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| | GPR137B | G protein-coupled receptor 137B. (399 aa) |
| | PIGR | PIGR isoform 1. (764 aa) |
| | ARL8A | ADP ribosylation factor like GTPase 8A; Belongs to the small GTPase superfamily. Arf family. (186 aa) |
| | TMEM9 | Transmembrane protein 9. (183 aa) |
| | GBA | Lysosomal acid glucosylceramidase; Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose. Thereby, plays a central role in the degradation of complex lipids and the turnover of cellular membranes. Through the production of ceramides, participates to the PKC-activated salvage pathway of ceramide formation. Also plays a role in cholesterol metabolism. May either catalyze the glucosylation of cholesterol, through a transglucosylation reaction that transfers glucose from glucosylceramide to cholesterol. [...] (626 aa) |
| | SLC30A7 | Solute carrier family 30 member 7. (376 aa) |
| | ENSPPYP00000001296 | annotation not available (120 aa) |
| | SH3GLB1 | Endophilin-B1; May be required for normal outer mitochondrial membrane dynamics. Required for coatomer-mediated retrograde transport in certain cells. May recruit other proteins to membranes with high curvature. May promote membrane fusion. Involved in activation of caspase-dependent apoptosis by promoting BAX/BAK1 activation. Involved in caspase-independent apoptosis during nutrition starvation and involved in the regulation of autophagy. Activates lipid kinase activity of PIK3C3 during autophagy probably by associating with the PI3K complex II (PI3KC3-C2). Associated with PI3KC3-C2 d [...] (365 aa) |
| | MCOLN3 | MCOLN3 isoform 4. (553 aa) |
| | ATP6V0B | ATP6V0B isoform 3; Belongs to the V-ATPase proteolipid subunit family. (156 aa) |
| | LAPTM5 | Lysosomal-associated transmembrane protein 5; May have a special functional role during embryogenesis and in adult hematopoietic cells. (262 aa) |
| | SLC66A1 | PQLC2 isoform 1. (247 aa) |
| | ATP13A2 | Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1175 aa) |
| | CLCN6 | CLCN6 isoform 2; Belongs to the chloride channel (TC 2.A.49) family. (824 aa) |
| | ENSPPYP00000002694 | annotation not available (159 aa) |
| | AP3M1 | AP-3 complex subunit mu-1; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals (By similarity); Belongs to the adaptor complexes medium subunit family. (418 aa) |
| | PSAP | PSAP isoform 2. (526 aa) |
| | SLC29A3 | Solute carrier family 29 member 3. (475 aa) |
| | FFAR4 | FFAR4 isoform 2. (318 aa) |
| | PI4K2A | Phosphatidylinositol 4-kinase type 2 alpha. (479 aa) |
| | IFITM10 | IFITM10 isoform 1. (130 aa) |
| | ENSPPYP00000003382 | annotation not available (390 aa) |
| | CR201_G0031594 | TPCN2 isoform 7. (717 aa) |
| | TCIRG1 | V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (559 aa) |
| | GPR137 | GPR137 isoform 14. (402 aa) |
| | TMEM179B | Transmembrane protein 179B. (219 aa) |
| | CYB561A3 | Cytochrome b561 family member A3. (242 aa) |
| | SLC15A3 | Solute carrier family 15 member 3. (582 aa) |
| | TMEM9B | TMEM9 domain family member B. (198 aa) |
| | LAMTOR1 | Ragulator complex protein LAMTOR1; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V- ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulat [...] (161 aa) |
| | NEU3 | NEU3 isoform 2. (404 aa) |
| | UVRAG | UV radiation resistance associated. (699 aa) |
| | CR201_G0023224 | MYO7A isoform 2. (1350 aa) |
| | PRCP | Lysosomal Pro-X carboxypeptidase; Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH (By similarity); Belongs to the peptidase S28 family. (496 aa) |
| | SIDT2 | SIDT2 isoform 3. (776 aa) |
| | NLRX1 | NLRX1 isoform 1. (974 aa) |
| | ITFG2 | KICSTOR complex protein ITFG2; As part of the KICSTOR complex functions in the amino acid- sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose. (447 aa) |
