STRINGSTRING
CNST CNST HTR7 HTR7 OPTN OPTN USP6NL USP6NL VAMP3 VAMP3 YIPF1 YIPF1 PLPP3 PLPP3 AP4B1 AP4B1 GOLPH3L GOLPH3L RAB13 RAB13 GBA GBA SYT11 SYT11 TMEM79 TMEM79 VAMP4 VAMP4 RAB29 RAB29 AP4S1 AP4S1 SLC39A9 SLC39A9 PLD4 PLD4 KLHL20 KLHL20 CALN1 CALN1 PLEKHA8 PLEKHA8 GSAP GSAP IMPAD1 IMPAD1 CLVS1 CLVS1 ARFGEF1 ARFGEF1 VPS13B VPS13B CR201_G0005484 CR201_G0005484 MLANA MLANA GCNT1 GCNT1 RABEPK RABEPK FUT7 FUT7 ENSPPYP00000022367 ENSPPYP00000022367 AP1S2 AP1S2 SLC9A7 SLC9A7 PCSK1N PCSK1N YIPF6 YIPF6 ATP7A ATP7A PIH1D3 PIH1D3 WDR44 WDR44 SNX9 SNX9 WDR11 WDR11 HOOK2 HOOK2 SLC24A5 SLC24A5 SCAMP2 SCAMP2 FURIN FURIN BAIAP3 BAIAP3 CORO7 CORO7 RBFOX1 RBFOX1 CR201_G0034261 CR201_G0034261 CLN3 CLN3 CHST4 CHST4 ATP2C2 ATP2C2 ENSPPYP00000008720 ENSPPYP00000008720 INPP5K INPP5K SLC2A4 SLC2A4 STX8 STX8 LLGL1 LLGL1 MYO18A MYO18A C17H17orf75 C17H17orf75 GRN GRN CA4 CA4 CR201_G0024013 CR201_G0024013 COG1 COG1 GGA3 GGA3 TEPSIN TEPSIN RAB31 RAB31 RELCH RELCH ATP9B ATP9B SLC66A2 SLC66A2 GPR108 GPR108 YIPF2 YIPF2 AP1M1 AP1M1 CLIP3 CLIP3 TMEM230 TMEM230 MMP24 MMP24 ARFGEF2 ARFGEF2 ATP9A ATP9A STX16 STX16 GNAS GNAS ARFRP1 ARFRP1 AP1B1 AP1B1 CABP7 CABP7 CBY1 CBY1 GCC2 GCC2 BIRC6 BIRC6 SLC30A6 SLC30A6 RAB10 RAB10 EIPR1 EIPR1 TGOLN2 TGOLN2 CR201_G0050356 CR201_G0050356 MARCHF4 MARCHF4 ATG9A ATG9A AP1S3 AP1S3 BOK BOK TBC1D23 TBC1D23 ATP2C1 ATP2C1 CHST2 CHST2 NSG1 NSG1 TMEM165 TMEM165 AP1AR AP1AR NDST4 NDST4 ENSPPYP00000016775 ENSPPYP00000016775 SLC10A7 SLC10A7 ARFIP1 ARFIP1 MARCHF1 MARCHF1 GOLPH3 GOLPH3 SCAMP1 SCAMP1 RHOBTB3 RHOBTB3 NDST1 NDST1 NSG2 NSG2 KIF13A KIF13A HLA-DRB5 HLA-DRB5 CR201_G0016196 CR201_G0016196 FUT9 FUT9 CLVS2 CLVS2 IGF2R IGF2R ENSPPYP00000019293 ENSPPYP00000019293 HLA-DQB2 HLA-DQB2 CR201_G0016218 CR201_G0016218 PRKD1 PRKD1 ATP7B ATP7B NBEA NBEA ATXN2 ATXN2 PHETA1 PHETA1 ARL1 ARL1 LGR5 LGR5 BICD1 BICD1 CCDC91 CCDC91 ENSPPYP00000004926 ENSPPYP00000004926 M6PR M6PR BACE1 BACE1 RAB30 RAB30 ARFIP2 ARFIP2 DENND5A DENND5A PIK3C2A PIK3C2A MS4A6A MS4A6A CR201_G0041652 CR201_G0041652 CHID1 CHID1 VTI1A VTI1A GBF1 GBF1 LOC100460187 LOC100460187 CR201_G0016218-2 CR201_G0016218-2 RAC1 RAC1 TMEM130 TMEM130 LGR6 LGR6 ENSPPYP00000000352 ENSPPYP00000000352 AP4M1 AP4M1 AP1S1 AP1S1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CNSTCNST isoform 1. (690 aa)
HTR7HTR7 isoform 3; Belongs to the G-protein coupled receptor 1 family. (459 aa)
OPTNOptineurin; Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex th [...] (532 aa)
USP6NLUSP6 N-terminal like. (827 aa)
VAMP3Vesicle associated membrane protein 3. (100 aa)
YIPF1Protein YIPF1; Belongs to the YIP1 family. (306 aa)
PLPP3T0071805 isoform 3. (313 aa)
AP4B1AP complex subunit beta; Belongs to the adaptor complexes large subunit family. (739 aa)
GOLPH3LGolgi phosphoprotein 3 like. (285 aa)
RAB13RAB13 isoform 2. (203 aa)
GBALysosomal acid glucosylceramidase; Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose. Thereby, plays a central role in the degradation of complex lipids and the turnover of cellular membranes. Through the production of ceramides, participates to the PKC-activated salvage pathway of ceramide formation. Also plays a role in cholesterol metabolism. May either catalyze the glucosylation of cholesterol, through a transglucosylation reaction that transfers glucose from glucosylceramide to cholesterol. [...] (626 aa)
SYT11SYT11 isoform 1. (388 aa)
TMEM79TMEM79 isoform 2. (394 aa)
VAMP4VAMP4 isoform 1. (134 aa)
RAB29Ras-related protein Rab-7L1; The small GTPases Rab are key regulators in vesicle trafficking (By similarity). Essential for maintaining the integrity of endosome-trans-Golgi network structure (By similarity). Together with LRRK2, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (By similarity). Recruits LRRK2 to the Golgi apparatus and stimulates LRRK2 kinase activity (By similarity). Regulates also neuronal process morphology in the intact cen [...] (203 aa)
