Your Input: | |
| | CR201_G0030856 | RNF187 isoform 1. (49 aa) |
| | CR201_G0030864 | TRIM17 isoform 7. (280 aa) |
| | TRIM11 | TRIM11 isoform 1. (436 aa) |
| | KDM5B | KDM5B isoform 2. (1404 aa) |
| | RNF2 | E3 ubiquitin-protein ligase RING2; E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation. H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. May be involved in the initiation of both imprinted and random X inactivation. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, i [...] (336 aa) |
| | COP1 | COP1 E3 ubiquitin ligase. (731 aa) |
| | RC3H1 | RC3H1 isoform 1. (1094 aa) |
| | TRIM46 | Tripartite motif containing 46. (759 aa) |
| | PYGO2 | PYGO2 isoform 1. (406 aa) |
| | PIAS3 | PIAS3 isoform 3. (619 aa) |
| | RNF115 | Ring finger protein 115. (304 aa) |
| | BCL9 | BCL9 transcription coactivator. (1426 aa) |
| | TRIM33 | Tripartite motif containing 33. (1127 aa) |
| | MTF2 | Metal-response element-binding transcription factor 2; Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex, leading to enhance PRC2 H3K27me3 methylation activity. Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation. Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated [...] (593 aa) |
| | USP33 | Ubiquitin carboxyl-terminal hydrolase 33; Deubiquitinating enzyme involved in various processes such as centrosome duplication, cellular migration and beta-2 adrenergic receptor/ADRB2 recycling. Involved in regulation of centrosome duplication by mediating deubiquitination of CCP110 in S and G2/M phase, leading to stabilize CCP110 during the period which centrioles duplicate and elongate. Involved in cell migration via its interaction with intracellular domain of ROBO1, leading to regulate the Slit signaling. Plays a role in commissural axon guidance cross the ventral midline of the ne [...] (910 aa) |
| | ZFYVE9 | Zinc finger FYVE domain-containing protein. (1390 aa) |
| | RNF220 | RNF220 isoform 1. (540 aa) |
| | KDM4A | Lysine-specific demethylase 4A; Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code (By similarity). Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F- responsive promoters via the recruitment of histone deacetylases and NCOR1, re [...] (1064 aa) |
| | RNF19B | RBR-type E3 ubiquitin transferase. (629 aa) |
| | MUL1 | Mitochondrial E3 ubiquitin protein ligase 1. (352 aa) |
| | PHF13 | PHD finger protein 13. (300 aa) |
| | RNF207 | RNF207 isoform 3. (634 aa) |
| | PEX10 | PEX10 isoform 2. (326 aa) |
| | CR201_G0053298 | MIB2 isoform 16. (744 aa) |
| | TAF3 | TAF3 isoform 1. (933 aa) |
| | MLLT10 | MLLT10 isoform 2. (1038 aa) |
| | BMI1 | Polycomb complex protein BMI-1; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A. In the PRC1-like complex, regulates the E3 ub [...] (326 aa) |
| | KAT6B | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (1785 aa) |
| | RUFY2 | RUN and FYVE domain-containing protein 2. (420 aa) |
| | ZFYVE27 | Protrudin; Key regulator of RAB11-dependent vesicular trafficking during neurite extension through polarized membrane transport. Promotes axonal elongation and contributes to the establishment of neuronal cell polarity. Involved in nerve growth factor-induced neurite formation in VAPA-dependent manner. Contributes to both the formation and stabilization of the tubular ER network. Involved in ER morphogenesis by regulating the sheet-to-tubule balance and possibly the density of tubule interconnections. Acts as an adapter protein that facilitates the interaction of KIF5A with VAPA, VAPB, [...] (480 aa) |
| | TRIM8 | TRIM8 isoform 1. (531 aa) |
| | PCGF6 | Polycomb group ring finger 6. (350 aa) |
| | KDM2A | KDM2A isoform 12. (723 aa) |
| | DPF2 | DPF2 isoform 5. (405 aa) |
