STRINGSTRING
GNA11 GNA11 AHCYL1 AHCYL1 PLA2G4A PLA2G4A GNG4 GNG4 PPP2R1A PPP2R1A PRKCG PRKCG PLCB1 PLCB1 PDYN PDYN CNBD2 CNBD2 ENSPPYP00000013398 ENSPPYP00000013398 THAP7 THAP7 CALM1-2 CALM1-2 POMC POMC ADCY3 ADCY3 PTRHD1 PTRHD1 PDE1A PDE1A CREB1 CREB1 ADCY5 ADCY5 ITPR1 ITPR1 PRKCD PRKCD GNAI2 GNAI2 PRKAR2A PRKAR2A THAP6 THAP6 GNG8 GNG8 ENSPPYP00000016612 ENSPPYP00000016612 PPP3CA PPP3CA CAMK2D CAMK2D LRBA LRBA ADCY2 ADCY2 PDE4D PDE4D CAMK4 CAMK4 CAMK2A CAMK2A ITPR3 ITPR3 PPP2R5D PPP2R5D GNB2 GNB2 ADCY1 ADCY1 CAMK2B CAMK2B PDE1C PDE1C GNG11 GNG11 GNGT1 GNGT1 GNAT3 GNAT3 GNAI1 GNAI1 PRKAR2B PRKAR2B ENSPPYP00000020348 ENSPPYP00000020348 CDK5 CDK5 ENSPPYP00000020490 ENSPPYP00000020490 PPP3CC PPP3CC PPP2CB PPP2CB ADCY8 ADCY8 PRKACG PRKACG GNA14 GNA14 GNAQ GNAQ ENSPPYP00000023095 ENSPPYP00000023095 CAMK2G CAMK2G MAPK1 MAPK1 PDE4C PDE4C PRKACA PRKACA PDE4A PDE4A CR201_G0044254 CR201_G0044254 GNAL GNAL PRKAR1A PRKAR1A GNGT2 GNGT2 KPNA2 KPNA2 PRKCA PRKCA ENSPPYP00000009605 ENSPPYP00000009605 PPP1R1B PPP1R1B CAMKK1 CAMKK1 ADCY7 ADCY7 ADCY9 ADCY9 GNG13 GNG13 ENSPPYP00000007387 ENSPPYP00000007387 GNB5 GNB5 CR201_G0038144 CR201_G0038144 CALM1 CALM1 GNG2 GNG2 ADCY4 ADCY4 DCLK1 DCLK1 NBEA NBEA CAMKK2 CAMKK2 PDE1B PDE1B ADCY6 ADCY6 ITPR2 ITPR2 GNB3 GNB3 PPP2R1B PPP2R1B GNG3 GNG3 PLCB3 PLCB3 GRK2 GRK2 PPP1CA PPP1CA PPP3CB PPP3CB ENSPPYP00000002678 ENSPPYP00000002678 PLCB4 PLCB4 OPRM1 OPRM1 GNB1 GNB1 PDE4B PDE4B GNG12 GNG12 PRKACB PRKACB GNG5 GNG5 GNAI3 GNAI3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GNA11GNA11 isoform 1. (358 aa)
AHCYL1Adenosylhomocysteinase like 1; Belongs to the adenosylhomocysteinase family. (530 aa)
PLA2G4ACytosolic phospholipase A2; Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response (By similarity). (749 aa)
GNG4Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
PPP2R1APPP2R1A isoform 7. (558 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (692 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1215 aa)
PDYNPDYN isoform 1. (254 aa)
CNBD2Cyclic nucleotide binding domain containing 2. (572 aa)
ENSPPYP00000013398annotation not available (195 aa)
THAP7THAP domain containing 7. (309 aa)
CALM1-2Calmodulin 2. (149 aa)
POMCPOMC isoform 1. (266 aa)
ADCY3Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1084 aa)
PTRHD1Peptidyl-tRNA hydrolase domain containing 1. (140 aa)
PDE1APhosphodiesterase. (545 aa)
CREB1CREB1 isoform 1. (341 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1100 aa)
ITPR1ITPR1 isoform 3. (2769 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
GNAI2GNAI2 isoform 1. (303 aa)
PRKAR2AProtein kinase cAMP-dependent type II regulatory subunit alpha. (382 aa)
THAP6THAP domain containing 6. (222 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
ENSPPYP00000016612annotation not available (511 aa)
PPP3CASerine/threonine-protein phosphatase. (514 aa)
CAMK2DCAMK2D isoform 6. (524 aa)
LRBALRBA isoform 2. (2807 aa)
ADCY2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1013 aa)
PDE4DPhosphodiesterase. (679 aa)
CAMK4CAMK4 isoform 2; Belongs to the protein kinase superfamily. (615 aa)
CAMK2ACalcium/calmodulin-dependent protein kinase type II subunit alpha; Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in synaptic plasticity, neurotransmitter release and long-term potentiation. Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (By similarity). Regulates dendritic spine development. Also regulates the migration of developing neurons. Phosphorylates the transcriptio [...] (540 aa)
ITPR3ITPR3 isoform 1. (2641 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (668 aa)
