Your Input: | |
| | CNST | CNST isoform 1. (690 aa) |
| | HTR7 | HTR7 isoform 3; Belongs to the G-protein coupled receptor 1 family. (459 aa) |
| | OPTN | Optineurin; Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex th [...] (532 aa) |
| | USP6NL | USP6 N-terminal like. (827 aa) |
| | VAMP3 | Vesicle associated membrane protein 3. (100 aa) |
| | YIPF1 | Protein YIPF1; Belongs to the YIP1 family. (306 aa) |
| | PLPP3 | T0071805 isoform 3. (313 aa) |
| | AP4B1 | AP complex subunit beta; Belongs to the adaptor complexes large subunit family. (739 aa) |
| | GOLPH3L | Golgi phosphoprotein 3 like. (285 aa) |
| | RAB13 | RAB13 isoform 2. (203 aa) |
| | GBA | Lysosomal acid glucosylceramidase; Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose. Thereby, plays a central role in the degradation of complex lipids and the turnover of cellular membranes. Through the production of ceramides, participates to the PKC-activated salvage pathway of ceramide formation. Also plays a role in cholesterol metabolism. May either catalyze the glucosylation of cholesterol, through a transglucosylation reaction that transfers glucose from glucosylceramide to cholesterol. [...] (626 aa) |
| | SYT11 | SYT11 isoform 1. (388 aa) |
| | TMEM79 | TMEM79 isoform 2. (394 aa) |
| | VAMP4 | VAMP4 isoform 1. (134 aa) |
| | RAB29 | Ras-related protein Rab-7L1; The small GTPases Rab are key regulators in vesicle trafficking (By similarity). Essential for maintaining the integrity of endosome-trans-Golgi network structure (By similarity). Together with LRRK2, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (By similarity). Recruits LRRK2 to the Golgi apparatus and stimulates LRRK2 kinase activity (By similarity). Regulates also neuronal process morphology in the intact cen [...] (203 aa) |
| | AP4S1 | Adaptor related protein complex 4 subunit sigma 1. (159 aa) |
| | SLC39A9 | Zinc transporter ZIP9; May act as a zinc-influx transporter; Belongs to the ZIP transporter (TC 2.A.5) family. (307 aa) |
| | PLD4 | PLD4 isoform 1. (506 aa) |
| | KLHL20 | Kelch-like protein 20; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. The BCR(KLHL20) E3 ubiquitin ligase complex mediates the ubiquitination of DAPK1, leading to its degradation by the proteasome, thereby acting as a negative regulator of apoptosis. The BCR(KLHL20) E3 ubiquitin ligase complex also specifically mediates 'Lys-33'-linked ubiquitination. Involved in anterograde Golgi to endosome transport by mediating 'Lys-33'-linked ubiquitination of CORO7, promoting inte [...] (582 aa) |
| | CALN1 | CALN1 isoform 1. (219 aa) |
| | PLEKHA8 | Pleckstrin homology domain containing A8. (519 aa) |
| | GSAP | Gamma-secretase activating protein. (854 aa) |
| | IMPAD1 | Inositol monophosphatase domain containing 1. (359 aa) |
| | CLVS1 | Clavesin-1; Required for normal morphology of late endosomes and/or lysosomes in neurons. Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (By similarity). (354 aa) |
| | ARFGEF1 | ARFGEF1 isoform 4. (1808 aa) |
| | VPS13B | VPS13B isoform 3. (3944 aa) |
| | CR201_G0005484 | FAM91A1 isoform 1. (511 aa) |
| | MLANA | MLANA isoform 1. (118 aa) |
| | GCNT1 | Glucosaminyl (N-acetyl) transferase 1. (428 aa) |
| | RABEPK | RABEPK isoform 2. (363 aa) |
| | FUT7 | Fucosyltransferase 7. (342 aa) |
| | ENSPPYP00000022367 | annotation not available (427 aa) |
| | AP1S2 | AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (160 aa) |
| | SLC9A7 | Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (728 aa) |
| | PCSK1N | Proprotein convertase subtilisin/kexin type 1 inhibitor. (260 aa) |
