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| | RBCK1 | RBCK1 isoform 5. (509 aa) |
| | DDB1 | DNA damage-binding protein 1; Required for DNA repair. Binds to DDB2 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiqui [...] (1135 aa) |
| | DDB2 | Damage specific DNA binding protein 2. (427 aa) |
| | AMBRA1 | AMBRA1 isoform 3. (1241 aa) |
| | USP47 | Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1375 aa) |
| | ANAPC15 | ANAPC15 isoform 10. (121 aa) |
| | KLHL35 | KLHL35 isoform 1. (437 aa) |
| | UBE4A | Ubiquitin conjugation factor E4 A; Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates. (1072 aa) |
| | FLI1 | FLI1 isoform 1. (466 aa) |
| | ENSPPYP00000004644 | annotation not available (118 aa) |
| | FBXL14 | FBXL14 isoform 1. (418 aa) |
| | PHC1 | PHC1 isoform 2. (1020 aa) |
| | CDKN1B | Cyclin dependent kinase inhibitor 1B. (198 aa) |
| | KLHL42 | Kelch like family member 42. (505 aa) |
| | OS9 | OS9 isoform 1. (611 aa) |
| | CAND1 | Cullin-associated NEDD8-dissociated protein 1; Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate- recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. The exchange activity of CAND1 is coupled with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1, increasing dissociation of the SCF complex and promoting exchange of the F-box protein. Probably plays a similar [...] (1230 aa) |
| | DYRK2 | Dual specificity tyrosine phosphorylation regulated kinase 2. (601 aa) |
| | UBE2N | Ubiquitin-conjugating enzyme E2 N; The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly- ubiquitination of [...] (152 aa) |
| | KCTD10 | Potassium channel tetramerization domain containing 10. (315 aa) |
| | BRAP | BRAP isoform 1. (528 aa) |
| | FBXW8 | FBXW8 isoform 2. (596 aa) |
| | FBXO21 | F-box only protein 21; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. (621 aa) |
| | ANAPC5 | Anaphase-promoting complex subunit 5; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). (755 aa) |
| | ENSPPYP00000005897 | annotation not available (603 aa) |
| | KBTBD6 | Kelch repeat and BTB domain containing 6. (674 aa) |
| | KBTBD7 | Kelch repeat and BTB domain containing 7. (684 aa) |
| | SUGT1 | SGT1 homolog, MIS12 kinetochore complex assembly cochaperone. (333 aa) |
| | LMO7 | LMO7 isoform 6. (1670 aa) |
| | FBXL3 | F-box and leucine rich repeat protein 3. (428 aa) |
| | CUL4A | CUL4A isoform 5; Belongs to the cullin family. (759 aa) |
| | CDC16 | CDC16 isoform 4. (575 aa) |
| | DCAF11 | DDB1- and CUL4-associated factor 11; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. (523 aa) |
| | RNF31 | T0114761 isoform 1. (1053 aa) |
| | FBXO33 | F-box protein 33. (555 aa) |
| | KLHDC1 | KLHDC1 isoform 3. (317 aa) |
| | KLHDC2 | Kelch domain containing 2. (406 aa) |
| | CR201_G0009767 | HIF1A isoform 5. (735 aa) |
| | DCAF5 | DDB1 and CUL4 associated factor 5. (942 aa) |
| | DCAF4 | DCAF4 isoform 2. (428 aa) |
| | SEL1L | SEL1L isoform 1. (738 aa) |
| | ASB2 | ASB2 isoform 6. (553 aa) |
| | BUB1B | Mitotic checkpoint serine/threonine-protein kinase BUB1 beta. (1050 aa) |
| | RAD51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa) |
| | FBXL22 | FBXL22 isoform 1. (234 aa) |
| | FEM1B | FEM1B isoform 1. (627 aa) |
| | KLHL25 | KLHL25 isoform 1. (558 aa) |
| | DET1 | DET1 isoform 5. (472 aa) |
| | STUB1 | STIP1 homology and U-box containing protein 1. (303 aa) |
| | TRAF7 | TNF receptor associated factor 7. (670 aa) |
| | CCNF | CCNF isoform 1; Belongs to the cyclin family. (783 aa) |
| | ELOB | ELOB isoform 1. (160 aa) |
| | KCTD13 | Potassium channel tetramerization domain containing 13. (329 aa) |
| | RNF40 | E3 ubiquitin-protein ligase BRE1B; Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradic [...] (1001 aa) |
