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| | PSD3 | PSD3 isoform 1. (974 aa) |
| | ARPC3 | Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (168 aa) |
| | CR201_G0001158 | MYO1H isoform 1. (124 aa) |
| | SSH1 | SSH1 isoform 1. (1004 aa) |
| | CORO1C | Coronin; Belongs to the WD repeat coronin family. (434 aa) |
| | VEZT | Vezatin; Plays a pivotal role in the establishment of adherens junctions and their maintenance in adult life. Required for morphogenesis of the preimplantation embryo, and for the implantation process. (779 aa) |
| | FGD6 | FGD6 isoform 2. (1428 aa) |
| | KITLG | Kit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (262 aa) |
| | AVIL | AVIL isoform 2. (819 aa) |
| | LIMA1 | LIMA1 isoform 1. (760 aa) |
| | FGD4 | FYVE, RhoGEF and PH domain containing 4. (766 aa) |
| | C2CD5 | C2 domain-containing protein 5; Required for insulin-stimulated glucose transport and glucose transporter SLC2A4/GLUT4 translocation from intracellular glucose storage vesicle (GSV) to the plasma membrane (PM) in adipocytes. Binds phospholipid membranes in a calcium-dependent manner and is necessary for the optimal membrane fusion between SLC2A4/GLUT4 GSV and the PM. (1029 aa) |
| | EPS8 | Epidermal growth factor receptor kinase substrate 8; Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can regulate different processes. Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac-specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and acti [...] (824 aa) |
| | RDX | RDX isoform 3. (604 aa) |
| | PAK1 | Non-specific serine/threonine protein kinase. (546 aa) |
| | CR201_G0023407 | T0080539 isoform 3. (405 aa) |
| | ENSPPYP00000004160 | annotation not available (140 aa) |
| | ENSPPYP00000004159 | annotation not available (150 aa) |
| | ENSPPYP00000004157 | annotation not available (93 aa) |
| | APBB1 | APBB1 isoform 1. (800 aa) |
| | ARFIP2 | ARFIP2 isoform 2. (342 aa) |
| | CR201_G0010942 | Diacylglycerol kinase. (919 aa) |
| | FAM89B | Family with sequence similarity 89 member B. (176 aa) |
| | CFL1 | CFL1 isoform 4; Belongs to the actin-binding proteins ADF family. (165 aa) |
| | SSH3 | SSH3 isoform 1. (637 aa) |
| | CORO1B | Coronin-1B; Regulates leading edge dynamics and cell motility in fibroblasts. May be involved in cytokinesis and signal transduction (By similarity); Belongs to the WD repeat coronin family. (510 aa) |
| | TESC | TESC isoform 2. (214 aa) |
| | CR201_G0000922 | PXN isoform 2; Belongs to the paxillin family. (381 aa) |
| | NME2 | Nucleoside diphosphate kinase B; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity). Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically. Binds to both single-stranded guanine- and cytosine-rich strands within the nuclease hypersensitive element (NHE) III(1) region of the MYC gene promoter. Does not bind to duplex NHE I [...] (152 aa) |
| | HIP1R | HIP1R isoform 1. (1038 aa) |
| | SPATA13 | SPATA13 isoform 1. (1274 aa) |
| | LCP1 | Lymphocyte cytosolic protein 1. (627 aa) |
| | ARHGEF7 | ARHGEF7 isoform 7. (803 aa) |
| | SALL2 | SALL2 isoform 1. (1042 aa) |
| | SYNE2 | SYNE2 isoform 1. (6862 aa) |
| | PLEK2 | PLEK2 isoform 1. (353 aa) |
| | EVL | Ena/VASP-like protein; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. EVL enhances actin nucleation and polymerization (By similarity). (422 aa) |
| | CDC42BPB | CDC42BPB isoform 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1617 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (413 aa) |