| | DTX4 | Deltex E3 ubiquitin ligase 4. (619 aa) |
| | RAPSN | Receptor associated protein of the synapse. (412 aa) |
| | PHF21A | PHF21A isoform 5. (681 aa) |
| | TRAF6 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (604 aa) |
| | RNF141 | RING finger protein 141; May be involved in spermatogenesis. (229 aa) |
| | TRIM66 | TRIM66 isoform 4. (848 aa) |
| | TRIM3 | TRIM3 isoform 1. (712 aa) |
| | TRIM22 | TRIM22 isoform 3. (498 aa) |
| | TRIM5 | Tripartite motif-containing protein 5; Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1- UBE2N (als [...] (493 aa) |
| | TRIM34 | TRIM34 isoform 1. (842 aa) |
| | RNF169 | Ring finger protein 169. (708 aa) |
| | RSF1 | Remodeling and spacing factor 1. (1441 aa) |
| | LOC100455080 | TRIM49 isoform 1. (452 aa) |
| | CR201_G0045887 | TRIM49 isoform 2. (318 aa) |
| | RNF214 | RNF214 isoform 2. (758 aa) |
| | UBE4A | Ubiquitin conjugation factor E4 A; Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates. (1072 aa) |
| | KMT2A | Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily. (3967 aa) |
| | RNF26 | RNF26 isoform 1. (433 aa) |
| | CR201_G0034040 | TRIM49D1 isoform 2. (206 aa) |
| | CHD4 | CHD4 isoform 1. (1908 aa) |
| | ING4 | Inhibitor of growth protein. (235 aa) |
| | USP5 | Ubiquitin carboxyl-terminal hydrolase 5; Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys- 48'-linked polyubiquitin disassembly. Binds linear and 'Lys-63'-linked polyubiquitin with a lower affinity (By similarity). (840 aa) |
| | FGD4 | FYVE, RhoGEF and PH domain containing 4. (766 aa) |
| | SCAF11 | SCAF11 isoform 1. (1451 aa) |
| | KMT2D | KMT2D isoform 2. (5283 aa) |
| | RNF41 | E3 ubiquitin-protein ligase NRDP1; Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88. Negatively regulates MYD88-dependent production of proinflammatory cytokines. Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus. Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progeni [...] (317 aa) |
| | MDM2 | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (496 aa) |
| | BRAP | BRAP isoform 1. (528 aa) |
| | TRAFD1 | TRAFD1 isoform 1. (583 aa) |
| | RNFT2 | RING finger and transmembrane domain-containing protein 2. (436 aa) |
| | RNF10 | RNF10 isoform 1. (725 aa) |
| | RNF34 | E3 ubiquitin-protein ligase RNF34; E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis. May mediate 'Lys-48'-linked polyubiquitination of RIPK1 and its subsequent proteasomal degradation thereby indirectly regulating the tumor necrosis factor-mediated signaling pathway. Negatively regulates p5 [...] (373 aa) |
| | KDM2B | KDM2B isoform 3. (1280 aa) |
| | CHFR | E3 ubiquitin-protein ligase CHFR; E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the 'Lys- 48'-linked ubiquitination of target proteins, leading to their degradation by the proteasome. Promotes the ubiquitination and subsequent degradation of AURK [...] (619 aa) |
| | LNX2 | Ligand of numb-protein X 2. (690 aa) |
| | PHF11 | PHD finger protein 11. (331 aa) |
| | WDFY2 | WD repeat and FYVE domain containing 2. (400 aa) |
| | OBI1 | ORC ubiquitin ligase 1; E3 ubiquitin ligase essential for DNA replication origin activation during S phase. Acts as a replication origin selector which selects the origins to be fired and catalyzes the multi-mono- ubiquitination of a subset of chromatin-bound ORC3 and ORC5 during S- phase. (726 aa) |
| | RNF113B | RNF113B isoform 1. (318 aa) |
| | RNF31 | T0114761 isoform 1. (1053 aa) |
| | G2E3 | G2E3 isoform 1. (706 aa) |
| | BAZ1A | BAZ1A isoform 2. (1488 aa) |
| | CGRRF1 | Cell growth regulator with ring finger domain 1. (331 aa) |
| | ZFYVE26 | ZFYVE26 isoform 2. (2539 aa) |
| | ZFYVE1 | Zinc finger FYVE domain-containing protein 1. (789 aa) |
| | ZFYVE21 | Zinc finger FYVE-type containing 21. (234 aa) |
