STRINGSTRING
IKBKE IKBKE S100A12 S100A12 SIKE1 SIKE1 CR201_G0053435 CR201_G0053435 ISG15 ISG15 CHUK CHUK NFKB2 NFKB2 IRF7 IRF7 FADD FADD RELA RELA TKFC TKFC UBE2L6 UBE2L6 TRAF6 TRAF6 SAA2 SAA2 NLRX1 NLRX1 PCBP2 PCBP2 TBK1 TBK1 UBC UBC ENSPPYP00000006214 ENSPPYP00000006214 HMGB1 HMGB1 NFKBIA NFKBIA HSP90AA1 HSP90AA1 TRAF3 TRAF3 CR201_G0003353 CR201_G0003353 CREBBP CREBBP CYLD CYLD NLRC5 NLRC5 RNF135 RNF135 TRIM25 TRIM25 NKIRAS2 NKIRAS2 RNF125 RNF125 PIN1 PIN1 NFKBIB NFKBIB IRF3 IRF3 MAVS MAVS ITCH ITCH APP APP S100B S100B ENSPPYP00000013015 ENSPPYP00000013015 EP300 EP300 TANK TANK IFIH1 IFIH1 CASP10 CASP10 CASP8 CASP8 TOMM70 TOMM70 ENSPPYP00000015333 ENSPPYP00000015333 UBA7 UBA7 NKIRAS1 NKIRAS1 ENSPPYP00000016040 ENSPPYP00000016040 UBE2K UBE2K ENSPPYP00000016659 ENSPPYP00000016659 HERC5 HERC5 NFKB1 NFKB1 ENSPPYP00000016980 ENSPPYP00000016980 ENSPPYP00000017056 ENSPPYP00000017056 ENSPPYP00000017058 ENSPPYP00000017058 ENSPPYP00000017062 ENSPPYP00000017062 MAP3K1 MAP3K1 ATG12 ATG12 RIPK1 RIPK1 AGER AGER HSP90AB1 HSP90AB1 ATG5 ATG5 TNFAIP3 TNFAIP3 RNF216 RNF216 TRIM4 TRIM4 VWC2 VWC2 TAX1BP1 TAX1BP1 CR201_G0036702 CR201_G0036702 IKBKB IKBKB DDX58 DDX58 IFNA8 IFNA8 LOC100433301 LOC100433301 CR201_G0001880 CR201_G0001880 IFNA6 IFNA6 IFNA5 IFNA5 IFNA14 IFNA14 IFNA21 IFNA21 ENSPPYP00000021491 ENSPPYP00000021491 IFNB1 IFNB1 TRAF2 TRAF2 IFNA21-2 IFNA21-2 ENSPPYP00000022638 ENSPPYP00000022638 OTUD5 OTUD5 IKBKG IKBKG ENSPPYP00000023500 ENSPPYP00000023500 ENSPPYP00000023537 ENSPPYP00000023537 ENSPPYP00000023562 ENSPPYP00000023562
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (716 aa)
S100A12S100 calcium binding protein A12; Belongs to the S-100 family. (92 aa)
SIKE1Suppressor of IKBKE 1; Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3- mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and DDX58/RIG-I. Does not inhibit NF-kappa-B activation pathways (By similarity). (207 aa)
CR201_G0053435UBB isoform 1. (128 aa)
ISG15ISG15 ubiquitin like modifier. (165 aa)
CHUKCHUK isoform 1. (746 aa)
NFKB2NFKB2 isoform 4. (868 aa)
IRF7IRF7 isoform 12. (396 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
TKFCTriokinase and FMN cyclase. (575 aa)
UBE2L6Ubiquitin conjugating enzyme E2 L6; Belongs to the ubiquitin-conjugating enzyme family. (153 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (604 aa)
SAA2Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (122 aa)
NLRX1NLRX1 isoform 1. (974 aa)
PCBP2Poly(rC) binding protein 2. (362 aa)
TBK1TANK binding kinase 1. (729 aa)
UBCUBC isoform 2. (625 aa)
ENSPPYP00000006214annotation not available (312 aa)
HMGB1High mobility group box 1. (215 aa)
NFKBIANFKBIA isoform 1. (317 aa)
HSP90AA1HSP90AA1 isoform 6. (615 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
CR201_G0003353RPS27A isoform 1. (155 aa)
CREBBPCREBBP isoform 1. (2328 aa)
CYLDUbiquitin carboxyl-terminal hydrolase CYLD; Deubiquitinase that specifically cleaves 'Lys-63'- and linear 'Met-1'-linked polyubiquitin chains and is involved in NF-kappa-B activation and TNF-alpha-induced necroptosis. Plays an important role in the regulation of pathways leading to NF-kappa-B activation. Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation. Negative regulator of Wnt signaling. Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules. Plays a role in the regul [...] (956 aa)
NLRC5NLRC5 isoform 2. (1632 aa)