| | KNSTRN | Kinetochore localized astrin (SPAG5) binding protein. (316 aa) |
| | PLA2G4F | Phospholipase A2. (851 aa) |
| | MYO5A | MYO5A isoform 5; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1795 aa) |
| | TPM1 | TPM1 isoform 2; Belongs to the tropomyosin family. (326 aa) |
| | AP3S2 | AP-3 complex subunit sigma-2; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals (By similarity). (193 aa) |
| | ENSPPYP00000007684 | annotation not available (127 aa) |
| | CR201_G0014777 | CIB1 isoform 1. (190 aa) |
| | ARPIN | C15orf38-AP3S2 isoform 2. (91 aa) |
| | CR201_G0015118 | RIPOR1 isoform 12. (1038 aa) |
| | CARMIL2 | CARMIL2 isoform 1. (1395 aa) |
| | BCAR1 | BCAR1 isoform 1. (849 aa) |
| | TUBB3 | T0170152 isoform 1; Belongs to the tubulin family. (450 aa) |
| | MYO1C | MYO1C isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1063 aa) |
| | INPP5K | INPP5K isoform 1. (446 aa) |
| | TRPV1 | TRPV1 isoform 1; Belongs to the transient receptor (TC 1.A.4) family. (837 aa) |
| | GAS7 | Growth arrest specific 7. (476 aa) |
| | ARHGAP44 | ARHGAP44 isoform 2. (736 aa) |
| | MYO1D | MYO1D isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1006 aa) |
| | ENSPPYP00000009291 | annotation not available (118 aa) |
| | MPP2 | Membrane palmitoylated protein 2; Belongs to the MAGUK family. (552 aa) |
| | ITGB4 | Integrin beta. (1814 aa) |
| | BAIAP2 | BAI1 associated protein 2. (521 aa) |
| | RAC3 | RAC3 isoform 1. (192 aa) |
| | ABI3 | ABI3 isoform 1. (366 aa) |
| | PPP1R9B | PPP1R9B isoform 1. (729 aa) |
| | PTPRM | PTPRM isoform 1. (1445 aa) |
| | SLC39A6 | Zinc transporter ZIP6; May act as a zinc-influx transporter. (742 aa) |
| | CR201_G0051651 | KANK3 isoform 1. (698 aa) |
| | ENSPPYP00000010854 | annotation not available (137 aa) |
| | RINL | RINL isoform 4. (453 aa) |
| | AKT2 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa) |
| | VASP | Vasodilator stimulated phosphoprotein; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Belongs to the Ena/VASP family. (380 aa) |
| | MYADM | Myeloid-associated differentiation marker. (322 aa) |
| | EPS8L1 | EPS8L1 isoform 4. (714 aa) |
| | LAMP5 | Lysosome-associated membrane glycoprotein 5; Plays a role in short-term synaptic plasticity in a subset of GABAergic neurons in the brain; Belongs to the LAMP family. (261 aa) |
| | PLCG1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1257 aa) |
| | PTK6 | Tyrosine-protein kinase. (451 aa) |
| | S100B | Protein S100; Belongs to the S-100 family. (92 aa) |
| | NF2 | Neurofibromin 2. (590 aa) |
| | INPP5J | Inositol polyphosphate-5-phosphatase J. (1007 aa) |
| | MYH9 | MYH9 isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1959 aa) |
| | RAC2 | Rac family small GTPase 2. (192 aa) |
| | CR201_G0031876-2 | PACSIN2 isoform 10. (375 aa) |
| | PARVB | Parvin beta. (334 aa) |
| | CR201_G0043139 | PSD4 isoform 2. (721 aa) |
| | ANTXR1 | ANTXR1 isoform 1. (215 aa) |
| | PLEK | PLEK isoform 1. (350 aa) |
| | CCDC88A | CCDC88A isoform 1. (1797 aa) |
| | SPTBN1 | Spectrin beta chain; Belongs to the spectrin family. (2342 aa) |
| | SH3YL1 | SH3 domain-containing YSC84-like protein 1. (342 aa) |
| | LOC100449402 | Uncharacterized protein LOC100449402. (79 aa) |
| | ENSPPYP00000014325 | LOW QUALITY PROTEIN: polyadenylate-binding protein 1. (270 aa) |
| | DPP4 | DPP4 isoform 1; Belongs to the peptidase S9B family. (766 aa) |
| | FAP | Fibroblast activation protein alpha; Belongs to the peptidase S9B family. (760 aa) |
