(32 nodes) SMAD/FHA domain superfamily network (Pongo abelii)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

Your Input:
	SMAD2	Mothers against decapentaplegic homolog 2; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator [...] (467 aa)
	PHF12	PHD finger protein 12. (1004 aa)
	IRF8	IRF8 isoform 1. (426 aa)
	SMAD3	Mothers against decapentaplegic homolog. (425 aa)
	STARD9	STARD9 isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (878 aa)
	IRF9	Interferon regulatory factor 9. (392 aa)
	CHFR	E3 ubiquitin-protein ligase CHFR; E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the 'Lys- 48'-linked ubiquitination of target proteins, leading to their degradation by the proteasome. Promotes the ubiquitination and subsequent degradation of AURK [...] (619 aa)
	MCRS1	MCRS1 isoform 1. (463 aa)
	PHLDB1	PHLDB1 isoform 1. (1423 aa)
	IRF7	IRF7 isoform 12. (396 aa)
	MKI67	MKI67 isoform 2. (3252 aa)
	KIF1B	KIF1B isoform 3; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1790 aa)
	PPP1R8	Protein phosphatase 1 regulatory subunit 8. (351 aa)
	SNIP1	Smad nuclear interacting protein 1. (396 aa)
	SLC4A1AP	SLC4A1AP isoform 1. (413 aa)
	APTX	APTX isoform 14. (356 aa)
	NBN	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand- specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. NBN modulate the DNA damage signal sensing by recr [...] (720 aa)
	IRF5	IRF5 isoform 3. (509 aa)
	KIF14	KIF14 isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1366 aa)
	IRF6	IRF6 isoform 2. (467 aa)
	RNF8	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (462 aa)
	MDC1	MDC1 isoform 1. (1887 aa)
	KIF13A	KIF13A isoform 3; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1788 aa)
	SMAD5	Mothers against decapentaplegic homolog 5; Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD5 is a receptor- regulated SMAD (R-SMAD) (By similarity). (465 aa)
	TIFAB	TIFAB isoform 1. (162 aa)
	AGGF1	AGGF1 isoform 1. (714 aa)
	SMAD1	Mothers against decapentaplegic homolog. (73 aa)
	TIFA	TIFA isoform 1. (185 aa)
	APLF	Aprataxin and PNKP like factor. (511 aa)
	CHEK2	CHEK2 isoform 5. (520 aa)
	PNKP	PNKP isoform 13. (521 aa)
	SMAD7	Mothers against decapentaplegic homolog. (426 aa)

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APLF	APTX	ENSPPYP00000013769	ENSPPYP00000021447	Aprataxin and PNKP like factor.	APTX isoform 14.	0.820
APLF	CHFR	ENSPPYP00000013769	ENSPPYP00000005869	Aprataxin and PNKP like factor.	E3 ubiquitin-protein ligase CHFR; E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the 'Lys- 48'-linked ubiquitination of target proteins, leading to their degradation by the proteasome. Promotes the ubiquitination and subsequent degradation of AURK [...]	0.813
APLF	PNKP	ENSPPYP00000013769	ENSPPYP00000011492	Aprataxin and PNKP like factor.	PNKP isoform 13.	0.671
APTX	APLF	ENSPPYP00000021447	ENSPPYP00000013769	APTX isoform 14.	Aprataxin and PNKP like factor.	0.820
APTX	CHFR	ENSPPYP00000021447	ENSPPYP00000005869	APTX isoform 14.	E3 ubiquitin-protein ligase CHFR; E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the 'Lys- 48'-linked ubiquitination of target proteins, leading to their degradation by the proteasome. Promotes the ubiquitination and subsequent degradation of AURK [...]	0.652
APTX	PNKP	ENSPPYP00000021447	ENSPPYP00000011492	APTX isoform 14.	PNKP isoform 13.	0.474
CHEK2	MDC1	ENSPPYP00000013022	ENSPPYP00000018356	CHEK2 isoform 5.	MDC1 isoform 1.	0.860
CHEK2	NBN	ENSPPYP00000013022	ENSPPYP00000021011	CHEK2 isoform 5.	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand- specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. NBN modulate the DNA damage signal sensing by recr [...]	0.817
CHEK2	RNF8	ENSPPYP00000013022	ENSPPYP00000018524	CHEK2 isoform 5.	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	0.758
CHFR	APLF	ENSPPYP00000005869	ENSPPYP00000013769	E3 ubiquitin-protein ligase CHFR; E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the 'Lys- 48'-linked ubiquitination of target proteins, leading to their degradation by the proteasome. Promotes the ubiquitination and subsequent degradation of AURK [...]	Aprataxin and PNKP like factor.	0.813
CHFR	APTX	ENSPPYP00000005869	ENSPPYP00000021447	E3 ubiquitin-protein ligase CHFR; E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the 'Lys- 48'-linked ubiquitination of target proteins, leading to their degradation by the proteasome. Promotes the ubiquitination and subsequent degradation of AURK [...]	APTX isoform 14.	0.652
IRF5	IRF8	ENSPPYP00000020182	ENSPPYP00000008597	IRF5 isoform 3.	IRF8 isoform 1.	0.569
IRF7	IRF9	ENSPPYP00000003337	ENSPPYP00000006466	IRF7 isoform 12.	Interferon regulatory factor 9.	0.726
IRF7	SMAD3	ENSPPYP00000003337	ENSPPYP00000007465	IRF7 isoform 12.	Mothers against decapentaplegic homolog.	0.631
IRF8	IRF5	ENSPPYP00000008597	ENSPPYP00000020182	IRF8 isoform 1.	IRF5 isoform 3.	0.569
IRF9	IRF7	ENSPPYP00000006466	ENSPPYP00000003337	Interferon regulatory factor 9.	IRF7 isoform 12.	0.726
MDC1	CHEK2	ENSPPYP00000018356	ENSPPYP00000013022	MDC1 isoform 1.	CHEK2 isoform 5.	0.860
MDC1	NBN	ENSPPYP00000018356	ENSPPYP00000021011	MDC1 isoform 1.	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand- specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. NBN modulate the DNA damage signal sensing by recr [...]	0.974
MDC1	RNF8	ENSPPYP00000018356	ENSPPYP00000018524	MDC1 isoform 1.	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	0.996
NBN	CHEK2	ENSPPYP00000021011	ENSPPYP00000013022	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand- specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. NBN modulate the DNA damage signal sensing by recr [...]	CHEK2 isoform 5.	0.817