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| | SAA2 | Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (122 aa) |
| | IKBKG | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (487 aa) |
| | IRAK1 | Interleukin 1 receptor associated kinase 1. (682 aa) |
| | UBE2NL | Ubiquitin conjugating enzyme E2 N like (gene/pseudogene). (152 aa) |
| | ENSPPYP00000022638 | annotation not available (210 aa) |
| | TAB3 | TAB3 isoform 2. (670 aa) |
| | RPS6KA3 | Ribosomal protein S6 kinase. (740 aa) |
| | ENSPPYP00000022487 | annotation not available (153 aa) |
| | ENSPPYP00000022319 | annotation not available (162 aa) |
| | TRAF2 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa) |
| | LRRC14 | Leucine rich repeat containing 14. (493 aa) |
| | TONSL | TONSL isoform 2. (1217 aa) |
| | MAPK15 | MAPK15 isoform 3. (546 aa) |
| | RIPK2 | Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa B kinase subunit beta. (697 aa) |
| | PPP2CB | Serine/threonine-protein phosphatase. (309 aa) |
| | DUSP4 | Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (394 aa) |
| | CUL1 | Cullin-1; Core component of multiple cullin-RING-based SCF (SKP1-CUL1- F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SCF complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the [...] (776 aa) |
| | CR201_G0036702 | CCDC71L isoform 2. (316 aa) |
| | CREB5 | Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (508 aa) |
| | NOD1 | NOD1 isoform 4. (953 aa) |
| | VWC2 | Von Willebrand factor C domain containing 2. (325 aa) |
| | RPS6KA2 | Ribosomal protein S6 kinase. (809 aa) |
| | TAB2 | TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa) |
| | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as a [...] (606 aa) |
| | PPP2R5D | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (668 aa) |
| | MAPK14 | Mitogen-activated protein kinase. (360 aa) |
| | AGER | AGER isoform 1. (352 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (424 aa) |
| | FBXW11 | FBXW11 isoform 1. (489 aa) |
| | SKP1 | S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] (163 aa) |
| | MAP3K1 | MAP3K1 isoform 1. (1505 aa) |
| | ALPK1 | ALPK1 isoform 3. (1181 aa) |
| | TIFA | TIFA isoform 1. (185 aa) |
| | NFKB1 | Nuclear factor kappa B subunit 1. (969 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (384 aa) |
| | TLR10 | Toll like receptor 10; Belongs to the Toll-like receptor family. (811 aa) |
| | TNIP2 | TNIP2 isoform 1. (337 aa) |
| | LRRC31 | LRRC31 isoform 1. (547 aa) |
| | LRRC34 | Leucine rich repeat containing 34. (432 aa) |
| | NKIRAS1 | NFKB inhibitor interacting Ras like 1. (192 aa) |
| | MYD88 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa) |
| | MAPKAPK3 | MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (382 aa) |
| | IRAK2 | Interleukin-1 receptor-associated kinase-like 2; Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. (625 aa) |
| | CREB1 | CREB1 isoform 1. (341 aa) |
| | CASP8 | CASP8 isoform 1; Belongs to the peptidase C14A family. (496 aa) |
| | ATF2 | Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa) |
| | MAP3K20 | MAP3K20 isoform 1. (457 aa) |
| | FOSL2 | FOS like 2, AP-1 transcription factor subunit. (318 aa) |
| | PELI1 | E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa) |
| | LRRC74B | LRRC74B isoform 4. (161 aa) |
| | ENSPPYP00000013398 | annotation not available (195 aa) |
| | ENSPPYP00000013364 | annotation not available (267 aa) |
| | SYNGR1 | Synaptogyrin-1; May play a role in regulated exocytosis. Modulates the localization of synaptophysin/SYP into synaptic-like microvesicles and may therefore play a role in synaptic-like microvesicle formation and/or maturation (By similarity). Involved in the regulation of short- term and long-term synaptic plasticity (By similarity). Belongs to the synaptogyrin family. (654 aa) |
| | ENSPPYP00000013015 | annotation not available (211 aa) |
| | S100B | Protein S100; Belongs to the S-100 family. (92 aa) |
| | APP | APP isoform 3. (736 aa) |
| | ENSPPYP00000012476 | annotation not available (955 aa) |
| | TMEM189-UBE2V1 | Ubiquitin-conjugating enzyme E2 variant 1; Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly- ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF- kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repa [...] (329 aa) |
| | ENSPPYP00000012086 | annotation not available (110 aa) |