| | ZFYVE19 | Zinc finger FYVE-type containing 19. (476 aa) |
| | PYGO1 | Pygopus family PHD finger 1. (419 aa) |
| | RNF111 | E3 ubiquitin-protein ligase Arkadia; E3 ubiquitin-protein ligase (By similarity). Required for mesoderm patterning during embryonic development (By similarity). Acts as an enhancer of the transcriptional responses of the SMAD2/SMAD3 effectors, which are activated downstream of BMP. Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD7, inducing their proteasomal degradation and thereby enhancing the transcriptional activity of TGF-beta and BMP (By similarity). In addition to enhance transcription of SMAD2/SMAD3 effectors, also regulates their turnover by med [...] (984 aa) |
| | USP3 | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (520 aa) |
| | PIAS1 | PIAS1 isoform 1. (683 aa) |
| | ARIH1 | RBR-type E3 ubiquitin transferase. (557 aa) |
| | MEX3B | MEX3B isoform 1. (528 aa) |
| | RNF151 | RNF151 isoform 2. (244 aa) |
| | CREBBP | CREBBP isoform 1. (2328 aa) |
| | MGRN1 | MGRN1 isoform 2. (576 aa) |
| | NSMCE1 | Non-structural maintenance of chromosomes element 1 homolog; RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. Within MAGE-RING ubiquitin ligase complex, MAGE stimulates and specifies ubiquitin ligase activity likely through recruitment and/or stabilization of the E2 ubiquitin-conjugating enzyme at the E3:substrate complex. Involved in maintenance of genome integrity, DNA damage response and DNA repair. NSMCE3/MAGEG1 and NSMCE [...] (269 aa) |
| | RNF40 | E3 ubiquitin-protein ligase BRE1B; Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradic [...] (1001 aa) |
| | FBXL19 | FBXL19 isoform 3. (630 aa) |
| | TRIM72 | Tripartite motif containing 72. (477 aa) |
| | RSPRY1 | RING finger and SPRY domain-containing protein 1. (576 aa) |
| | RFWD3 | RFWD3 isoform 1. (774 aa) |
| | RPH3AL | RPH3AL isoform 1. (270 aa) |
| | ANKFY1 | Ankyrin repeat and FYVE domain containing 1. (1170 aa) |
| | XAF1 | XIAP associated factor 1. (300 aa) |
| | CR201_G0048121 | PHF23 isoform 2. (264 aa) |
| | TRAF4 | TNF receptor-associated factor. (422 aa) |
| | PHF12 | PHD finger protein 12. (1004 aa) |
| | RNF135 | Ring finger protein 135. (432 aa) |
| | RNF43 | RNF43 isoform 2. (452 aa) |
| | TRIM25 | Tripartite motif containing 25. (630 aa) |
| | PCGF2 | PCGF2 isoform 1. (347 aa) |
| | BPTF | BPTF isoform 5. (2811 aa) |
| | TRIM47 | TRIM47 isoform 1. (640 aa) |
| | RNF157 | RNF157 isoform 1. (619 aa) |
| | RNF213 | RNF213 isoform 1. (4365 aa) |
| | RNFT1 | Ring finger protein, transmembrane 1. (434 aa) |
| | TRIM37 | TRIM37 isoform 1. (946 aa) |
| | RNF138 | Ring finger protein 138. (245 aa) |
| | PIAS2 | Protein inhibitor of activated STAT 2. (621 aa) |
| | RNF152 | Ring finger protein 152. (203 aa) |
| | MEX3D | MEX3D isoform 2. (498 aa) |
| | UHRF1 | UHRF1 isoform 6. (802 aa) |
| | KDM4B | KDM4B isoform 1. (1083 aa) |
| | KMT2B | KMT2B isoform 1. (2499 aa) |
| | DPF1 | Double PHD fingers 1. (414 aa) |
| | NOSIP | Nitric oxide synthase-interacting protein; Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity; Belongs to the NOSIP family. (335 aa) |
| | LOC100432849 | RFPL4AL1 isoform 1. (287 aa) |
| | TRIM28 | TRIM28 isoform 3. (528 aa) |
| | RNF24 | RNF24 isoform 3. (148 aa) |
| | UBOX5 | UBOX5 isoform 2. (512 aa) |
| | ZMYND8 | ZMYND8 isoform 16. (1233 aa) |
| | DIDO1 | DIDO1 isoform 1. (2239 aa) |
| | LTN1 | LTN1 isoform 1. (1700 aa) |
| | USP16 | Ubiquitin carboxyl-terminal hydrolase 16; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. (643 aa) |
| | PPIL2 | PPIL2 isoform 1. (495 aa) |
| | ZNRF3 | ZNRF3 isoform 2. (881 aa) |
| | MTMR3 | Myotubularin related protein 3. (1198 aa) |
