STRINGSTRING
MAP2 MAP2 VIL1 VIL1 ARL4C ARL4C ESPNL ESPNL SLC6A6 SLC6A6 GAP43 GAP43 TWF2 TWF2 HYAL2 HYAL2 VILL VILL PLS1 PLS1 CLRN1 CLRN1 FXR1 FXR1 S100P S100P PROM1 PROM1 CLRN2 CLRN2 RUFY3 RUFY3 UNC5C UNC5C GPM6A GPM6A MYO10 MYO10 IQGAP2 IQGAP2 S100Z S100Z ADGRV1 ADGRV1 GRXCR2 GRXCR2 TENM2 TENM2 CDHR2 CDHR2 RIPOR2 RIPOR2 MYO6 MYO6 UTRN UTRN EZR EZR CR201_G0040964 CR201_G0040964 FSCN1 FSCN1 OCM OCM CR201_G0010042 CR201_G0010042 PODXL PODXL ENSPPYP00000020473 ENSPPYP00000020473 ANGPT1 ANGPT1 CR201_G0001936 CR201_G0001936 TMC1 TMC1 NINJ1 NINJ1 ABITRAM ABITRAM TPRN TPRN DMD DMD MSN MSN FGF13 FGF13 FMR1 FMR1 MTM1 MTM1 ENSPPYP00000023721 ENSPPYP00000023721 EPS8L2 EPS8L2 ENSPPYP00000023937 ENSPPYP00000023937 HOMER2 HOMER2 TMC3 TMC3 CR201_G0042177 CR201_G0042177 MYO5A MYO5A GLDN GLDN CR201_G0045973 CR201_G0045973 AMN AMN SYNE2 SYNE2 ARF6 ARF6 SLC7A8 SLC7A8 LCP1 LCP1 SPATA13 SPATA13 CR201_G0001158 CR201_G0001158 VEZT VEZT KITLG KITLG EPS8 EPS8 CR201_G0026161 CR201_G0026161 RDX RDX CR201_G0023224 CR201_G0023224 FCHSD2 FCHSD2 USH1C USH1C CR201_G0011084 CR201_G0011084 CBLIF CBLIF TBC1D10C TBC1D10C CDHR5 CDHR5 CR201_G0048733 CR201_G0048733 SHTN1 SHTN1 PDZD7 PDZD7 MORN4 MORN4 PCDH15 PCDH15 ABI1 ABI1 MYO3A MYO3A CUBN CUBN ESPN ESPN CLIC4 CLIC4 SYTL1 SYTL1 MCOLN3 MCOLN3 RHOC RHOC NFASC NFASC USH2A USH2A ACTN2 ACTN2 RAPH1 RAPH1 ABI2 ABI2 MYO3B MYO3B MYO7B MYO7B ANTXR1 ANTXR1 PROM2 PROM2 TRIOBP TRIOBP TBC1D10A TBC1D10A NF2 NF2 TSPEAR TSPEAR CXADR CXADR SRC SRC TMC2 TMC2 VASP VASP CEACAM16 CEACAM16 ENSPPYP00000010854 ENSPPYP00000010854 PALM PALM LOXHD1 LOXHD1 PPP1R9B PPP1R9B ITGA3 ITGA3 BAIAP2 BAIAP2 ENPP7 ENPP7 SLC9A3R1 SLC9A3R1 ICAM2 ICAM2 MYO15A MYO15A FXR2 FXR2 MYO1C MYO1C TUBB3 TUBB3 SLC7A5 SLC7A5 SPN SPN ANKS4B ANKS4B CR201_G0014777 CR201_G0014777
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAP2Microtubule-associated protein. (1770 aa)
VIL1VIL1 isoform 1. (839 aa)
ARL4CADP ribosylation factor like GTPase 4C; Belongs to the small GTPase superfamily. Arf family. (201 aa)
ESPNLESPNL isoform 1. (1002 aa)
SLC6A6Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (601 aa)
GAP43Neuromodulin; This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction (By similarity). (238 aa)
TWF2Twinfilin-2; Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G- actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles. May play a role in regulating the mature length of the middle and short rows of stereocilia (By similarity); Belongs to the actin-binding proteins ADF family. Twinfilin subfamily. (349 aa)
HYAL2Hyaluronidase. (473 aa)
VILLVILL isoform 1. (855 aa)
PLS1PLS1 isoform 1. (631 aa)
CLRN1CLRN1 isoform 2. (232 aa)
FXR1FMR1 autosomal homolog 1. (621 aa)
S100PS100 calcium binding protein P. (95 aa)
PROM1PROM1 isoform 12. (865 aa)
CLRN2CLRN2 isoform 1. (249 aa)
RUFY3Protein RUFY3; Plays a role in the generation of neuronal polarity formation and axon growth. Implicated in the formation of a single axon by developing neurons. May inhibit the formation of additional axons by inhibition of PI3K in minor neuronal processes. Plays a role in the formation of F-actin-enriched protrusive structures at the cell periphery. Plays a role in cytoskeletal organization by regulating the subcellular localization of FSCN1 and DBN1 at axonal growth cones. Promotes gastric cancer cell migration and invasion in a PAK1-dependent manner. (620 aa)
UNC5CUNC5C isoform 1. (931 aa)
GPM6ANeuronal membrane glycoprotein M6-a; Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells. Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation. GPM6A-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways. May be involved in neuronal NGF-dependent Ca(2+) influx. May be involved in regulation of endocytosis and intracellular trafficking of G-protein-coupled receptors (GPCRs); enhances internalization and re [...] (257 aa)
MYO10MYO10 isoform 2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2027 aa)
IQGAP2IQ motif containing GTPase activating protein 2. (1575 aa)
S100ZS100 calcium binding protein Z; Belongs to the S-100 family. (99 aa)
ADGRV1ADGRV1 isoform 3; Belongs to the G-protein coupled receptor 2 family. (6076 aa)
GRXCR2Glutaredoxin and cysteine rich domain containing 2. (248 aa)
TENM2TENM2 isoform 3. (2577 aa)
