| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| GARS1 | HARS1 | ENSPPYP00000019811 | ENSPPYP00000017740 | Glycine--tRNA ligase; Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis. | Histidine--tRNA ligase, cytoplasmic; Catalyzes the ATP-dependent ligation of histidine to the 3'- end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP). Plays a role in axon guidance. Belongs to the class-II aminoacyl-tRNA synthetase family. | 0.790 |
| GARS1 | HARS2 | ENSPPYP00000019811 | ENSPPYP00000017743 | Glycine--tRNA ligase; Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis. | Histidine--tRNA ligase, mitochondrial; Mitochondrial aminoacyl-tRNA synthetase that catalyzes the ATP-dependent ligation of histidine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP). | 0.761 |
| GARS1 | TARS1 | ENSPPYP00000019811 | ENSPPYP00000017181 | Glycine--tRNA ligase; Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis. | TARS isoform 1. | 0.671 |
| GARS1 | TARS2 | ENSPPYP00000019811 | ENSPPYP00000001051 | Glycine--tRNA ligase; Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis. | TARS2 isoform 3. | 0.660 |
| GARS1 | TARS3 | ENSPPYP00000019811 | ENSPPYP00000007749 | Glycine--tRNA ligase; Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis. | TARSL2 isoform 1. | 0.712 |
| HARS1 | GARS1 | ENSPPYP00000017740 | ENSPPYP00000019811 | Histidine--tRNA ligase, cytoplasmic; Catalyzes the ATP-dependent ligation of histidine to the 3'- end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP). Plays a role in axon guidance. Belongs to the class-II aminoacyl-tRNA synthetase family. | Glycine--tRNA ligase; Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis. | 0.790 |
| HARS1 | TARS1 | ENSPPYP00000017740 | ENSPPYP00000017181 | Histidine--tRNA ligase, cytoplasmic; Catalyzes the ATP-dependent ligation of histidine to the 3'- end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP). Plays a role in axon guidance. Belongs to the class-II aminoacyl-tRNA synthetase family. | TARS isoform 1. | 0.713 |
| HARS1 | TARS2 | ENSPPYP00000017740 | ENSPPYP00000001051 | Histidine--tRNA ligase, cytoplasmic; Catalyzes the ATP-dependent ligation of histidine to the 3'- end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP). Plays a role in axon guidance. Belongs to the class-II aminoacyl-tRNA synthetase family. | TARS2 isoform 3. | 0.719 |
| HARS1 | TARS3 | ENSPPYP00000017740 | ENSPPYP00000007749 | Histidine--tRNA ligase, cytoplasmic; Catalyzes the ATP-dependent ligation of histidine to the 3'- end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP). Plays a role in axon guidance. Belongs to the class-II aminoacyl-tRNA synthetase family. | TARSL2 isoform 1. | 0.720 |
| HARS2 | GARS1 | ENSPPYP00000017743 | ENSPPYP00000019811 | Histidine--tRNA ligase, mitochondrial; Mitochondrial aminoacyl-tRNA synthetase that catalyzes the ATP-dependent ligation of histidine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP). | Glycine--tRNA ligase; Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis. | 0.761 |
| HARS2 | TARS1 | ENSPPYP00000017743 | ENSPPYP00000017181 | Histidine--tRNA ligase, mitochondrial; Mitochondrial aminoacyl-tRNA synthetase that catalyzes the ATP-dependent ligation of histidine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP). | TARS isoform 1. | 0.710 |
| HARS2 | TARS2 | ENSPPYP00000017743 | ENSPPYP00000001051 | Histidine--tRNA ligase, mitochondrial; Mitochondrial aminoacyl-tRNA synthetase that catalyzes the ATP-dependent ligation of histidine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP). | TARS2 isoform 3. | 0.711 |
| HARS2 | TARS3 | ENSPPYP00000017743 | ENSPPYP00000007749 | Histidine--tRNA ligase, mitochondrial; Mitochondrial aminoacyl-tRNA synthetase that catalyzes the ATP-dependent ligation of histidine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP). | TARSL2 isoform 1. | 0.712 |
| TARS1 | GARS1 | ENSPPYP00000017181 | ENSPPYP00000019811 | TARS isoform 1. | Glycine--tRNA ligase; Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis. | 0.671 |
| TARS1 | HARS1 | ENSPPYP00000017181 | ENSPPYP00000017740 | TARS isoform 1. | Histidine--tRNA ligase, cytoplasmic; Catalyzes the ATP-dependent ligation of histidine to the 3'- end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP). Plays a role in axon guidance. Belongs to the class-II aminoacyl-tRNA synthetase family. | 0.713 |
| TARS1 | HARS2 | ENSPPYP00000017181 | ENSPPYP00000017743 | TARS isoform 1. | Histidine--tRNA ligase, mitochondrial; Mitochondrial aminoacyl-tRNA synthetase that catalyzes the ATP-dependent ligation of histidine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP). | 0.710 |
| TARS1 | TARS2 | ENSPPYP00000017181 | ENSPPYP00000001051 | TARS isoform 1. | TARS2 isoform 3. | 0.903 |
| TARS1 | TARS3 | ENSPPYP00000017181 | ENSPPYP00000007749 | TARS isoform 1. | TARSL2 isoform 1. | 0.401 |
| TARS2 | GARS1 | ENSPPYP00000001051 | ENSPPYP00000019811 | TARS2 isoform 3. | Glycine--tRNA ligase; Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis. | 0.660 |
| TARS2 | HARS1 | ENSPPYP00000001051 | ENSPPYP00000017740 | TARS2 isoform 3. | Histidine--tRNA ligase, cytoplasmic; Catalyzes the ATP-dependent ligation of histidine to the 3'- end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP). Plays a role in axon guidance. Belongs to the class-II aminoacyl-tRNA synthetase family. | 0.719 |