| | ALS2 | ALS2 isoform 1. (1638 aa) |
| | ABI2 | ABI2 isoform 1. (551 aa) |
| | ENSPPYP00000014963 | annotation not available (78 aa) |
| | FGD5 | FGD5 isoform 2. (1462 aa) |
| | MYLK | MYLK isoform 5. (1913 aa) |
| | ATP2B2 | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1243 aa) |
| | MTMR14 | MTMR14 isoform 3. (647 aa) |
| | FAM107A | Actin-associated protein FAM107A; Stress-inducible actin-binding protein that plays a role in synaptic and cognitive functions by modulating actin filamentous (F- actin) dynamics. Mediates polymerization of globular actin to F-actin. Also binds to, stabilizes and bundles F-actin. Involved in synaptic function by regulating neurite outgrowth in an actin-dependent manner and for the acquisition of hippocampus-dependent cognitive function, such as learning and long-term memory (By similarity). Plays a role in the actin and microtubule cytoskeleton organization; negatively regulates focal [...] (144 aa) |
| | ARF4 | ADP-ribosylation factor 4; GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus (By similarity); Belongs to the small GTPase superfamily. Arf family. (180 aa) |
| | APPL1 | APPL1 isoform 1. (708 aa) |
| | RHOA | Transforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essent [...] (196 aa) |
| | CLRN1 | CLRN1 isoform 2. (232 aa) |
| | ACAP2 | ACAP2 isoform 1. (773 aa) |
| | CLRN2 | CLRN2 isoform 1. (249 aa) |
| | APBB2 | Amyloid beta precursor protein binding family B member 2. (759 aa) |
| | RUFY3 | Protein RUFY3; Plays a role in the generation of neuronal polarity formation and axon growth. Implicated in the formation of a single axon by developing neurons. May inhibit the formation of additional axons by inhibition of PI3K in minor neuronal processes. Plays a role in the formation of F-actin-enriched protrusive structures at the cell periphery. Plays a role in cytoskeletal organization by regulating the subcellular localization of FSCN1 and DBN1 at axonal growth cones. Promotes gastric cancer cell migration and invasion in a PAK1-dependent manner. (620 aa) |
| | PTPN13 | PTPN13 isoform 2. (2426 aa) |
| | UNC5C | UNC5C isoform 1. (931 aa) |
| | PALLD | PALLD isoform 1. (1101 aa) |
| | SH3RF1 | E3 ubiquitin-protein ligase SH3RF1; Has E3 ubiquitin-protein ligase activity. In the absence of an external substrate, it can catalyze self-ubiquitination. Stimulates ubiquitination of potassium channel KCNJ1, enhancing it's dynamin- dependent and clathrin-independent endocytosis. Acts as a scaffold protein that coordinates with MAPK8IP1/JIP1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pa [...] (888 aa) |
| | IQGAP2 | IQ motif containing GTPase activating protein 2. (1575 aa) |
| | JMY | JMY isoform 1. (618 aa) |
| | ADGRV1 | ADGRV1 isoform 3; Belongs to the G-protein coupled receptor 2 family. (6076 aa) |
| | PDLIM4 | PDZ and LIM domain 4. (330 aa) |
| | PSD2 | PSD2 isoform 1. (693 aa) |
| | ABLIM3 | ABLIM3 isoform 2. (705 aa) |
| | GRIA1 | GRIA1 isoform 7. (888 aa) |
| | WWC1 | WWC1 isoform 1. (1044 aa) |
| | UNC5A | UNC5A isoform 1. (840 aa) |
| | DUSP22 | Dual specificity phosphatase 22; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (184 aa) |
| | ENSPPYP00000018135 | Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1. (503 aa) |
| | NEDD9 | NEDD9 isoform 1. (834 aa) |
| | RIPOR2 | T0162759 isoform 1. (1097 aa) |
| | CARMIL1 | CARMIL1 isoform 2. (1366 aa) |
