STRINGSTRING
PCSK9 PCSK9 ATP1B1 ATP1B1 ENSPPYP00000024195 ENSPPYP00000024195 NETO1 NETO1 WNK4 WNK4 SLC9A3R1 SLC9A3R1 GRP GRP DNM2 DNM2 SCN1B SCN1B FXYD1 FXYD1 YWHAH YWHAH PRKCE PRKCE OSR1 OSR1 STK39 STK39 CAV3 CAV3 SLMAP SLMAP KLHL24 KLHL24 FGF12 FGF12 CAMK2D CAMK2D GLRX GLRX UTRN UTRN HECW1 HECW1 WNK2 WNK2 PTPN3 PTPN3 STOM STOM DMD DMD WNK3 WNK3 WNK1 WNK1 HECW2 HECW2 RANGRF RANGRF CR201_G0048088 CR201_G0048088 NETO2 NETO2 CHP2 CHP2 NEDD4 NEDD4 CHP1 CHP1 FGF14 FGF14 TESC TESC SCN3B SCN3B SCN2B SCN2B SCN4B SCN4B LOC103891919 LOC103891919 KCNQ1 KCNQ1 DRD4 DRD4 ANK3 ANK3 SLC9A1 SLC9A1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PCSK9PCSK9 isoform 1. (809 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta-1; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane (By similarity). (303 aa)
ENSPPYP00000024195annotation not available (83 aa)
NETO1Neuropilin and tolloid like 1. (533 aa)
WNK4WNK4 isoform 3. (642 aa)
SLC9A3R1Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (357 aa)
GRPGastrin releasing peptide. (142 aa)
DNM2DNM2 isoform 6; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (866 aa)
SCN1BSCN1B isoform 1. (218 aa)
FXYD1FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (92 aa)
YWHAHTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta; Belongs to the 14-3-3 family. (246 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
OSR1OSR1 isoform 1. (265 aa)
STK39STK39 isoform 1. (546 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (196 aa)
SLMAPSLMAP isoform 6. (825 aa)
KLHL24Kelch like family member 24. (600 aa)
FGF12Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (242 aa)
CAMK2DCAMK2D isoform 6. (524 aa)
GLRXGLRX isoform 1. (106 aa)
UTRNUTRN isoform 2. (3433 aa)
HECW1HECW1 isoform 1. (1608 aa)
WNK2WNK2 isoform 7. (2270 aa)
PTPN3Tyrosine-protein phosphatase non-receptor type; May act at junctions between the membrane and the cytoskeleton. (1024 aa)
STOMSTOM isoform 3. (288 aa)
DMDDMD isoform 3. (3618 aa)
WNK3WNK3 isoform 2. (1777 aa)
WNK1WNK1 isoform 4. (2694 aa)
HECW2HECW2 isoform 3. (1572 aa)
RANGRFRANGRF isoform 1. (186 aa)
CR201_G0048088Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (164 aa)
NETO2NETO2 isoform 1. (525 aa)
CHP2Calcineurin like EF-hand protein 2. (196 aa)
NEDD4E3 ubiquitin-protein ligase. (937 aa)
CHP1Calcineurin B homologous protein 1; Calcium-binding protein involved in different processes such as regulation of vesicular trafficking, plasma membrane Na(+)/H(+) exchanger and gene transcription. Involved in the constitutive exocytic membrane traffic. Mediates the association between microtubules and membrane-bound organelles of the endoplasmic reticulum and Golgi apparatus and is also required for the targeting and fusion of transcytotic vesicles (TCV) with the plasma membrane. Functions as an integral cofactor in cell pH regulation by controlling plasma membrane- type Na(+)/H(+) ex [...] (195 aa)
FGF14Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (247 aa)
TESCTESC isoform 2. (214 aa)
SCN3BSodium voltage-gated channel beta subunit 3. (215 aa)
SCN2BSodium voltage-gated channel beta subunit 2. (215 aa)
SCN4BSodium voltage-gated channel beta subunit 4. (228 aa)
LOC103891919Sodium/potassium-transporting ATPase subunit gamma isoform X1. (66 aa)
KCNQ1KCNQ1 isoform 3; Belongs to the potassium channel family. (301 aa)
DRD4DRD4 isoform 1; Belongs to the G-protein coupled receptor 1 family. (417 aa)
ANK3ANK3 isoform 1. (4275 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (815 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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