AP4S1Adaptor related protein complex 4 subunit sigma 1. (159 aa)
SLC39A9Zinc transporter ZIP9; May act as a zinc-influx transporter; Belongs to the ZIP transporter (TC 2.A.5) family. (307 aa)
PLD4PLD4 isoform 1. (506 aa)
KLHL20Kelch-like protein 20; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. The BCR(KLHL20) E3 ubiquitin ligase complex mediates the ubiquitination of DAPK1, leading to its degradation by the proteasome, thereby acting as a negative regulator of apoptosis. The BCR(KLHL20) E3 ubiquitin ligase complex also specifically mediates 'Lys-33'-linked ubiquitination. Involved in anterograde Golgi to endosome transport by mediating 'Lys-33'-linked ubiquitination of CORO7, promoting inte [...] (582 aa)
CALN1CALN1 isoform 1. (219 aa)
PLEKHA8Pleckstrin homology domain containing A8. (519 aa)
GSAPGamma-secretase activating protein. (854 aa)
IMPAD1Inositol monophosphatase domain containing 1. (359 aa)
CLVS1Clavesin-1; Required for normal morphology of late endosomes and/or lysosomes in neurons. Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (By similarity). (354 aa)
ARFGEF1ARFGEF1 isoform 4. (1808 aa)
VPS13BVPS13B isoform 3. (3944 aa)
CR201_G0005484FAM91A1 isoform 1. (511 aa)
MLANAMLANA isoform 1. (118 aa)
GCNT1Glucosaminyl (N-acetyl) transferase 1. (428 aa)
RABEPKRABEPK isoform 2. (363 aa)
FUT7Fucosyltransferase 7. (342 aa)
ENSPPYP00000022367annotation not available (427 aa)
AP1S2AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (160 aa)
SLC9A7Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (728 aa)
PCSK1NProprotein convertase subtilisin/kexin type 1 inhibitor. (260 aa)
YIPF6Protein YIPF. (236 aa)
ATP7AATPase copper transporting alpha. (1500 aa)
PIH1D3PIH1 domain containing 3. (214 aa)
WDR44WDR44 isoform 2. (902 aa)
SNX9Sorting nexin. (618 aa)
WDR11WDR11 isoform 1. (652 aa)
HOOK2Hook microtubule tethering protein 2. (719 aa)
SLC24A5SLC24A5 isoform 1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (498 aa)
SCAMP2Secretory carrier-associated membrane protein. (329 aa)
FURINFurin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family. (794 aa)
BAIAP3BAIAP3 isoform 3. (1072 aa)
CORO7Coronin-7; F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post-Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology (By similarity). (955 aa)
RBFOX1RNA binding protein fox-1 homolog 1; RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Prevents binding of U2AF2 to the 3'-splice site. Regulates alternative splicing of tissue- specific exons and of differentially spliced exons during erythropoiesis (By similarity). (394 aa)
CR201_G0034261GGA2 isoform 1. (451 aa)
CLN3Battenin. (438 aa)
CHST4Sulfotransferase; Belongs to the sulfotransferase 1 family. (386 aa)
ATP2C2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (946 aa)
ENSPPYP00000008720annotation not available (160 aa)
INPP5KINPP5K isoform 1. (446 aa)
SLC2A4Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
STX8STX8 isoform 2. (236 aa)
LLGL1LLGL1 isoform 2. (1051 aa)
MYO18AMYO18A isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2049 aa)
C17H17orf75C17orf75 isoform 2. (396 aa)
GRNGRN isoform 1. (578 aa)
CA4Carbonic anhydrase 4; Belongs to the alpha-carbonic anhydrase family. (312 aa)
CR201_G0024013WIPI1 isoform 2. (251 aa)
COG1COG1 isoform 2. (980 aa)
GGA3GGA3 isoform 1. (716 aa)
TEPSINTEPSIN isoform 1. (492 aa)
RAB31RAB31, member RAS oncogene family. (195 aa)
RELCHRAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1216 aa)
ATP9BPhospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1183 aa)
SLC66A2Solute carrier family 66 member 2. (271 aa)
GPR108GPR108 isoform 1. (463 aa)
YIPF2Protein YIPF. (287 aa)
AP1M1Protein FAM32A; May induce G2 arrest and apoptosis. May also increase cell sensitivity to apoptotic stimuli; Belongs to the FAM32 family. (493 aa)
