STRINGSTRING
LDLRAP1 LDLRAP1 CNPY4 CNPY4 CR201_G0044109-2 CR201_G0044109-2 EPM2A EPM2A EPHB2 EPHB2 ACSL3 ACSL3 DKFZp468G2216 DKFZp468G2216 WNK3 WNK3 CR201_G0052920 CR201_G0052920 RACK1 RACK1 ANXA13 ANXA13 ZDHHC2 ZDHHC2 CDK5 CDK5 RAMP3 RAMP3 EGFR EGFR ACTB ACTB EZR EZR STX7 STX7 GOPC GOPC MRAP2 MRAP2 TREM2 TREM2 TNF TNF NHLRC1 NHLRC1 PIK3R1 PIK3R1 DAB2 DAB2 NKD2 NKD2 DLG1 DLG1 LRRC15 LRRC15 AP2M1 AP2M1 PRKCI PRKCI PLS1 PLS1 ATP2C1 ATP2C1 STAC STAC APPL1 APPL1 EPHA3 EPHA3 PID1 PID1 VIL1 VIL1 TMBIM1 TMBIM1 R3HDM1 R3HDM1 LYPD1 LYPD1 DPP10 DPP10 PKDCC PKDCC PRKCE PRKCE RHOQ RHOQ NRXN1 NRXN1 SPTBN1 SPTBN1 VAMP8 VAMP8 MRAP MRAP BCL2L1 BCL2L1 PRNP PRNP TGFB1 TGFB1 CLIP3 CLIP3 CR201_G0037390 CR201_G0037390 PPP1R9B PPP1R9B ITGA3 ITGA3 ABI3 ABI3 CLTC CLTC STAC2 STAC2 ARHGAP44 ARHGAP44 STX8 STX8 RANGRF RANGRF ZDHHC7 ZDHHC7 VPS4A VPS4A STX4 STX4 CLN3 CLN3 PDPK1 PDPK1 CR201_G0014777 CR201_G0014777 PTPN9 PTPN9 CSK CSK AKT1 AKT1 NUMB NUMB VTI1B VTI1B AKAP5 AKAP5 LGALS3 LGALS3 ARF6 ARF6 HECTD1 HECTD1 MMP14 MMP14 R3HDM2 R3HDM2 LRP1 LRP1 GRASP GRASP PICALM PICALM RHOG RHOG CSRP3 CSRP3 ZDHHC5 ZDHHC5 STX3 STX3 SORBS1 SORBS1 ENSPPYP00000002577 ENSPPYP00000002577 ITGB1 ITGB1 KIF5B KIF5B CR201_G0044109 CR201_G0044109 ARHGEF16 ARHGEF16 EPHA2 EPHA2 TMEM59 TMEM59 GBP1 GBP1 ATP2B4 ATP2B4 PPP2R5A PPP2R5A WNT3A WNT3A CNST CNST
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LDLRAP1LDLRAP1 isoform 1. (308 aa)
CNPY4Canopy FGF signaling regulator 4. (257 aa)
CR201_G0044109-2RACK1 isoform 22. (230 aa)
EPM2AEPM2A glucan phosphatase, laforin. (331 aa)
EPHB2EPHB2 isoform 2. (792 aa)
ACSL3Long-chain-fatty-acid--CoA ligase 3; Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta- oxidation (By similarity). ACSL3 is required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins) (By similarity). Has mainly an anabolic role in energy metabolism. Mediates hepatic lipogenesis. Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates. Both isoforms exhibit the same level of activity [...] (720 aa)
DKFZp468G2216AR isoform 8. (388 aa)
WNK3WNK3 isoform 2. (1777 aa)
CR201_G0052920GRIPAP1 isoform 14. (643 aa)
RACK1RACK1 isoform 13. (372 aa)
ANXA13Annexin. (355 aa)
ZDHHC2Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (367 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
RAMP3Receptor activity modifying protein 3. (148 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
ACTBActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa)
EZREZR isoform 1. (586 aa)
STX7Syntaxin-7; May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes (By similarity). (261 aa)
GOPCGolgi-associated PDZ and coiled-coil motif-containing protein; Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes (By similarity). (445 aa)
MRAP2MRAP2 isoform 1. (181 aa)
TREM2TREM2 isoform 1. (202 aa)
TNFTumor necrosis factor ligand 1F; Belongs to the tumor necrosis factor family. (233 aa)
NHLRC1NHL repeat containing E3 ubiquitin protein ligase 1. (395 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha; Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling. Modulates the cellular response to ER stress by promoting nuclear translocation [...] (723 aa)
DAB2DAB adaptor protein 2. (770 aa)
NKD2NKD2 isoform 1. (455 aa)
DLG1DLG1 isoform 5; Belongs to the MAGUK family. (922 aa)
LRRC15Leucine rich repeat containing 15. (581 aa)
AP2M1AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...] (435 aa)
PRKCIProtein kinase C iota type; Calcium- and diacylglycerol-independent serine/ threonine- protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis. In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell death process [...] (690 aa)
PLS1PLS1 isoform 1. (631 aa)
ATP2C1Calcium-transporting ATPase type 2C member 1; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium. (949 aa)
STACSH3 and cysteine rich domain. (402 aa)
APPL1APPL1 isoform 1. (708 aa)
EPHA3EPHA3 isoform 1. (983 aa)
PID1PID1 isoform 1. (267 aa)
VIL1VIL1 isoform 1. (839 aa)
TMBIM1Transmembrane BAX inhibitor motif containing 1; Belongs to the BI1 family. (311 aa)
R3HDM1R3HDM1 isoform 1. (1100 aa)
