STRINGSTRING
RASGRP2 RASGRP2 EPS15L1 EPS15L1 PLS3 PLS3 RHOT1 RHOT1 CALB2 CALB2 VSNL1 VSNL1 CETN2 CETN2 PPEF1 PPEF1 REPS2 REPS2 S100G S100G NCS1 NCS1 NCALD NCALD NECAB1 NECAB1 CALB1 CALB1 CALU-2 CALU-2 SRI SRI DGKB DGKB FKBP14 FKBP14 MYL10 MYL10 REPS1 REPS1 DST DST CR201_G0016546 CR201_G0016546 SCGN SCGN KCNIP1 KCNIP1 CETN3 CETN3 FSTL5 FSTL5 SPARCL1 SPARCL1 KCNIP4 KCNIP4 LETM1 LETM1 PLS1 PLS1 PLCD1 PLCD1 TNNC1 TNNC1 GUCA1C GUCA1C PLCD4 PLCD4 FKBP7 FKBP7 SLC25A12 SLC25A12 GCA GCA GPD2 GPD2 HPCAL1 HPCAL1 EHD3 EHD3 RASGRP3 RASGRP3 MCFD2 MCFD2 CR201_G0030271 CR201_G0030271 EFCAB6 EFCAB6 ITSN1 ITSN1 MYL9 MYL9 RPTN RPTN RCN3 RCN3 NUCB1 NUCB1 ACTN4 ACTN4 CAPNS1 CAPNS1 PRKCSH PRKCSH SLC25A23 SLC25A23 CAPS CAPS CETN1 CETN1 MYL12A MYL12A MYL12B MYL12B USP32 USP32 RCVRN RCVRN CR201_G0036829 CR201_G0036829 NKD1 NKD1 CHP2 CHP2 CR201_G0014777 CR201_G0014777 RCN2 RCN2 DUOX1 DUOX1 DUOX2 DUOX2 CAPN3 CAPN3 RASGRP1 RASGRP1 CALM1 CALM1 EFCAB11 EFCAB11 ACTN1 ACTN1 TESC TESC DGKA DGKA CR201_G0036182 CR201_G0036182 NUCB2 NUCB2 EHD1 EHD1 CAPN1 CAPN1 CABP4 CABP4 CABP2 CABP2 MICU1 MICU1 CALML5 CALML5 CALML6 CALML6 PLCH2 PLCH2 PEF1 PEF1 MACF1 MACF1 HPCAL4 HPCAL4 EPS15 EPS15 S100A11 S100A11 HRNR HRNR CR201_G0018963 CR201_G0018963 CRNN CRNN S100A9 S100A9 S100A8 S100A8 S100A15A S100A15A CR201_G0019020 CR201_G0019020 S100A7L2 S100A7L2 CR201_G0019027 CR201_G0019027 S100A2 S100A2 S100A16 S100A16 S100A1 S100A1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RASGRP2RASGRP2 isoform 1. (302 aa)
EPS15L1Epidermal growth factor receptor pathway substrate 15 like 1. (926 aa)
PLS3PLS3 isoform 2. (639 aa)
RHOT1Mitochondrial Rho GTPase; Mitochondrial GTPase involved in mitochondrial trafficking. Belongs to the mitochondrial Rho GTPase family. (755 aa)
CALB2CALB2 isoform 1. (179 aa)
VSNL1Visinin-like protein 1; Regulates (in vitro) the inhibition of rhodopsin phosphorylation in a calcium-dependent manner; Belongs to the recoverin family. (191 aa)
CETN2CETN2 isoform 1. (172 aa)
PPEF1Serine/threonine-protein phosphatase with EF-hands. (653 aa)
REPS2REPS2 isoform 2. (655 aa)
S100GProtein S100; Belongs to the S-100 family. (79 aa)
NCS1Neuronal calcium sensor 1; Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin (By similarity). Stimulates PI4KB kinase activity (By similarity). Involved in long-term synaptic plasticity through its interaction with PICK1 (By similarity). May also play a role in neuron differentiation through inhibition of the activity of N-type voltage- gated calcium channel (By similarity); Belongs to the recoverin family. (190 aa)
NCALDNeurocalcin-delta; May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds three calcium ions (By similarity). Belongs to the recoverin family. (193 aa)
NECAB1N-terminal EF-hand calcium-binding protein 1. (436 aa)
CALB1Calbindin; Buffers cytosolic calcium. May stimulate a membrane Ca(2+)- ATPase and a 3',5'-cyclic nucleotide phosphodiesterase (By similarity). (261 aa)
CALU-2Calumenin; Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma- carboxylase GGCX. Binds 7 calcium ions with a low affinity (By similarity). (315 aa)
SRISorcin; Calcium-binding protein that modulates excitation-contraction coupling in the heart. Contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Modulates the activity of RYR2 calcium channels (By similarity). (198 aa)