| | M6PR | Mannose-6-phosphate receptor, cation dependent. (278 aa) |
| | GABARAPL1 | Gamma-aminobutyric acid receptor-associated protein-like 1. (85 aa) |
| | BORCS5 | BLOC-1 related complex subunit 5. (196 aa) |
| | MGST1 | Microsomal glutathione S-transferase 1. (155 aa) |
| | LRP1 | LRP1 isoform 1. (4377 aa) |
| | GLIPR1 | GLI pathogenesis related 1; Belongs to the CRISP family. (266 aa) |
| | CKAP4 | CKAP4 isoform 3. (475 aa) |
| | TPCN1 | TPCN1 isoform 2. (798 aa) |
| | ATP6V0A2 | V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (856 aa) |
| | SCARB1 | SCARB1 isoform 7; Belongs to the CD36 family. (471 aa) |
| | SLC15A4 | SLC15A4 isoform 1. (577 aa) |
| | ULK1 | Serine/threonine-protein kinase; Serine/threonine-protein kinase involved in autophagy in response to starvation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. (924 aa) |
| | LRMP | LRMP isoform 1. (496 aa) |
| | SLC46A3 | Solute carrier family 46 member 3. (463 aa) |
| | CR201_G0016717 | RUBCNL isoform 6. (570 aa) |
| | CLN5 | T0025243 isoform 1. (378 aa) |
| | LAMP1 | LAMP1 isoform 1. (368 aa) |
| | CHMP4A | CHMP4A isoform 4. (258 aa) |
| | PRKD1 | Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (912 aa) |
| | ATP6V1D | V-type proton ATPase subunit D; Subunit of the peripheral V1 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (By similarity). (247 aa) |
| | VTI1B | Vesicle transport through interaction with t-SNAREs 1B. (232 aa) |
| | ZFYVE26 | ZFYVE26 isoform 2. (2539 aa) |
| | ABCD4 | ATP binding cassette subfamily D member 4. (606 aa) |
| | VPS39 | VPS39 isoform 1. (875 aa) |
| | SPG11 | SPG11 isoform 3. (2431 aa) |
| | TM6SF1 | Transmembrane 6 superfamily member 1; May function as sterol isomerase. Belongs to the TM6SF family. (366 aa) |
| | ANPEP | Aminopeptidase. (892 aa) |
| | LOC100445631 | GABARAPL1 isoform 2. (113 aa) |
| | CLCN7 | Chloride channel protein. (781 aa) |
| | ATP6V0C | V-type H+-transporting ATPase 16kDa proteolipid subunit. (128 aa) |
| | CDIP1 | Cell death inducing p53 target 1. (208 aa) |
| | ENSPPYP00000008037 | annotation not available (125 aa) |
| | SPNS1 | Sphingolipid transporter 1 (putative). (528 aa) |
| | CLN3 | Battenin. (438 aa) |
| | ATP6V0D1 | V-type proton ATPase subunit d 1; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis. May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (By similarity). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the acti [...] (351 aa) |
| | VPS4A | VPS4A isoform 1; Belongs to the AAA ATPase family. (437 aa) |
| | VAC14 | VAC14 component of PIKFYVE complex. (782 aa) |
| | GABARAPL2 | GABA type A receptor associated protein like 2. (117 aa) |
| | MEAK7 | MTOR associated protein, eak-7 homolog. (456 aa) |
| | MAP1LC3B | MAP1LC3B isoform 1. (129 aa) |
| | CR201_G0054316 | LITAF isoform 8. (126 aa) |
| | RILP | RILP isoform 2. (400 aa) |
| | CR201_G0041408 | WDR81 isoform 4. (691 aa) |
| | CTNS | Cystinosin, lysosomal cystine transporter. (400 aa) |
| | TAX1BP3 | Tax1-binding protein 3; May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. (124 aa) |
| | TM4SF5 | Transmembrane 4 L six family member 5. (197 aa) |
| | GABARAP | Gamma-aminobutyric acid receptor-associated protein-like 1; Ubiquitin-like modifier that increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor. Involved in formation of autophagosomal vacuoles. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (By similarity); Belongs to the ATG8 family. (117 aa) |
| | CD68 | CD68 isoform 1. (354 aa) |