| | YIPF6 | Protein YIPF. (236 aa) |
| | ATP7A | ATPase copper transporting alpha. (1500 aa) |
| | PIH1D3 | PIH1 domain containing 3. (214 aa) |
| | WDR44 | WDR44 isoform 2. (902 aa) |
| | SNX9 | Sorting nexin. (618 aa) |
| | WDR11 | WDR11 isoform 1. (652 aa) |
| | HOOK2 | Hook microtubule tethering protein 2. (719 aa) |
| | SLC24A5 | SLC24A5 isoform 1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (498 aa) |
| | SCAMP2 | Secretory carrier-associated membrane protein. (329 aa) |
| | FURIN | Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family. (794 aa) |
| | BAIAP3 | BAIAP3 isoform 3. (1072 aa) |
| | CORO7 | Coronin-7; F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post-Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology (By similarity). (955 aa) |
| | RBFOX1 | RNA binding protein fox-1 homolog 1; RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Prevents binding of U2AF2 to the 3'-splice site. Regulates alternative splicing of tissue- specific exons and of differentially spliced exons during erythropoiesis (By similarity). (394 aa) |
| | CR201_G0034261 | GGA2 isoform 1. (451 aa) |
| | CLN3 | Battenin. (438 aa) |
| | CHST4 | Sulfotransferase; Belongs to the sulfotransferase 1 family. (386 aa) |
| | ATP2C2 | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (946 aa) |
| | ENSPPYP00000008720 | annotation not available (160 aa) |
| | INPP5K | INPP5K isoform 1. (446 aa) |
| | SLC2A4 | Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa) |
| | STX8 | STX8 isoform 2. (236 aa) |
| | LLGL1 | LLGL1 isoform 2. (1051 aa) |
| | MYO18A | MYO18A isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2049 aa) |
| | C17H17orf75 | C17orf75 isoform 2. (396 aa) |
| | GRN | GRN isoform 1. (578 aa) |
| | CA4 | Carbonic anhydrase 4; Belongs to the alpha-carbonic anhydrase family. (312 aa) |
| | CR201_G0024013 | WIPI1 isoform 2. (251 aa) |
| | COG1 | COG1 isoform 2. (980 aa) |
| | GGA3 | GGA3 isoform 1. (716 aa) |
| | TEPSIN | TEPSIN isoform 1. (492 aa) |
| | RAB31 | RAB31, member RAS oncogene family. (195 aa) |
| | RELCH | RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1216 aa) |
| | ATP9B | Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1183 aa) |
| | SLC66A2 | Solute carrier family 66 member 2. (271 aa) |
| | GPR108 | GPR108 isoform 1. (463 aa) |
| | YIPF2 | Protein YIPF. (287 aa) |
| | AP1M1 | Protein FAM32A; May induce G2 arrest and apoptosis. May also increase cell sensitivity to apoptotic stimuli; Belongs to the FAM32 family. (493 aa) |
| | CLIP3 | CAP-Gly domain-containing linker protein 3; Functions as a cytoplasmic linker protein. Involved in TGN- endosome dynamics. May modulate the cellular compartmentalization of AKT kinase family and promote its cell membrane localization, thereby playing a role in glucose transport in adipocytes (By similarity). (547 aa) |
| | TMEM230 | Transmembrane protein 230; Involved in trafficking and recycling of synaptic vesicles. Belongs to the TMEM134/TMEM230 family. (120 aa) |
| | MMP24 | MMP24 isoform 1. (514 aa) |
| | ARFGEF2 | ARFGEF2 isoform 1. (1779 aa) |
| | ATP9A | Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1022 aa) |
| | STX16 | STX16-NPEPL1 isoform 1; Belongs to the syntaxin family. (308 aa) |
| | GNAS | GNAS isoform 2. (1037 aa) |
| | ARFRP1 | ADP-ribosylation factor-related protein 1; Trans-Golgi-associated GTPase that regulates protein sorting. Controls the targeting of ARL1 and its effector to the trans-Golgi. Required for the lipidation of chylomicrons in the intestine and required for VLDL lipidation in the liver. (201 aa) |
| | AP1B1 | AP complex subunit beta. (946 aa) |