| | AIF1 | Allograft inflammatory factor 1. (147 aa) |
| | PACSIN1 | Protein kinase C and casein kinase substrate in neurons protein 1; Binds to membranes via its F-BAR domain and mediates membrane tubulation. Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell corte [...] (444 aa) |
| | FGD2 | FGD2 isoform 2. (655 aa) |
| | CD2AP | CD2 associated protein. (639 aa) |
| | PTPRK | PTPRK isoform 7. (1485 aa) |
| | ARHGAP18 | ARHGAP18 isoform 1. (636 aa) |
| | EZR | EZR isoform 1. (586 aa) |
| | FSCN1 | FSCN1 isoform 3. (444 aa) |
| | RAC1 | Rac family small GTPase 1. (211 aa) |
| | LIMK1 | LIMK1 isoform 2. (468 aa) |
| | AMPH | AMPH isoform 1. (695 aa) |
| | CTTN | CTTN isoform 1. (508 aa) |
| | CR201_G0048733 | ANTXRL isoform 3. (477 aa) |
| | SHTN1 | Shootin-1; Involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth. Mediates netrin-1-induced F-actin-substrate coupling or 'clutch engagement' within the axon growth cone through activation of CDC42, RAC1 and PAK1- dependent signaling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium extension and axon outgrowth. Plays a role in cytoskeletal organization by regulating the subcellular localization of phosphoinositide 3-kinase (PI3K) activity at the axonal growth cone. Pl [...] (647 aa) |
| | ABLIM1 | ABLIM1 isoform 1. (771 aa) |
| | SLK | STE20 like kinase. (1236 aa) |
| | GBF1 | GBF1 isoform 1. (1855 aa) |
| | PLCE1 | Phosphoinositide phospholipase C. (2303 aa) |
| | IFIT5 | Interferon induced protein with tetratricopeptide repeats 5. (482 aa) |
| | JCAD | JCAD isoform 1. (1358 aa) |
| | ABI1 | Abl interactor 1. (481 aa) |
| | PLEKHG5 | PLEKHG5 isoform 5. (905 aa) |
| | PDPN | PDPN isoform 1. (236 aa) |
| | EPHA2 | EPHA2 isoform 1. (959 aa) |
| | CR201_G0042751 | ASAP3 isoform 8. (517 aa) |
| | SLC9A1 | Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (815 aa) |
| | PHACTR4 | Phosphatase and actin regulator 4; Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to [...] (687 aa) |
| | MACF1 | Microtubule actin crosslinking factor 1. (5430 aa) |
| | MCOLN3 | MCOLN3 isoform 4. (553 aa) |
| | KCNA2 | KCNA2 isoform 1; Belongs to the potassium channel family. (356 aa) |
| | PIP5K1A | Phosphatidylinositol-4-phosphate 5-kinase type 1 alpha. (549 aa) |
| | S100A11 | Protein S100; Belongs to the S-100 family. (105 aa) |
| | S100A6 | Protein S100; Belongs to the S-100 family. (90 aa) |
| | RAB13 | RAB13 isoform 2. (203 aa) |
| | ARHGEF2 | Rho/Rac guanine nucleotide exchange factor 2. (986 aa) |
| | SCYL3 | SCY1 like pseudokinase 3. (742 aa) |
| | USH2A | USH2A isoform 2. (4749 aa) |
| | CDC42BPA | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1690 aa) |
| | CR201_G0010042 | PPP1R9A isoform 2. (1098 aa) |
| | CDK6 | Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa) |
| | MKLN1 | Muskelin; Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (By similarity). Required for internalization of the GABA receptor GABRA1 from the cell membrane via endosomes and subsequent GABRA1 degradation. Acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component THBS1 (By similarity). (700 aa) |
| | DLC1 | DLC1 isoform 1. (1515 aa) |
| | PTK2B | PTK2B isoform 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa) |
| | STMN2 | Stathmin; Belongs to the stathmin family. (179 aa) |
| | PABPC1 | Polyadenylate-binding protein 1; Binds the poly(A) tail of mRNA, including that of its own transcript, and regulates processes of mRNA metabolism such as pre-mRNA splicing and mRNA stability. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region deter [...] (636 aa) |