GNB2GNB2 isoform 1. (340 aa)
ADCY1Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (636 aa)
CAMK2BCAMK2B isoform 9. (654 aa)
PDE1CPhosphodiesterase. (709 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
GNAT3GNAT3 isoform 1. (355 aa)
GNAI1Guanine nucleotide-binding protein G(i) subunit alpha-1. (302 aa)
PRKAR2BPRKAR2B isoform 1. (390 aa)
ENSPPYP00000020348annotation not available (364 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
ENSPPYP00000020490annotation not available (78 aa)
PPP3CCSerine/threonine-protein phosphatase. (511 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa)
PRKACGProtein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (351 aa)
GNA14G protein subunit alpha 14. (355 aa)
GNAQG protein subunit alpha q. (359 aa)
ENSPPYP00000023095annotation not available (68 aa)
CAMK2GCAMK2G isoform 1. (545 aa)
MAPK1Mitogen-activated protein kinase 1 isoform X1. (158 aa)
PDE4CPhosphodiesterase. (713 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha. (299 aa)
PDE4APhosphodiesterase. (789 aa)
CR201_G0044254GNA15 isoform 1. (287 aa)
GNALGNAL isoform 3. (381 aa)
PRKAR1AcAMP-dependent protein kinase type I-alpha regulatory subunit; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. (381 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
KPNA2Importin subunit alpha; Functions in nuclear protein import. (526 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (645 aa)
ENSPPYP00000009605annotation not available (424 aa)
PPP1R1BProtein phosphatase 1 regulatory inhibitor subunit 1B. (204 aa)
CAMKK1CAMKK1 isoform 1. (541 aa)
ADCY7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa)
ADCY9ADCY9 isoform 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (570 aa)
GNG13GNG13 isoform 1. (67 aa)
ENSPPYP00000007387annotation not available (61 aa)
GNB5Guanine nucleotide-binding protein subunit beta-5; Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation (Probable). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors (By similarity). May play an important role in neuronal signaling, incl [...] (609 aa)
CR201_G0038144PLCB2 isoform 2. (355 aa)
CALM1Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases (By similarity). Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity). (149 aa)
GNG2Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity). (71 aa)
ADCY4Adenylate cyclase type 4 isoform X1. (1077 aa)
DCLK1DCLK1 isoform 4. (701 aa)
NBEANBEA isoform 4. (2941 aa)
CAMKK2Calcium/calmodulin dependent protein kinase kinase 2. (588 aa)
PDE1BPhosphodiesterase. (536 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1165 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
GNB3G protein subunit beta 3. (340 aa)
PPP2R1BPPP2R1B isoform 5. (667 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1204 aa)
GRK2G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (689 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
PPP3CBSerine/threonine-protein phosphatase. (438 aa)
ENSPPYP00000002678annotation not available (281 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
OPRM1Opioid receptor mu 1; Belongs to the G-protein coupled receptor 1 family. (400 aa)
GNB1Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (340 aa)
PDE4BPhosphodiesterase. (736 aa)
GNG12Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
PRKACBPRKACB isoform 9; Belongs to the protein kinase superfamily. (354 aa)
GNG5Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
GNAI3Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...] (354 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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