STRINGSTRING
MEMO1 MEMO1 PRKCE PRKCE PTK6 PTK6 PLCG1 PLCG1 SRC SRC AKT2 AKT2 UBA52 UBA52 CDC37 CDC37 MATK MATK YES1 YES1 ENSPPYP00000009931 ENSPPYP00000009931 GRB2 GRB2 PRKCA PRKCA ERBB2 ERBB2 GRB7 GRB7 ENSPPYP00000008172 ENSPPYP00000008172 STUB1 STUB1 CR201_G0003353 CR201_G0003353 NRG4 NRG4 USP8 USP8 AKT1 AKT1 HSP90AA1 HSP90AA1 FNDC3A FNDC3A UBC UBC RNF41 RNF41 ERBB3 ERBB3 KRAS KRAS CUL5 CUL5 HRAS HRAS CR201_G0036525 CR201_G0036525 CR201_G0053435 CR201_G0053435 NRAS NRAS CSDE1 CSDE1 SHC1 SHC1 AKT3 AKT3 PIK3CA PIK3CA ENSPPYP00000023562 ENSPPYP00000023562 ERBIN ERBIN ENSPPYP00000023500 ENSPPYP00000023500 ERAS ERAS NRG1 NRG1 PTPN12 PTPN12 EGFR EGFR FYN FYN DIAPH1 DIAPH1 HBEGF HBEGF NRG2 NRG2 PIK3R1 PIK3R1 ENSPPYP00000017062 ENSPPYP00000017062 ENSPPYP00000017056 ENSPPYP00000017056 ENSPPYP00000016980 ENSPPYP00000016980 GAB1 GAB1 EGF EGF BTC BTC EREG EREG FNDC3B FNDC3B RHOA RHOA PRKCD PRKCD PTPN18 PTPN18 ERBB4 ERBB4 SOS1 SOS1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MEMO1MEMO1 isoform 1. (277 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
PTK6Tyrosine-protein kinase. (451 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1257 aa)
SRCTyrosine-protein kinase. (553 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
UBA52UBA52 isoform 10. (128 aa)
CDC37CDC37 isoform 2. (338 aa)
MATKTyrosine-protein kinase. (474 aa)
YES1Tyrosine-protein kinase. (485 aa)
ENSPPYP00000009931annotation not available (76 aa)
GRB2Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Belongs to the GRB2/sem-5/DRK family. (217 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (645 aa)
ERBB2Receptor protein-tyrosine kinase. (1256 aa)
GRB7GRB7 isoform 9. (532 aa)
ENSPPYP00000008172annotation not available (229 aa)
STUB1STIP1 homology and U-box containing protein 1. (303 aa)
CR201_G0003353RPS27A isoform 1. (155 aa)
NRG4NRG4 isoform 5. (115 aa)
USP8USP8 isoform 3; Belongs to the peptidase C19 family. (1118 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (413 aa)
HSP90AA1HSP90AA1 isoform 6. (615 aa)
FNDC3AFibronectin type-III domain-containing protein 3A; Mediates spermatid-Sertoli adhesion during spermatogenesis. Belongs to the FNDC3 family. (1198 aa)
UBCUBC isoform 2. (625 aa)
RNF41E3 ubiquitin-protein ligase NRDP1; Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88. Negatively regulates MYD88-dependent production of proinflammatory cytokines. Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus. Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progeni [...] (317 aa)
ERBB3Receptor tyrosine-protein kinase erbB-3; Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. May also be activated by CSPG5. Involved in the regulation of myeloid cell differentiation. (1342 aa)
KRASKRAS proto-oncogene, GTPase. (188 aa)
CUL5Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...] (732 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
CR201_G0036525NRG3 isoform 1. (396 aa)
CR201_G0053435UBB isoform 1. (128 aa)
NRASGTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa)
CSDE1Cold shock domain containing E1. (798 aa)
SHC1SHC-transforming protein 1; Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis (By similarity). (583 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (832 aa)
ENSPPYP00000023562annotation not available (156 aa)
ERBINErbb2 interacting protein. (1419 aa)
ENSPPYP00000023500annotation not available (140 aa)
ERASES cell expressed Ras. (233 aa)
NRG1NRG1 isoform 10. (692 aa)
PTPN12Tyrosine-protein phosphatase non-receptor type 12; Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades. (750 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
FYNTyrosine-protein kinase. (537 aa)
DIAPH1DIAPH1 isoform 1. (1134 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
NRG2NRG2 isoform 2. (448 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha; Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling. Modulates the cellular response to ER stress by promoting nuclear translocation [...] (723 aa)
ENSPPYP00000017062annotation not available (62 aa)
ENSPPYP00000017056annotation not available (412 aa)
ENSPPYP00000016980annotation not available (100 aa)
GAB1GAB1 isoform 1. (724 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1177 aa)
BTCBTC isoform 1. (178 aa)
EREGEREG isoform 1. (169 aa)
FNDC3BFibronectin type III domain containing 3B. (1204 aa)
RHOATransforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essent [...] (196 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
PTPN18PTPN18 isoform 2. (460 aa)
ERBB4Receptor protein-tyrosine kinase. (1284 aa)
SOS1SOS1 isoform 2. (1290 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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