STRINGSTRING
NOTCH1 NOTCH1 JAG1 JAG1 UBA52 UBA52 TLE2 TLE2 HDAC5 HDAC5 NCOR1 NCOR1 ARRB2 ARRB2 CREBBP CREBBP CR201_G0003353 CR201_G0003353 TLE3 TLE3 APH1B APH1B ADAM10 ADAM10 ENSPPYP00000007046 ENSPPYP00000007046 DLK1 DLK1 SNW1 SNW1 NUMB NUMB PSEN1 PSEN1 CCNC CCNC HDAC2 HDAC2 HEY2 HEY2 DLL1 DLL1 DTX2 DTX2 HDAC9 HDAC9 CUL1 CUL1 HEY1 HEY1 MYC MYC TLE4 TLE4 TLE1 TLE1 ITCH ITCH ENSPPYP00000022269 ENSPPYP00000022269 ENSPPYP00000022319 ENSPPYP00000022319 TBL1X TBL1X HDAC6 HDAC6 MAMLD1 MAMLD1 ENSPPYP00000023500 ENSPPYP00000023500 ENSPPYP00000023562 ENSPPYP00000023562 MIB1 MIB1 NEURL1 NEURL1 DLL4 DLL4 CR201_G0009767 CR201_G0009767 APH1A APH1A NCSTN NCSTN PSEN2 PSEN2 CDK8 CDK8 UBC UBC NCOR2 NCOR2 DTX1 DTX1 HDAC7 HDAC7 CNTN1 CNTN1 MAML2 MAML2 ARRB1 ARRB1 DTX4 DTX4 CR201_G0053298 CR201_G0053298 NBEA NBEA CR201_G0053435 CR201_G0053435 HDAC1 HDAC1 HEYL HEYL LRBA LRBA FBXW7 FBXW7 SKP1 SKP1 HDAC3 HDAC3 NEURL1B NEURL1B MAML1 MAML1 ENSPPYP00000018739 ENSPPYP00000018739 RBPJ RBPJ HES1 HES1 TBL1XR1 TBL1XR1 KAT2B KAT2B HDAC11 HDAC11 CR201_G0011709 CR201_G0011709 DNER DNER ADAM17 ADAM17 HDAC10 HDAC10 EP300 EP300 RBX1 RBX1 ENSPPYP00000012589 ENSPPYP00000012589
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NOTCH1NOTCH1 isoform 1. (2107 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
UBA52UBA52 isoform 10. (128 aa)
TLE2TLE2 isoform 1. (604 aa)
HDAC5Histone deacetylase 5; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By s [...] (1111 aa)
NCOR1NCOR1 isoform 1. (2467 aa)
ARRB2Beta-arrestin-2; Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta- arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin- associated sorting proteins) and re [...] (321 aa)
CREBBPCREBBP isoform 1. (2328 aa)
CR201_G0003353RPS27A isoform 1. (155 aa)
TLE3TLE family member 3, transcriptional corepressor. (769 aa)
APH1BGamma-secretase subunit APH-1B; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (amyloid-beta precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Probably present in a minority of gamma-secretase complexes compared to APH1A (By similarity). (257 aa)
ADAM10ADAM10 isoform 1. (748 aa)
ENSPPYP00000007046annotation not available (868 aa)
DLK1Delta like non-canonical Notch ligand 1. (383 aa)
SNW1SNW domain-containing protein 1; Involved in pre-mRNA splicing as component of the spliceosome. Is required in the specific splicing of CDKN1A pre-mRNA; the function probably involves the recruitment of U2AF2 to the mRNA. Is proposed to recruit PPIL1 to the spliceosome. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in transcriptional regulation. Modulates TGF-beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, [...] (538 aa)
NUMBNUMB endocytic adaptor protein. (651 aa)
PSEN1Presenilin-1 CTF subunit; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. Stimulates cell-cell adhesion via its interaction with CDH1; this stabili [...] (463 aa)
CCNCCCNC isoform 1; Belongs to the cyclin family. (283 aa)
HDAC2Histone deacetylase 2. (580 aa)
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
DTX2Deltex E3 ubiquitin ligase 2. (622 aa)
HDAC9Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1066 aa)
CUL1Cullin-1; Core component of multiple cullin-RING-based SCF (SKP1-CUL1- F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SCF complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the [...] (776 aa)
HEY1Hes related family bHLH transcription factor with YRPW motif 1. (304 aa)
MYCMYC isoform 1. (453 aa)
TLE4TLE4 isoform 4. (743 aa)
TLE1TLE1 isoform 1. (762 aa)
ITCHE3 ubiquitin-protein ligase. (849 aa)
ENSPPYP00000022269annotation not available (383 aa)
ENSPPYP00000022319annotation not available (162 aa)
TBL1XTBL1X isoform 1. (587 aa)
HDAC6HDAC6 isoform 2. (1208 aa)
MAMLD1MAMLD1 isoform 2. (783 aa)
ENSPPYP00000023500annotation not available (140 aa)
ENSPPYP00000023562annotation not available (156 aa)
MIB1MIB1 isoform 1. (539 aa)
NEURL1Neuralized E3 ubiquitin protein ligase 1. (661 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
CR201_G0009767HIF1A isoform 5. (735 aa)
APH1AAph-1 homolog A, gamma-secretase subunit. (265 aa)
NCSTNNCSTN isoform 1. (639 aa)
PSEN2Presenilin-2 CTF subunit; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the other members of the gamma- secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. The holoprotein functions as a calcium-leak channel that allows the passive movement o [...] (448 aa)
CDK8Cyclin dependent kinase 8; Belongs to the protein kinase superfamily. (464 aa)
UBCUBC isoform 2. (625 aa)
NCOR2NCOR2 isoform 6. (2461 aa)
DTX1DTX1 isoform 1. (599 aa)
HDAC7Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (918 aa)
CNTN1CNTN1 isoform 3. (1018 aa)
MAML2MAML2 isoform 2. (984 aa)
ARRB1ARRB1 isoform 2. (473 aa)
DTX4Deltex E3 ubiquitin ligase 4. (619 aa)
CR201_G0053298MIB2 isoform 16. (744 aa)
NBEANBEA isoform 4. (2941 aa)
CR201_G0053435UBB isoform 1. (128 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium st [...] (482 aa)
HEYLHes related family bHLH transcription factor with YRPW motif like. (328 aa)
LRBALRBA isoform 2. (2807 aa)
FBXW7FBXW7 isoform 8. (627 aa)
SKP1S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] (163 aa)
HDAC3Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys-27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activi [...] (428 aa)
NEURL1BNeuralized E3 ubiquitin protein ligase 1B. (555 aa)
MAML1MAML1 isoform 1. (911 aa)
ENSPPYP00000018739annotation not available (186 aa)
RBPJRecombining binding protein suppressor of hairless; Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling [...] (487 aa)
HES1HES1 isoform 1. (198 aa)
TBL1XR1Transducin beta like 1 X-linked receptor 1. (514 aa)
KAT2BHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (755 aa)
HDAC11HDAC11 isoform 10. (370 aa)
CR201_G0011709HDAC7 isoform 6. (40 aa)
DNERDNER isoform 1. (573 aa)
ADAM17ADAM17 isoform 1. (725 aa)
HDAC10HDAC10 isoform 10. (624 aa)
EP300EP300 isoform 1. (2380 aa)
RBX1RBX1 isoform 1. (108 aa)
ENSPPYP00000012589Putative nuclear receptor corepressor 1-like protein NCOR1P1. (101 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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