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| | CXCR4 | C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (352 aa) |
| | KIDINS220 | KIDINS220 isoform 8. (1733 aa) |
| | LAPTM4A | Lysosomal-associated transmembrane protein 4A; May function in the transport of nucleosides and/or nucleoside derivatives between the cytosol and the lumen of an intracellular membrane-bound compartment. (233 aa) |
| | VAMP8 | Vesicle-associated membrane protein 8; SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. VAMP8 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane via its interaction with the STX17-SNAP29 binary t- SNARE complex. Also required for dense-granule secretion in platelets. Plays als [...] (253 aa) |
| | ENSPPYP00000013398 | annotation not available (195 aa) |
| | SRC | Tyrosine-protein kinase. (553 aa) |
| | AP5S1 | Adaptor related protein complex 5 subunit sigma 1. (200 aa) |
| | TMEM230 | Transmembrane protein 230; Involved in trafficking and recycling of synaptic vesicles. Belongs to the TMEM134/TMEM230 family. (120 aa) |
| | CST7 | CST7 isoform 1. (145 aa) |
| | MAP2K2 | MAP2K2 isoform 6. (213 aa) |
| | PLD3 | 5'-3' exonuclease PLD3; 5'->3' DNA exonuclease which digests single-stranded DNA (ssDNA) (By similarity). Regulates inflammatory cytokine responses via the degradation of nucleic acids, by reducing the concentration of ssDNA able to stimulate TLR9, a nucleotide-sensing receptor in collaboration with PLD4 (By similarity). May be important in myotube formation. Plays a role in lysosomal homeostasis. Involved in the regulation of endosomal protein sorting (By similarity). (490 aa) |
| | LDLR | LDLR isoform 3. (815 aa) |
| | UBXN6 | UBXN6 isoform 3. (436 aa) |
| | MFSD12 | MFSD12 isoform 7. (479 aa) |
| | NEDD4L | E3 ubiquitin-protein ligase NEDD4-like; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF- beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, KCNH2, EAAT1 or CLC5. Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiq [...] (964 aa) |
| | RAB27B | RAB27B, member RAS oncogene family. (218 aa) |
| | OSBPL1A | Oxysterol-binding protein; Belongs to the OSBP family. (437 aa) |
| | NPC1 | NPC1 isoform 1. (1243 aa) |
| | RMC1 | Regulator of MON1-CCZ1. (657 aa) |
| | CR201_G0021153 | Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (616 aa) |
| | NBR1 | Next to BRCA1 gene 1 protein; Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets. (966 aa) |
| | GRN | GRN isoform 1. (578 aa) |
| | ANKRD13B | ANKRD13B isoform 3. (588 aa) |
| | STX8 | STX8 isoform 2. (236 aa) |
| | CTNS | Cystinosin, lysosomal cystine transporter. (400 aa) |
| | CR201_G0041408 | WDR81 isoform 4. (691 aa) |
| | RILP | RILP isoform 2. (400 aa) |
| | CR201_G0054316 | LITAF isoform 8. (126 aa) |
| | MON1B | MON1B isoform 2. (494 aa) |
| | VPS4A | VPS4A isoform 1; Belongs to the AAA ATPase family. (437 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (381 aa) |
| | CLN3 | Battenin. (438 aa) |
| | CR201_G0046980 | ZP2 isoform 1. (637 aa) |
| | ENSPPYP00000008037 | annotation not available (125 aa) |
| | CR201_G0047293 | T0166643 isoform 1. (158 aa) |
| | CDIP1 | Cell death inducing p53 target 1. (208 aa) |
| | BAIAP3 | BAIAP3 isoform 3. (1072 aa) |
| | MAP2K1 | MAP2K1 isoform 1; Belongs to the protein kinase superfamily. (395 aa) |
| | VPS13C | VPS13C isoform 1. (3448 aa) |
| | RAB27A | RAB27A, member RAS oncogene family. (221 aa) |
| | ENSPPYP00000007304 | annotation not available (318 aa) |
| | VPS39 | VPS39 isoform 1. (875 aa) |
| | VIPAS39 | VIPAS39 isoform 6. (433 aa) |
| | SLC39A9 | Zinc transporter ZIP9; May act as a zinc-influx transporter; Belongs to the ZIP transporter (TC 2.A.5) family. (307 aa) |
| | ZFYVE26 | ZFYVE26 isoform 2. (2539 aa) |
| | VTI1B | Vesicle transport through interaction with t-SNAREs 1B. (232 aa) |
| | AP5M1 | Adaptor related protein complex 5 subunit mu 1; Belongs to the adaptor complexes medium subunit family. (490 aa) |
| | CHMP4A | CHMP4A isoform 4. (258 aa) |
| | ATP7B | ATP7B isoform 3. (1434 aa) |
| | TPT1 | TPT1 isoform 1; Belongs to the TCTP family. (172 aa) |
| | ANKRD13A | Ankyrin repeat domain 13A. (590 aa) |
| | PMEL | PMEL isoform 9. (574 aa) |
| | VPS26B | Vacuolar protein sorting-associated protein 26B; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans- Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for car [...] (336 aa) |
| | SORL1 | SORL1 isoform 1. (2118 aa) |
| | BACE1 | Beta-secretase 1; Belongs to the peptidase A1 family. (501 aa) |
| | UVRAG | UV radiation resistance associated. (699 aa) |
| | LAMTOR1 | Ragulator complex protein LAMTOR1; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V- ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulat [...] (161 aa) |
