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| | PAIP1 | Poly(A) binding protein interacting protein 1. (400 aa) |
| | NIPBL | Nipped-B protein. (2684 aa) |
| | LRBA | LRBA isoform 2. (2807 aa) |
| | RAP1GDS1 | RAP1GDS1 isoform 5. (527 aa) |
| | SDAD1 | Protein SDA1; Required for 60S pre-ribosomal subunits export to the cytoplasm; Belongs to the SDA1 family. (687 aa) |
| | FRYL | FRYL isoform 1. (2955 aa) |
| | PDS5A | PDS5 cohesin associated factor A. (1337 aa) |
| | NCAPG | Non-SMC condensin I complex subunit G. (1015 aa) |
| | PSMD2 | 26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. (909 aa) |
| | EIF2B5 | Eukaryotic translation initiation factor 2B subunit epsilon. (721 aa) |
| | KPNA4 | Importin subunit alpha; Functions in nuclear protein import. (521 aa) |
| | VEPH1 | VEPH1 isoform 1. (793 aa) |
| | NCAPD3 | Condensin-2 complex subunit D3; Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis. (1197 aa) |
| | TTC12 | TTC12 isoform 5. (705 aa) |
| | PPP2R1B | PPP2R1B isoform 5. (667 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3003 aa) |
| | EIF4G2 | Eukaryotic translation initiation factor 4 gamma 2; Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases (By similarity); Belongs to the eukaryotic initiation factor 4G family. (906 aa) |
| | COPB1 | Coatomer subunit beta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also infl [...] (953 aa) |
| | PIK3C2A | Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha; Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. Has a role in several intracellular trafficking events. Functions in insulin signaling and secretion. Required for translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane and glucose uptake in response to insulin-mediated RHOQ activation. Regulates insulin secretion through two different mechanisms: involved in glucose-induced insulin secretion dow [...] (1684 aa) |
| | EIF3M | Eukaryotic translation initiation factor 3 subunit M; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] (374 aa) |
| | API5 | Apoptosis inhibitor 5; Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis (By similarity); Belongs to the API5 family. (498 aa) |
| | CTNND1 | CTNND1 isoform 19. (968 aa) |
| | PPP2R5B | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (497 aa) |
| | CR201_G0031416 | SCYL1 isoform 7. (642 aa) |
| | PPP6R3 | PPP6R3 isoform 7. (845 aa) |
| | AP2A2 | AP-1 complex subunit gamma; Belongs to the adaptor complexes large subunit family. (767 aa) |
| | DOCK1 | DOCK1 isoform 1; Belongs to the DOCK family. (1735 aa) |
| | PDCD4 | Programmed cell death protein 4; Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity). Belongs to the PDCD4 family. (468 aa) |
| | RRP12 | RRP12 isoform 4. (1273 aa) |
| | NOC3L | Nucleolar complex protein 3 homolog; May be required for adipogenesis; Belongs to the CBF/MAK21 family. (800 aa) |
| | BTAF1 | B-TFIID TATA-box binding protein associated factor 1. (1849 aa) |
| | KAT6B | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (1785 aa) |
| | WDFY4 | WDFY4 isoform 1. (1009 aa) |
| | ARMC3 | ARMC3 isoform 2. (833 aa) |
| | ARMC8 | Armadillo repeat-containing protein 8; Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. (595 aa) |
| | PIK3R4 | Phosphoinositide 3-kinase regulatory subunit 4; Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (By similarity). (1357 aa) |
| | NEK10 | NEK10 isoform 3. (527 aa) |
| | CLASP2 | CLASP2 isoform 2. (1505 aa) |
| | ULK4 | Serine/threonine-protein kinase ULK4; May be involved in the remodeling of cytoskeletal components, such as alpha-tubulin, and in this way regulates neurite branching and elongation, as well as cell motility. (1257 aa) |
| | NBEAL2 | NBEAL2 isoform 1. (2538 aa) |
| | IQCB1 | IQ motif containing B1. (598 aa) |