CDHR2CDHR2 isoform 1. (778 aa)
RIPOR2T0162759 isoform 1. (1097 aa)
MYO6MYO6 isoform 6; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1294 aa)
UTRNUTRN isoform 2. (3433 aa)
EZREZR isoform 1. (586 aa)
CR201_G0040964PDGFA isoform 2; Belongs to the PDGF/VEGF growth factor family. (135 aa)
FSCN1FSCN1 isoform 3. (444 aa)
OCMOCM isoform 1; Belongs to the parvalbumin family. (109 aa)
CR201_G0010042PPP1R9A isoform 2. (1098 aa)
PODXLPodocalyxin; Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Belongs to the podocalyxin family. (513 aa)
ENSPPYP00000020473annotation not available (129 aa)
ANGPT1ANGPT1 isoform 2. (498 aa)
CR201_G0001936TEK isoform 5. (1014 aa)
TMC1Transmembrane channel-like protein. (761 aa)
NINJ1NINJ1 isoform 1. (152 aa)
ABITRAMProtein Abitram; Actin-binding protein that regulates actin polymerization, filopodia dynamics and increases the branching of proximal dendrites of developing neurons; Belongs to the ABITRAM family. (181 aa)
TPRNTPRN isoform 2. (404 aa)
DMDDMD isoform 3. (3618 aa)
MSNMSN isoform 6. (577 aa)
FGF13Fibroblast growth factor 13; Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and stabilization of microtubules (By similarity). Through its action on microtubules, may participate to the refinement of axons by negatively regulating axonal and leading processes branching (By similarity). Plays a crucial role in neuron polarization and migration in the cerebral cortex and the hippocampus (By similarity). May regulate voltage-gated sodium channels transport and function (By similarity). May also play a role in MAPK signaling (By similarity). [...] (245 aa)
FMR1Synaptic functional regulator FMR1; Multifunctional polyribosome-associated RNA-binding protein that plays a central role in neuronal development and synaptic plasticity through the regulation of alternative mRNA splicing, mRNA stability, mRNA dendritic transport and postsynaptic local protein synthesis of a subset of mRNAs. Plays a role in the alternative splicing of its own mRNA. Plays a role in mRNA nuclear export. Together with export factor NXF2, is involved in the regulation of the NXF1 mRNA stability in neurons. Stabilizes the scaffolding postsynaptic density protein DLG4/PSD-95 [...] (590 aa)
MTM1Myotubularin; Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2). Has also been shown to dephosphorylate phosphotyrosine- and phosphoserine-containing peptides. Negatively regulates EGFR degradation through regulation of EGFR trafficking from the late endosome to the lysosome. Plays a role in vacuolar formation and morphology. Regulates desmin intermediate filament assembly and architecture. Plays a role in mitochondrial morphology and positioning. Required for skeletal muscle maintenance but not fo [...] (603 aa)
ENSPPYP00000023721annotation not available (169 aa)
EPS8L2Epidermal growth factor receptor kinase substrate 8-like protein 2; Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton (By similarity). In the cochlea, is required for stereocilia maintenance in adult hair cells (By similarity). (1531 aa)
ENSPPYP00000023937annotation not available (62 aa)
HOMER2HOMER2 isoform 1. (397 aa)
TMC3Transmembrane channel-like protein. (1107 aa)
CR201_G0042177CIB2 isoform 1. (346 aa)
MYO5AMYO5A isoform 5; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1795 aa)
GLDNGLDN isoform 1. (551 aa)
CR201_G0045973STRC isoform 2. (1473 aa)
AMNAMN isoform 2. (446 aa)
SYNE2SYNE2 isoform 1. (6862 aa)
ARF6ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
SLC7A8Large neutral amino acids transporter small subunit 2; Sodium-independent, high-affinity transport of small and large neutral amino acids such as alanine, serine, threonine, cysteine, phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Acts as an amino acid exchanger. Has higher affinity for L-phenylalanine than LAT1 but lower affinity for glutamine and serine. L-alanine is transported at physiological concentrations. Plays a role in basolateral (re)absorption of neutral amino acids. Involved in the uptake of methylmercury (MeHg) when administe [...] (535 aa)
LCP1Lymphocyte cytosolic protein 1. (627 aa)
SPATA13SPATA13 isoform 1. (1274 aa)
CR201_G0001158MYO1H isoform 1. (124 aa)