| | TMEM9B | TMEM9 domain family member B. (198 aa) |
| | PG | PGA5 isoform 1; Belongs to the peptidase A1 family. (388 aa) |
| | CYB561A3 | Cytochrome b561 family member A3. (242 aa) |
| | CHID1 | Chitinase domain-containing protein 1; Saccharide- and LPS-binding protein with possible roles in pathogen sensing and endotoxin neutralization. Ligand-binding specificity relates to the length of the oligosaccharides, with preference for chitotetraose (in vitro) (By similarity). (370 aa) |
| | DENND10 | FAM45A isoform 2. (405 aa) |
| | SLC29A3 | Solute carrier family 29 member 3. (475 aa) |
| | PSAP | PSAP isoform 2. (526 aa) |
| | LOC100433557 | Annexin. (327 aa) |
| | ATP13A2 | Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1175 aa) |
| | TMEM59 | Transmembrane protein 59; Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy. Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. Inhibits APP transport to the cell surface and further shedding. (323 aa) |
| | PCSK9 | PCSK9 isoform 1. (809 aa) |
| | ANKRD13C | ANKRD13C isoform 1. (511 aa) |
| | LAMTOR5 | LAMTOR5 isoform 1. (182 aa) |
| | RAP1A | RAP1A, member of RAS oncogene family. (184 aa) |
| | CTSS | CTSS isoform 1; Belongs to the peptidase C1 family. (330 aa) |
| | LAMTOR2 | Late endosomal/lysosomal adaptor, MAPK and MTOR activator 2. (125 aa) |
| | NTRK1 | Tyrosine-protein kinase receptor. (796 aa) |
| | CD1E | CD1E isoform 2. (404 aa) |
| | TMEM9 | Transmembrane protein 9. (183 aa) |
| | RAPGEF2 | RAPGEF2 isoform 1. (1331 aa) |
| | C9H9orf85 | C9orf85 isoform 3. (155 aa) |
| | STEAP3 | STEAP3 metalloreductase. (488 aa) |
| | C7orf25 | Chromosome 7 open reading frame 25. (479 aa) |
| | MAPK1 | Mitogen-activated protein kinase 1 isoform X1. (158 aa) |
| | VAMP7 | Vesicle-associated membrane protein 7; Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocy [...] (220 aa) |
| | MTM1 | Myotubularin; Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2). Has also been shown to dephosphorylate phosphotyrosine- and phosphoserine-containing peptides. Negatively regulates EGFR degradation through regulation of EGFR trafficking from the late endosome to the lysosome. Plays a role in vacuolar formation and morphology. Regulates desmin intermediate filament assembly and architecture. Plays a role in mitochondrial morphology and positioning. Required for skeletal muscle maintenance but not fo [...] (603 aa) |
| | ATP7A | ATPase copper transporting alpha. (1500 aa) |
| | HDAC6 | HDAC6 isoform 2. (1208 aa) |
| | ENSPPYP00000022466 | annotation not available (172 aa) |
| | MITD1 | MIT domain-containing protein. (215 aa) |
| | ENSPPYP00000022291 | annotation not available (35 aa) |
| | CR201_G0040173 | C9orf85 isoform 4. (35 aa) |
| | ECPAS | Proteasome adapter and scaffold protein ECM29; Adapter/scaffolding protein that binds to the 26S proteasome, motor proteins and other compartment specific proteins. May couple the proteasome to different compartments including endosome, endoplasmic reticulum and centrosome. May play a role in ERAD and other enhanced proteolysis. Promotes proteasome dissociation under oxidative stress. (1839 aa) |
| | CTSL | CTSL isoform 2; Belongs to the peptidase C1 family. (333 aa) |
| | CHMP5 | Charged multivesicular body protein 5; Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the [...] (219 aa) |
| | LAPTM4B | LAPTM4B isoform 1. (193 aa) |
| | SNX16 | Sorting nexin-16; May be involved in several stages of intracellular trafficking. Plays a role in protein transport from early to late endosomes. Plays a role in protein transport to the lysosome. Promotes degradation of EGFR after EGF signaling (By similarity); Belongs to the sorting nexin family. (344 aa) |
| | SLC39A14 | Zinc transporter ZIP14; Broad-scope metal ion transporter with a preference for zinc uptake. Also mediates cellular uptake of nontransferrin-bound iron. (507 aa) |
| | WDR91 | WD repeat-containing protein 91; Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3- phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport. It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome. May play a role in meiosis. (747 aa) |
| | EGFR | Receptor protein-tyrosine kinase. (1210 aa) |
| | LAMTOR4 | Ragulator complex protein LAMTOR4, N-terminally processed; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V- ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated (By similarity). (99 aa) |
| | CCZ1 | CCZ1B isoform 5. (482 aa) |
| | MICALL2 | MICALL2 isoform 9. (905 aa) |
| | LOC100460187 | MHC class II protein; Belongs to the MHC class II family. (254 aa) |
| | HLA-DMA | HLA class II histocompatibility antigen, DM alpha chain isoform X1. (261 aa) |