| | FBXL19 | FBXL19 isoform 3. (630 aa) |
| | LRRC29 | LRRC29 isoform 3. (223 aa) |
| | RANBP10 | RAN binding protein 10. (619 aa) |
| | CHTF8 | Chromosome transmission fidelity factor 8. (121 aa) |
| | WWP2 | E3 ubiquitin-protein ligase. (874 aa) |
| | GAN | GAN isoform 1. (647 aa) |
| | FBXO31 | FBXO31 isoform 4. (610 aa) |
| | NCBP3 | NCBP3 isoform 1. (632 aa) |
| | GID4 | GID complex subunit 4 homolog. (300 aa) |
| | TNFAIP1 | BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(TNFAIP1) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA- dependent DNA polymerase delta activity (By similarity). (315 aa) |
| | BRCA1 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1863 aa) |
| | PCGF2 | PCGF2 isoform 1. (347 aa) |
| | APPBP2 | Amyloid beta precursor protein binding protein 2. (585 aa) |
| | SMURF2 | E3 ubiquitin-protein ligase. (877 aa) |
| | CR201_G0021349 | KCTD2 isoform 7. (185 aa) |
| | RBFOX3 | RBFOX3 isoform 4. (317 aa) |
| | CR201_G0021544 | CBX2 isoform 1. (184 aa) |
| | CBX4 | CBX4 isoform 2. (494 aa) |
| | SPOP | Speckle-type POZ protein; Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. In complex with CUL3, involved in ubiquitination and proteasomal degradation of BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. In complex with CUL3, involved in ubiquitination of MACROH2A1 and BMI1; this does not lead to their proteasomal degradation. Inhibits transcriptional activation of PDX1/IPF1 targets, such as insulin, by promoting PDX1/IPF1 degradation. The cullin-RING- [...] (374 aa) |
| | CDC27 | CDC27 isoform 1. (824 aa) |
| | ENSPPYP00000010071 | annotation not available (610 aa) |
| | FZR1 | FZR1 isoform 4. (420 aa) |
| | FEM1A | FEM1A isoform 1. (581 aa) |
| | FBXL12 | F-box and leucine rich repeat protein 12. (326 aa) |
| | KEAP1 | Kelch-like ECH-associated protein 1; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting NFE2L2/NRF2 for ubiquitination. KEAP1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradation of NFE2L2/NRF2, a transcription factor regulating expression of many cytoprotective genes. In response to oxidative stress, different electrophile metabolites trigger non-enzymatic covalent modifications of highly reactive cysteine [...] (624 aa) |
| | DCAF15 | DCAF15 isoform 1. (567 aa) |
| | DDA1 | DET1- and DDB1-associated protein 1; May be involved in ubiquitination and subsequent proteasomal degradation of target proteins. Component of the DDD-E2 complexes which may provide a platform for interaction with CUL4A and WD repeat proteins (By similarity); Belongs to the DDA1 family. (102 aa) |
| | KLHL26 | KLHL26 isoform 1. (614 aa) |
| | FBXO17 | F-box only protein 17. (278 aa) |
| | FBXO27 | FBXO27 isoform 2. (267 aa) |
| | UBE2S | UBE2S isoform 1; Belongs to the ubiquitin-conjugating enzyme family. (222 aa) |
| | ENSPPYP00000011752 | annotation not available (89 aa) |
| | ZSWIM4 | ZSWIM4 isoform 2. (663 aa) |
| | ENSPPYP00000011890 | annotation not available (224 aa) |
| | CR201_G0055582 | PRAMEF5 isoform 1. (476 aa) |
| | ENSPPYP00000011914 | annotation not available (334 aa) |
| | LOC100448423 | PRAMEF25 isoform 2. (478 aa) |
| | CR201_G0056130 | PRAMEF27 isoform 1. (476 aa) |
| | LOC100431880 | PRAMEF15 isoform 1. (477 aa) |
| | TRPC4AP | Transient receptor potential cation channel subfamily C member 4 associated protein. (797 aa) |
| | UBE2C | Ubiquitin conjugating enzyme E2 C; Belongs to the ubiquitin-conjugating enzyme family. (179 aa) |
| | TMEM189-UBE2V1 | Ubiquitin-conjugating enzyme E2 variant 1; Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly- ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF- kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repa [...] (329 aa) |