| | DDX58 | DDX58 isoform 2. (875 aa) |
| | KANK1 | KANK1 isoform 1. (1319 aa) |
| | DOCK8 | DOCK8 isoform 2; Belongs to the DOCK family. (2024 aa) |
| | FGD3 | FYVE, RhoGEF and PH domain-containing protein 3; Promotes the formation of filopodia. May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape (By similarity). (737 aa) |
| | ABITRAM | Protein Abitram; Actin-binding protein that regulates actin polymerization, filopodia dynamics and increases the branching of proximal dendrites of developing neurons; Belongs to the ABITRAM family. (181 aa) |
| | ARF1 | ADP ribosylation factor 1; Belongs to the small GTPase superfamily. Arf family. (181 aa) |
| | BSPRY | B-box and SPRY domain containing. (400 aa) |
| | ENSPPYP00000022286 | annotation not available (199 aa) |
| | ENSPPYP00000022338 | Uncharacterized protein LOC112130482. (78 aa) |
| | BMX | Tyrosine-protein kinase. (675 aa) |
| | NHS | NHS actin remodeling regulator. (1474 aa) |
| | ATP6AP2 | Renin receptor extracellular fragment; Multifunctional protein which functions as a renin, prorenin cellular receptor and is involved in the assembly of the proton- transporting vacuolar (V)-ATPase protein pump. May mediate renin- dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, it may also play a role in the renin-angiotensin system (RAS) (By similarity). Probably by controlling the assembly of the V- ATPase pump and thus the acidification of the endo-lysosomal system, plays a [...] (350 aa) |
| | DDX3X | ATP-dependent RNA helicase DDX3Y; Probable ATP-dependent RNA helicase. May play a role in spermatogenesis (By similarity); Belongs to the DEAD box helicase family. DDX3/DED1 subfamily. (662 aa) |
| | HDAC6 | HDAC6 isoform 2. (1208 aa) |
| | FGD1 | FGD1 isoform 1. (961 aa) |
| | AMOT | AMOT isoform 3. (1088 aa) |
| | ARHGEF6 | Rac/Cdc42 guanine nucleotide exchange factor 6. (776 aa) |
| | MTM1 | Myotubularin; Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2). Has also been shown to dephosphorylate phosphotyrosine- and phosphoserine-containing peptides. Negatively regulates EGFR degradation through regulation of EGFR trafficking from the late endosome to the lysosome. Plays a role in vacuolar formation and morphology. Regulates desmin intermediate filament assembly and architecture. Plays a role in mitochondrial morphology and positioning. Required for skeletal muscle maintenance but not fo [...] (603 aa) |
| | ITGB1BP1 | Integrin beta-1-binding protein 1; Key regulator of the integrin-mediated cell-matrix interaction signaling by binding to the ITGB1 cytoplasmic tail and preventing the activation of integrin alpha-5/beta-1 (heterodimer of ITGA5 and ITGB1) by talin or FERMT1. Plays a role in cell proliferation, differentiation, spreading, adhesion and migration in the context of mineralization and bone development and angiogenesis. Stimulates cellular proliferation in a fibronectin-dependent manner. Involved in the regulation of beta-1 integrin-containing focal adhesion (FA) site dynamics by controlling [...] (200 aa) |
| | SNX9 | Sorting nexin. (618 aa) |
| | PLEKHA1 | PLEKHA1 isoform 4. (383 aa) |
| | SGCE | Epsilon-sarcoglycan; Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. (473 aa) |
| | CAPRIN1 | CAPRIN1 isoform 1. (410 aa) |
| | SNX2 | Sorting nexin-2; Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called en [...] (523 aa) |