| | TMEM199 | Transmembrane protein 199; In aerobic conditions, required for intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. Necessary for endolysosomal acidification and lysosomal degradation (By similarity). May be involved in Golgi homeostasis (By similarity). (208 aa) |
| | AP2B1 | AP complex subunit beta. (951 aa) |
| | SPAG9 | Sperm associated antigen 9. (1307 aa) |
| | NSF | Vesicle-fusing ATPase; Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin. Interaction with AMPAR subunit GRIA2 leads to influence GRIA2 membrane cycling (By similarity); Belongs to the AAA ATPase family. (816 aa) |
| | GRN | GRN isoform 1. (578 aa) |
| | ATP6V0A1 | V-type proton ATPase 116 kDa subunit a isoform 1; Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle (By similarity). (862 aa) |
| | RAB5C | Ras-related protein Rab-5C; Protein transport. Probably involved in vesicular traffic (By similarity); Belongs to the small GTPase superfamily. Rab family. (216 aa) |
| | CR201_G0024013 | WIPI1 isoform 2. (251 aa) |
| | CR201_G0021330 | RAB37 isoform 13. (197 aa) |
| | SLC26A11 | SLC26A11 isoform 12. (622 aa) |
| | VMP1 | Vacuole membrane protein 1; Stress-induced protein that, when overexpressed, promotes formation of intracellular vacuoles followed by cell death. May be involved in the cytoplasmic vacuolization of acinar cells during the early stage of acute pancreatitis. Involved in cell-cell adhesion. Plays an essential role in formation of cell junctions. Plays a role in the initial stages of the autophagic process through its interaction with BECN1. Required for autophagosome formation (By similarity). Belongs to the VMP1 family. (406 aa) |
| | CALCOCO2 | Calcium-binding and coiled-coil domain-containing protein 2; Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation (By similarity). Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens upon entry into the cytosol by targeting LGALS8-associated bacteria for autophagy (By similarity). Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen- containing autophagosome maturation (By similarity). Bacteria targeting [...] (447 aa) |
| | SEH1L | Nucleoporin SEH1; Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. This subunit plays a role in recruitment of the Nup107-160 subcomplex to the kinetochore. Belongs to the WD repeat SEC13 family. (360 aa) |
| | NPC1 | NPC1 isoform 1. (1243 aa) |
| | RNF152 | Ring finger protein 152. (203 aa) |
| | AZU1 | AZU1 isoform 1. (250 aa) |
| | UBXN6 | UBXN6 isoform 3. (436 aa) |
| | LRRC8E | Leucine rich repeat containing 8 VRAC subunit E. (796 aa) |
| | LDLR | LDLR isoform 3. (815 aa) |
| | RAB3D | RAB3D isoform 1. (194 aa) |
| | CEACAM6 | Carcinoembryonic antigen related cell adhesion molecule 6. (344 aa) |
| | AP2S1 | AP-2 complex subunit sigma; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein Transport via Transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (142 aa) |
| | SPHK2 | SPHK2 isoform 2. (635 aa) |
| | NKG7 | Natural killer cell granule protein 7. (165 aa) |
| | FPR1 | Formyl peptide receptor 1; Belongs to the G-protein coupled receptor 1 family. (352 aa) |
| | MAP1LC3C | MAP1LC3C isoform 1. (147 aa) |
| | TASP1 | TASP1 isoform 1. (420 aa) |
| | MAP1LC3A | Microtubule associated protein 1 light chain 3 alpha. (121 aa) |
| | EEF1A2 | EEF1A2 isoform 3. (415 aa) |
| | DNAJC5 | DnaJ heat shock protein family (Hsp40) member C5. (198 aa) |
| | TRPM2 | TRPM2 isoform 3. (1302 aa) |
| | ATP6V1E1 | ATP6V1E1 isoform 1. (203 aa) |
| | TOM1 | TOM1 isoform 6; Belongs to the TOM1 family. (459 aa) |
| | NFAM1 | NFAM1 isoform 1. (218 aa) |
| | VAMP8 | Vesicle-associated membrane protein 8; SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. VAMP8 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane via its interaction with the STX17-SNAP29 binary t- SNARE complex. Also required for dense-granule secretion in platelets. Plays als [...] (253 aa) |