LYPD1LYPD1 isoform 2. (141 aa)
DPP10DPP10 isoform 7; Belongs to the peptidase S9B family. (776 aa)
PKDCCPKDCC isoform 1. (281 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
RHOQRHOQ isoform 1. (228 aa)
NRXN1NRXN1 isoform 9. (1145 aa)
SPTBN1Spectrin beta chain; Belongs to the spectrin family. (2342 aa)
VAMP8Vesicle-associated membrane protein 8; SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. VAMP8 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane via its interaction with the STX17-SNAP29 binary t- SNARE complex. Also required for dense-granule secretion in platelets. Plays als [...] (253 aa)
MRAPMRAP isoform 4. (101 aa)
BCL2L1BCL2L1 isoform 2. (233 aa)
PRNPMajor prion protein; Belongs to the prion family. (253 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (386 aa)
CLIP3CAP-Gly domain-containing linker protein 3; Functions as a cytoplasmic linker protein. Involved in TGN- endosome dynamics. May modulate the cellular compartmentalization of AKT kinase family and promote its cell membrane localization, thereby playing a role in glucose transport in adipocytes (By similarity). (547 aa)
CR201_G0037390PIK3R2 isoform 1. (641 aa)
PPP1R9BPPP1R9B isoform 1. (729 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1051 aa)
ABI3ABI3 isoform 1. (366 aa)
CLTCClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1675 aa)
STAC2SH3 and cysteine rich domain 2. (411 aa)
ARHGAP44ARHGAP44 isoform 2. (736 aa)
STX8STX8 isoform 2. (236 aa)
RANGRFRANGRF isoform 1. (186 aa)
ZDHHC7Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (308 aa)
VPS4AVPS4A isoform 1; Belongs to the AAA ATPase family. (437 aa)
STX4STX4 isoform 4; Belongs to the syntaxin family. (296 aa)
CLN3Battenin. (438 aa)
PDPK1PDPK1 isoform 1. (495 aa)
CR201_G0014777CIB1 isoform 1. (190 aa)
PTPN9PTPN9 isoform 1. (619 aa)
CSKTyrosine-protein kinase. (437 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (413 aa)
NUMBNUMB endocytic adaptor protein. (651 aa)
VTI1BVesicle transport through interaction with t-SNAREs 1B. (232 aa)
AKAP5A-kinase anchoring protein 5. (427 aa)
LGALS3Galectin. (309 aa)
ARF6ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
HECTD1HECT domain E3 ubiquitin protein ligase 1. (2610 aa)
MMP14Matrix metalloproteinase-14; Endopeptidase that degrades various components of the extracellular matrix, such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15 in association with pro-MMP2. Involved in the formation of the fibrovascular tissues in association with pro-MMP2. Cleaves ADGRB1 to release vasculostatin-40 which i [...] (582 aa)
R3HDM2R3HDM2 isoform 2. (1150 aa)
LRP1LRP1 isoform 1. (4377 aa)
GRASPGRASP isoform 4. (394 aa)
PICALMPICALM isoform 11. (686 aa)
RHOGRas homolog family member G. (191 aa)
CSRP3CSRP3 isoform 1. (233 aa)
ZDHHC5Palmitoyltransferase ZDHHC5; Palmitoyl acyltransferase for the G-protein coupled receptor SSTR5 and for FLOT2; Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily. (715 aa)
STX3STX3 isoform 3; Belongs to the syntaxin family. (289 aa)
SORBS1SORBS1 isoform 10. (1292 aa)
ENSPPYP00000002577annotation not available (662 aa)
ITGB1Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] (887 aa)
KIF5BKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (964 aa)
CR201_G0044109RACK1 isoform 5. (346 aa)
ARHGEF16ARHGEF16 isoform 1. (683 aa)
EPHA2EPHA2 isoform 1. (959 aa)
TMEM59Transmembrane protein 59; Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy. Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. Inhibits APP transport to the cell surface and further shedding. (323 aa)
GBP1Guanylate-binding protein 1; Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promotes oxidative killing and delivers antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes (By similarity). (590 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1110 aa)
PPP2R5ASerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (486 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (385 aa)
CNSTCNST isoform 1. (690 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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