| | KPNA1 | Importin subunit alpha-5, N-terminally processed; Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and impo [...] (538 aa) |
| | MROH2A | MROH2A isoform 1. (1704 aa) |
| | ARMC9 | LisH domain-containing protein ARMC9; Required for ciliogenesis. (804 aa) |
| | PSMD1 | 26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa) |
| | PUM2 | Pumilio RNA binding family member 2. (1065 aa) |
| | CEBPZ | CCAAT enhancer binding protein zeta. (1054 aa) |
| | THADA | THADA isoform 1. (1867 aa) |
| | PSME4 | Proteasome activator subunit 4. (1843 aa) |
| | CLHC1 | Clathrin heavy chain linker domain-containing protein 1. (585 aa) |
| | PPP4R3B | Protein phosphatase 4 regulatory subunit 3B. (849 aa) |
| | ATXN10 | Ataxin-10; Necessary for the survival of cerebellar neurons. Induces neuritogenesis by activating the Ras-MAP kinase pathway. May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis. (475 aa) |
| | AP1B1 | AP complex subunit beta. (946 aa) |
| | ARVCF | ARVCF isoform 1. (877 aa) |
| | LTN1 | LTN1 isoform 1. (1700 aa) |
| | ZNFX1 | ZNFX1 isoform 3. (1864 aa) |
| | ELMO2 | Engulfment and cell motility protein 2; Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1 (By similarity). (720 aa) |
| | CTNNBL1 | Catenin beta like 1. (563 aa) |
| | MROH8 | MROH8 isoform 1. (1021 aa) |
| | TRPC4AP | Transient receptor potential cation channel subfamily C member 4 associated protein. (797 aa) |
| | IPO13 | Importin-13; Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis re [...] (830 aa) |
| | HSPBP1 | HSPBP1 isoform 1. (240 aa) |
| | PPP6R1 | PPP6R1 isoform 1. (942 aa) |
| | PPP2R1A | PPP2R1A isoform 7. (558 aa) |
| | CR201_G0029663 | AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (749 aa) |
| | SYMPK | SYMPK isoform 3. (1114 aa) |
| | ARMC6 | Armadillo repeat-containing protein 6; Belongs to the ARMC6 family. (501 aa) |
| | AP3D1 | AP-3 complex subunit delta; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane. (1099 aa) |
| | APC2 | APC2 isoform 1. (2148 aa) |
| | RELCH | RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1216 aa) |
| | MRO | MRO isoform 1. (285 aa) |
| | DOCK10 | DOCK10 isoform 2; Belongs to the DOCK family. (1145 aa) |
| | STK36 | Serine/threonine-protein kinase 36; Serine/threonine protein kinase which plays an important role in the sonic hedgehog (Shh) pathway by regulating the activity of GLI transcription factors. Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization. GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur. Required for postnatal development, possibly by regulating the homeostasis of c [...] (1315 aa) |
| | CTIF | CTIF isoform 1. (505 aa) |
| | ZBTB7C | Zinc finger and BTB domain containing 7C. (620 aa) |
| | CNOT9 | CCR4-NOT transcription complex subunit 9; Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in down- regulation of MYB- and JUN-dependent transcription. Enhances ligand- dependent transcriptional activity of nuclear hormone receptors. May play a role in cell d [...] (299 aa) |
| | BZW1 | Basic leucine zipper and W2 domain-containing protein 1; Enhances histone H4 gene transcription but does not seem to bind DNA directly. (399 aa) |
| | ANKAR | ANKAR isoform 4. (1363 aa) |
| | CWC22 | Pre-mRNA-splicing factor CWC22 homolog; Required for pre-mRNA splicing as component of the spliceosome. Promotes exon-junction complex (EJC) assembly. Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay. (908 aa) |
| | IPO11 | IPO11 isoform 4. (953 aa) |
| | AP3B1 | AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family. (1094 aa) |
| | SIL1 | SIL1 isoform 3. (397 aa) |
| | TMCO6 | Transmembrane and coiled-coil domains 6. (499 aa) |
| | DIAPH1 | DIAPH1 isoform 1. (1134 aa) |
| | RANBP17 | RAN binding protein 17. (1088 aa) |