| | ATP6V1B1 | V-type proton ATPase subunit B, brain isoform; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells (By similarity). (509 aa) |
| | SNRNP27 | SNRNP27 isoform 3. (159 aa) |
| | ATP6V1E2 | ATPase H+ transporting V1 subunit E2. (226 aa) |
| | SLC35F6 | Solute carrier family 35 member F6; Involved in the maintenance of mitochondrial membrane potential in pancreatic ductal adenocarcinoma (PDAC) cells. Promotes pancreatic ductal adenocarcinoma (PDAC) cell growth. May play a role as a nucleotide-sugar transporter (By similarity). (371 aa) |
| | LAPTM4A | Lysosomal-associated transmembrane protein 4A; May function in the transport of nucleosides and/or nucleoside derivatives between the cytosol and the lumen of an intracellular membrane-bound compartment. (233 aa) |
| | ATP6V1C2 | V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (389 aa) |
| | LRP2 | LRP2 isoform 1. (4512 aa) |
| | ATG16L1 | Autophagy-related protein 16-1; Plays an essential role in autophagy: interacts with ATG12- ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Thereby, controls the elongation of the nascent autophagosomal membrane. Regulates mitochondrial antiviral signaling (MAVS)-dependent type I interferon (IFN-I) production. Negatively regulates NOD1- and NOD2-driven inflammatory cytokine response. Instead, promotes with NOD2 an autophagy-dependent antibacterial pathway. Plays a r [...] (624 aa) |
| | IQCA1 | IQCA1 isoform 1. (832 aa) |
| | RAB7A | Ras-related protein Rab-7a; Key regulator in endo-lysosomal trafficking. Governs early- to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades (By similarity). Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth- factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism (By simi [...] (208 aa) |
| | ATP6V1A | V-type proton ATPase catalytic subunit A; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. May play a role in neurite development and synaptic connectivity. Belongs to the ATPase alpha/beta chains family. (578 aa) |
| | CR201_G0007982 | V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa) |
| | TEX264 | TEX264 isoform 10. (304 aa) |
| | ACPP | Acid phosphatase, prostate; Belongs to the histidine acid phosphatase family. (421 aa) |
| | DNAJC13 | DNAJC13 isoform 1. (2243 aa) |
| | CP | Ceruloplasmin; Belongs to the multicopper oxidase family. (1065 aa) |
| | RNF13 | E3 ubiquitin-protein ligase RNF13; E3 ubiquitin-protein ligase that may play a role in controlling cell proliferation. Involved in apoptosis regulation. Mediates ER stress-induced activation of JNK signaling pathway and apoptosis by promoting ERN1 activation and splicing of XBP1 mRNA. (381 aa) |
| | PLD1 | Phospholipase. (1074 aa) |
| | TMEM175 | TMEM175 isoform 4. (229 aa) |
| | ATP8A1 | Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1164 aa) |
| | TMEM165 | GDT1 family protein. (324 aa) |
| | SCARB2 | SCARB2 isoform 16; Belongs to the CD36 family. (478 aa) |
| | HPSE | HPSE isoform 1. (545 aa) |
| | WDFY3 | WDFY3 isoform 1. (3520 aa) |
| | LAMTOR3 | Ragulator complex protein LAMTOR3; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V- ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP k [...] (124 aa) |
| | SLC39A8 | SLC39A8 isoform 4. (424 aa) |
| | MANBA | MANBA isoform 1. (879 aa) |
| | EGF | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1177 aa) |
| | MFSD8 | MFSD8 isoform 10. (518 aa) |
| | TMEM192 | Transmembrane protein 192; Belongs to the TMEM192 family. (271 aa) |