DGKBDiacylglycerol kinase. (780 aa)
FKBP14Peptidyl-prolyl cis-trans isomerase FKBP14; PPIase which accelerates the folding of proteins during protein synthesis. Has a preference for substrates containing 4- hydroxylproline modifications, including type III collagen. May also target type VI and type X collagens. (231 aa)
MYL10Myosin light chain 10. (226 aa)
REPS1RALBP1 associated Eps domain containing 1. (796 aa)
DSTDST isoform 3. (5421 aa)
CR201_G0016546CAPN11 isoform 2; Belongs to the peptidase C2 family. (519 aa)
SCGNSecretagogin, EF-hand calcium binding protein. (276 aa)
KCNIP1Potassium voltage-gated channel interacting protein 1. (227 aa)
CETN3CETN3 isoform 1. (167 aa)
FSTL5FSTL5 isoform 3. (804 aa)
SPARCL1SPARCL1 isoform 1. (663 aa)
KCNIP4KCNIP4 isoform 1. (213 aa)
LETM1Leucine zipper and EF-hand containing transmembrane protein 1. (739 aa)
PLS1PLS1 isoform 1. (631 aa)
PLCD1Phosphoinositide phospholipase C. (756 aa)
TNNC1Troponin C1, slow skeletal and cardiac type. (161 aa)
GUCA1CGuanylate cyclase activator 1C. (209 aa)
PLCD41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4; Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration [...] (762 aa)
FKBP7Peptidyl-prolyl cis-trans isomerase FKBP7; PPIases accelerate the folding of proteins during protein synthesis. (263 aa)
SLC25A12Calcium-binding mitochondrial carrier protein Aralar1; Mitochondrial and calcium-binding carrier that catalyzes the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartate across the mitochondrial inner membrane. May have a function in the urea cycle. (675 aa)
GCAGrancalcin; Calcium-binding protein that may play a role in the adhesion of neutrophils to fibronectin. May play a role in the formation of focal adhesions (By similarity). (218 aa)
GPD2Glycerol-3-phosphate dehydrogenase; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. (601 aa)
HPCAL1Hippocalcin-like protein 1; May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. (193 aa)
EHD3EHD3 isoform 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (535 aa)
RASGRP3RASGRP3 isoform 1. (688 aa)
MCFD2Multiple coagulation factor deficiency protein 2 homolog; The MCFD2-LMAN1 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins. (266 aa)
CR201_G0030271MICU1 isoform 4. (129 aa)
EFCAB6EF-hand calcium-binding domain-containing protein 6; Negatively regulates the androgen receptor by recruiting histone deacetylase complex, and protein DJ-1 antagonizes this inhibition by abrogation of this complex. (1533 aa)
ITSN1ITSN1 isoform 4. (1610 aa)
MYL9Myosin regulatory light polypeptide 9; Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion. (172 aa)
RPTNRPTN isoform 1. (641 aa)
RCN3Reticulocalbin 3. (328 aa)
NUCB1Nucleobindin-1; Major calcium-binding protein of the Golgi which may have a role in calcium homeostasis (By similarity). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates alpha subunits of guanine nucleotide-binding proteins (G proteins) (By similarity). (212 aa)
ACTN4Alpha-actinin-4; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions. May also function as a transcriptional coactivator, stimulating transcri [...] (827 aa)
CAPNS1CAPNS1 isoform 1. (268 aa)
PRKCSHProtein kinase C substrate 80K-H. (534 aa)
SLC25A23SLC25A23 isoform 6; Belongs to the mitochondrial carrier (TC 2.A.29) family. (442 aa)
