STRINGSTRING
CR201_G0025521 CR201_G0025521 BIRC2 BIRC2 TRAF6 TRAF6 CHUK CHUK CR201_G0053435 CR201_G0053435 CASP9 CASP9 ENSPPYP00000023562 ENSPPYP00000023562 ENSPPYP00000023500 ENSPPYP00000023500 IKBKG IKBKG IRAK1 IRAK1 UBE2NL UBE2NL TAB3 TAB3 CARD9 CARD9 RIPK2 RIPK2 IKBKB IKBKB CASP2 CASP2 NOD1 NOD1 TAB2 TAB2 TNFAIP3 TNFAIP3 MAP3K7 MAP3K7 MAPK13 MAPK13 MAPK14 MAPK14 NAIP NAIP IRAK2 IRAK2 AAMP AAMP CASP8 CASP8 MAP3K20 MAP3K20 ENSPPYP00000013364 ENSPPYP00000013364 MAPK12 MAPK12 SYNGR1 SYNGR1 BIRC7 BIRC7 TMEM189-UBE2V1 TMEM189-UBE2V1 ITCH ITCH ENSPPYP00000012086 ENSPPYP00000012086 UBA52 UBA52 ENSPPYP00000009931 ENSPPYP00000009931 MAP2K6 MAP2K6 CYLD CYLD NOD2 NOD2 CR201_G0003353 CR201_G0003353 UBC UBC UBE2N UBE2N CASP1 CASP1 CASP4 CASP4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CR201_G0025521CASP12 isoform 3; Belongs to the peptidase C14A family. (408 aa)
BIRC2Baculoviral IAP repeat containing 2. (597 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (604 aa)
CHUKCHUK isoform 1. (746 aa)
CR201_G0053435UBB isoform 1. (128 aa)
CASP9CASP9 isoform 2; Belongs to the peptidase C14A family. (421 aa)
ENSPPYP00000023562annotation not available (156 aa)
ENSPPYP00000023500annotation not available (140 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (487 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (682 aa)
UBE2NLUbiquitin conjugating enzyme E2 N like (gene/pseudogene). (152 aa)
TAB3TAB3 isoform 2. (670 aa)
CARD9CARD9 isoform 1. (434 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (697 aa)
CASP2CASP2 isoform 1; Belongs to the peptidase C14A family. (452 aa)
NOD1NOD1 isoform 4. (953 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
TNFAIP3TNFAIP3 isoform 1. (790 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as a [...] (606 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
NAIPNAIP isoform 3. (1403 aa)
IRAK2Interleukin-1 receptor-associated kinase-like 2; Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. (625 aa)
AAMPAngio-associated migratory cell protein; Plays a role in angiogenesis and cell migration. In smooth muscle cell migration, may act through the RhoA pathway (By similarity). (434 aa)
CASP8CASP8 isoform 1; Belongs to the peptidase C14A family. (496 aa)
MAP3K20MAP3K20 isoform 1. (457 aa)
ENSPPYP00000013364annotation not available (267 aa)
MAPK12Mitogen-activated protein kinase. (351 aa)
SYNGR1Synaptogyrin-1; May play a role in regulated exocytosis. Modulates the localization of synaptophysin/SYP into synaptic-like microvesicles and may therefore play a role in synaptic-like microvesicle formation and/or maturation (By similarity). Involved in the regulation of short- term and long-term synaptic plasticity (By similarity). Belongs to the synaptogyrin family. (654 aa)
BIRC7Baculoviral IAP repeat containing 7. (280 aa)
TMEM189-UBE2V1Ubiquitin-conjugating enzyme E2 variant 1; Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly- ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF- kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repa [...] (329 aa)
ITCHE3 ubiquitin-protein ligase. (849 aa)
ENSPPYP00000012086annotation not available (110 aa)
UBA52UBA52 isoform 10. (128 aa)
ENSPPYP00000009931annotation not available (76 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
CYLDUbiquitin carboxyl-terminal hydrolase CYLD; Deubiquitinase that specifically cleaves 'Lys-63'- and linear 'Met-1'-linked polyubiquitin chains and is involved in NF-kappa-B activation and TNF-alpha-induced necroptosis. Plays an important role in the regulation of pathways leading to NF-kappa-B activation. Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation. Negative regulator of Wnt signaling. Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules. Plays a role in the regul [...] (956 aa)
NOD2NOD2 isoform 4. (1040 aa)
CR201_G0003353RPS27A isoform 1. (155 aa)
UBCUBC isoform 2. (625 aa)
UBE2NUbiquitin-conjugating enzyme E2 N; The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly- ubiquitination of [...] (152 aa)
CASP1CASP1 isoform 4; Belongs to the peptidase C14A family. (404 aa)
CASP4CASP4 isoform 2; Belongs to the peptidase C14A family. (377 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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