| | SPAG6 | Sperm associated antigen 6. (509 aa) |
| | UPF2 | UPF2 isoform 1. (836 aa) |
| | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1027 aa) |
| | EIF4G3 | EIF4G3 isoform 2. (1575 aa) |
| | PUM1 | Pumilio homolog 1; Sequence-specific RNA-binding protein that acts as a post- transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'- UGUANAUA-3', that is related to the Nanos Response Element (NRE). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation. Also mediates deadenylation-independent repression by promoting accessibility of miRNAs. Following growth [...] (1212 aa) |
| | KPNA6 | Importin subunit alpha-7; Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are [...] (493 aa) |
| | ARMH1 | C1orf228 isoform 2. (307 aa) |
| | ZYG11B | Zyg-11 family member B, cell cycle regulator. (744 aa) |
| | ZYG11A | Zyg-11 family member A, cell cycle regulator. (759 aa) |
| | USP24 | Ubiquitin specific peptidase 24; Belongs to the peptidase C19 family. (2619 aa) |
| | AP4B1 | AP complex subunit beta; Belongs to the adaptor complexes large subunit family. (739 aa) |
| | PKP1 | PKP1 isoform 2. (745 aa) |
| | PIK3C2B | Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta; Belongs to the PI3/PI4-kinase family. (1634 aa) |
| | INTS7 | Integrator complex subunit 7. (962 aa) |
| | PPP2R5A | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (486 aa) |
| | NCAPG2 | NCAPG2 isoform 2. (1134 aa) |
| | COPG2 | Coatomer subunit gamma; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. (726 aa) |
| | PIK3CG | PIK3CG isoform 1; Belongs to the PI3/PI4-kinase family. (1102 aa) |
| | ECPAS | Proteasome adapter and scaffold protein ECM29; Adapter/scaffolding protein that binds to the 26S proteasome, motor proteins and other compartment specific proteins. May couple the proteasome to different compartments including endosome, endoplasmic reticulum and centrosome. May play a role in ERAD and other enhanced proteolysis. Promotes proteasome dissociation under oxidative stress. (1839 aa) |
| | SARM1 | Sterile alpha and TIR motif containing 1. (724 aa) |
| | CR201_G0047047 | SMG1 isoform 2. (163 aa) |
| | TEX10 | Testis-expressed protein 10; Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit. (929 aa) |
| | ARMC12 | Armadillo repeat containing 12. (367 aa) |
| | VPS35 | Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (796 aa) |
| | ARMC5 | ARMC5 isoform 5. (523 aa) |
| | NCBP1 | Nuclear cap binding protein subunit 1. (790 aa) |
| | AOPEP | Aminopeptidase O (putative). (819 aa) |
| | TANGO6 | TANGO6 isoform 2. (1006 aa) |
| | VAC14 | VAC14 component of PIKFYVE complex. (782 aa) |
| | AP1G1 | AP-1 complex subunit gamma-1; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules (By similarity). (822 aa) |
| | CLTC | Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1675 aa) |
| | TBCD | TBCD isoform 3. (1192 aa) |
| | KPNA2 | Importin subunit alpha; Functions in nuclear protein import. (526 aa) |
| | HEATR6 | HEAT repeat-containing protein 6. (1145 aa) |
| | DAAM2 | Dishevelled associated activator of morphogenesis 2. (1077 aa) |
| | CUL7 | Cullin-7; Core component of the 3M and Cul7-RING(FBXW8) complexes, which mediates the ubiquitination of target proteins. Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer. Interaction with CUL9 is required to inhibit CUL9 activity and ubiquitination of BIRC5. Core component of a Cul7-RING ubiquitin- protein ligase with FBXW8, which mediates ubiquitination and consequent degradation of target proteins such as [...] (1723 aa) |
| | ARMC2 | ARMC2 isoform 2. (862 aa) |
| | KPNA5 | Importin subunit alpha; Functions in nuclear protein import. (583 aa) |
| | SERAC1 | SERAC1 isoform 1. (744 aa) |
| | INTS1 | INTS1 isoform 1. (2157 aa) |
