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| | TIAM1 | TIAM1 isoform 1. (1591 aa) |
| | DOK5 | Docking protein 5. (270 aa) |
| | ELMO2 | Engulfment and cell motility protein 2; Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1 (By similarity). (720 aa) |
| | EPB41L1 | Erythrocyte membrane protein band 4.1 like 1. (881 aa) |
| | CR201_G0018530 | CCM2L isoform 2. (473 aa) |
| | FERMT1 | Fermitin family homolog 1; Involved in cell adhesion. Contributes to integrin activation. When coexpressed with talin, potentiates activation of ITGA2B. Required for normal keratinocyte proliferation. Required for normal polarization of basal keratinocytes in skin, and for normal cell shape. Required for normal adhesion of keratinocytes to fibronectin and laminin, and for normal keratinocyte migration to wound sites (By similarity); Belongs to the kindlin family. (677 aa) |
| | EXOC8 | EXOC8 isoform 1. (728 aa) |
| | PLEKHA4 | PLEKHA4 isoform 2. (725 aa) |
| | PRKD2 | Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (801 aa) |
| | PHLDB3 | PHLDB3 isoform 2. (396 aa) |
| | CR201_G0044078 | ARHGEF1 isoform 7. (764 aa) |
| | CR201_G0043999 | SPTBN4 isoform 1. (2409 aa) |
| | AKT2 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa) |
| | JAK3 | Tyrosine-protein kinase. (1013 aa) |
| | DNM2 | DNM2 isoform 6; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (866 aa) |
| | CR201_G0051707 | T0183294 isoform 1. (932 aa) |
| | RANBP3 | Ran-binding protein 3; Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export (By similarity). (499 aa) |
| | APBA3 | Amyloid beta precursor protein binding family A member 3. (575 aa) |
| | PLEKHJ1 | PLEKHJ1 isoform 1. (149 aa) |
| | DOK6 | Docking protein 6. (331 aa) |
| | OSBPL1A | Oxysterol-binding protein; Belongs to the OSBP family. (437 aa) |
| | EPB41L3 | EPB41L3 isoform 2. (792 aa) |
| | SKAP1 | SKAP1 isoform 2. (347 aa) |
| | CYTH1 | CYTH1 isoform 4. (399 aa) |
| | GRB7 | GRB7 isoform 9. (532 aa) |
| | TNS4 | TNS4 isoform 2. (137 aa) |
| | ARHGAP27 | ARHGAP27 isoform 2. (607 aa) |
| | NF1 | NF1 isoform 6. (2838 aa) |
| | MPRIP | MPRIP isoform 9. (2203 aa) |
| | ARHGEF15 | ARHGEF15 isoform 1. (839 aa) |
| | ABR | ABR isoform 1. (818 aa) |
| | CARMIL2 | CARMIL2 isoform 1. (1395 aa) |
| | PLEKHG4 | PLEKHG4 isoform 2. (989 aa) |
| | DOK4 | Docking protein 4; DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK4 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway (By similarity). Putative link with downstream effectors of RET in neuronal differentiation. May be involved in the regulation of the immune response induced by T-cells (By similarity). (326 aa) |
| | PDPK1 | PDPK1 isoform 1. (495 aa) |
| | AKAP13 | AKAP13 isoform 5. (2833 aa) |
| | HOMER2 | HOMER2 isoform 1. (397 aa) |
| | TBC1D2B | TBC1D2B isoform 2. (790 aa) |
| | GRAMD2A | GRAM domain containing 2A. (354 aa) |
| | CR201_G0050964 | MTMR10 isoform 1. (454 aa) |
| | APBA2 | Amyloid-beta A4 precursor protein-binding family A member 2; Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta (By similarity). (749 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (413 aa) |
| | EVL | Ena/VASP-like protein; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. EVL enhances actin nucleation and polymerization (By similarity). (422 aa) |