CLIP3CAP-Gly domain-containing linker protein 3; Functions as a cytoplasmic linker protein. Involved in TGN- endosome dynamics. May modulate the cellular compartmentalization of AKT kinase family and promote its cell membrane localization, thereby playing a role in glucose transport in adipocytes (By similarity). (547 aa)
TMEM230Transmembrane protein 230; Involved in trafficking and recycling of synaptic vesicles. Belongs to the TMEM134/TMEM230 family. (120 aa)
MMP24MMP24 isoform 1. (514 aa)
ARFGEF2ARFGEF2 isoform 1. (1779 aa)
ATP9APhospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1022 aa)
STX16STX16-NPEPL1 isoform 1; Belongs to the syntaxin family. (308 aa)
GNASGNAS isoform 2. (1037 aa)
ARFRP1ADP-ribosylation factor-related protein 1; Trans-Golgi-associated GTPase that regulates protein sorting. Controls the targeting of ARL1 and its effector to the trans-Golgi. Required for the lipidation of chylomicrons in the intestine and required for VLDL lipidation in the liver. (201 aa)
AP1B1AP complex subunit beta. (946 aa)
CABP7Calcium binding protein 7. (215 aa)
CBY1Chibby family member 1, beta catenin antagonist. (169 aa)
GCC2GCC2 isoform 3. (1686 aa)
BIRC6BIRC6 isoform 1. (4803 aa)
SLC30A6SLC30A6 isoform 7. (412 aa)
RAB10Ras-related protein Rab-10; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (By similarity). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane (By similarity). Regulates, for instance, SLC [...] (199 aa)
EIPR1EARP and GARP complex-interacting protein 1; Acts as a component of endosomal retrieval machinery that is involved in protein transport from early endosomes to either recycling endosomes or the trans-Golgi network. Mediates the recruitment of Golgi-associated retrograde protein (GARP) complex to the trans-Golgi network and controls early endosome-to-Golgi transport of internalized protein. Promotes the recycling of internalized transferrin receptor (TFRC) to the plasma membrane through interaction with endosome- associated recycling protein (EARP) complex. (409 aa)
TGOLN2TGOLN2 isoform 3. (369 aa)
CR201_G0050356CERKL isoform 11. (420 aa)
MARCHF4Membrane associated ring-CH-type finger 4. (410 aa)
ATG9AAutophagy-related protein 9A; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Cycles between a juxta-nuclear trans-Golgi network compartment and late endosomes. Nutrient starvation induces accumulation on autophagosomes. Starvation-dependent trafficking requires ULK1, ATG13 and SUPT20H (By similarity). (838 aa)
AP1S3AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (154 aa)
BOKBCL2 family apoptosis regulator BOK. (212 aa)
TBC1D23TBC1 domain family member 23; Putative Rab GTPase-activating protein which plays a role in vesicular trafficking. Involved in endosome-to-Golgi trafficking. Acts as a bridging protein by binding simultaneously to golgins, including GOLGA1 and GOLGA4, located at the trans-Golgi, and to the WASH complex, located on endosome-derived vesicles. Together with WDR11 complex facilitates the golgin-mediated capture of vesicles generated using AP- 1 (By similarity). Plays a role in brain development, including in cortical neuron positioning (By similarity). May also be important for neurite outg [...] (699 aa)
ATP2C1Calcium-transporting ATPase type 2C member 1; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium. (949 aa)
CHST2Sulfotransferase; Belongs to the sulfotransferase 1 family. (530 aa)
NSG1Neuronal vesicle trafficking-associated protein 1; Plays a role in the recycling mechanism in neurons of multiple receptors, including AMPAR, APP and L1CAM and acts at the level of early endosomes to promote sorting of receptors toward a recycling pathway. Regulates sorting and recycling of GRIA2 through interaction with GRIP1 and then contributes to the regulation of synaptic transmission and plasticity by affecting the recycling and targeting of AMPA receptors to the synapse (By similarity). Is required for faithful sorting of L1CAM to axons by facilitating trafficking from somatoden [...] (185 aa)
