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RAB4A RAB4A SLC30A10 SLC30A10 GPR161 GPR161 SYT11 SYT11 RAB13 RAB13 RNF11 RNF11 LDLRAP1 LDLRAP1 VAMP3 VAMP3 TBC1D12 TBC1D12 ZFYVE27 ZFYVE27 VPS51 VPS51 EHD1 EHD1 TPP1 TPP1 NEU3 NEU3 BACE1 BACE1 PHETA1 PHETA1 TPCN1 TPCN1 RAB35 RAB35 RAN RAN ULK1 ULK1 RAP2A RAP2A ATP11A ATP11A VTI1B VTI1B VIPAS39 VIPAS39 ENSPPYP00000007009 ENSPPYP00000007009 EHD4 EHD4 RAB11A RAB11A SCAMP2 SCAMP2 LOC100437697 LOC100437697 BAIAP3 BAIAP3 CLN3 CLN3 VPS53 VPS53 CR201_G0053168 CR201_G0053168 RABEP1 RABEP1 STX8 STX8 RAB11FIP4 RAB11FIP4 GGA3 GGA3 MYO5B MYO5B RELCH RELCH ABHD17A ABHD17A RAB11B RAB11B RAB8A RAB8A CLIP3 CLIP3 EHD2 EHD2 TBC1D17 TBC1D17 LAMP5 LAMP5 TMEM230 TMEM230 ARFGEF2 ARFGEF2 ATP9A ATP9A PLA2G3 PLA2G3 LZTR1 LZTR1 RAB11FIP5 RAB11FIP5 CR201_G0003257 CR201_G0003257 EHD3 EHD3 RAB10 RAB10 ABCB11 ABCB11 FZD7 FZD7 ATG9A ATG9A RAB17 RAB17 BOK BOK DENND6A DENND6A NISCH NISCH ACKR2 ACKR2 CMTM6 CMTM6 TF TF SLC9A9 SLC9A9 RAP2B RAP2B TNIK TNIK ATP13A4 ATP13A4 ATP13A3 ATP13A3 TFRC TFRC NSG1 NSG1 CLCN3 CLCN3 SNX18 SNX18 SCAMP1 SCAMP1 PDLIM4 PDLIM4 SLC36A2 SLC36A2 GRIA1 GRIA1 HFE HFE HLA-A HLA-A STX7 STX7 MICALL2 MICALL2 RAC1 RAC1 LMTK2 LMTK2 AVL9 AVL9 DYNC1I1 DYNC1I1 VPS50 VPS50 ZDHHC2 ZDHHC2 SGK3 SGK3 NDRG1 NDRG1 CD274 CD274 ABHD17B ABHD17B RAB14 RAB14 ENTR1 ENTR1 CLCN4 CLCN4 SLC9A7 SLC9A7 CR201_G0052920 CR201_G0052920 RAP2C RAP2C SLC9A6 SLC9A6 ABHD17C ABHD17C ATP11B ATP11B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RAB4ARAB4A, member RAS oncogene family. (218 aa)
SLC30A10Solute carrier family 30 member 10. (485 aa)
GPR161G protein-coupled receptor 161; Belongs to the G-protein coupled receptor 1 family. (549 aa)
SYT11SYT11 isoform 1. (388 aa)
RAB13RAB13 isoform 2. (203 aa)
RNF11Ring finger protein 11. (154 aa)
LDLRAP1LDLRAP1 isoform 1. (308 aa)
VAMP3Vesicle associated membrane protein 3. (100 aa)
TBC1D12TBC1D12 isoform 1. (772 aa)
ZFYVE27Protrudin; Key regulator of RAB11-dependent vesicular trafficking during neurite extension through polarized membrane transport. Promotes axonal elongation and contributes to the establishment of neuronal cell polarity. Involved in nerve growth factor-induced neurite formation in VAPA-dependent manner. Contributes to both the formation and stabilization of the tubular ER network. Involved in ER morphogenesis by regulating the sheet-to-tubule balance and possibly the density of tubule interconnections. Acts as an adapter protein that facilitates the interaction of KIF5A with VAPA, VAPB, [...] (480 aa)
VPS51VPS51 isoform 3. (303 aa)
EHD1EH domain-containing protein 1; ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis. Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Recruited to endosomal membranes upon nerve growth factor stimulation, indirectly regulates neurite outgrowth. Plays a role in myoblast fusion. Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to axons implicating a function in neuronal APP processing. Plays a role in the formation of the ciliary v [...] (534 aa)
TPP1Tripeptidyl-peptidase 1; Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus (By similarity). (583 aa)
NEU3NEU3 isoform 2. (404 aa)
BACE1Beta-secretase 1; Belongs to the peptidase A1 family. (501 aa)
PHETA1PH domain containing endocytic trafficking adaptor 1. (247 aa)
TPCN1TPCN1 isoform 2. (798 aa)
RAB35RAB35, member RAS oncogene family. (201 aa)
RANGTP-binding nuclear protein Ran; GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP- bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment [...] (236 aa)
ULK1Serine/threonine-protein kinase; Serine/threonine-protein kinase involved in autophagy in response to starvation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. (924 aa)
RAP2ARas-related protein Rap-2a; Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. In its active form interacts with and regulates several effectors including MAP4K4, MINK1 and TNIK. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it is part of several signaling cascades and may regulate cytoskeletal rearrangements, cell migration, cell adhesion and cell spreading (By similarity). (197 aa)