| | RNF215 | Ring finger protein 215. (377 aa) |
| | RNF185 | E3 ubiquitin-protein ligase RNF185; E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination of BNIP1. Acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation. Protects cells from ER stress-induced apoptosis. Responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway. Preferentially associates with the E2 enzymes UB [...] (192 aa) |
| | CR201_G0024573 | RFPL2 isoform 1. (289 aa) |
| | CR201_G0024582 | RFPL3 isoform 2. (317 aa) |
| | RBX1 | RBX1 isoform 1. (108 aa) |
| | EP300 | EP300 isoform 1. (2380 aa) |
| | PHF21B | PHF21B isoform 2. (492 aa) |
| | BRD1 | BRD1 isoform 1. (995 aa) |
| | USP39 | U4/U6.U5 tri-snRNP-associated protein 2; Plays a role in pre-mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the precatalytic spliceosome. Regulates AURKB mRNA levels, and thereby plays a role in cytokinesis and in the spindle checkpoint. Does not have ubiquitin- specific peptidase activity. (565 aa) |
| | RNF181 | Ring finger protein 181. (153 aa) |
| | PCGF1 | Polycomb group ring finger 1. (259 aa) |
| | FANCL | FA complementation group L. (375 aa) |
| | TRIM54 | Tripartite motif-containing protein 54; May bind and stabilize microtubules during myotubes formation. (358 aa) |
| | RNF144A | RBR-type E3 ubiquitin transferase. (292 aa) |
| | WDSUB1 | WDSUB1 isoform 1. (389 aa) |
| | BAZ2B | BAZ2B isoform 1. (1983 aa) |
| | MARCHF7 | E3 ubiquitin-protein ligase MARCHF7; E3 ubiquitin-protein ligase which may specifically enhance the E2 activity of HIP2. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates (By similarity). May be involved in T-cell proliferation by regulating LIF secretion (By similarity). May play a role in lysosome homeostasis (By similarity). (704 aa) |
| | MARCHF4 | Membrane associated ring-CH-type finger 4. (410 aa) |
| | WDFY1 | WDFY1 isoform 2. (410 aa) |
| | MLPH | MLPH isoform 1. (553 aa) |
| | ZSWIM2 | ZSWIM2 isoform 2. (593 aa) |
| | MKRN2 | Makorin ring finger protein 2. (416 aa) |
| | FBXO40 | F-box protein 40. (709 aa) |
| | GTF2E1 | General transcription factor IIE subunit 1; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase (By similarity). (439 aa) |
| | DZIP3 | DZIP3 isoform 1. (1176 aa) |
| | CBLB | Cbl proto-oncogene B. (982 aa) |
| | BRPF1 | BRPF1 isoform 3. (1213 aa) |
| | RAD18 | RAD18 isoform 2. (495 aa) |
| | PDZRN3 | PDZ domain containing ring finger 3. (1066 aa) |
| | ARIH2 | RBR-type E3 ubiquitin transferase. (456 aa) |
| | FYCO1 | FYVE and coiled-coil domain containing 1. (1478 aa) |
| | MYRIP | MYRIP isoform 1. (858 aa) |
| | MSL2 | MSL2 isoform 4. (286 aa) |
| | HLTF | HLTF isoform 1. (1063 aa) |
| | RNF13 | E3 ubiquitin-protein ligase RNF13; E3 ubiquitin-protein ligase that may play a role in controlling cell proliferation. Involved in apoptosis regulation. Mediates ER stress-induced activation of JNK signaling pathway and apoptosis by promoting ERN1 activation and splicing of XBP1 mRNA. (381 aa) |
| | SIAH2 | E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (324 aa) |
| | VPS8 | VPS8 isoform 6. (1428 aa) |
| | PCGF3 | PCGF3 isoform 1. (244 aa) |
| | NSD2 | NSD2 isoform 1. (1433 aa) |
| | LNX1 | LNX1 isoform 2. (556 aa) |
| | RCHY1 | Ring finger and CHY zinc finger domain containing 1. (261 aa) |
| | INTS12 | Integrator complex subunit 12; Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'- box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex. (462 aa) |
| | TRIM2 | Tripartite motif containing 2. (744 aa) |
| | MARCHF1 | MARCH1 isoform 2. (542 aa) |
| | TRIM61 | TRIM61 isoform 1. (177 aa) |