| | CLCN3 | H(+)/Cl(-) exchange transporter 3; Mediates the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the endosome and synaptic vesicle lumen, and may thereby affect vesicle trafficking and exocytosis. May play an important role in neuronal cell function through regulation of membrane excitability by protein kinase C. It could help neuronal cells to establish short-term memory (By similarity). (866 aa) |
| | TLR3 | Toll like receptor 3; Belongs to the Toll-like receptor family. (904 aa) |
| | LPCAT1 | Lysophosphatidylcholine acyltransferase 1. (534 aa) |
| | SLC38A9 | SLC38A9 isoform 14. (541 aa) |
| | AP3B1 | AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family. (1094 aa) |
| | JMY | JMY isoform 1. (618 aa) |
| | SLCO4C1 | Solute carrier organic anion transporter family member 4C1; Organic anion transporter, capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate and cAMP. May participate in the regulation of membrane transport of ouabain. Involved in the uptake of the dipeptidyl peptidase-4 inhibitor sitagliptin and hence may play a role in its transport into and out of renal proximal tubule cells. May be involved in the first step of the transport pathway of digoxin and various compounds into the urine in the kidney. May be involved in sperm maturation by en [...] (724 aa) |
| | ANXA6 | Annexin. (660 aa) |
| | SLC36A1 | Solute carrier family 36 member 1. (476 aa) |
| | ATP10B | Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1460 aa) |
| | LOC100442029 | Inorganic pyrophosphatase; Belongs to the PPase family. (292 aa) |
| | ATP6V1G2 | V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa) |
| | HLA-DRB5 | Ig-like domain-containing protein. (266 aa) |
| | CR201_G0016196 | HLA-DQB1 isoform 5. (304 aa) |
| | TFEB | TFEB isoform 3. (581 aa) |
| | ABCC10 | ABCC10 isoform 3. (1492 aa) |
| | LMBRD1 | LMBRD1 isoform 1. (518 aa) |
| | SLC17A5 | SLC17A5 isoform 1. (453 aa) |
| | OSTM1 | OSTM1 isoform 4. (295 aa) |
| | STX7 | Syntaxin-7; May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes (By similarity). (261 aa) |
| | VNN1 | VNN1 isoform 1. (513 aa) |
| | ENSPPYP00000019293 | HLA class II histocompatibility antigen, DRB1-11 beta chain isoform X1. (266 aa) |
| | HLA-DOB | HLA class II histocompatibility antigen, DO beta chain. (272 aa) |
| | LOC100448477 | HLA-DMB isoform 5. (263 aa) |
| | HLA-DMA | HLA class II histocompatibility antigen, DM alpha chain isoform X1. (261 aa) |
| | CR201_G0016218 | HLA-DPA1 isoform 1; Belongs to the MHC class II family. (260 aa) |
| | LOC100460187 | MHC class II protein; Belongs to the MHC class II family. (254 aa) |
| | CR201_G0016218-2 | HLA-DPA1 isoform 3. (239 aa) |
| | TECPR1 | Tectonin beta-propeller repeat-containing protein 1; Tethering factor involved in autophagy. Involved in autophagosome maturation by promoting the autophagosome fusion with lysosomes: acts by associating with both the ATG5-ATG12 conjugate and phosphatidylinositol-3-phosphate (PtdIns(3)P) present at the surface of autophagosomes. Also involved in selective autophagy against bacterial pathogens, by being required for phagophore/preautophagosomal structure biogenesis and maturation (By similarity); Belongs to the TECPR1 family. (1165 aa) |
| | TMEM130 | Transmembrane protein 130. (641 aa) |
| | LAMTOR4 | Ragulator complex protein LAMTOR4, N-terminally processed; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V- ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated (By similarity). (99 aa) |
| | ABCA13 | ABCA13 isoform 2. (4952 aa) |
| | VPS41 | Vacuolar protein sorting-associated protein 41 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways; Belongs to the VPS41 family. (854 aa) |
| | TMEM106B | Transmembrane protein 106B. (274 aa) |
| | MIOS | GATOR complex protein MIOS; As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex. It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1. (875 aa) |