| | CABP7 | Calcium binding protein 7. (215 aa) |
| | CBY1 | Chibby family member 1, beta catenin antagonist. (169 aa) |
| | GCC2 | GCC2 isoform 3. (1686 aa) |
| | BIRC6 | BIRC6 isoform 1. (4803 aa) |
| | SLC30A6 | SLC30A6 isoform 7. (412 aa) |
| | RAB10 | Ras-related protein Rab-10; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (By similarity). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane (By similarity). Regulates, for instance, SLC [...] (199 aa) |
| | EIPR1 | EARP and GARP complex-interacting protein 1; Acts as a component of endosomal retrieval machinery that is involved in protein transport from early endosomes to either recycling endosomes or the trans-Golgi network. Mediates the recruitment of Golgi-associated retrograde protein (GARP) complex to the trans-Golgi network and controls early endosome-to-Golgi transport of internalized protein. Promotes the recycling of internalized transferrin receptor (TFRC) to the plasma membrane through interaction with endosome- associated recycling protein (EARP) complex. (409 aa) |
| | TGOLN2 | TGOLN2 isoform 3. (369 aa) |
| | CR201_G0050356 | CERKL isoform 11. (420 aa) |
| | MARCHF4 | Membrane associated ring-CH-type finger 4. (410 aa) |
| | ATG9A | Autophagy-related protein 9A; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Cycles between a juxta-nuclear trans-Golgi network compartment and late endosomes. Nutrient starvation induces accumulation on autophagosomes. Starvation-dependent trafficking requires ULK1, ATG13 and SUPT20H (By similarity). (838 aa) |
| | AP1S3 | AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (154 aa) |
| | BOK | BCL2 family apoptosis regulator BOK. (212 aa) |
| | TBC1D23 | TBC1 domain family member 23; Putative Rab GTPase-activating protein which plays a role in vesicular trafficking. Involved in endosome-to-Golgi trafficking. Acts as a bridging protein by binding simultaneously to golgins, including GOLGA1 and GOLGA4, located at the trans-Golgi, and to the WASH complex, located on endosome-derived vesicles. Together with WDR11 complex facilitates the golgin-mediated capture of vesicles generated using AP- 1 (By similarity). Plays a role in brain development, including in cortical neuron positioning (By similarity). May also be important for neurite outg [...] (699 aa) |
| | ATP2C1 | Calcium-transporting ATPase type 2C member 1; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium. (949 aa) |
| | CHST2 | Sulfotransferase; Belongs to the sulfotransferase 1 family. (530 aa) |
| | NSG1 | Neuronal vesicle trafficking-associated protein 1; Plays a role in the recycling mechanism in neurons of multiple receptors, including AMPAR, APP and L1CAM and acts at the level of early endosomes to promote sorting of receptors toward a recycling pathway. Regulates sorting and recycling of GRIA2 through interaction with GRIP1 and then contributes to the regulation of synaptic transmission and plasticity by affecting the recycling and targeting of AMPA receptors to the synapse (By similarity). Is required for faithful sorting of L1CAM to axons by facilitating trafficking from somatoden [...] (185 aa) |
| | TMEM165 | GDT1 family protein. (324 aa) |
| | AP1AR | Adaptor related protein complex 1 associated regulatory protein. (302 aa) |
| | NDST4 | NDST4 isoform 1. (798 aa) |
| | ENSPPYP00000016775 | annotation not available (586 aa) |
| | SLC10A7 | Sodium/bile acid cotransporter; Does not show transport activity towards bile acids or steroid sulfates; Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family. (327 aa) |
| | ARFIP1 | ARFIP1 isoform 2. (373 aa) |