| | PPP4R3A | PPP4R3A isoform 5. (802 aa) |
| | PTPN21 | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. (1153 aa) |
| | PLEK2 | PLEK2 isoform 1. (353 aa) |
| | CR201_G0009827 | Spectrin beta chain; Belongs to the spectrin family. (1818 aa) |
| | FERMT2 | FERMT2 isoform 1. (623 aa) |
| | SOS2 | SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa) |
| | SUPT16H | SPT16 homolog, facilitates chromatin remodeling subunit. (1047 aa) |
| | RASA3 | RASA3 isoform 1. (833 aa) |
| | MCF2L | MCF2L isoform 10. (1211 aa) |
| | ARHGEF7 | ARHGEF7 isoform 7. (803 aa) |
| | DOCK9 | DOCK9 isoform 5; Belongs to the DOCK family. (2107 aa) |
| | FARP1 | FERM, ARHGEF and pleckstrin domain-containing protein 1; Functions as guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity). (1045 aa) |
| | DGKH | Diacylglycerol kinase. (1241 aa) |
| | NBEA | NBEA isoform 4. (2941 aa) |
| | MTMR6 | Myotubularin related protein 6. (621 aa) |
| | SPATA13 | SPATA13 isoform 1. (1274 aa) |
| | RASAL1 | RASAL1 isoform 2. (782 aa) |
| | APPL2 | APPL2 isoform 1. (564 aa) |
| | PLEKHG7 | PLEKHG7 isoform 2. (352 aa) |
| | OSBPL8 | Oxysterol-binding protein; Belongs to the OSBP family. (889 aa) |
| | FRS2 | Fibroblast growth factor receptor substrate 2. (508 aa) |
| | AGAP2 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 2. (1192 aa) |
| | ARHGEF25 | ARHGEF25 isoform 6. (473 aa) |
| | ARHGAP9 | ARHGAP9 isoform 2. (802 aa) |
| | FGD4 | FYVE, RhoGEF and PH domain containing 4. (766 aa) |
| | PLEKHA5 | PLEKHA5 isoform 2. (1151 aa) |
| | EPS8 | Epidermal growth factor receptor kinase substrate 8; Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can regulate different processes. Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac-specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and acti [...] (824 aa) |
| | NECAP1 | Adaptin ear-binding coat-associated protein 1; Involved in endocytosis; Belongs to the NECAP family. (275 aa) |
| | PLEKHG6 | PLEKHG6 isoform 1. (790 aa) |
| | DCP1B | mRNA-decapping enzyme 1B; May play a role in the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. May remove the 7- methyl guanine cap structure from mRNA molecules, yielding a 5'- phosphorylated mRNA fragment and 7m-GDP (By similarity). (536 aa) |
| | IQSEC3 | IQSEC3 isoform 5. (748 aa) |
| | CR201_G0005896 | GRAMD1B isoform 5. (590 aa) |
| | APLP2 | Amyloid beta precursor like protein 2. (763 aa) |
| | ARHGEF12 | Rho guanine nucleotide exchange factor 12. (1544 aa) |
| | PHLDB1 | PHLDB1 isoform 1. (1423 aa) |
| | ARHGAP20 | Rho GTPase activating protein 20. (1191 aa) |
| | MTMR2 | Myotubularin-related protein 2; Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3- phosphate and phosphatidylinositol 3,5-bisphosphate (By similarity). Binds phosphatidylinositol 4-phosphate, phosphatidylinositol 5- phosphate, phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Stabilizes SBF2/MTMR13 at the membranes. Specifically in peripheral nerves, stabilizes SBF2/MTMR13 protein (By similarity). (640 aa) |
| | CEP57 | Centrosomal protein 57. (499 aa) |
| | GAB2 | GRB2 associated binding protein 2. (638 aa) |
