Your Input: | |
| | FSCN1 | FSCN1 isoform 3. (444 aa) |
| | STYXL1 | STYXL1 isoform 1. (303 aa) |
| | ENSPPYP00000020088 | annotation not available (138 aa) |
| | ARHGEF5 | ARHGEF35 isoform 1. (1585 aa) |
| | ENSPPYP00000020360 | annotation not available (272 aa) |
| | ENSPPYP00000020444 | annotation not available (45 aa) |
| | CHMP7 | Charged multivesicular body protein 7; ESCRT-III-like protein required to recruit the ESCRT-III complex to the nuclear envelope during late anaphase. Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase. Plays a role in the endosomal sorting pathway. (453 aa) |
| | VDAC3 | Voltage-dependent anion-selective channel protein 3; Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules; Belongs to the eukaryotic mitochondrial porin family. (283 aa) |
| | RP1 | RP1 axonemal microtubule associated. (2157 aa) |
| | SDCBP | SDCBP isoform 3. (297 aa) |
| | ENSPPYP00000020880 | annotation not available (223 aa) |
| | CHMP4C | Charged multivesicular body protein 4C. (233 aa) |
| | ENSPPYP00000021091 | annotation not available (270 aa) |
| | ASAP1 | ASAP1 isoform 2. (1079 aa) |
| | MAPK15 | MAPK15 isoform 3. (546 aa) |
| | TESK1 | TESK1 isoform 2. (369 aa) |
| | KIF24 | KIF24 isoform 2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1234 aa) |
| | CHMP5 | Charged multivesicular body protein 5; Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the [...] (219 aa) |
| | C9orf72 | C9orf72-SMCR8 complex subunit. (481 aa) |
| | SAXO1 | SAXO1 isoform 1. (477 aa) |
| | PTPRD | PTPRD isoform 1. (1682 aa) |
| | SNX30 | Sorting nexin family member 30. (437 aa) |
| | CDK5RAP2 | CDK5RAP2 isoform 3. (1893 aa) |
| | GSN | GSN isoform 1. (732 aa) |
| | LRSAM1 | LRSAM1 isoform 1. (689 aa) |
| | ENTR1 | SDCCAG3 isoform 2. (362 aa) |
| | ENSPPYP00000022408 | annotation not available (45 aa) |
| | CDKL5 | CDKL5 isoform 1. (1007 aa) |
| | ENSPPYP00000022712 | annotation not available (241 aa) |
| | UBQLN2 | UBQLN2 isoform 1. (624 aa) |
| | NBDY | Negative regulator of P-body association; Promotes dispersal of P-body components and is likely to play a role in the mRNA decapping process. (68 aa) |
| | MSN | MSN isoform 6. (577 aa) |
| | ENSPPYP00000022952 | annotation not available (197 aa) |
| | ENSPPYP00000023230 | annotation not available (111 aa) |
| | RNF4 | Ring finger protein 4. (190 aa) |
| | PIP4K2B | Phosphatidylinositol-5-phosphate 4-kinase type 2 beta. (435 aa) |
| | CNOT6 | CCR4-NOT transcription complex subunit 6. (559 aa) |
| | LRRK2 | LRRK2 isoform 3. (1560 aa) |
| | HNRNPU | HNRNPU isoform 9. (780 aa) |
| | SDCCAG8 | Serologically defined colon cancer antigen 8. (713 aa) |
| | RAB3GAP2 | RAB3GAP2 isoform 1. (1393 aa) |
| | TPR | TPR isoform 1. (1308 aa) |
| | PDE4DIP | PDE4DIP isoform 7. (2553 aa) |
| | SEC22B | Vesicle-trafficking protein SEC22b; SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER. (215 aa) |
| | KIAA1324 | KIAA1324 isoform 4. (1013 aa) |
| | GPSM2 | GPSM2 isoform 1. (684 aa) |
| | SASS6 | SAS-6 centriolar assembly protein. (657 aa) |
| | SNX7 | SNX7 isoform 1. (473 aa) |
| | CR201_G0042150 | ODF2L isoform 6. (759 aa) |
| | PRKAA2 | 5'-AMP-activated protein kinase catalytic subunit alpha-2; Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts a [...] (552 aa) |
| | STIL | STIL isoform 3. (1288 aa) |
| | TMEM39B | TMEM39B isoform 5. (424 aa) |
| | PINK1 | PTEN induced kinase 1. (581 aa) |
| | CROCC | CROCC isoform 3. (1866 aa) |
| | ENSPPYP00000002111 | LOW QUALITY PROTEIN: rootletin-like. (210 aa) |
| | WRAP73 | WRAP73 isoform 3. (460 aa) |
| | GDI2 | Rab GDP dissociation inhibitor beta; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. (445 aa) |
| | STAM | Signal transducing adaptor molecule. (540 aa) |
| | PIP4K2A | Phosphatidylinositol-5-phosphate 4-kinase type 2 alpha. (347 aa) |
| | TBC1D12 | TBC1D12 isoform 1. (772 aa) |
| | CR201_G0012618 | C10orf90 isoform 4. (555 aa) |
| | LRRC27 | LRRC27 isoform 3. (486 aa) |
| | LRFN4 | Leucine rich repeat and fibronectin type III domain containing 4. (635 aa) |