| | SH3RF1 | E3 ubiquitin-protein ligase SH3RF1; Has E3 ubiquitin-protein ligase activity. In the absence of an external substrate, it can catalyze self-ubiquitination. Stimulates ubiquitination of potassium channel KCNJ1, enhancing it's dynamin- dependent and clathrin-independent endocytosis. Acts as a scaffold protein that coordinates with MAPK8IP1/JIP1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pa [...] (888 aa) |
| | ING2 | Inhibitor of growth protein. (280 aa) |
| | MARCHF6 | E3 ubiquitin-protein ligase MARCHF6; E3 ubiquitin-protein ligase that promotes 'Lys-48'-linked ubiquitination of target proteins, leading to their proteasomal degradation. Promotes ubiquitination of DIO2, leading to its degradation. Promotes ubiquitination of SQLE, leading to its degradation. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May cooperate with UBE2G1. (910 aa) |
| | RNF180 | E3 ubiquitin-protein ligase RNF180; E3 ubiquitin-protein ligase which promotes polyubiquitination and degradation by the proteasome pathway of ZIC2. (579 aa) |
| | ZFYVE16 | Zinc finger FYVE domain-containing protein. (1539 aa) |
| | PJA2 | E3 ubiquitin-protein ligase Praja-2; Has E2-dependent E3 ubiquitin-protein ligase activity. Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA-mediated long-term memory processes. Through the ubiquitination of MFHAS1, positively regulates the TLR2 signaling pathway that leads to the activation of the downstream p38 and JNK MAP kinases and promotes the polarization of macrophages toward the pro-inflammatory M1 phenotype. (708 aa) |
| | JADE2 | JADE2 isoform 7. (919 aa) |
| | RNF145 | RNF145 isoform 7. (663 aa) |
| | NEURL1B | Neuralized E3 ubiquitin protein ligase 1B. (555 aa) |
| | NSD1 | NSD1 isoform 2. (2427 aa) |
| | RUFY1 | RUFY1 isoform 1. (725 aa) |
| | CR201_G0051583 | RNF44 isoform 1. (291 aa) |
| | RNF182 | RNF182 isoform 1. (247 aa) |
| | MYLIP | Myosin regulatory light chain interacting protein. (445 aa) |
| | NHLRC1 | NHL repeat containing E3 ubiquitin protein ligase 1. (395 aa) |
| | RNF144B | RBR-type E3 ubiquitin transferase. (303 aa) |
| | TRIM38 | Tripartite motif containing 38. (465 aa) |
| | RNF5 | Ring finger protein 5. (180 aa) |
| | PHF1 | PHD finger protein 1. (567 aa) |
| | BRPF3 | Bromodomain and PHD finger containing 3. (1205 aa) |
| | RNF8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (462 aa) |
| | USP49 | Ubiquitinyl hydrolase 1. (585 aa) |
| | PHF3 | PHF3 isoform 4. (2013 aa) |
| | RFPL4B | T0108171 isoform 1. (263 aa) |
| | RNF146 | E3 ubiquitin-protein ligase RNF146; E3 ubiquitin-protein ligase that specifically binds poly-ADP- ribosylated (PARsylated) proteins and mediates their ubiquitination and subsequent degradation. May regulate many important biological processes, such as cell survival and DNA damage response. Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of PARsylated AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex. Acts in cooperation with tankyrase proteins (TNKS and TNKS2), which mediate PARsylation of target proteins AXIN1, AXIN2, BLZF1, CA [...] (355 aa) |
| | FBXO30 | FBXO30 isoform 1. (708 aa) |
| | RNF39 | RNF39 isoform 1. (419 aa) |
| | TRIM10 | TRIM10 isoform 2. (395 aa) |
| | TRIM15 | Tripartite motif containing 15. (465 aa) |
| | RING1 | Ring finger protein 1. (406 aa) |
| | RNF216 | Ring finger protein 216. (866 aa) |
| | TRIM4 | Tripartite motif containing 4. (474 aa) |
| | BAZ1B | BAZ1B isoform 1. (1407 aa) |
| | TRIM50 | TRIM73 isoform 3. (487 aa) |
| | PHF14 | PHD finger protein 14. (948 aa) |
| | KMT2E | KMT2E isoform 2. (1624 aa) |
| | CBLL1 | CBLL1 isoform 1. (402 aa) |
| | ING3 | Inhibitor of growth protein 3; Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicat [...] (418 aa) |
| | CNOT4 | CCR4-NOT transcription complex subunit 4. (710 aa) |
| | TRIM24 | TRIM24 isoform 1. (1050 aa) |