| | LOC100448477 | HLA-DMB isoform 5. (263 aa) |
| | ENSPPYP00000019293 | HLA class II histocompatibility antigen, DRB1-11 beta chain isoform X1. (266 aa) |
| | IGF2R | IGF2R isoform 1. (2446 aa) |
| | VTA1 | Vacuolar protein sorting-associated protein VTA1 homolog; Involved in the endosomal multivesicular bodies (MVB) pathway. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. Thought to be a cofactor of VPS4A/B, which catalyzes disassembles membrane-associated ESCRT-III assemblies. Involved in the sorting and down-regulation of EGFR (By similarity). (307 aa) |
| | STX7 | Syntaxin-7; May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes (By similarity). (261 aa) |
| | FIG4 | FIG4 isoform 1. (891 aa) |
| | SNX14 | Sorting nexin-14; Plays a role in maintaining normal neuronal excitability and synaptic transmission. May be involved in several stages of intracellular trafficking; Belongs to the sorting nexin family. (943 aa) |
| | HLA-DRB5 | Ig-like domain-containing protein. (266 aa) |
| | NSG2 | Neuronal vesicle trafficking associated 2. (171 aa) |
| | ATP10B | Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1460 aa) |
| | ANXA6 | Annexin. (660 aa) |
| | CRHBP | Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (282 aa) |
| | SLC38A9 | SLC38A9 isoform 14. (541 aa) |
| | CLCN3 | H(+)/Cl(-) exchange transporter 3; Mediates the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the endosome and synaptic vesicle lumen, and may thereby affect vesicle trafficking and exocytosis. May play an important role in neuronal cell function through regulation of membrane excitability by protein kinase C. It could help neuronal cells to establish short-term memory (By similarity). (866 aa) |
| | TMEM192 | Transmembrane protein 192; Belongs to the TMEM192 family. (271 aa) |
| | MARCHF1 | MARCH1 isoform 2. (542 aa) |
| | LRAT | LRAT isoform 2. (233 aa) |
| | AP1AR | Adaptor related protein complex 1 associated regulatory protein. (302 aa) |
| | LAMTOR3 | Ragulator complex protein LAMTOR3; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V- ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP k [...] (124 aa) |
| | SCARB2 | SCARB2 isoform 16; Belongs to the CD36 family. (478 aa) |
| | PARM1 | Prostate androgen-regulated mucin-like protein 1 homolog; May regulate TLP1 expression and telomerase activity, thus enabling certain prostatic cells to resist apoptosis. (275 aa) |
| | TMEM165 | GDT1 family protein. (324 aa) |
| | NSG1 | Neuronal vesicle trafficking-associated protein 1; Plays a role in the recycling mechanism in neurons of multiple receptors, including AMPAR, APP and L1CAM and acts at the level of early endosomes to promote sorting of receptors toward a recycling pathway. Regulates sorting and recycling of GRIA2 through interaction with GRIP1 and then contributes to the regulation of synaptic transmission and plasticity by affecting the recycling and targeting of AMPA receptors to the synapse (By similarity). Is required for faithful sorting of L1CAM to axons by facilitating trafficking from somatoden [...] (185 aa) |
| | HTT | HTT isoform 1. (3130 aa) |
| | RUBCN | RUBCN isoform 2. (817 aa) |
| | ATP13A3 | Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1207 aa) |
| | ATP13A4 | Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1151 aa) |
| | IL12A | Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa) |
| | RNF13 | E3 ubiquitin-protein ligase RNF13; E3 ubiquitin-protein ligase that may play a role in controlling cell proliferation. Involved in apoptosis regulation. Mediates ER stress-induced activation of JNK signaling pathway and apoptosis by promoting ERN1 activation and splicing of XBP1 mRNA. (381 aa) |
| | SLC9A9 | Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (619 aa) |
| | TF | TF isoform 1; Belongs to the transferrin family. (703 aa) |
| | PIK3R4 | Phosphoinositide 3-kinase regulatory subunit 4; Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (By similarity). (1357 aa) |
| | FYCO1 | FYVE and coiled-coil domain containing 1. (1478 aa) |
| | MON1A | Vacuolar fusion protein MON1 homolog A. (555 aa) |
| | APPL1 | APPL1 isoform 1. (708 aa) |
| | ABHD6 | Abhydrolase domain containing 6. (337 aa) |
| | RAB7A | Ras-related protein Rab-7a; Key regulator in endo-lysosomal trafficking. Governs early- to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades (By similarity). Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth- factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism (By simi [...] (208 aa) |
| | ABCB6 | ATP binding cassette subfamily B member 6 (Langereis blood group). (843 aa) |
| | MREG | MREG isoform 1. (214 aa) |
| | PIKFYVE | PIKFYVE isoform 1. (2088 aa) |