| | RBM14 | RNA-binding protein 14; May function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1. Regulates centriole biogenesis by suppressing the formation of aberrant centriolar protein complexes in the cytoplasm and thus preserving mitotic spindle integrity. Prevents the formation of the STIL-CENPJ complex (which can induce the formation of aberrant centriolar protein complexes) by interfering with the interaction of STIL with CENPJ. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the [...] (669 aa) |
| | ATG2A | ATG2A isoform 1. (1932 aa) |
| | EML3 | EML3 isoform 4. (868 aa) |
| | TSG101 | TSG101 isoform 4. (352 aa) |
| | NUMA1 | Nuclear mitotic apparatus protein 1. (2114 aa) |
| | CEP295 | CEP295 isoform 1. (2471 aa) |
| | YAP1 | YAP1 isoform 2. (326 aa) |
| | RDX | RDX isoform 3. (604 aa) |
| | VPS11 | Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family. (941 aa) |
| | FEZ1 | Fasciculation and elongation protein zeta 1. (392 aa) |
| | PAN2 | PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent [...] (1059 aa) |
| | PIP4K2C | Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma; May play an important role in the production of Phosphatidylinositol bisphosphate (PIP2), in the endoplasmic reticulum. (421 aa) |
| | TBC1D30 | TBC1 domain family member 30. (848 aa) |
| | MDM1 | Nuclear protein MDM1; Microtubule-binding protein that negatively regulates centriole duplication. Binds to and stabilizes microtubules. Belongs to the MDM1 family. (738 aa) |
| | CNOT2 | CNOT2 isoform 22. (466 aa) |
| | TCHP | Trichoplein keratin filament-binding protein; Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells (By similarity). Is a negative regulator of ciliogenesis (By similarity). Belongs to the TCHP family. (498 aa) |
| | MPHOSPH9 | MPHOSPH9 isoform 7. (1116 aa) |
| | ULK1 | Serine/threonine-protein kinase; Serine/threonine-protein kinase involved in autophagy in response to starvation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. (924 aa) |
| | IFT88 | IFT88 isoform 2. (768 aa) |
| | CENPJ | CENPJ isoform 2. (1290 aa) |
| | PAN3 | PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA deca [...] (741 aa) |
| | LCP1 | Lymphocyte cytosolic protein 1. (627 aa) |
| | CHMP4A | CHMP4A isoform 4. (258 aa) |
| | SCFD1 | SCFD1 isoform 1; Belongs to the STXBP/unc-18/SEC1 family. (644 aa) |
| | CDKL1 | CDKL1 isoform 1; Belongs to the protein kinase superfamily. (339 aa) |
| | SYNE2 | SYNE2 isoform 1. (6862 aa) |
| | MOAP1 | MOAP1 isoform 1. (351 aa) |
| | BBS4 | BBS4 isoform 3. (495 aa) |
| | SAXO2 | Stabilizer of axonemal microtubules 2. (398 aa) |
| | CR201_G0042289 | SAXO2 isoform 8. (448 aa) |
| | IFT140 | Intraflagellar transport 140. (1462 aa) |
| | CCP110 | Centriolar coiled-coil protein 110. (1012 aa) |
| | PLK1 | Serine/threonine-protein kinase PLK. (603 aa) |
| | RABEP2 | Rab GTPase-binding effector protein 2; Plays a role in membrane trafficking and in homotypic early endosome fusion. Participates in arteriogenesis by regulating vascular endothelial growth factor receptor 2/VEGFR2 cell surface expression and endosomal trafficking. By interacting with SDCCAG8, localizes to centrosomes and plays a critical role in ciliogenesis. (569 aa) |
| | NUPR1 | NUPR1 isoform 3. (68 aa) |
| | CBLN1 | Cerebellin 1 precursor. (193 aa) |
| | CYLD | Ubiquitin carboxyl-terminal hydrolase CYLD; Deubiquitinase that specifically cleaves 'Lys-63'- and linear 'Met-1'-linked polyubiquitin chains and is involved in NF-kappa-B activation and TNF-alpha-induced necroptosis. Plays an important role in the regulation of pathways leading to NF-kappa-B activation. Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation. Negative regulator of Wnt signaling. Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules. Plays a role in the regul [...] (956 aa) |
| | CNOT1 | CCR4-NOT transcription complex subunit 1. (2376 aa) |
| | ATMIN | ATMIN isoform 4. (667 aa) |
| | CHMP1A | Charged multivesicular body protein 1a; Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the [...] (196 aa) |
