STRINGSTRING
PSME4 PSME4 PSMD14 PSMD14 CR201_G0007171 CR201_G0007171 ENSPPYP00000014618 ENSPPYP00000014618 PSMD1 PSMD1 PSMD6 PSMD6 UBE2E1 UBE2E1 PSMD2 PSMD2 ZCCHC4 ZCCHC4 MAD2L1 MAD2L1 CCNA2 CCNA2 ANAPC10 ANAPC10 SKP2 SKP2 CDC20B CDC20B CCNB1 CCNB1 SKP1 SKP1 CDC23 CDC23 PTTG1 PTTG1 FBXO5 FBXO5 PSMB1 PSMB1 PSMB8 PSMB8 PSMD4 PSMD4 PSMA6 PSMA6 TM7SF3 TM7SF3 PSMC1 PSMC1 ANAPC16 ANAPC16 LOC100457600 LOC100457600 ENSPPYP00000023569 ENSPPYP00000023569 ENSPPYP00000023562 ENSPPYP00000023562 PSME2 PSME2 PSME1 PSME1 PSMB11 PSMB11 PSMB5 PSMB5 CDC16 CDC16 RB1 RB1 CCNA1 CCNA1 UBC UBC PSMD9 PSMD9 ANAPC5 ANAPC5 CDK2 CDK2 ANAPC15 ANAPC15 PSMA1 PSMA1 PSMC3 PSMC3 FAM89B FAM89B ENSPPYP00000003414 ENSPPYP00000003414 BUB3 BUB3 BTRC BTRC UBE2D1 UBE2D1 CDK1 CDK1 CR201_G0053435 CR201_G0053435 PSMB2 PSMB2 CDC20 CDC20 CDC14A CDC14A ENSPPYP00000023561 ENSPPYP00000023561 PSMD7 PSMD7 PSMB1-2 PSMB1-2 ENSPPYP00000023500 ENSPPYP00000023500 PSMD10 PSMD10 ENSPPYP00000022487 ENSPPYP00000022487 PSMD13 PSMD13 ENSPPYP00000022319 ENSPPYP00000022319 ANAPC2 ANAPC2 PSMB7 PSMB7 PSMB9 PSMB9 PSMD5 PSMD5 CDC26 CDC26 FBXO43 FBXO43 CUL1 CUL1 PSMC2 PSMC2 ENSPPYP00000019816 ENSPPYP00000019816 PSMA2 PSMA2 PSMA5 PSMA5 PSMD3 PSMD3 PSMB4 PSMB4 NEK2 NEK2 FAM89A FAM89A ANAPC1 ANAPC1 PSMA7 PSMA7 AURKA AURKA UBE2C UBE2C PSMF1 PSMF1 ENSPPYP00000011752 ENSPPYP00000011752 AURKC AURKC UBE2S UBE2S PSMC4 PSMC4 PSMD8 PSMD8 UBA52 UBA52 FZR1 FZR1 PSMA8 PSMA8 CDC27 CDC27 ENSPPYP00000009931 ENSPPYP00000009931 CDK3 CDK3 PSMD12 PSMD12 PSMC5 PSMC5 PSMB3 PSMB3 PSME3 PSME3 PSMD11 PSMD11 ENSPPYP00000008980 ENSPPYP00000008980 AURKB AURKB PSMB6 PSMB6 PSMB10 PSMB10 PLK1 PLK1 CR201_G0003353 CR201_G0003353 PSMA4 PSMA4 BUB1B BUB1B PSMA3 PSMA3 PSMC6 PSMC6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PSME4Proteasome activator subunit 4. (1843 aa)
PSMD14Proteasome 26S subunit, non-ATPase 14. (310 aa)
CR201_G0007171KIAA2012 isoform 5. (648 aa)
ENSPPYP00000014618Uncharacterized protein KIAA2012 homolog. (553 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa)
PSMD6Proteasome 26S subunit, non-ATPase 6. (389 aa)
UBE2E1Ubiquitin conjugating enzyme E2 E1; Belongs to the ubiquitin-conjugating enzyme family. (193 aa)
PSMD226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. (909 aa)
ZCCHC4Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). (1106 aa)
MAD2L1MAD2L1 isoform 1. (300 aa)
CCNA2CCNA2 isoform 1; Belongs to the cyclin family. (432 aa)
ANAPC10Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (161 aa)
SKP2SKP2 isoform 1. (410 aa)
CDC20BCDC20B isoform 4. (518 aa)
CCNB1CCNB1 isoform 1; Belongs to the cyclin family. (433 aa)
SKP1S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] (163 aa)
CDC23Cell division cycle 23. (597 aa)
PTTG1PTTG1 regulator of sister chromatid separation, securin. (202 aa)
FBXO5F-box protein 5. (447 aa)
PSMB1Proteasome subunit beta. (241 aa)
PSMB8Proteasome subunit beta. (272 aa)
PSMD4PSMD4 isoform 1. (384 aa)
PSMA6Proteasome endopeptidase complex. (167 aa)
TM7SF3Transmembrane 7 superfamily member 3. (570 aa)
PSMC1Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family. (440 aa)
ANAPC16Anaphase-promoting complex subunit 16; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity); Belongs to the APC16 family. (110 aa)
LOC100457600Proteasome subunit beta type-5-like. (263 aa)
ENSPPYP00000023569annotation not available (247 aa)
ENSPPYP00000023562annotation not available (156 aa)
PSME2Proteasome activator subunit 2. (239 aa)
PSME1Proteasome activator subunit 1. (249 aa)
PSMB11Proteasome subunit beta. (300 aa)
PSMB5Proteasome subunit beta type-5; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pro [...] (263 aa)
CDC16CDC16 isoform 4. (575 aa)
RB1RB1 isoform 1. (928 aa)
CCNA1CCNA1 isoform 3; Belongs to the cyclin family. (464 aa)
UBCUBC isoform 2. (625 aa)
PSMD9PSMD9 isoform 1. (223 aa)
ANAPC5Anaphase-promoting complex subunit 5; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). (755 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
ANAPC15ANAPC15 isoform 10. (121 aa)
PSMA1Proteasome subunit alpha type-1; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pr [...] (263 aa)
PSMC3Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (439 aa)
FAM89BFamily with sequence similarity 89 member B. (176 aa)
