STRINGSTRING
DTL DTL POLD1 POLD1 UBA52 UBA52 ENSPPYP00000009931 ENSPPYP00000009931 ENSPPYP00000008980 ENSPPYP00000008980 ENSPPYP00000023562 ENSPPYP00000023562 ENSPPYP00000023500 ENSPPYP00000023500 CUL4B CUL4B ENSPPYP00000022487 ENSPPYP00000022487 POLE3 POLE3 RPA3 RPA3 POLD2 POLD2 RFC2 RFC2 RFC1 RFC1 RFC4 RFC4 WDR48 WDR48 RAD18 RAD18 POLE4 POLE4 RBX1 RBX1 MEIOB MEIOB CR201_G0003353 CR201_G0003353 POLE2 POLE2 CUL4A CUL4A PCNA PCNA USP1 USP1 CR201_G0053435 CR201_G0053435 POLD4 POLD4 DDB1 DDB1 POLD3 POLD3 RFC5 RFC5 UBC UBC POLE POLE RFC3 RFC3 RCBTB2 RCBTB2 RCBTB1 RCBTB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DTLDTL isoform 2. (659 aa)
POLD1DNA polymerase delta catalytic subunit. (1121 aa)
UBA52UBA52 isoform 10. (128 aa)
ENSPPYP00000009931annotation not available (76 aa)
ENSPPYP00000008980annotation not available (158 aa)
ENSPPYP00000023562annotation not available (156 aa)
ENSPPYP00000023500annotation not available (140 aa)
CUL4BCUL4B isoform 4; Belongs to the cullin family. (843 aa)
ENSPPYP00000022487annotation not available (153 aa)
POLE3DNA polymerase epsilon subunit 3; Accessory component of the DNA polymerase epsilon complex (By similarity). Participates in DNA repair and in chromosomal DNA replication (By similarity). Forms a complex with CHRAC1 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome-remodeling activity of ISWI/SNF2H and ACF1 (By similarity). (147 aa)
RPA3Replication protein A3. (121 aa)
POLD2DNA polymerase delta 2, accessory subunit. (504 aa)
RFC2RFC2 isoform 5. (306 aa)
RFC1Replication factor C subunit 1. (1020 aa)
RFC4Replication factor C subunit 4. (363 aa)
WDR48WD repeat-containing protein 48; Regulator of deubiquitinating complexes. Acts as a strong activator of USP1 and USP46. Enhances the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself. Also activates deubiquitinating activity of complexes containing USP12. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. May play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes; Belongs to the WD repeat WDR48 family. (677 aa)
RAD18RAD18 isoform 2. (495 aa)
POLE4DNA polymerase epsilon 4, accessory subunit. (117 aa)
RBX1RBX1 isoform 1. (108 aa)
MEIOBMEIOB isoform 4. (441 aa)
CR201_G0003353RPS27A isoform 1. (155 aa)
POLE2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (372 aa)
CUL4ACUL4A isoform 5; Belongs to the cullin family. (759 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
USP1Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (785 aa)
CR201_G0053435UBB isoform 1. (128 aa)
POLD4POLD4 isoform 5. (107 aa)
DDB1DNA damage-binding protein 1; Required for DNA repair. Binds to DDB2 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiqui [...] (1135 aa)
POLD3DNA polymerase delta 3, accessory subunit. (466 aa)
RFC5Replication factor C subunit 5. (340 aa)
UBCUBC isoform 2. (625 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2039 aa)
RFC3Replication factor C subunit 3. (356 aa)
RCBTB2RCC1 and BTB domain-containing protein 2. (551 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (531 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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