STRINGSTRING
DEFB135 DEFB135 CR201_G0035435 CR201_G0035435 LOC112131868 LOC112131868 CR201_G0055244 CR201_G0055244 CR201_G0055471 CR201_G0055471 LOC100434671 LOC100434671 LOC100436028 LOC100436028 LOC112131749 LOC112131749 MPEG1 MPEG1 HP HP DEFB114 DEFB114 DEFB113 DEFB113 DEFB110 DEFB110 DEFB112 DEFB112 DEFA6 DEFA6 LOC100433911 LOC100433911 LOC100434290 LOC100434290 HAMP HAMP DEFB132 DEFB132 DEFB129 DEFB129 DEFB128 DEFB128 DEFB127 DEFB127 DEFB126 DEFB126 DEFB125 DEFB125 DEFB118 DEFB118 DEFB119 DEFB119 DEFB121 DEFB121 DEFB123 DEFB123 DEFB124 DEFB124 WFDC12 WFDC12 LOC100439336 LOC100439336 DEFB133 DEFB133
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DEFB135Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (77 aa)
CR201_G0035435DEFA5 isoform 1. (94 aa)
LOC112131868DEFA1 isoform 1. (101 aa)
CR201_G0055244Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (50 aa)
CR201_G0055471Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (69 aa)
LOC100434671Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (72 aa)
LOC100436028DEFB4A isoform 1. (64 aa)
LOC112131749Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (84 aa)
MPEG1Macrophage-expressed gene 1 protein; Plays a key role in the innate immune response following bacterial infection by polymerizing and inserting into the bacterial surface to form pores (By similarity). By breaching the surface of phagocytosed bacteria, allows antimicrobial effectors to enter the bacterial periplasmic space and degrade bacterial proteins such as superoxide dismutase sodC which contributes to bacterial virulence (By similarity). Shows antibacterial activity against a wide spectrum of Gram-positive, Gram-negative and acid-fast bacteria (By similarity). Reduces the viabili [...] (716 aa)
HPHaptoglobin alpha chain; As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pat [...] (361 aa)
DEFB114Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (69 aa)
DEFB113Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (82 aa)
DEFB110Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (67 aa)
DEFB112Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (113 aa)
DEFA6Defensin alpha 6. (100 aa)
LOC100433911Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (78 aa)
LOC100434290Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (65 aa)
HAMPHepcidin; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages (By similarity); Belongs to the hepcidin family. (85 aa)
DEFB132Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (95 aa)
DEFB129Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (183 aa)
DEFB128Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (88 aa)
DEFB127Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (100 aa)
DEFB126Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (118 aa)
DEFB125Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (157 aa)
DEFB118Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (123 aa)
DEFB119Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (88 aa)
DEFB121Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (76 aa)
DEFB123Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (67 aa)
DEFB124Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (33 aa)
WFDC12WAP four-disulfide core domain protein 12; Antibacterial protein. Putative acid-stable proteinase inhibitor (By similarity). (110 aa)
LOC100439336Histone H2B type 1; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (126 aa)
DEFB133Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (61 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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