| | MKRN1 | Makorin ring finger protein 1. (418 aa) |
| | KMT2C | Uncharacterized protein. (4714 aa) |
| | LONRF1 | LONRF1 isoform 1. (746 aa) |
| | TRIM35 | Tripartite motif-containing protein 35; Reduces FGFR1-dependent tyrosine phosphorylation of PKM, inhibiting PKM-dependent lactate production, glucose metabolism, and cell growth (By similarity). Implicated in the cell death mechanism (By similarity). (492 aa) |
| | KAT6A | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (2006 aa) |
| | RNF170 | RNF170 isoform 3. (227 aa) |
| | TRIM55 | TRIM55 isoform 1. (544 aa) |
| | RNF139 | E3 ubiquitin-protein ligase RNF139; E3-ubiquitin ligase; acts as a negative regulator of the cell proliferation through mechanisms involving G2/M arrest and cell death. Required for MHC class I ubiquitination in cells expressing the cytomegalovirus protein US2 before dislocation from the endoplasmic reticulum (ER). Affects SREBP processing by hindering the SREBP/SCAP complex translocation from the ER to the Golgi, thereby reducing SREBF2 target gene expression. Required for INSIG1 ubiquitination. May be required for EIF3 complex ubiquitination. May function as a signaling receptor. (664 aa) |
| | PHF20L1 | PHF20L1 isoform 5. (897 aa) |
| | CYHR1 | CYHR1 isoform 3. (289 aa) |
| | PHF24 | PHD finger protein 24. (210 aa) |
| | KDM4C | Lysine demethylase 4C. (1056 aa) |
| | UHRF2 | Ubiquitin like with PHD and ring finger domains 2. (802 aa) |
| | FGD3 | FYVE, RhoGEF and PH domain-containing protein 3; Promotes the formation of filopodia. May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape (By similarity). (737 aa) |
| | TRIM32 | Tripartite motif containing 32. (653 aa) |
| | PHF19 | PHF19 isoform 2. (580 aa) |
| | RC3H2 | RC3H2 isoform 1. (1143 aa) |
| | LRSAM1 | LRSAM1 isoform 1. (689 aa) |
| | USP20 | Ubiquitin carboxyl-terminal hydrolase 20; Deubiquitinating enzyme involved in beta-2 adrenergic receptor (ADRB2) recycling. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins de [...] (913 aa) |
| | TRIM52 | TRIM52 isoform 2. (319 aa) |
| | LOC100445599 | TRIM49B isoform 1. (452 aa) |
| | CR201_G0055502 | TRIM48 isoform 1. (209 aa) |
| | CBLL2 | Cbl proto-oncogene like 2. (425 aa) |
| | HDAC6 | HDAC6 isoform 2. (1208 aa) |
| | KDM5C | KDM5C isoform 2. (1278 aa) |
| | SYTL4 | SYTL4 isoform 2. (672 aa) |
| | RNF128 | E3 ubiquitin-protein ligase RNF128; E3 ubiquitin-protein ligase that catalyzes 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains formation. Functions as an inhibitor of cytokine gene transcription. Inhibits IL2 and IL4 transcription, thereby playing an important role in the induction of the anergic phenotype, a long-term stable state of T-lymphocyte unresponsiveness to antigenic stimulation associated with the blockade of interleukin production. Ubiquitinates ARPC5 with 'Lys-48' linkages and COR1A with 'Lys-63' linkages leading to their degradation, down- regulation of these cytoslele [...] (428 aa) |
| | MID2 | MID2 isoform 2. (705 aa) |
| | RNF113A | Ring finger protein 113A. (343 aa) |
| | XIAP | XIAP isoform 2. (513 aa) |
| | PHF6 | PHD finger protein 6; Transcriptional regulator that associates with ribosomal RNA promoters and suppresses ribosomal RNA (rRNA) transcription. (365 aa) |
| | PCLO | PCLO isoform 1. (731 aa) |
| | RNF149 | RNF149 isoform 1. (414 aa) |
| | RFFL | T0183779 isoform 1. (369 aa) |
| | MEX3C | MEX3C isoform 1. (258 aa) |
| | ING5 | Inhibitor of growth protein. (195 aa) |
| | ANKIB1 | RBR-type E3 ubiquitin transferase. (1089 aa) |
| | MYCBP2 | MYCBP2 isoform 1. (3875 aa) |
| | TRIM23 | Tripartite motif containing 23. (574 aa) |
| | RNF130 | RNF130 isoform 4. (420 aa) |
| | TRIM27 | Tripartite motif containing 27. (513 aa) |