| | GID8 | GID8 isoform 1. (200 aa) |
| | ENSPPYP00000012602 | annotation not available (613 aa) |
| | CR201_G0047492 | PRAME isoform 2. (377 aa) |
| | DERL3 | Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (231 aa) |
| | CR201_G0024440 | RHBDD3 isoform 1. (237 aa) |
| | KCTD17 | Potassium channel tetramerization domain containing 17. (321 aa) |
| | RBX1 | RBX1 isoform 1. (108 aa) |
| | LZTR1 | Leucine-zipper-like transcriptional regulator 1; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates ubiquitination of Ras (K-Ras/KRAS, N-Ras/NRAS and H-Ras/HRAS). Is a negative regulator of RAS-MAPK signaling that acts by controlling Ras levels and decreasing Ras association with membranes. (820 aa) |
| | ANAPC1 | ANAPC1 isoform 2. (1855 aa) |
| | AUP1 | AUP1 lipid droplet regulating VLDL assembly factor. (410 aa) |
| | PCGF1 | Polycomb group ring finger 1. (259 aa) |
| | FBXO41 | FBXO41 isoform 2. (302 aa) |
| | CR201_G0003257 | COMMD1 isoform 4. (146 aa) |
| | FBXO11 | F-box protein 11. (926 aa) |
| | EPAS1 | Endothelial PAS domain protein 1. (869 aa) |
| | ANKRD23 | ANKRD23 isoform 2. (205 aa) |
| | ANKRD39 | ANKRD39 isoform 1. (155 aa) |
| | SPOPL | Speckle type BTB/POZ protein like. (392 aa) |
| | DCAF17 | DCAF17 isoform 2. (495 aa) |
| | BARD1 | BARD1 isoform 3. (777 aa) |
| | CUL3 | CUL3 isoform 1; Belongs to the cullin family. (768 aa) |
| | CR201_G0033078 | KLHL30 isoform 1. (497 aa) |
| | ASB1 | Ankyrin repeat and SOCS box containing 1. (335 aa) |
| | KLHL30 | Kelch-like protein 30. (380 aa) |
| | ATG3 | Autophagy-related protein 3. (313 aa) |
| | VHL | VHL isoform 1. (213 aa) |
| | RAD18 | RAD18 isoform 2. (495 aa) |
| | CRBN | Protein cereblon; Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8 (By similarity). May play a role in memory and learning by regulating the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1 (By simi [...] (442 aa) |
| | CR201_G0046097 | KBTBD8 isoform 2. (415 aa) |
| | DCAF1 | DCAF1 isoform 2. (1483 aa) |
| | FBXL2 | F-box/LRR-repeat protein 2; Calcium-activated substrate recognition component of the SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex, SCF(FBXL2), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Unlike many F-box proteins, FBXL2 does not seem to target phosphodegron within its substrates but rather calmodulin-binding motifs and is thereby antagonized by calmodulin. This is the case for the cyclins CCND2 and CCND3 which polyubiquitination and subsequent degradation are inhibited by calmodulin. Through CCND2 and CCND3 degrad [...] (423 aa) |
| | UBE2E1 | Ubiquitin conjugating enzyme E2 E1; Belongs to the ubiquitin-conjugating enzyme family. (193 aa) |
| | ANAPC13 | Anaphase-promoting complex subunit 13; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity); Belongs to the APC13 family. (74 aa) |
| | ARMC8 | Armadillo repeat-containing protein 8; Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. (595 aa) |
| | RNF7 | Ring finger protein 7. (113 aa) |
| | PHC3 | Polyhomeotic homolog 3. (995 aa) |
| | KLHL24 | Kelch like family member 24. (600 aa) |
| | RNF168 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (571 aa) |
| | PCGF3 | PCGF3 isoform 1. (244 aa) |
| | FBXL5 | F-box/LRR-repeat protein 5; Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. Upon high iron and oxygen level, it specifically recognizes and binds IREB2/IRP2, promoting its ubiquitination and degradation by the proteasome. Promotes ubiquitination and subsequent degradation of DCTN1/p150-glued (By similarity). (664 aa) |
| | DCAF16 | DDB1 and CUL4 associated factor 16. (216 aa) |
| | ZCCHC4 | Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). (1106 aa) |
| | DCAF4L1 | DCAF4L1 isoform 1. (406 aa) |