ENSPPYP00000003414annotation not available (440 aa)
BUB3Mitotic checkpoint protein BUB3; Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. T [...] (328 aa)
BTRCBTRC isoform 2. (605 aa)
UBE2D1Ubiquitin conjugating enzyme E2 D1; Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
CDK1Cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins. Required in higher cells for entry into S-phase and mitosis. Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl-xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CENPA, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, G [...] (297 aa)
CR201_G0053435UBB isoform 1. (128 aa)
PSMB2Proteasome subunit beta. (201 aa)
CDC20Cell division cycle 20. (499 aa)
CDC14ACell division cycle 14A. (594 aa)
ENSPPYP00000023561annotation not available (122 aa)
PSMD7PSMD7 isoform 1. (324 aa)
PSMB1-2Proteasome subunit beta type-1. (241 aa)
ENSPPYP00000023500annotation not available (140 aa)
PSMD10Proteasome 26S subunit, non-ATPase 10. (226 aa)
ENSPPYP00000022487annotation not available (153 aa)
PSMD13PSMD13 isoform 6. (376 aa)
ENSPPYP00000022319annotation not available (162 aa)
ANAPC2Anaphase promoting complex subunit 2; Belongs to the cullin family. (822 aa)
PSMB7Proteasome subunit beta. (277 aa)
PSMB9Proteasome subunit beta. (218 aa)
PSMD5PSMD5 isoform 8. (97 aa)
CDC26Anaphase-promoting complex subunit CDC26; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex (By similarity); Belongs to the CDC26 [...] (85 aa)
FBXO43FBXO43 isoform 1. (674 aa)
CUL1Cullin-1; Core component of multiple cullin-RING-based SCF (SKP1-CUL1- F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SCF complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the [...] (776 aa)
PSMC226S proteasome regulatory subunit 7; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with [...] (433 aa)
ENSPPYP00000019816annotation not available (197 aa)
PSMA2Proteasome subunit alpha type. (234 aa)
PSMA5Proteasome subunit alpha type. (278 aa)
PSMD3PSMD3 isoform 1. (536 aa)
PSMB4Proteasome subunit beta; Belongs to the peptidase T1B family. (264 aa)
NEK2NIMA related kinase 2. (445 aa)
FAM89AFAM89A isoform 1. (167 aa)
ANAPC1ANAPC1 isoform 2. (1855 aa)
PSMA7Proteasome subunit alpha type-7; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pr [...] (248 aa)
AURKAAURKA isoform 10; Belongs to the protein kinase superfamily. (404 aa)
UBE2CUbiquitin conjugating enzyme E2 C; Belongs to the ubiquitin-conjugating enzyme family. (179 aa)
PSMF1Proteasome inhibitor PI31 subunit; Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28 (By similarity). (271 aa)
ENSPPYP00000011752annotation not available (89 aa)
AURKCAURKC isoform 3; Belongs to the protein kinase superfamily. (309 aa)
UBE2SUBE2S isoform 1; Belongs to the ubiquitin-conjugating enzyme family. (222 aa)
PSMC4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa)
PSMD826S proteasome non-ATPase regulatory subunit 8; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S14 family. (350 aa)
UBA52UBA52 isoform 10. (128 aa)
FZR1FZR1 isoform 4. (420 aa)
PSMA8Proteasome subunit alpha type. (256 aa)
CDC27CDC27 isoform 1. (824 aa)
ENSPPYP00000009931annotation not available (76 aa)
CDK3CDK3 isoform 1; Belongs to the protein kinase superfamily. (305 aa)
PSMD1226S proteasome non-ATPase regulatory subunit 12; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit p55 family. (456 aa)
PSMC5PSMC5 isoform 2; Belongs to the AAA ATPase family. (406 aa)
PSMB3Proteasome subunit beta. (218 aa)
PSME3Proteasome activator complex subunit 3; Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regul [...] (254 aa)
PSMD11Proteasome 26S subunit, non-ATPase 11. (422 aa)
ENSPPYP00000008980annotation not available (158 aa)
AURKBAURKB isoform 2; Belongs to the protein kinase superfamily. (344 aa)
PSMB6Proteasome subunit beta. (239 aa)
PSMB10Proteasome subunit beta. (256 aa)
PLK1Serine/threonine-protein kinase PLK. (603 aa)
CR201_G0003353RPS27A isoform 1. (155 aa)
PSMA4Proteasome subunit alpha type. (261 aa)
BUB1BMitotic checkpoint serine/threonine-protein kinase BUB1 beta. (1050 aa)
PSMA3Proteasome subunit alpha type. (255 aa)
PSMC6Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (403 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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