RNF135Ring finger protein 135. (432 aa)
TRIM25Tripartite motif containing 25. (630 aa)
NKIRAS2NFKB inhibitor interacting Ras like 2. (191 aa)
RNF125RNF125 isoform 1. (196 aa)
PIN1Peptidyl-prolyl cis-trans isomerase. (163 aa)
NFKBIBNFKBIB isoform 6. (354 aa)
IRF3IRF3 isoform 6. (427 aa)
MAVSMAVS isoform 2. (539 aa)
ITCHE3 ubiquitin-protein ligase. (849 aa)
APPAPP isoform 3. (736 aa)
S100BProtein S100; Belongs to the S-100 family. (92 aa)
ENSPPYP00000013015annotation not available (211 aa)
EP300EP300 isoform 1. (2380 aa)
TANKTANK isoform 2. (424 aa)
IFIH1IFIH1 isoform 1. (1024 aa)
CASP10CASP10 isoform 3; Belongs to the peptidase C14A family. (521 aa)
CASP8CASP8 isoform 1; Belongs to the peptidase C14A family. (496 aa)
TOMM70Translocase of outer mitochondrial membrane 70. (608 aa)
ENSPPYP00000015333annotation not available (74 aa)
UBA7UBA7 isoform 1; Belongs to the ubiquitin-activating E1 family. (956 aa)
NKIRAS1NFKB inhibitor interacting Ras like 1. (192 aa)
ENSPPYP00000016040LOW QUALITY PROTEIN: putative heat shock protein HSP 90-alpha A5. (166 aa)
UBE2KUbiquitin conjugating enzyme E2 K; Belongs to the ubiquitin-conjugating enzyme family. (200 aa)
ENSPPYP00000016659annotation not available (592 aa)
HERC5HERC5 isoform 1. (433 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
ENSPPYP00000016980annotation not available (100 aa)
ENSPPYP00000017056annotation not available (412 aa)
ENSPPYP00000017058annotation not available (377 aa)
ENSPPYP00000017062annotation not available (62 aa)
MAP3K1MAP3K1 isoform 1. (1505 aa)
ATG12Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. The ATG12-ATG5 conjugate also regulates negatively the innate antiviral immune response by blocking the type I IFN production pathway through direct [...] (187 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (671 aa)
AGERAGER isoform 1. (352 aa)
HSP90AB1Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...] (724 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3- like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is ess [...] (275 aa)
TNFAIP3TNFAIP3 isoform 1. (790 aa)
RNF216Ring finger protein 216. (866 aa)
TRIM4Tripartite motif containing 4. (474 aa)
VWC2Von Willebrand factor C domain containing 2. (325 aa)
TAX1BP1Tax1-binding protein 1 homolog; Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti- apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade (By similarity). (771 aa)
CR201_G0036702CCDC71L isoform 2. (316 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (697 aa)
DDX58DDX58 isoform 2. (875 aa)
IFNA8IFNA5 isoform 1. (189 aa)
LOC100433301IFNA13 isoform 1. (189 aa)
CR201_G0001880IFNA1 isoform 1. (189 aa)
IFNA6IFNA6 isoform 1. (189 aa)
IFNA5IFNA8 isoform 1. (189 aa)
IFNA14Interferon alpha 14. (189 aa)
IFNA21Interferon alpha 21. (189 aa)
ENSPPYP00000021491annotation not available (138 aa)
IFNB1Interferon beta 1. (187 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa)
IFNA21-2Interferon alpha-21. (153 aa)
ENSPPYP00000022638annotation not available (210 aa)
OTUD5OTUD5 isoform 2. (533 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (487 aa)
ENSPPYP00000023500annotation not available (140 aa)
ENSPPYP00000023537annotation not available (121 aa)
ENSPPYP00000023562annotation not available (156 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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