| | ATP6V1F | V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (119 aa) |
| | ATP6V0A4 | V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (876 aa) |
| | IQCA1L | IQCA1L isoform 1. (815 aa) |
| | RHEB | RHEB isoform 1. (167 aa) |
| | ATP6V1B2 | V-type proton ATPase subunit B, brain isoform. (278 aa) |
| | ENTPD4 | ENTPD4 isoform 4; Belongs to the GDA1/CD39 NTPase family. (541 aa) |
| | HGSNAT | HGSNAT isoform 1. (645 aa) |
| | ATP6V1H | V-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (465 aa) |
| | LYN | Tyrosine-protein kinase. (512 aa) |
| | ATP6V1C1 | V-type proton ATPase subunit C 1; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells (By similarity). (382 aa) |
| | CHMP5 | Charged multivesicular body protein 5; Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the [...] (219 aa) |
| | B4GALT1 | Beta-1,4-galactosyltransferase 1. (398 aa) |
| | STX17 | STX17 isoform 1; Belongs to the syntaxin family. (302 aa) |
| | STOM | STOM isoform 3. (288 aa) |
| | SLC2A8 | SLC2A8 isoform 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (477 aa) |
| | LRRC8A | Leucine rich repeat containing 8 VRAC subunit A. (810 aa) |
| | SURF4 | Surfeit locus protein 4; May play a role in the maintenance of the architecture of the endoplasmic reticulum-Golgi intermediate compartment and of the Golgi. Belongs to the SURF4 family. (254 aa) |
| | SLC2A6 | Solute carrier family 2 member 6; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (507 aa) |
| | ABCA2 | ABCA2 isoform 9. (2330 aa) |
| | CLCN4 | Chloride channel protein. (760 aa) |
| | TLR8 | TLR8 isoform 1; Belongs to the Toll-like receptor family. (1041 aa) |
| | CXorf21 | CXorf21 isoform 1. (301 aa) |
| | ATP6AP2 | Renin receptor extracellular fragment; Multifunctional protein which functions as a renin, prorenin cellular receptor and is involved in the assembly of the proton- transporting vacuolar (V)-ATPase protein pump. May mediate renin- dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, it may also play a role in the renin-angiotensin system (RAS) (By similarity). Probably by controlling the assembly of the V- ATPase pump and thus the acidification of the endo-lysosomal system, plays a [...] (350 aa) |
| | LAMP2 | Lysosomal associated membrane protein 2. (410 aa) |
| | ABCD1 | ABCD1 isoform 1. (710 aa) |
| | VAMP7 | Vesicle-associated membrane protein 7; Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocy [...] (220 aa) |
| | BRI3 | BRI3 isoform 4. (123 aa) |
| | ATP6V1G1 | V-type H+-transporting ATPase subunit G. (115 aa) |
| | PPA1 | Inorganic pyrophosphatase. (244 aa) |
| | GPR137C | GPR137C isoform 1. (258 aa) |
| | ATP6V0E1 | V-type proton ATPase subunit e 1; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (81 aa) |
| | BST2 | BST2 isoform 1. (200 aa) |
| | CLCN5 | H(+)/Cl(-) exchange transporter 5; Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons. Important for normal acidification of the endosome lumen. May play an important role in renal tubular function (By similarity). (816 aa) |
| | TMEM150C | TMEM150C isoform 1. (278 aa) |
| | ATP11B | Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (599 aa) |
| | WDR41 | WDR41 isoform 3. (419 aa) |
| | RNF167 | Ring finger protein 167. (375 aa) |
| | TMEM63A | CSC1-like protein 1; Acts as an osmosensitive calcium-permeable cation channel (By similarity). Mechanosensitive ion channel that converts mechanical stimuli into a flow of ion (By similarity). Belongs to the CSC1 (TC 1.A.17) family. (717 aa) |
| | ENSPPYP00000024559 | annotation not available (71 aa) |
| | VNN3 | Vascular non-inflammatory molecule 3 isoform X1. (501 aa) |