| | TAF6 | TAF6 isoform 4. (585 aa) |
| | STAG3 | STAG3 isoform 3. (835 aa) |
| | ELMO1 | ELMO1 isoform 1. (715 aa) |
| | ARMC10 | Armadillo repeat containing 10. (343 aa) |
| | RPTOR | RPTOR isoform 4. (708 aa) |
| | NUP188 | NUP188 isoform 1. (1753 aa) |
| | EIF5 | Eukaryotic translation initiation factor 5; Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]) (By similarity); Belongs to the eIF-2-beta/eIF-5 family. (431 aa) |
| | IFRD1 | IFRD1 isoform 4. (405 aa) |
| | PELP1 | PELP1 isoform 1. (922 aa) |
| | CSE1L | Exportin-2; Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause releas [...] (1016 aa) |
| | WAPL | WAPL isoform 2. (1324 aa) |
| | EIF4G1 | EIF4G1 isoform 19. (1606 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (832 aa) |
| | EIF3K | Eukaryotic translation initiation factor 3 subunit K; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] (176 aa) |
| | STAG2 | STAG2 isoform 10. (1242 aa) |
| | DOCK11 | DOCK11 isoform 1; Belongs to the DOCK family. (2065 aa) |
| | GPRASP2 | G-protein coupled receptor-associated sorting protein 2; May play a role in regulation of a variety of G-protein coupled receptors; Belongs to the GPRASP family. (838 aa) |
| | ARMCX5 | Armadillo repeat-containing X-linked protein 5; Belongs to the eutherian X-chromosome-specific Armcx family. (558 aa) |
| | ARMCX2 | Armadillo repeat containing X-linked 2. (626 aa) |
| | ARMCX3 | Armadillo repeat-containing X-linked protein 3; Regulates mitochondrial aggregation and transport in axons in living neurons. May link mitochondria to the TRAK2-kinesin motor complex via its interaction with Miro and TRAK2. Mitochondrial distribution and dynamics is regulated through ARMCX3 protein degradation, which is promoted by PCK and negatively regulated by WNT1. Enhances the SOX10-mediated transactivation of the neuronal acetylcholine receptor subunit alpha-3 and beta-4 subunit gene promoters. (379 aa) |
| | ARMCX1 | Armadillo repeat-containing X-linked protein 1; Regulates mitochondrial transport during axon regeneration. Increases the proportion of motile mitochondria by recruiting stationary mitochondria into the motile pool. Enhances mitochondria movement and neurite growth in both adult axons and embryonic neurons. Promotes neuronal survival and axon regeneration after nerve injury. May link mitochondria to the Trak1-kinesin motor complex via its interaction with MIRO1. (453 aa) |
| | DIAPH2 | DIAPH2 isoform 2. (1101 aa) |
| | UBQLN2 | UBQLN2 isoform 1. (624 aa) |
| | HUWE1 | HUWE1 isoform 1. (4373 aa) |
| | USP9X | Ubiquitin specific peptidase 9 X-linked; Belongs to the peptidase C19 family. (2554 aa) |
| | JUP | JUP isoform 1. (670 aa) |
| | MROH1 | MROH1 isoform 6. (1633 aa) |
| | AGTPBP1 | AGTPBP1 isoform 6. (1193 aa) |
| | DOCK8 | DOCK8 isoform 2; Belongs to the DOCK family. (2024 aa) |
| | FOCAD | FOCAD isoform 1. (1801 aa) |
| | PLAA | PLAA isoform 1. (869 aa) |
| | STKLD1 | STKLD1 isoform 1. (665 aa) |
| | TSC1 | TSC1 isoform 8. (1157 aa) |
| | ZER1 | Protein zer-1 homolog; Serves as substrate adapter subunit in the E3 ubiquitin ligase complex ZYG11B-CUL2-Elongin BC. Acts redudantly with ZYG11B to target substrates bearing N-terminal glycine degrons for proteasomal degradation. Involved in the clearance of proteolytic fragments generated by caspase cleavage during apoptosis since N-terminal glycine degrons are strongly enriched at caspase cleavage sites. Also important in the quality control of protein N-myristoylation in which N-terminal glycine degrons are conditionally exposed after a failure of N- myristoylation; Belongs to the [...] (730 aa) |
| | HGH1 | HGH1 isoform 1. (390 aa) |
| | ARMC1 | Armadillo repeat-containing protein 1. (225 aa) |
| | ATP6V1H | V-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (465 aa) |