| | CLNS1A | Methylosome subunit pICln; Involved in both the assembly of spliceosomal snRNPs and the methylation of Sm proteins. Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (By similarity). Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cyto [...] (237 aa) |
| | CR201_G0023224 | MYO7A isoform 2. (1350 aa) |
| | APBB1 | APBB1 isoform 1. (800 aa) |
| | SWAP70 | Switching B cell complex subunit SWAP70. (585 aa) |
| | SBF2 | SET binding factor 2. (1849 aa) |
| | MAPK8IP1 | MAPK8IP1 isoform 1. (539 aa) |
| | OSBP | Oxysterol-binding protein; Belongs to the OSBP family. (808 aa) |
| | SPTBN2 | Spectrin beta chain; Belongs to the spectrin family. (2389 aa) |
| | GRK2 | G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (689 aa) |
| | PHLDA2 | Pleckstrin homology like domain family A member 2. (155 aa) |
| | CR201_G0054746 | AGAP5 isoform 2. (662 aa) |
| | PLEKHS1 | PLEKHS1 isoform 7. (459 aa) |
| | PSD | PSD isoform 2. (982 aa) |
| | RTKN2 | RTKN2 isoform 2. (609 aa) |
| | ARHGAP22 | ARHGAP22 isoform 1. (632 aa) |
| | ACAP3 | ACAP3 isoform 1. (563 aa) |
| | PLCH2 | Phosphoinositide phospholipase C. (1416 aa) |
| | PLEKHG5 | PLEKHG5 isoform 5. (905 aa) |
| | KIF1B | KIF1B isoform 3; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1790 aa) |
| | NECAP2 | NECAP2 isoform 1. (263 aa) |
| | ANKS1A | ANKS1A isoform 2. (1089 aa) |
| | PLEKHA1 | PLEKHA1 isoform 4. (383 aa) |
| | CR201_G0002453 | EPB41L3 isoform 10. (218 aa) |
| | CR201_G0023353 | ARHGEF17 isoform 1. (1097 aa) |
| | SSRP1 | FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (712 aa) |
| | ARAP3 | ARAP3 isoform 1. (830 aa) |
| | FRMD5 | FRMD5 isoform 8. (419 aa) |
| | EPS8L2 | Epidermal growth factor receptor kinase substrate 8-like protein 2; Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton (By similarity). In the cochlea, is required for stereocilia maintenance in adult hair cells (By similarity). (1531 aa) |
| | GAB3 | GRB2 associated binding protein 3. (586 aa) |
| | MTMR1 | MTMR1 isoform 9. (685 aa) |
| | OBSCN | OBSCN isoform 2. (7677 aa) |
| | SNAP47 | SNAP47 isoform 1. (459 aa) |
| | CDC42BPA | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1690 aa) |
| | ENAH | ENAH isoform 1. (579 aa) |
| | PTPN14 | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. (1187 aa) |
| | PLEKHA6 | PLEKHA6 isoform 2. (1024 aa) |
| | RALGPS2 | Ral GEF with PH domain and SH3 binding motif 2. (583 aa) |
| | RABGAP1L | Rab GTPase-activating protein 1-like; GTP-hydrolysis activating protein (GAP) for small GTPase RAB22A, converting active RAB22A-GTP to the inactive form RAB22A-GDP (By similarity). Plays a role in endocytosis and intracellular protein transport. Recruited by ANK2 to phosphatidylinositol 3-phosphate (PI3P)-positive early endosomes, where it inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables [...] (1052 aa) |
| | ARHGEF2 | Rho/Rac guanine nucleotide exchange factor 2. (986 aa) |
| | SHC1 | SHC-transforming protein 1; Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis (By similarity). (583 aa) |
| | EPS8L3 | EPS8L3 isoform 5. (593 aa) |
| | DAB1 | DAB adaptor protein 1. (555 aa) |
| | OSBPL9 | Oxysterol-binding protein-related protein 9; Belongs to the OSBP family. (736 aa) |
| | CR201_G0015864 | EPB41 isoform 1. (655 aa) |
| | CR201_G0042751 | ASAP3 isoform 8. (517 aa) |