ATP11APhospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1159 aa)
VTI1BVesicle transport through interaction with t-SNAREs 1B. (232 aa)
VIPAS39VIPAS39 isoform 6. (433 aa)
ENSPPYP00000007009annotation not available (143 aa)
EHD4EH domain containing 4; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (541 aa)
RAB11ARas-related protein Rab-11A; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The small Rab GTPase RAB11A regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial c [...] (216 aa)
SCAMP2Secretory carrier-associated membrane protein. (329 aa)
LOC100437697RAB11FIP3 isoform 1. (536 aa)
BAIAP3BAIAP3 isoform 3. (1072 aa)
CLN3Battenin. (438 aa)
VPS53Vacuolar protein sorting-associated protein 53 homolog; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4- positive endosomes and promotes recycling of internalized t [...] (770 aa)
CR201_G0053168T0188308 isoform 2. (1404 aa)
RABEP1Rabaptin, RAB GTPase binding effector protein 1. (862 aa)
STX8STX8 isoform 2. (236 aa)
RAB11FIP4RAB11FIP4 isoform 1. (557 aa)
GGA3GGA3 isoform 1. (716 aa)
MYO5BT0098307 isoform 1. (1849 aa)
RELCHRAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1216 aa)
ABHD17AABHD17A isoform 5. (383 aa)
RAB11BRAB11B, member RAS oncogene family. (218 aa)
RAB8ARas-related protein Rab-8A; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes t [...] (207 aa)
CLIP3CAP-Gly domain-containing linker protein 3; Functions as a cytoplasmic linker protein. Involved in TGN- endosome dynamics. May modulate the cellular compartmentalization of AKT kinase family and promote its cell membrane localization, thereby playing a role in glucose transport in adipocytes (By similarity). (547 aa)
EHD2EHD2 isoform 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (605 aa)
TBC1D17TBC1 domain family member 17. (648 aa)
LAMP5Lysosome-associated membrane glycoprotein 5; Plays a role in short-term synaptic plasticity in a subset of GABAergic neurons in the brain; Belongs to the LAMP family. (261 aa)
TMEM230Transmembrane protein 230; Involved in trafficking and recycling of synaptic vesicles. Belongs to the TMEM134/TMEM230 family. (120 aa)
ARFGEF2ARFGEF2 isoform 1. (1779 aa)
ATP9APhospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1022 aa)
PLA2G3PLA2G3 isoform 1. (505 aa)
LZTR1Leucine-zipper-like transcriptional regulator 1; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates ubiquitination of Ras (K-Ras/KRAS, N-Ras/NRAS and H-Ras/HRAS). Is a negative regulator of RAS-MAPK signaling that acts by controlling Ras levels and decreasing Ras association with membranes. (820 aa)
RAB11FIP5RAB11FIP5 isoform 2. (589 aa)
CR201_G0003257COMMD1 isoform 4. (146 aa)
EHD3EHD3 isoform 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (535 aa)
RAB10Ras-related protein Rab-10; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (By similarity). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane (By similarity). Regulates, for instance, SLC [...] (199 aa)
ABCB11ABCB11 isoform 1. (1321 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
ATG9AAutophagy-related protein 9A; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Cycles between a juxta-nuclear trans-Golgi network compartment and late endosomes. Nutrient starvation induces accumulation on autophagosomes. Starvation-dependent trafficking requires ULK1, ATG13 and SUPT20H (By similarity). (838 aa)
RAB17RAB17 isoform 2. (212 aa)
BOKBCL2 family apoptosis regulator BOK. (212 aa)
DENND6ADENND6A isoform 1. (608 aa)
NISCHNISCH isoform 1. (1505 aa)
ACKR2ACKR2 isoform 3; Belongs to the G-protein coupled receptor 1 family. (407 aa)
CMTM6CKLF-like MARVEL transmembrane domain-containing protein 6; Master regulator of recycling and plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Associates with both constitutive and IFNG-induced PD-L1/CD274 at recycling endosomes, where it protects PD-L1/CD274 from being targeted for lysosomal degradation, likely by preventing its ubiquitination. May stabilize PD-L1/CD274 expression on antigen presenting cells and potentiates inhibitory signaling by PDCD1/CD279, its receptor on T-cells, ultimately trigge [...] (183 aa)