VEZTVezatin; Plays a pivotal role in the establishment of adherens junctions and their maintenance in adult life. Required for morphogenesis of the preimplantation embryo, and for the implantation process. (779 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (262 aa)
EPS8Epidermal growth factor receptor kinase substrate 8; Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can regulate different processes. Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac-specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and acti [...] (824 aa)
CR201_G0026161USH1C isoform 8. (559 aa)
RDXRDX isoform 3. (604 aa)
CR201_G0023224MYO7A isoform 2. (1350 aa)
FCHSD2FCH and double SH3 domains 2. (764 aa)
USH1CUSH1C isoform 9. (403 aa)
CR201_G0011084CD44 isoform 1. (351 aa)
CBLIFCobalamin binding intrinsic factor. (417 aa)
TBC1D10CTBC1D10C isoform 5. (435 aa)
CDHR5CDHR5 isoform 1. (768 aa)
CR201_G0048733ANTXRL isoform 3. (477 aa)
SHTN1Shootin-1; Involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth. Mediates netrin-1-induced F-actin-substrate coupling or 'clutch engagement' within the axon growth cone through activation of CDC42, RAC1 and PAK1- dependent signaling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium extension and axon outgrowth. Plays a role in cytoskeletal organization by regulating the subcellular localization of phosphoinositide 3-kinase (PI3K) activity at the axonal growth cone. Pl [...] (647 aa)
PDZD7PDZ domain-containing protein 7; In cochlear developing hair cells, essential in organizing the USH2 complex at stereocilia ankle links. Blocks inhibition of adenylate cyclase activity mediated by ADGRV1. (477 aa)
MORN4MORN repeat-containing protein 4; Plays a role in promoting axonal degeneration following neuronal injury by toxic insult or trauma. (146 aa)
PCDH15PCDH15 isoform 18. (1163 aa)
ABI1Abl interactor 1. (481 aa)
MYO3AMYO3A isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1575 aa)
CUBNCUBN isoform 1. (3507 aa)
ESPNESPN isoform 1. (848 aa)
CLIC4Chloride intracellular channel protein 4; Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell-surface expression of HRH3. May play a role in angiogenesis (By similarity). (253 aa)
SYTL1Synaptotagmin like 1. (550 aa)
MCOLN3MCOLN3 isoform 4. (553 aa)
RHOCRho-related GTP-binding protein RhoC; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells (By similarity). (192 aa)
NFASCNFASC isoform 1. (1342 aa)
USH2AUSH2A isoform 2. (4749 aa)
ACTN2ACTN2 isoform 1. (887 aa)
RAPH1RAPH1 isoform 10. (1303 aa)
ABI2ABI2 isoform 1. (551 aa)
MYO3BMYO3B isoform 3; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1306 aa)
MYO7BMYO7B isoform 2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2036 aa)
ANTXR1ANTXR1 isoform 1. (215 aa)
PROM2PROM2 isoform 1. (803 aa)
TRIOBPTRIOBP isoform 1. (2199 aa)
TBC1D10ATBC1 domain family member 10A. (503 aa)
NF2Neurofibromin 2. (590 aa)
TSPEARTSPEAR isoform 1. (670 aa)
CXADRCoxsackievirus and adenovirus receptor homolog; Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induc [...] (365 aa)
SRCTyrosine-protein kinase. (553 aa)
TMC2Transmembrane channel-like protein. (905 aa)
VASPVasodilator stimulated phosphoprotein; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Belongs to the Ena/VASP family. (380 aa)
CEACAM16CEACAM16 isoform 1. (482 aa)
ENSPPYP00000010854annotation not available (137 aa)
PALMPALM isoform 3. (368 aa)
LOXHD1LOXHD1 isoform 1. (1714 aa)
PPP1R9BPPP1R9B isoform 1. (729 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1051 aa)
BAIAP2BAI1 associated protein 2. (521 aa)
ENPP7Ectonucleotide pyrophosphatase/phosphodiesterase 7. (458 aa)
SLC9A3R1Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (357 aa)
ICAM2ICAM2 isoform 4. (275 aa)
MYO15AMYO15A isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (3281 aa)
FXR2FXR2 isoform 2. (658 aa)
MYO1CMYO1C isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1063 aa)
TUBB3T0170152 isoform 1; Belongs to the tubulin family. (450 aa)
SLC7A5Solute carrier family 7 member 5. (507 aa)
SPNSPN isoform 1. (400 aa)
ANKS4BAnkyrin repeat and sterile alpha motif domain containing 4B. (417 aa)
CR201_G0014777CIB1 isoform 1. (190 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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