| | NLRP13 | NLRP13 isoform 2. (1044 aa) |
| | NLRP9 | NLRP9 isoform 1. (937 aa) |
| | PPP2R1A | PPP2R1A isoform 7. (558 aa) |
| | VRK3 | VRK3 isoform 3. (424 aa) |
| | NFKBIB | NFKBIB isoform 6. (354 aa) |
| | UBA52 | UBA52 isoform 10. (128 aa) |
| | ECSIT | ECSIT isoform 1. (210 aa) |
| | MAP2K7 | Mitogen-activated protein kinase kinase 7. (435 aa) |
| | RELCH | RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1216 aa) |
| | USP14 | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (435 aa) |
| | PPP4R1 | PPP4R1 isoform 1. (947 aa) |
| | ENSPPYP00000009931 | annotation not available (76 aa) |
| | LRRC45 | LRRC45 isoform 1. (674 aa) |
| | MAP2K6 | Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa) |
| | NKIRAS2 | NFKB inhibitor interacting Ras like 2. (191 aa) |
| | DUSP3 | Dual specificity protein phosphatase 3; Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Specifically dephosphorylates and inactivates ERK1 and ERK2 (By similarity); Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (185 aa) |
| | MAP2K3 | Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa) |
| | ENSPPYP00000008980 | annotation not available (158 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa) |
| | NLRC5 | NLRC5 isoform 2. (1632 aa) |
| | NOD2 | NOD2 isoform 4. (1040 aa) |
| | N4BP1 | N4BP1 isoform 1. (894 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (381 aa) |
| | MEF2A | Myocyte-specific enhancer factor 2A; Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylate [...] (494 aa) |
| | CR201_G0003353 | RPS27A isoform 1. (155 aa) |
| | MAP2K1 | MAP2K1 isoform 1; Belongs to the protein kinase superfamily. (395 aa) |
| | PPP4R4 | Protein phosphatase 4 regulatory subunit 4. (873 aa) |
| | RPS6KA5 | Ribosomal protein S6 kinase alpha-5; Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional act [...] (896 aa) |
| | LRRC74A | Leucine rich repeat containing 74A. (488 aa) |
| | FOS | Fos proto-oncogene, AP-1 transcription factor subunit. (380 aa) |
| | PELI2 | E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (420 aa) |
| | NFKBIA | NFKBIA isoform 1. (317 aa) |
| | KHNYN | KHNYN isoform 1. (608 aa) |
| | HMGB1 | High mobility group box 1. (215 aa) |
| | UBC | UBC isoform 2. (625 aa) |
| | UBE2N | Ubiquitin-conjugating enzyme E2 N; The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly- ubiquitination of [...] (152 aa) |
| | DUSP6 | Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa) |
| | ATF7 | Cyclic AMP-dependent transcription factor ATF-7; Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. Activator of the NF-ELAM1/delta-A site of the E-selectin promoter. Has no intrinsic transcriptional activity, but activates transcription on formation of JUN or FOS heterodimers. Also can bind TRE promoter sequences when heterodimerized with members of the JUN family (By similarity). (491 aa) |
| | ATF1 | ATF1 isoform 1. (223 aa) |
| | IRAK4 | IRAK4 isoform 6. (438 aa) |
| | NLRX1 | NLRX1 isoform 1. (974 aa) |
| | PPP2R1B | PPP2R1B isoform 5. (667 aa) |
| | TRAF6 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (604 aa) |
| | FNBP4 | FNBP4 isoform 3. (1008 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (551 aa) |
| | PELI3 | E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (445 aa) |
| | NLRP6 | NLRP6 isoform 2. (812 aa) |
| | MAP3K8 | Mitogen-activated protein kinase kinase kinase 8. (384 aa) |
| | NFKB2 | NFKB2 isoform 4. (868 aa) |
| | BTRC | BTRC isoform 2. (605 aa) |
| | CHUK | CHUK isoform 1. (746 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (384 aa) |
| | CREM | cAMP responsive element modulator. (299 aa) |
| | CR201_G0053435 | UBB isoform 1. (128 aa) |
| | RPS6KA1 | Ribosomal protein S6 kinase. (735 aa) |
| | JUN | JUN isoform 1; Belongs to the bZIP family. (334 aa) |
| | S100A12 | S100 calcium binding protein A12; Belongs to the S-100 family. (92 aa) |
| | LRRC71 | LRRC71 isoform 1. (559 aa) |
| | MAPKAPK2 | MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (401 aa) |
| | ENSPPYP00000023500 | annotation not available (140 aa) |
| | ENSPPYP00000023537 | annotation not available (121 aa) |
| | ENSPPYP00000023562 | annotation not available (156 aa) |
| | MAP2K4 | Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (410 aa) |
| | MAPK1 | Mitogen-activated protein kinase 1 isoform X1. (158 aa) |
| | ELK1 | ETS transcription factor ELK1. (429 aa) |