CAPSCAPS isoform 1. (324 aa)
CETN1CETN1 isoform 1. (172 aa)
MYL12AMyosin regulatory light chain 12A; Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion (By similarity). (177 aa)
MYL12BMyosin light chain 12B. (172 aa)
USP32USP32 isoform 1. (1602 aa)
RCVRNRCVRN isoform 1. (200 aa)
CR201_G0036829NECAB2 isoform 3. (322 aa)
NKD1NKD inhibitor of WNT signaling pathway 1. (470 aa)
CHP2Calcineurin like EF-hand protein 2. (196 aa)
CR201_G0014777CIB1 isoform 1. (190 aa)
RCN2RCN2 isoform 1. (371 aa)
DUOX1DUOX1 isoform 1. (1544 aa)
DUOX2DUOX2 isoform 1. (1545 aa)
CAPN3CAPN3 isoform 16; Belongs to the peptidase C2 family. (815 aa)
RASGRP1RASGRP1 isoform 2. (787 aa)
CALM1Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases (By similarity). Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity). (149 aa)
EFCAB11EF-hand calcium binding domain 11. (163 aa)
ACTN1ACTN1 isoform 1. (980 aa)
TESCTESC isoform 2. (214 aa)
DGKADiacylglycerol kinase. (786 aa)
CR201_G0036182CRACR2A isoform 1. (319 aa)
NUCB2NUCB2 isoform 11. (420 aa)
EHD1EH domain-containing protein 1; ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis. Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Recruited to endosomal membranes upon nerve growth factor stimulation, indirectly regulates neurite outgrowth. Plays a role in myoblast fusion. Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to axons implicating a function in neuronal APP processing. Plays a role in the formation of the ciliary v [...] (534 aa)
CAPN1Calpain-1 catalytic subunit; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. (714 aa)
CABP4Calcium binding protein 4. (275 aa)
CABP2Calcium binding protein 2. (220 aa)
MICU1Mitochondrial calcium uptake 1. (480 aa)
CALML5Calmodulin like 5. (146 aa)
CALML6Calmodulin like 6. (181 aa)
PLCH2Phosphoinositide phospholipase C. (1416 aa)
PEF1Penta-EF-hand domain containing 1. (284 aa)
MACF1Microtubule actin crosslinking factor 1. (5430 aa)
HPCAL4Hippocalcin-like protein 4; May be involved in the calcium-dependent regulation of rhodopsin phosphorylation; Belongs to the recoverin family. (211 aa)
EPS15Epidermal growth factor receptor pathway substrate 15. (896 aa)
S100A11Protein S100; Belongs to the S-100 family. (105 aa)
HRNRHRNR isoform 1. (2852 aa)
CR201_G0018963FLG isoform 1. (1212 aa)
CRNNCRNN isoform 1. (495 aa)
S100A9Protein S100; Belongs to the S-100 family. (114 aa)
S100A8Protein S100; Belongs to the S-100 family. (93 aa)
S100A15AProtein S100-A15A; Belongs to the S-100 family. (108 aa)
CR201_G0019020Protein S100; Belongs to the S-100 family. (69 aa)
S100A7L2S100A7L2 isoform 1. (101 aa)
CR201_G0019027Protein S100; Belongs to the S-100 family. (84 aa)
S100A2Protein S100; Belongs to the S-100 family. (98 aa)
S100A16Protein S100; Belongs to the S-100 family. (130 aa)
S100A1Protein S100-A1; Probably acts as a Ca(2+) signal transducer. In response to an increase in intracellular Ca(2+) levels, binds calcium which triggers a conformational change. This conformational change allows interaction of S1001A with specific target proteins, such as TPR- containing proteins, and the modulation of their activity. Belongs to the S-100 family. (147 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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