| | CDK10 | Cyclin dependent kinase 10; Belongs to the protein kinase superfamily. (360 aa) |
| | CR201_G0048121 | PHF23 isoform 2. (264 aa) |
| | CNTROB | Centrobin, centriole duplication and spindle assembly protein. (903 aa) |
| | IFT20 | IFT20 isoform 6. (158 aa) |
| | ENSPPYP00000009110 | Uncharacterized serine/threonine-protein kinase SgK494. (274 aa) |
| | BECN1 | Beclin-1-C 35 kDa; Plays a central role in autophagy. Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3- phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex f [...] (452 aa) |
| | HAP1 | HAP1 isoform 2. (662 aa) |
| | CR201_G0024013 | WIPI1 isoform 2. (251 aa) |
| | CR201_G0021476 | SEPT9 isoform 10; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (273 aa) |
| | NPTX1 | Neuronal pentraxin 1. (432 aa) |
| | CHMP6 | Charged multivesicular body protein 6; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function [...] (178 aa) |
| | TRIM37 | TRIM37 isoform 1. (946 aa) |
| | SEPT9 | SEPT9 isoform 29; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (186 aa) |
| | ABI3 | ABI3 isoform 1. (366 aa) |
| | CEP76 | Centrosomal protein of 76 kDa; Centrosomal protein involved in regulation of centriole duplication. Required to limit centriole duplication to once per cell cycle by preventing centriole reduplication (By similarity). (659 aa) |
| | SMAD4 | Mothers against decapentaplegic homolog. (552 aa) |
| | PTPRS | PTPRS isoform 2. (1616 aa) |
| | EVI5L | EVI5L isoform 1. (708 aa) |
| | DNM2 | DNM2 isoform 6; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (866 aa) |
| | CCDC151 | CCDC151 isoform 4. (595 aa) |
| | LRFN1 | LRFN1 isoform 1. (771 aa) |
| | ENSPPYP00000011173 | annotation not available (222 aa) |
| | MARK4 | Non-specific serine/threonine protein kinase. (744 aa) |
| | ARHGAP35 | Rho GTPase activating protein 35. (1513 aa) |
| | FUZ | Fuzzy planar cell polarity protein. (418 aa) |
| | NUP62 | NUP62 isoform 1. (521 aa) |
| | CHMP2A | CHMP2A isoform 1. (222 aa) |
| | ENSPPYP00000011890 | annotation not available (224 aa) |
| | ENSPPYP00000011927 | annotation not available (116 aa) |
| | ENSPPYP00000011942 | annotation not available (117 aa) |
| | HCK | Tyrosine-protein kinase. (449 aa) |
| | CHMP4B | CHMP4B isoform 1. (210 aa) |
| | SRC | Tyrosine-protein kinase. (553 aa) |
| | SDC4 | Syndecan-4; Cell surface proteoglycan that bears heparan sulfate. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP. Belongs to the syndecan proteoglycan family. (198 aa) |
| | MTMR3 | Myotubularin related protein 3. (1198 aa) |
| | CR201_G0024533 | LIMK2 isoform 3. (579 aa) |
| | KCTD17 | Potassium channel tetramerization domain containing 17. (321 aa) |
| | CHMP3 | Charged multivesicular body protein 3; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function [...] (222 aa) |
| | ALMS1 | ALMS1 isoform 2. (4160 aa) |
| | NOTO | NOTO isoform 1. (243 aa) |
| | WDPCP | WDPCP isoform 4. (745 aa) |
| | CCDC88A | CCDC88A isoform 1. (1797 aa) |
| | NRXN1 | NRXN1 isoform 9. (1145 aa) |
| | DYNC2LI1 | DYNC2LI1 isoform 1. (334 aa) |
| | SDC1 | Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (310 aa) |
| | TRAPPC12 | Trafficking protein particle complex 12. (736 aa) |
| | FEZ2 | FEZ2 isoform 2. (379 aa) |
| | RAB3GAP1 | RAB3GAP1 isoform 3. (975 aa) |
| | ENSPPYP00000014638 | annotation not available (242 aa) |
| | PIKFYVE | PIKFYVE isoform 1. (2088 aa) |
| | SNX4 | Sorting nexin-4; Involved in the regulation of endocytosis and in several stages of intracellular trafficking. Plays a role in recycling endocytosed transferrin receptor and prevent its degradation. Belongs to the sorting nexin family. (450 aa) |
| | GSK3B | GSK3B isoform 2; Belongs to the protein kinase superfamily. (380 aa) |
| | ADPRH | ADPRH isoform 1. (357 aa) |
| | TMEM39A | Transmembrane protein 39A. (488 aa) |
| | SPICE1 | Spindle and centriole-associated protein 1; Regulator required for centriole duplication, for proper bipolar spindle formation and chromosome congression in mitosis. (855 aa) |
| | ATG3 | Autophagy-related protein 3. (313 aa) |