| | RCHY1 | Ring finger and CHY zinc finger domain containing 1. (261 aa) |
| | KLHL8 | Kelch like family member 8. (620 aa) |
| | UBE2D3 | Ubiquitin-conjugating enzyme E2 D3; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'-linked polyubiquitination. Cooperates with the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains from the UBE2D3-primed [...] (149 aa) |
| | ANAPC10 | Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (161 aa) |
| | FBXW7 | FBXW7 isoform 8. (627 aa) |
| | KLHL2 | KLHL2 isoform 2. (593 aa) |
| | FBXO8 | F-box protein 8. (319 aa) |
| | PDCD6 | Programmed cell death protein 6 isoform X1. (191 aa) |
| | OTULIN | OTU deubiquitinase with linear linkage specificity. (352 aa) |
| | FBXL7 | F-box and leucine rich repeat protein 7. (444 aa) |
| | SKP2 | SKP2 isoform 1. (410 aa) |
| | FBXO4 | FBXO4 isoform 2. (387 aa) |
| | ERCC8 | ERCC excision repair 8, CSA ubiquitin ligase complex subunit. (396 aa) |
| | ENC1 | Ectodermal-neural cortex 1. (589 aa) |
| | FBXL17 | FBXL17 isoform 1. (751 aa) |
| | FEM1C | FEM1C isoform 1. (617 aa) |
| | SKP1 | S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] (163 aa) |
| | UBE2B | Ubiquitin conjugating enzyme E2 B; Belongs to the ubiquitin-conjugating enzyme family. (152 aa) |
| | FBXL21 | F-box and leucine-rich repeat protein 21. (377 aa) |
| | KLHL3 | Kelch-like protein 3; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of ion transport in the distal nephron. The BCR(KLHL3) complex acts by mediating ubiquitination of WNK4, an inhibitor of potassium channel KCNJ1, leading to WNK4 degradation (By similarity). The BCR(KLHL3) complex also mediates ubiquitination and degradation of CLDN8, a tight-junction protein required for paracellular chloride transport in the kidney (By similarity). (587 aa) |
| | CDC23 | Cell division cycle 23. (597 aa) |
| | UBE2D2 | Ubiquitin conjugating enzyme E2 D2; Belongs to the ubiquitin-conjugating enzyme family. (147 aa) |
| | FBXO38 | FBXO38 isoform 1. (1188 aa) |
| | FBXW11 | FBXW11 isoform 1. (489 aa) |
| | TSPAN17 | Tetraspanin. (329 aa) |
| | RANBP9 | RANBP9 isoform 1. (656 aa) |
| | FAM8A1 | RDD domain-containing protein. (413 aa) |
| | RNF8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (462 aa) |
| | KLHDC3 | Kelch domain containing 3. (382 aa) |
| | CUL7 | Cullin-7; Core component of the 3M and Cul7-RING(FBXW8) complexes, which mediates the ubiquitination of target proteins. Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer. Interaction with CUL9 is required to inhibit CUL9 activity and ubiquitination of BIRC5. Core component of a Cul7-RING ubiquitin- protein ligase with FBXW8, which mediates ubiquitination and consequent degradation of target proteins such as [...] (1723 aa) |
| | CUL9 | CUL9 isoform 1; Belongs to the cullin family. (2448 aa) |
| | FBXO9 | F-box protein 9. (437 aa) |
| | UBE3D | E3 ubiquitin-protein ligase E3D; E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. (360 aa) |
| | FBXL4 | F-box and leucine rich repeat protein 4. (621 aa) |
| | RING1 | Ring finger protein 1. (406 aa) |
| | CR201_G0040308 | FBXO24 isoform 5. (315 aa) |
| | RHBDD2 | Rhomboid domain containing 2. (364 aa) |
| | KLHL7 | Kelch like family member 7. (586 aa) |
| | ASB4 | Ankyrin repeat and SOCS box containing 4. (426 aa) |
| | CBLL1 | CBLL1 isoform 1. (402 aa) |
| | CR201_G0030452 | GPR37 isoform 1. (473 aa) |
| | ZC3HC1 | Nuclear-interacting partner of ALK; Essential component of a SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry (By similarity). (503 aa) |
| | KLHDC10 | Kelch domain containing 10. (442 aa) |