| | SH2D5 | SH2 domain-containing protein 5; May be involved in synaptic plasticity regulation through the control of Rac-GTP levels. (464 aa) |
| | ARHGEF10L | Rho guanine nucleotide exchange factor 10-like protein; Acts as guanine nucleotide exchange factor (GEF) for RHOA, RHOB and RHOC. (1034 aa) |
| | MTM1 | Myotubularin; Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2). Has also been shown to dephosphorylate phosphotyrosine- and phosphoserine-containing peptides. Negatively regulates EGFR degradation through regulation of EGFR trafficking from the late endosome to the lysosome. Plays a role in vacuolar formation and morphology. Regulates desmin intermediate filament assembly and architecture. Plays a role in mitochondrial morphology and positioning. Required for skeletal muscle maintenance but not fo [...] (603 aa) |
| | ARHGEF6 | Rac/Cdc42 guanine nucleotide exchange factor 6. (776 aa) |
| | FRMD7 | FERM domain containing 7. (714 aa) |
| | DOCK11 | DOCK11 isoform 1; Belongs to the DOCK family. (2065 aa) |
| | IRS4 | Insulin receptor substrate 4. (1262 aa) |
| | OPHN1 | OPHN1 isoform 1. (802 aa) |
| | MSN | MSN isoform 6. (577 aa) |
| | CR201_G0031402 | FRMD8 isoform 1. (462 aa) |
| | MTMR8 | MTMR8 isoform 1. (704 aa) |
| | ARHGEF9 | Rho guanine nucleotide exchange factor 9; Acts as guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters (By similarity). (523 aa) |
| | CR201_G0049527 | IQSEC2 isoform 7. (773 aa) |
| | PPP4R3C | PPP4R3CP isoform 1. (825 aa) |
| | GAB4 | GAB4 isoform 1. (442 aa) |
| | NIBAN2 | FAM129B isoform 2. (702 aa) |
| | CR201_G0027646 | RALGPS1 isoform 3. (486 aa) |
| | MAPKAP1 | Target of rapamycin complex 2 subunit MAPKAP1; Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the [...] (522 aa) |
| | RABGAP1 | Rab GTPase-activating protein 1; May act as a GTPase-activating protein of RAB6A. May play a role in microtubule nucleation by centrosome. May participate in a RAB6A-mediated pathway involved in the metaphase-anaphase transition (By similarity). (1065 aa) |
| | DAB2IP | DAB2IP isoform 2. (1130 aa) |
| | RGS3 | RGS3 isoform 4. (1094 aa) |
| | FGD3 | FYVE, RhoGEF and PH domain-containing protein 3; Promotes the formation of filopodia. May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape (By similarity). (737 aa) |
| | FRMD3 | FERM domain-containing protein 3; Putative tumor suppressor gene that may be implicated in the origin and progression of lung cancer. (556 aa) |
| | JAK2 | Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN- beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors [...] (1132 aa) |
| | ARHGEF39 | ARHGEF39 isoform 2. (335 aa) |
| | TLN1 | TLN1 isoform 1. (2541 aa) |
| | FRMPD1 | FRMPD1 isoform 1. (1575 aa) |
| | PTK2 | PTK2 isoform 11; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1095 aa) |
| | SNX31 | Sorting nexin 31. (440 aa) |
| | NSMAF | NSMAF isoform 1. (901 aa) |
| | CR201_G0026651 | SNTG1 isoform 1. (377 aa) |
| | PLEKHA2 | PLEKHA2 isoform 1. (302 aa) |
| | DOK2 | Docking protein 2. (412 aa) |
| | PSD3 | PSD3 isoform 1. (974 aa) |
| | MTMR7 | Myotubularin-related protein 7; Phosphatase that specifically dephosphorylates phosphatidylinositol 3-phosphate (PtdIns(3)P) and inositol 1,3- bisphosphate (Ins(1,3)P2); Belongs to the protein-tyrosine phosphatase family. Non- receptor class myotubularin subfamily. (660 aa) |