| | CEP97 | Centrosomal protein 97. (865 aa) |
| | CHMP2B | Charged multivesicular body protein 2b; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential functio [...] (213 aa) |
| | CAV3 | Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (196 aa) |
| | ZMYND10 | Zinc finger MYND domain-containing protein 10; Plays a role in axonemal structure organization and motility. Involved in axonemal pre-assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility. May act by indirectly regulating transcription of dynein proteins. Belongs to the ZMYND10 family. (474 aa) |
| | RHOA | Transforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essent [...] (196 aa) |
| | MAP4 | Microtubule-associated protein. (1126 aa) |
| | KIF9 | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (790 aa) |
| | KIF15 | Kinesin family member 15; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1388 aa) |
| | PDCD6IP | PDCD6IP isoform 2. (945 aa) |
| | KAT2B | Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (755 aa) |
| | RAB5A | RAB5A, member RAS oncogene family. (215 aa) |
| | TCTEX1D2 | TCTEX1D2 isoform 2. (142 aa) |
| | HTT | HTT isoform 1. (3130 aa) |
| | TAPT1 | TAPT1 isoform 2. (532 aa) |
| | CEP135 | CEP135 isoform 2. (1140 aa) |
| | G3BP2 | Ras GTPase-activating protein-binding protein 2; Scaffold protein that plays an essential role in cytoplasmic stress granule formation which acts as a platform for antiviral signaling. (482 aa) |
| | CNOT6L | CNOT6L isoform 1. (550 aa) |
| | GRID2 | GRID2 isoform 1. (926 aa) |
| | INTU | INTU isoform 1. (942 aa) |
| | PLK4 | Serine/threonine-protein kinase PLK4; Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit [...] (970 aa) |
| | ADAMTS16 | ADAM metallopeptidase with thrombospondin type 1 motif 16. (1224 aa) |
| | PRKAA1 | 5'-AMP-activated protein kinase catalytic subunit alpha-1; Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts a [...] (559 aa) |
| | SNX18 | Sorting nexin. (624 aa) |
| | PLK2 | Serine/threonine-protein kinase PLK2; Tumor suppressor serine/threonine-protein kinase involved in synaptic plasticity, centriole duplication and G1/S phase transition. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates CENPJ, NPM1, RAPGEF2, RASGRF1, SNCA, SIPA1L1 and SYNGAP1. Plays a key role in synaptic plasticity and memory by regulating the Ras and Rap protein signaling: required for overactivity-dependent spine remodeling by phosphorylating the Ras activator RASGRF1 an [...] (685 aa) |
| | CEP120 | Centrosomal protein 120. (986 aa) |
| | CSF2 | Colony stimulating factor 2. (144 aa) |
| | IL5 | Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa) |
| | LRRTM2 | Leucine rich repeat transmembrane neuronal 2. (516 aa) |
| | G3BP1 | Ras GTPase-activating protein-binding protein 1; ATP- and magnesium-dependent helicase that plays an essential role in innate immunity. Participates in the DNA-triggered cGAS/STING pathway by promoting the DNA binding and activation of CGAS. Enhances also DDX58-induced type I interferon production probably by helping DDX58 at sensing pathogenic RNA. In addition, plays an essential role in stress granule formation. Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends. Unwinds DNA/DNA, RN [...] (466 aa) |
| | NPM1 | NPM1 isoform 1. (274 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (424 aa) |
| | MAK | MAK isoform 1. (530 aa) |
| | TBC1D7 | TBC1 domain family member 7. (293 aa) |
| | DCDC2 | Doublecortin domain containing 2. (476 aa) |
| | TNF | Tumor necrosis factor ligand 1F; Belongs to the tumor necrosis factor family. (233 aa) |
| | HSPA1A | Heat shock 70 kDa protein 1; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP [...] (641 aa) |
| | EHMT2 | EHMT2 isoform 5. (1267 aa) |
| | RNF5 | Ring finger protein 5. (180 aa) |
| | SENP6 | SENP6 isoform 3. (1110 aa) |
| | ATG5 | Autophagy protein 5; Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3- like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is ess [...] (275 aa) |
| | EZR | EZR isoform 1. (586 aa) |
| | CR201_G0048550 | PPP1R35 isoform 3. (127 aa) |