| | CUL1 | Cullin-1; Core component of multiple cullin-RING-based SCF (SKP1-CUL1- F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SCF complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the [...] (776 aa) |
| | GPR37 | Prosaposin receptor GPR37. (342 aa) |
| | ATXN7L1 | ATXN7L1 isoform 1. (833 aa) |
| | FBXO25 | FBXO25 isoform 5. (357 aa) |
| | WWP1 | E3 ubiquitin-protein ligase. (773 aa) |
| | DCAF4L2 | DDB1 and CUL4 associated factor 4 like 2. (395 aa) |
| | ANKRD46 | Ankyrin repeat domain-containing protein 46. (228 aa) |
| | DCAF13 | DDB1- and CUL4-associated factor 13; Possible role in ribosomal RNA processing. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex (By similarity); Belongs to the WD repeat DCAF13/WDSOF1 family. (445 aa) |
| | EBAG9 | Receptor-binding cancer antigen expressed on SiSo cells; May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases. (213 aa) |
| | DERL1 | Derlin-1; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the misfolded protein. Also involved in endoplasmic reticulum stress-induced pre- emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for pro [...] (201 aa) |
| | FBXO32 | FBXO32 isoform 2. (254 aa) |
| | SHARPIN | SHARPIN isoform 2. (410 aa) |
| | DCAF10 | DCAF10 isoform 2. (559 aa) |
| | FBXO10 | FBXO10 isoform 3. (1098 aa) |
| | DCAF12 | DDB1 and CUL4 associated factor 12. (453 aa) |
| | KLHL9 | Kelch like family member 9. (617 aa) |
| | RNF20 | E3 ubiquitin protein ligase; Belongs to the BRE1 family. (975 aa) |
| | CDC26 | Anaphase-promoting complex subunit CDC26; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex (By similarity); Belongs to the CDC26 [...] (85 aa) |
| | ZER1 | Protein zer-1 homolog; Serves as substrate adapter subunit in the E3 ubiquitin ligase complex ZYG11B-CUL2-Elongin BC. Acts redudantly with ZYG11B to target substrates bearing N-terminal glycine degrons for proteasomal degradation. Involved in the clearance of proteolytic fragments generated by caspase cleavage during apoptosis since N-terminal glycine degrons are strongly enriched at caspase cleavage sites. Also important in the quality control of protein N-myristoylation in which N-terminal glycine degrons are conditionally exposed after a failure of N- myristoylation; Belongs to the [...] (730 aa) |
| | ASB6 | Ankyrin repeat and SOCS box protein 6; Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. (370 aa) |
| | FBXW5 | FBXW5 isoform 4. (565 aa) |
| | ANAPC2 | Anaphase promoting complex subunit 2; Belongs to the cullin family. (822 aa) |
| | CUL2 | Cullin-2; Core component of multiple cullin-RING-based ECS (ElonginB/C- CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (By similarity). May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the associati [...] (745 aa) |
| | ENSPPYP00000022319 | annotation not available (162 aa) |
| | KLHL34 | Kelch like family member 34. (648 aa) |
| | DCAF8L1 | DCAF8L1 isoform 1. (597 aa) |
| | BCOR | BCOR isoform 2. (1745 aa) |
| | CCNB3 | CCNB3 isoform 3; Belongs to the cyclin family. (1394 aa) |
| | ASB12 | Ankyrin repeat and SOCS box containing 12. (318 aa) |
| | DCX | DCX isoform 10. (446 aa) |
| | KLHL13 | KLHL13 isoform 9. (586 aa) |
| | UBE2A | Ubiquitin conjugating enzyme E2 A; Belongs to the ubiquitin-conjugating enzyme family. (152 aa) |
| | CUL4B | CUL4B isoform 4; Belongs to the cullin family. (843 aa) |
| | DCAF12L1 | DDB1 and CUL4 associated factor 12 like 1. (463 aa) |
| | BCORL1 | BCORL1 isoform 3. (1751 aa) |
| | CKS2 | Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa) |
| | RNF4 | Ring finger protein 4. (190 aa) |
| | ZSWIM6 | SWIM-type domain-containing protein. (1125 aa) |
| | CKS2-2 | CDC28 protein kinase regulatory subunit 2. (79 aa) |
| | KLHL6 | KLHL6 isoform 1. (457 aa) |