| | MARCHF1 | MARCH1 isoform 2. (542 aa) |
| | GOLPH3 | Golgi phosphoprotein 3. (298 aa) |
| | SCAMP1 | Secretory carrier-associated membrane protein. (338 aa) |
| | RHOBTB3 | RHOBTB3 isoform 7. (548 aa) |
| | NDST1 | N-deacetylase and N-sulfotransferase 1. (882 aa) |
| | NSG2 | Neuronal vesicle trafficking associated 2. (171 aa) |
| | KIF13A | KIF13A isoform 3; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1788 aa) |
| | HLA-DRB5 | Ig-like domain-containing protein. (266 aa) |
| | CR201_G0016196 | HLA-DQB1 isoform 5. (304 aa) |
| | FUT9 | Fucosyltransferase 9. (359 aa) |
| | CLVS2 | CLVS2 isoform 1. (327 aa) |
| | IGF2R | IGF2R isoform 1. (2446 aa) |
| | ENSPPYP00000019293 | HLA class II histocompatibility antigen, DRB1-11 beta chain isoform X1. (266 aa) |
| | HLA-DQB2 | Major histocompatibility complex, class II, DQ beta 2. (264 aa) |
| | CR201_G0016218 | HLA-DPA1 isoform 1; Belongs to the MHC class II family. (260 aa) |
| | PRKD1 | Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (912 aa) |
| | ATP7B | ATP7B isoform 3. (1434 aa) |
| | NBEA | NBEA isoform 4. (2941 aa) |
| | ATXN2 | ATXN2 isoform 2. (1245 aa) |
| | PHETA1 | PH domain containing endocytic trafficking adaptor 1. (247 aa) |
| | ARL1 | ADP ribosylation factor like GTPase 1; Belongs to the small GTPase superfamily. Arf family. (181 aa) |
| | LGR5 | LGR5 isoform 1. (907 aa) |
| | BICD1 | BICD1 isoform 4. (975 aa) |
| | CCDC91 | Coiled-coil domain-containing protein 91; Involved in the regulation of membrane traffic through the trans-Golgi network (TGN). Functions in close cooperation with the GGAs in the sorting of hydrolases to lysosomes. (441 aa) |
| | ENSPPYP00000004926 | annotation not available (398 aa) |
| | M6PR | Mannose-6-phosphate receptor, cation dependent. (278 aa) |
| | BACE1 | Beta-secretase 1; Belongs to the peptidase A1 family. (501 aa) |
| | RAB30 | RAB30, member RAS oncogene family. (203 aa) |
| | ARFIP2 | ARFIP2 isoform 2. (342 aa) |
| | DENND5A | DENND5A isoform 1. (1191 aa) |
| | PIK3C2A | Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha; Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. Has a role in several intracellular trafficking events. Functions in insulin signaling and secretion. Required for translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane and glucose uptake in response to insulin-mediated RHOQ activation. Regulates insulin secretion through two different mechanisms: involved in glucose-induced insulin secretion dow [...] (1684 aa) |
| | MS4A6A | MS4A6A isoform 4. (248 aa) |
| | CR201_G0041652 | MS4A6E isoform 2. (192 aa) |
| | CHID1 | Chitinase domain-containing protein 1; Saccharide- and LPS-binding protein with possible roles in pathogen sensing and endotoxin neutralization. Ligand-binding specificity relates to the length of the oligosaccharides, with preference for chitotetraose (in vitro) (By similarity). (370 aa) |
| | VTI1A | Vesicle transport through interaction with t-SNAREs 1A. (217 aa) |
| | GBF1 | GBF1 isoform 1. (1855 aa) |
| | LOC100460187 | MHC class II protein; Belongs to the MHC class II family. (254 aa) |
| | CR201_G0016218-2 | HLA-DPA1 isoform 3. (239 aa) |
| | RAC1 | Rac family small GTPase 1. (211 aa) |
| | TMEM130 | Transmembrane protein 130. (641 aa) |
| | LGR6 | LGR6 isoform 2. (892 aa) |
| | ENSPPYP00000000352 | annotation not available (88 aa) |
| | AP4M1 | AP-4 complex subunit mu-1; Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin- associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asym [...] (453 aa) |
| | AP1S1 | AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (245 aa) |