TFTF isoform 1; Belongs to the transferrin family. (703 aa)
SLC9A9Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (619 aa)
RAP2BRAP2B, member of RAS oncogene family. (183 aa)
TNIKTRAF2 and NCK interacting kinase. (1360 aa)
ATP13A4Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1151 aa)
ATP13A3Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1207 aa)
TFRCTransferrin receptor protein 1; Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Positively regulates T and B cell proliferation through iron uptake (By similarity). (760 aa)
NSG1Neuronal vesicle trafficking-associated protein 1; Plays a role in the recycling mechanism in neurons of multiple receptors, including AMPAR, APP and L1CAM and acts at the level of early endosomes to promote sorting of receptors toward a recycling pathway. Regulates sorting and recycling of GRIA2 through interaction with GRIP1 and then contributes to the regulation of synaptic transmission and plasticity by affecting the recycling and targeting of AMPA receptors to the synapse (By similarity). Is required for faithful sorting of L1CAM to axons by facilitating trafficking from somatoden [...] (185 aa)
CLCN3H(+)/Cl(-) exchange transporter 3; Mediates the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the endosome and synaptic vesicle lumen, and may thereby affect vesicle trafficking and exocytosis. May play an important role in neuronal cell function through regulation of membrane excitability by protein kinase C. It could help neuronal cells to establish short-term memory (By similarity). (866 aa)
SNX18Sorting nexin. (624 aa)
SCAMP1Secretory carrier-associated membrane protein. (338 aa)
PDLIM4PDZ and LIM domain 4. (330 aa)
SLC36A2SLC36A2 isoform 1. (486 aa)
GRIA1GRIA1 isoform 7. (888 aa)
HFEHomeostatic iron regulator; Belongs to the MHC class I family. (348 aa)
HLA-APopy Class I histocompatibility antigen, A-1 alpha chain. (365 aa)
STX7Syntaxin-7; May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes (By similarity). (261 aa)
MICALL2MICALL2 isoform 9. (905 aa)
RAC1Rac family small GTPase 1. (211 aa)
LMTK2LMTK2 isoform 1. (1474 aa)
AVL9Late secretory pathway protein AVL9 homolog; Functions in cell migration; Belongs to the AVL9 family. (648 aa)
DYNC1I1Dynein cytoplasmic 1 intermediate chain 1. (645 aa)
VPS50VPS50 isoform 2. (964 aa)
ZDHHC2Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (367 aa)
SGK3Serine/threonine-protein kinase Sgk3; Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, proliferation, survival and migration. Up-regulates Na(+) channels: SCNN1A/ENAC and SCN5A, K(+) channels: KCNA3/KV1.3, KCNE1, KCNQ1 and KCNH2/HERG, epithelial Ca(2+) channels: TRPV5 and TRPV6, chloride channel: BSND, creatine transporter: SLC6A8, Na(+)/dicarboxylate cotransporter: SLC13A2/NADC1, Na(+)-dependent phosphate cotransporter: SLC34A2/NAPI-2B, amino acid transporters: SLC1A5/ASCT2 and SLC6A19, glutamate [...] (466 aa)
NDRG1NDRG1 isoform 2. (408 aa)
CD274CD274 isoform 2. (290 aa)
ABHD17BAbhydrolase domain containing 17B. (293 aa)
RAB14Ras-related protein Rab-14; Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes. Regulates, together with its guanine nucleotide exchange factor DENND6A, the specific endocytic transport of ADAM10, N- cadherin/CDH2 shedding and cell [...] (179 aa)
ENTR1SDCCAG3 isoform 2. (362 aa)
CLCN4Chloride channel protein. (760 aa)
SLC9A7Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (728 aa)
CR201_G0052920GRIPAP1 isoform 14. (643 aa)
RAP2CRAP2C isoform 1. (144 aa)
SLC9A6Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (701 aa)
ABHD17CABHD17C isoform 2. (207 aa)
ATP11BPhospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (599 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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