| | WASL | WASL isoform 1. (505 aa) |
| | CADPS2 | CADPS2 isoform 1. (1197 aa) |
| | KRIT1 | KRIT1 isoform 18. (471 aa) |
| | SKAP2 | Src kinase-associated phosphoprotein 2; May be involved in B-cell and macrophage adhesion processes. In B-cells, may act by coupling the B-cell receptor (BCR) to integrin activation. May play a role in src signaling pathway (By similarity). Belongs to the SKAP family. (359 aa) |
| | ELMO1 | ELMO1 isoform 1. (715 aa) |
| | CCM2 | CCM2 scaffold protein. (466 aa) |
| | TNS3 | TNS3 isoform 1. (1514 aa) |
| | GRB10 | GRB10 isoform 1. (594 aa) |
| | RASA4B | T0142405 isoform 1. (806 aa) |
| | TECPR1 | Tectonin beta-propeller repeat-containing protein 1; Tethering factor involved in autophagy. Involved in autophagosome maturation by promoting the autophagosome fusion with lysosomes: acts by associating with both the ATG5-ATG12 conjugate and phosphatidylinositol-3-phosphate (PtdIns(3)P) present at the surface of autophagosomes. Also involved in selective autophagy against bacterial pathogens, by being required for phagophore/preautophagosomal structure biogenesis and maturation (By similarity); Belongs to the TECPR1 family. (1165 aa) |
| | TIAM2 | TIAM2 isoform 10. (1675 aa) |
| | IPCEF1 | IPCEF1 isoform 2. (437 aa) |
| | EPB41L2 | EPB41L2 isoform 10. (917 aa) |
| | SYNGAP1 | SYNGAP1 isoform 3. (1304 aa) |
| | MYLIP | Myosin regulatory light chain interacting protein. (445 aa) |
| | TBC1D9B | TBC1 domain family member 9B. (1250 aa) |
| | ITK | Tyrosine-protein kinase. (620 aa) |
| | AFAP1L1 | AFAP1L1 isoform 2. (734 aa) |
| | ARHGAP26 | Rho GTPase activating protein 26. (814 aa) |
| | APBB3 | APBB3 isoform 14. (493 aa) |
| | GRAMD2B | GRAM domain-containing protein 2B. (432 aa) |
| | EPB41L4A | EPB41L4A isoform 1. (651 aa) |
| | HOMER1 | Homer scaffold protein 1. (354 aa) |
| | CERT1 | Ceramide transfer protein; Shelters ceramides and diacylglycerol lipids inside its START domain and mediates the intracellular trafficking of ceramides and diacylglycerol lipids in a non-vesicular manner. (548 aa) |
| | ARHGEF28 | ARHGEF28 isoform 1. (669 aa) |
| | DAB2 | DAB adaptor protein 2. (770 aa) |
| | MTMR12 | Myotubularin-related protein 12; Acts as an adapter for the myotubularin-related phosphatases. Regulates phosphatase MTM1 protein stability and possibly its intracellular location. By stabilizing MTM1 protein levels, required for skeletal muscle maintenance but not for myogenesis. (737 aa) |
| | MYO10 | MYO10 isoform 2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2027 aa) |
| | LRBA | LRBA isoform 2. (2807 aa) |
| | ARHGAP10 | Rho GTPase activating protein 10. (786 aa) |
| | DAPP1 | Dual adaptor of phosphotyrosine and 3-phosphoinositides 1. (280 aa) |
| | PTPN13 | PTPN13 isoform 2. (2426 aa) |
| | ARHGAP24 | Rho GTPase activating protein 24. (748 aa) |
| | STAP1 | STAP1 isoform 1. (294 aa) |
| | APBB2 | Amyloid beta precursor protein binding family B member 2. (759 aa) |
| | RGS12 | RGS12 isoform 6. (1389 aa) |
| | SH3BP2 | SH3BP2 isoform 3. (563 aa) |
| | FAM43A | FAM43A isoform 1. (426 aa) |
| | PLD1 | Phospholipase. (1074 aa) |
| | VEPH1 | VEPH1 isoform 1. (793 aa) |
| | ARHGEF26 | ARHGEF26 isoform 4. (870 aa) |
