STRINGSTRING
MTM1 MTM1 MYO10 MYO10 GPM6A GPM6A UNC5C UNC5C RUFY3 RUFY3 FXR1 FXR1 VILL VILL GAP43 GAP43 ARL4C ARL4C VIL1 VIL1 MAP2 MAP2 ACTN2 ACTN2 MYO3A MYO3A ABI1 ABI1 MORN4 MORN4 SHTN1 SHTN1 CR201_G0048733 CR201_G0048733 TBC1D10C TBC1D10C RDX RDX KITLG KITLG SPATA13 SPATA13 LCP1 LCP1 ARF6 ARF6 SYNE2 SYNE2 MYO5A MYO5A CR201_G0014777 CR201_G0014777 TUBB3 TUBB3 FXR2 FXR2 BAIAP2 BAIAP2 ITGA3 ITGA3 PPP1R9B PPP1R9B PALM PALM RAPH1 RAPH1 ABI2 ABI2 ENSPPYP00000010854 ENSPPYP00000010854 ANTXR1 ANTXR1 NF2 NF2 CXADR CXADR SRC SRC VASP VASP TENM2 TENM2 IQGAP2 IQGAP2 UTRN UTRN EZR EZR FSCN1 FSCN1 CR201_G0010042 CR201_G0010042 NINJ1 NINJ1 ABITRAM ABITRAM DMD DMD MSN MSN FGF13 FGF13 FMR1 FMR1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MTM1Myotubularin; Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2). Has also been shown to dephosphorylate phosphotyrosine- and phosphoserine-containing peptides. Negatively regulates EGFR degradation through regulation of EGFR trafficking from the late endosome to the lysosome. Plays a role in vacuolar formation and morphology. Regulates desmin intermediate filament assembly and architecture. Plays a role in mitochondrial morphology and positioning. Required for skeletal muscle maintenance but not fo [...] (603 aa)
MYO10MYO10 isoform 2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2027 aa)
GPM6ANeuronal membrane glycoprotein M6-a; Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells. Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation. GPM6A-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways. May be involved in neuronal NGF-dependent Ca(2+) influx. May be involved in regulation of endocytosis and intracellular trafficking of G-protein-coupled receptors (GPCRs); enhances internalization and re [...] (257 aa)
UNC5CUNC5C isoform 1. (931 aa)
RUFY3Protein RUFY3; Plays a role in the generation of neuronal polarity formation and axon growth. Implicated in the formation of a single axon by developing neurons. May inhibit the formation of additional axons by inhibition of PI3K in minor neuronal processes. Plays a role in the formation of F-actin-enriched protrusive structures at the cell periphery. Plays a role in cytoskeletal organization by regulating the subcellular localization of FSCN1 and DBN1 at axonal growth cones. Promotes gastric cancer cell migration and invasion in a PAK1-dependent manner. (620 aa)
FXR1FMR1 autosomal homolog 1. (621 aa)
VILLVILL isoform 1. (855 aa)
GAP43Neuromodulin; This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction (By similarity). (238 aa)
ARL4CADP ribosylation factor like GTPase 4C; Belongs to the small GTPase superfamily. Arf family. (201 aa)
VIL1VIL1 isoform 1. (839 aa)
MAP2Microtubule-associated protein. (1770 aa)
ACTN2ACTN2 isoform 1. (887 aa)
MYO3AMYO3A isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1575 aa)
ABI1Abl interactor 1. (481 aa)
MORN4MORN repeat-containing protein 4; Plays a role in promoting axonal degeneration following neuronal injury by toxic insult or trauma. (146 aa)
SHTN1Shootin-1; Involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth. Mediates netrin-1-induced F-actin-substrate coupling or 'clutch engagement' within the axon growth cone through activation of CDC42, RAC1 and PAK1- dependent signaling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium extension and axon outgrowth. Plays a role in cytoskeletal organization by regulating the subcellular localization of phosphoinositide 3-kinase (PI3K) activity at the axonal growth cone. Pl [...] (647 aa)
CR201_G0048733ANTXRL isoform 3. (477 aa)
TBC1D10CTBC1D10C isoform 5. (435 aa)
RDXRDX isoform 3. (604 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (262 aa)
SPATA13SPATA13 isoform 1. (1274 aa)
LCP1Lymphocyte cytosolic protein 1. (627 aa)
ARF6ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
SYNE2SYNE2 isoform 1. (6862 aa)
MYO5AMYO5A isoform 5; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1795 aa)
CR201_G0014777CIB1 isoform 1. (190 aa)
TUBB3T0170152 isoform 1; Belongs to the tubulin family. (450 aa)
FXR2FXR2 isoform 2. (658 aa)
BAIAP2BAI1 associated protein 2. (521 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1051 aa)
PPP1R9BPPP1R9B isoform 1. (729 aa)
PALMPALM isoform 3. (368 aa)
RAPH1RAPH1 isoform 10. (1303 aa)
ABI2ABI2 isoform 1. (551 aa)
ENSPPYP00000010854annotation not available (137 aa)
ANTXR1ANTXR1 isoform 1. (215 aa)
NF2Neurofibromin 2. (590 aa)
CXADRCoxsackievirus and adenovirus receptor homolog; Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induc [...] (365 aa)
SRCTyrosine-protein kinase. (553 aa)
VASPVasodilator stimulated phosphoprotein; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Belongs to the Ena/VASP family. (380 aa)
TENM2TENM2 isoform 3. (2577 aa)
IQGAP2IQ motif containing GTPase activating protein 2. (1575 aa)
UTRNUTRN isoform 2. (3433 aa)
EZREZR isoform 1. (586 aa)
FSCN1FSCN1 isoform 3. (444 aa)
CR201_G0010042PPP1R9A isoform 2. (1098 aa)
NINJ1NINJ1 isoform 1. (152 aa)
ABITRAMProtein Abitram; Actin-binding protein that regulates actin polymerization, filopodia dynamics and increases the branching of proximal dendrites of developing neurons; Belongs to the ABITRAM family. (181 aa)
DMDDMD isoform 3. (3618 aa)
MSNMSN isoform 6. (577 aa)
FGF13Fibroblast growth factor 13; Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and stabilization of microtubules (By similarity). Through its action on microtubules, may participate to the refinement of axons by negatively regulating axonal and leading processes branching (By similarity). Plays a crucial role in neuron polarization and migration in the cerebral cortex and the hippocampus (By similarity). May regulate voltage-gated sodium channels transport and function (By similarity). May also play a role in MAPK signaling (By similarity). [...] (245 aa)
FMR1Synaptic functional regulator FMR1; Multifunctional polyribosome-associated RNA-binding protein that plays a central role in neuronal development and synaptic plasticity through the regulation of alternative mRNA splicing, mRNA stability, mRNA dendritic transport and postsynaptic local protein synthesis of a subset of mRNAs. Plays a role in the alternative splicing of its own mRNA. Plays a role in mRNA nuclear export. Together with export factor NXF2, is involved in the regulation of the NXF1 mRNA stability in neurons. Stabilizes the scaffolding postsynaptic density protein DLG4/PSD-95 [...] (590 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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