| | TTI2 | TTI2 isoform 2. (508 aa) |
| | XPO7 | Exportin-7; Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO7 then return to the nuclear compartment and mediate ano [...] (1086 aa) |
| | NF1 | NF1 isoform 6. (2838 aa) |
| | PPP4R3C | PPP4R3CP isoform 1. (825 aa) |
| | RIC8A | Synembryn-A; Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)- alpha-GDP complex. Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation (By similarity). (530 aa) |
| | FHOD1 | FHOD1 isoform 2. (1162 aa) |
| | RSPRY1 | RING finger and SPRY domain-containing protein 1. (576 aa) |
| | SMG1 | SMG1 isoform 8; Belongs to the PI3/PI4-kinase family. (2434 aa) |
| | RRN3 | RNA polymerase I-specific transcription initiation factor RRN3; Required for efficient transcription initiation by RNA polymerase I. Required for the formation of the competent preinitiation complex (PIC). Dissociates from pol I as a consequence of transcription. In vitro, cannot activate transcription in a subsequent transcription reaction (By similarity); Belongs to the RRN3 family. (567 aa) |
| | AP3B2 | AP-3 complex subunit beta. (1038 aa) |
| | UNC45A | Protein unc-45 homolog A; May act as co-chaperone for HSP90 (Potential). Prevents the stimulation of HSP90AB1 ATPase activity by AHSA1. Positive factor in promoting PGR function in the cell (By similarity). May be necessary for proper folding of myosin (Potential). Necessary for normal cell proliferation. Necessary for normal myotube formation and myosin accumulation during muscle cell development. May play a role in erythropoiesis in stroma cells in the spleen (By similarity). (929 aa) |
| | AGBL1 | AGBL1 isoform 3. (1060 aa) |
| | AP4E1 | AP-4 complex subunit epsilon; Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin- associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. (1137 aa) |
| | RYR3 | RYR3 isoform 3. (4565 aa) |
| | AP1G2 | AP-1 complex subunit gamma. (785 aa) |
| | INF2 | INF2 isoform 5. (782 aa) |
| | PPP2R5C | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (524 aa) |
| | PPP4R4 | Protein phosphatase 4 regulatory subunit 4. (873 aa) |
| | PPP4R3A | PPP4R3A isoform 5. (802 aa) |
| | HEATR4 | HEATR4 isoform 1. (997 aa) |
| | PPP2R5E | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (403 aa) |
| | DAAM1 | Dishevelled associated activator of morphogenesis 1. (1078 aa) |
| | RALGAPA1 | RALGAPA1 isoform 3. (2036 aa) |
| | NOP9 | NOP9 nucleolar protein. (634 aa) |
| | IPO4 | IPO4 isoform 1. (1080 aa) |
| | DOCK9 | DOCK9 isoform 5; Belongs to the DOCK family. (2107 aa) |
| | KPNA3 | Importin subunit alpha; Functions in nuclear protein import. (487 aa) |
| | NBEA | NBEA isoform 4. (2941 aa) |
| | PDS5B | PDS5 cohesin associated factor B. (1447 aa) |
| | FRY | FRY isoform 3. (3017 aa) |
| | XPO4 | XPO4 isoform 1. (1151 aa) |
| | RIC8B | RIC8 guanine nucleotide exchange factor B. (560 aa) |
| | SCYL2 | SCYL2 isoform 1. (924 aa) |
| | CAND1 | Cullin-associated NEDD8-dissociated protein 1; Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate- recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. The exchange activity of CAND1 is coupled with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1, increasing dissociation of the SCF complex and promoting exchange of the F-box protein. Probably plays a similar [...] (1230 aa) |
| | XPOT | Exportin-T; Mediates the nuclear export of aminoacylated tRNAs. In the nucleus binds to tRNA and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the tRNA from the export receptor. XPOT then return to the nuclear compartment and mediate another round of transport. The directionality of nucl [...] (962 aa) |
| | MON2 | MON2 isoform 1. (1716 aa) |
| | ITPR2 | Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa) |