| | PLCL2 | Phosphoinositide phospholipase C. (1127 aa) |
| | PLCD1 | Phosphoinositide phospholipase C. (756 aa) |
| | NBEAL2 | NBEAL2 isoform 1. (2538 aa) |
| | ARHGEF3 | Rho guanine nucleotide exchange factor 3; Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases. (526 aa) |
| | FRMD4B | FRMD4B isoform 1. (932 aa) |
| | GRAMD1C | Protein Aster-C; Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol [...] (659 aa) |
| | KALRN | KALRN isoform 1. (2858 aa) |
| | DGKD | Diacylglycerol kinase. (1106 aa) |
| | NGEF | Ephexin-1; Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity). (708 aa) |
| | PID1 | PID1 isoform 1. (267 aa) |
| | DOCK10 | DOCK10 isoform 2; Belongs to the DOCK family. (1145 aa) |
| | PLCD4 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4; Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration [...] (762 aa) |
| | TNS1 | TNS1 isoform 2. (1727 aa) |
| | PLEKHM3 | Pleckstrin homology domain containing M3. (761 aa) |
| | RAPH1 | RAPH1 isoform 10. (1303 aa) |
| | PLCL1 | Phosphoinositide phospholipase C. (1016 aa) |
| | PLEKHA3 | Pleckstrin homology domain containing A3. (300 aa) |
| | OSBPL6 | Oxysterol-binding protein; Belongs to the OSBP family. (959 aa) |
| | BBS5 | T0057746 isoform 1. (341 aa) |
| | ARHGAP15 | ARHGAP15 isoform 1. (475 aa) |
| | EPB41L5 | Erythrocyte membrane protein band 4.1 like 5. (733 aa) |
| | MYO7B | MYO7B isoform 2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2036 aa) |
| | ARHGEF4 | ARHGEF4 isoform 1. (1000 aa) |
| | PLEKHB2 | Pleckstrin homology domain-containing family B member 2; Involved in retrograde transport of recycling endosomes. (222 aa) |
| | ROCK2 | Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1388 aa) |
| | SNX17 | Sorting nexin-17; Critical regulator of endosomal recycling of numerous surface proteins, including integrins, signaling receptor and channels. Binds to NPxY sequences in the cytoplasmic tails of target cargos. Associates with retriever and CCC complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGB1, ITGB5 and their associated alpha subunits. Also required for maintenance of normal cell surface levels of APP and LRP1. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)). (470 aa) |
| | SOS1 | SOS1 isoform 2. (1290 aa) |
| | PLEKHH2 | Pleckstrin homology, MyTH4 and FERM domain containing H2. (1493 aa) |
| | SPTBN1 | Spectrin beta chain; Belongs to the spectrin family. (2342 aa) |
| | PPP4R3B | Protein phosphatase 4 regulatory subunit 3B. (849 aa) |
| | SPRED2 | Sprouty-related, EVH1 domain-containing protein 2; Negatively regulates Ras signaling pathways and downstream activation of MAP kinases. (418 aa) |
| | CR201_G0034363 | SH2B1 isoform 11. (426 aa) |
| | DOK1 | Docking protein 1. (481 aa) |
| | CR201_G0043139 | PSD4 isoform 2. (721 aa) |
| | CR201_G0054913 | RGPD3 isoform 1. (2354 aa) |
| | SBF1 | SBF1 isoform 1. (1900 aa) |
| | GRAMD4 | GRAMD4 isoform 1. (540 aa) |
| | NUP50 | NUP50 isoform 1. (468 aa) |
| | PHETA2 | PH domain containing endocytic trafficking adaptor 2. (259 aa) |
| | TRIOBP | TRIOBP isoform 1. (2199 aa) |
| | CYTH4 | CYTH4 isoform 2. (394 aa) |
| | OSBP2 | Oxysterol-binding protein; Belongs to the OSBP family. (829 aa) |
| | ITSN1 | ITSN1 isoform 4. (1610 aa) |