| | ANAPC16 | Anaphase-promoting complex subunit 16; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity); Belongs to the APC16 family. (110 aa) |
| | UBE2D4 | UBE2D4 isoform 3; Belongs to the ubiquitin-conjugating enzyme family. (171 aa) |
| | CBX8 | CBX8 isoform 1. (301 aa) |
| | CR201_G0043708 | RBFOX1 isoform 24. (109 aa) |
| | DCUN1D1 | DCN1-like protein. (162 aa) |
| | FAM89A | FAM89A isoform 1. (167 aa) |
| | DTL | DTL isoform 2. (659 aa) |
| | TMEM183A | Transmembrane protein 183. (375 aa) |
| | KLHL12 | KLHL12 isoform 2. (567 aa) |
| | RNF2 | E3 ubiquitin-protein ligase RING2; E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation. H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. May be involved in the initiation of both imprinted and random X inactivation. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, i [...] (336 aa) |
| | COP1 | COP1 E3 ubiquitin ligase. (731 aa) |
| | KLHL20 | Kelch-like protein 20; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. The BCR(KLHL20) E3 ubiquitin ligase complex mediates the ubiquitination of DAPK1, leading to its degradation by the proteasome, thereby acting as a negative regulator of apoptosis. The BCR(KLHL20) E3 ubiquitin ligase complex also specifically mediates 'Lys-33'-linked ubiquitination. Involved in anterograde Golgi to endosome transport by mediating 'Lys-33'-linked ubiquitination of CORO7, promoting inte [...] (582 aa) |
| | DCAF6 | DDB1- and CUL4-associated factor 6; Ligand-dependent coactivator of nuclear receptors. Enhance transcriptional activity of the nuclear receptors NR3C1 and AR. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex (By similarity). (828 aa) |
| | DCAF8 | DDB1- and CUL4-associated factor 8; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex; Belongs to the WD repeat DCAF8 family. (642 aa) |
| | CKS1B | Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa) |
| | ATXN7L2 | ATXN7L2 isoform 2. (721 aa) |
| | GLMN | Glomulin, FKBP associated protein. (594 aa) |
| | ZYG11A | Zyg-11 family member A, cell cycle regulator. (759 aa) |
| | ZYG11B | Zyg-11 family member B, cell cycle regulator. (744 aa) |
| | RNF11 | Ring finger protein 11. (154 aa) |
| | ZSWIM5 | Zinc finger SWIM-type containing 5. (1185 aa) |
| | CDC20 | Cell division cycle 20. (499 aa) |
| | PHC2 | PHC2 isoform 4. (857 aa) |
| | PEF1 | Penta-EF-hand domain containing 1. (284 aa) |
| | FBXO42 | F-box only protein 42; Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Specifically recognizes p53/TP53, promoting its ubiquitination and degradation (By similarity). (717 aa) |
| | ENSPPYP00000002152 | annotation not available (356 aa) |
| | ENSPPYP00000002155 | annotation not available (361 aa) |
| | LOC100441622 | LOW QUALITY PROTEIN: PRAME family member 8. (473 aa) |
| | PRAMEF12 | Uncharacterized protein. (483 aa) |
| | FBXO44 | F-box protein 44. (224 aa) |
| | FBXO2 | F-box protein 2. (295 aa) |
| | UBE4B | UBE4B isoform 1. (1106 aa) |
| | KLHL21 | Kelch like family member 21. (597 aa) |
| | FBH1 | FBXO18 isoform 2. (1006 aa) |
| | BMI1 | Polycomb complex protein BMI-1; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A. In the PRC1-like complex, regulates the E3 ub [...] (326 aa) |
| | ZFAND4 | Zinc finger AN1-type containing 4. (726 aa) |
| | ZSWIM8 | ZSWIM8 isoform 5. (1893 aa) |
| | UBE2D1 | Ubiquitin conjugating enzyme E2 D1; Belongs to the ubiquitin-conjugating enzyme family. (147 aa) |
| | PCGF5 | Polycomb group ring finger 5. (256 aa) |
| | BTRC | BTRC isoform 2. (605 aa) |
| | FBXW4 | FBXW4 isoform 2. (592 aa) |
| | FBXL15 | FBXL15 isoform 4. (388 aa) |
| | PCGF6 | Polycomb group ring finger 6. (350 aa) |
| | CACUL1 | CACUL1 isoform 2; Belongs to the cullin family. (340 aa) |
| | SYVN1 | SYVN1 isoform 3. (616 aa) |