TMEM165GDT1 family protein. (324 aa)
AP1ARAdaptor related protein complex 1 associated regulatory protein. (302 aa)
NDST4NDST4 isoform 1. (798 aa)
ENSPPYP00000016775annotation not available (586 aa)
SLC10A7Sodium/bile acid cotransporter; Does not show transport activity towards bile acids or steroid sulfates; Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family. (327 aa)
ARFIP1ARFIP1 isoform 2. (373 aa)
MARCHF1MARCH1 isoform 2. (542 aa)
GOLPH3Golgi phosphoprotein 3. (298 aa)
SCAMP1Secretory carrier-associated membrane protein. (338 aa)
RHOBTB3RHOBTB3 isoform 7. (548 aa)
NDST1N-deacetylase and N-sulfotransferase 1. (882 aa)
NSG2Neuronal vesicle trafficking associated 2. (171 aa)
KIF13AKIF13A isoform 3; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1788 aa)
HLA-DRB5Ig-like domain-containing protein. (266 aa)
CR201_G0016196HLA-DQB1 isoform 5. (304 aa)
FUT9Fucosyltransferase 9. (359 aa)
CLVS2CLVS2 isoform 1. (327 aa)
IGF2RIGF2R isoform 1. (2446 aa)
ENSPPYP00000019293HLA class II histocompatibility antigen, DRB1-11 beta chain isoform X1. (266 aa)
HLA-DQB2Major histocompatibility complex, class II, DQ beta 2. (264 aa)
CR201_G0016218HLA-DPA1 isoform 1; Belongs to the MHC class II family. (260 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (912 aa)
ATP7BATP7B isoform 3. (1434 aa)
NBEANBEA isoform 4. (2941 aa)
ATXN2ATXN2 isoform 2. (1245 aa)
PHETA1PH domain containing endocytic trafficking adaptor 1. (247 aa)
ARL1ADP ribosylation factor like GTPase 1; Belongs to the small GTPase superfamily. Arf family. (181 aa)
LGR5LGR5 isoform 1. (907 aa)
BICD1BICD1 isoform 4. (975 aa)
CCDC91Coiled-coil domain-containing protein 91; Involved in the regulation of membrane traffic through the trans-Golgi network (TGN). Functions in close cooperation with the GGAs in the sorting of hydrolases to lysosomes. (441 aa)
ENSPPYP00000004926annotation not available (398 aa)
M6PRMannose-6-phosphate receptor, cation dependent. (278 aa)
BACE1Beta-secretase 1; Belongs to the peptidase A1 family. (501 aa)
RAB30RAB30, member RAS oncogene family. (203 aa)
ARFIP2ARFIP2 isoform 2. (342 aa)
DENND5ADENND5A isoform 1. (1191 aa)
PIK3C2APhosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha; Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. Has a role in several intracellular trafficking events. Functions in insulin signaling and secretion. Required for translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane and glucose uptake in response to insulin-mediated RHOQ activation. Regulates insulin secretion through two different mechanisms: involved in glucose-induced insulin secretion dow [...] (1684 aa)
MS4A6AMS4A6A isoform 4. (248 aa)
CR201_G0041652MS4A6E isoform 2. (192 aa)
CHID1Chitinase domain-containing protein 1; Saccharide- and LPS-binding protein with possible roles in pathogen sensing and endotoxin neutralization. Ligand-binding specificity relates to the length of the oligosaccharides, with preference for chitotetraose (in vitro) (By similarity). (370 aa)
VTI1AVesicle transport through interaction with t-SNAREs 1A. (217 aa)
GBF1GBF1 isoform 1. (1855 aa)
LOC100460187MHC class II protein; Belongs to the MHC class II family. (254 aa)
CR201_G0016218-2HLA-DPA1 isoform 3. (239 aa)
RAC1Rac family small GTPase 1. (211 aa)
TMEM130Transmembrane protein 130. (641 aa)
LGR6LGR6 isoform 2. (892 aa)
ENSPPYP00000000352annotation not available (88 aa)
AP4M1AP-4 complex subunit mu-1; Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin- associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asym [...] (453 aa)
AP1S1AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (245 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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