093FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (69 aa)
SCN1BSCN1B isoform 1. (218 aa)
SLC9A3R1Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (357 aa)
CACNG1Voltage-dependent calcium channel gamma-1 subunit; Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics. (222 aa)
CACNG4Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (268 aa)
WNK4WNK4 isoform 3. (642 aa)
CNTD1Cyclin N-terminal domain containing 1. (330 aa)
STX8STX8 isoform 2. (236 aa)
RANGRFRANGRF isoform 1. (186 aa)
KCNAB3KCNAB3 isoform 2. (405 aa)
CR201_G0048088Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (164 aa)
TRPV1TRPV1 isoform 1; Belongs to the transient receptor (TC 1.A.4) family. (837 aa)
YWHAETyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (255 aa)
CIAO2BFAM96B isoform 1. (441 aa)
PRSS8Serine protease 8; Belongs to the peptidase S1 family. (343 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
PRSS41Serine protease 41; Belongs to the peptidase S1 family. (318 aa)
STOML1STOML1 isoform 1. (398 aa)
NEDD4E3 ubiquitin-protein ligase. (937 aa)
ARPP19ARPP19 isoform 1; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. Belongs to the endosulfine family. (120 aa)
CHRNA7CHRNA7 isoform 8. (502 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (413 aa)
CALM1Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases (By similarity). Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity). (149 aa)
NRXN3NRXN3 isoform 6. (1060 aa)
VTI1BVesicle transport through interaction with t-SNAREs 1B. (232 aa)
REM2GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (340 aa)
FGF14Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (247 aa)
CR201_G0000897CABP1 isoform 4. (202 aa)
NOS1NOS1 isoform 2. (1456 aa)
KCNMB4Potassium calcium-activated channel subfamily M regulatory beta subunit 4. (210 aa)
CACNB3Calcium voltage-gated channel auxiliary subunit beta 3. (484 aa)
AMIGO2Amphoterin-induced protein 2; Required for depolarization-dependent survival of cultured cerebellar granule neurons. May mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. May contribute to signal transduction through its intracellular domain (By similarity). (522 aa)
PKP2PKP2 isoform 2. (829 aa)
ABCC9ABCC9 isoform 4. (1451 aa)
SCN3BSodium voltage-gated channel beta subunit 3. (215 aa)
PDZD3PDZ domain containing 3. (491 aa)
SCN2BSodium voltage-gated channel beta subunit 2. (215 aa)
SCN4BSodium voltage-gated channel beta subunit 4. (228 aa)
FXYD6FXYD domain-containing ion transport regulator 6. (95 aa)
LOC103891919Sodium/potassium-transporting ATPase subunit gamma isoform X1. (66 aa)
KCNE3Potassium voltage-gated channel subfamily E regulatory subunit 3. (103 aa)
STIM1Stromal interaction molecule 1. (685 aa)
PACSIN3Protein kinase C and casein kinase substrate in neurons 3. (424 aa)
LRRC55Leucine rich repeat containing 55. (341 aa)
NRXN2NRXN2 isoform 3. (1655 aa)
CABP4Calcium binding protein 4. (275 aa)
CABP2Calcium binding protein 2. (220 aa)
DRD4DRD4 isoform 1; Belongs to the G-protein coupled receptor 1 family. (417 aa)
KCNIP2KCNIP2 isoform 8. (284 aa)
CR201_G0008310PRKG1 isoform 3. (124 aa)
PRKG1PRKG1 isoform 4; Belongs to the protein kinase superfamily. (251 aa)
CR201_G0044958FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (82 aa)
CR201_G0025573Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (529 aa)
KCNAB2KCNAB2 isoform 13. (367 aa)
HPCAL4Hippocalcin-like protein 4; May be involved in the calcium-dependent regulation of rhodopsin phosphorylation; Belongs to the recoverin family. (211 aa)
PCSK9PCSK9 isoform 1. (809 aa)
AMIGO1Adhesion molecule with Ig like domain 1. (493 aa)
PIAS3PIAS3 isoform 3. (619 aa)
ENSAEndosulfine alpha. (137 aa)
CR201_G0007169SUMO1 isoform 5. (143 aa)
LRRC52Leucine rich repeat containing 52. (313 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1110 aa)
SLC30A1Solute carrier family 30 member 1. (507 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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