STRINGSTRING
HLA-DPB1 HLA-DPB1 CD247 CD247 PSMB4 PSMB4 BCL10 BCL10 PSMB2 PSMB2 LCK LCK CR201_G0053435 CR201_G0053435 PRKCQ PRKCQ PTEN PTEN CHUK CHUK BTRC BTRC ENSPPYP00000003414 ENSPPYP00000003414 RELA RELA PSMC3 PSMC3 TRAF6 TRAF6 PSMA1 PSMA1 CD3E CD3E CD3D CD3D CD3G CD3G CD4 CD4 UBE2N UBE2N PSMD9 PSMD9 UBC UBC TRAV14DV4 TRAV14DV4 TRAV19 TRAV19 TRAV23DV6 TRAV23DV6 TRAV38-1 TRAV38-1 TRAV38-2DV8 TRAV38-2DV8 CR201_G0032742 CR201_G0032742 PSMB5 PSMB5 PSMB11 PSMB11 PSME1 PSME1 PSME2 PSME2 NFKBIA NFKBIA PSMC6 PSMC6 PSMA3 PSMA3 PGBD4 PGBD4 PSMA4 PSMA4 CR201_G0003353 CR201_G0003353 PDPK1 PDPK1 PSMB10 PSMB10 PSMB6 PSMB6 ENSPPYP00000008980 ENSPPYP00000008980 PSMD11 PSMD11 PSME3 PSME3 PSMB3 PSMB3 PSMC5 PSMC5 PSMD12 PSMD12 ENSPPYP00000009931 ENSPPYP00000009931 PSMA8 PSMA8 MALT1 MALT1 CDC34 CDC34 CR201_G0037390 CR201_G0037390 UBA52 UBA52 PSMD8 PSMD8 PSMC4 PSMC4 ENSPPYP00000012086 ENSPPYP00000012086 PSMF1 PSMF1 TMEM189-UBE2V1 TMEM189-UBE2V1 PSMA7 PSMA7 PSME4 PSME4 PSMD14 PSMD14 MAP3K20 MAP3K20 PSMD1 PSMD1 INPP5D INPP5D TRAT1 TRAT1 PSMD6 PSMD6 PIK3CB PIK3CB PSMD2 PSMD2 NFKB1 NFKB1 PIK3R1 PIK3R1 SKP1 SKP1 FBXW11 FBXW11 HLA-DRB5 HLA-DRB5 CR201_G0016196 CR201_G0016196 MAP3K7 MAP3K7 TAB2 TAB2 PSMB1 PSMB1 CR201_G0016191 CR201_G0016191 ENSPPYP00000019293 ENSPPYP00000019293 HLA-DQB2 HLA-DQB2 PSMB8 PSMB8 PSMB9 PSMB9 CR201_G0016218 CR201_G0016218 CR201_G0016219 CR201_G0016219 LOC100460187 LOC100460187 ENSPPYP00000019322 ENSPPYP00000019322 CR201_G0016218-2 CR201_G0016218-2 CARD11 CARD11 PSMA2 PSMA2 ENSPPYP00000019816 ENSPPYP00000019816 PSMC2 PSMC2 CR201_G0036702 CR201_G0036702 TRBV4-1 TRBV4-1 TRBV5-1 TRBV5-1 TRBV7-2 TRBV7-2 TRBV6-7 TRBV6-7 TRBV5-3 TRBV5-3 TRBV9 TRBV9 TRBV10-1 TRBV10-1 TRBV10-2 TRBV10-2 CR201_G0022781 CR201_G0022781 TRBV11-3 TRBV11-3 TRBV12-5 TRBV12-5 TRBV15 TRBV15 TRBV17 TRBV17 TRBV18 TRBV18 TRBV19 TRBV19 TRBV20-1 TRBV20-1 TRBV23-1 TRBV23-1 TRBV24-1 TRBV24-1 TRBV25-1 TRBV25-1 TRBV29-1 TRBV29-1 TRBV30 TRBV30 CUL1 CUL1 CR201_G0022785 CR201_G0022785 ENSPPYP00000020459 ENSPPYP00000020459 ENSPPYP00000020461 ENSPPYP00000020461 CR201_G0022737 CR201_G0022737 CR201_G0022753 CR201_G0022753 CR201_G0022752 CR201_G0022752 CR201_G0022776 CR201_G0022776 TRBV13 TRBV13 IKBKB IKBKB RIPK2 RIPK2 PSMD5 PSMD5 PSMB7 PSMB7 ENSPPYP00000022259 ENSPPYP00000022259 CR201_G0039019 CR201_G0039019 ENSPPYP00000022319 ENSPPYP00000022319 PSMD13 PSMD13 ENSPPYP00000022407 ENSPPYP00000022407 ENSPPYP00000022487 ENSPPYP00000022487 PSMD10 PSMD10 UBE2NL UBE2NL IKBKG IKBKG ENSPPYP00000023500 ENSPPYP00000023500 PSMB1-2 PSMB1-2 PIK3CA PIK3CA PSMD7 PSMD7 ENSPPYP00000023561 ENSPPYP00000023561 ENSPPYP00000023562 ENSPPYP00000023562 ENSPPYP00000023569 ENSPPYP00000023569 CR201_G0022801 CR201_G0022801 LOC100457600 LOC100457600 PSMC1 PSMC1 PSMA6 PSMA6 PSMD4 PSMD4 ENSPPYP00000024608 ENSPPYP00000024608 PSMD3 PSMD3 PSMA5 PSMA5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HLA-DPB1Major histocompatibility complex, class II, DP beta 1. (258 aa)
CD247CD247 isoform 2. (165 aa)
PSMB4Proteasome subunit beta; Belongs to the peptidase T1B family. (264 aa)
BCL10BCL10 isoform 1. (263 aa)
PSMB2Proteasome subunit beta. (201 aa)
LCKTyrosine-protein kinase. (487 aa)
CR201_G0053435UBB isoform 1. (128 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
PTENPongo abelii phosphatase and tensin homolog (PTEN), mRNA; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
CHUKCHUK isoform 1. (746 aa)
BTRCBTRC isoform 2. (605 aa)
ENSPPYP00000003414annotation not available (440 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
PSMC3Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (439 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (604 aa)
PSMA1Proteasome subunit alpha type-1; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pr [...] (263 aa)
CD3ECD3E isoform 2. (198 aa)
CD3DCD3D isoform 1. (171 aa)
CD3GCD3G isoform 1. (182 aa)
CD4CD4 isoform 2. (414 aa)
UBE2NUbiquitin-conjugating enzyme E2 N; The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly- ubiquitination of [...] (152 aa)
PSMD9PSMD9 isoform 1. (223 aa)
UBCUBC isoform 2. (625 aa)
TRAV14DV4T cell receptor alpha variable 14/delta variable 4. (117 aa)
TRAV19T cell receptor alpha variable 19. (117 aa)
TRAV23DV6T cell receptor alpha variable 23/delta variable 6. (121 aa)
TRAV38-1T cell receptor alpha variable 38-1. (116 aa)
TRAV38-2DV8T cell receptor alpha variable 38-2/delta variable 8. (116 aa)
CR201_G0032742TRAC isoform 1. (177 aa)
PSMB5Proteasome subunit beta type-5; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pro [...] (263 aa)
PSMB11Proteasome subunit beta. (300 aa)
PSME1Proteasome activator subunit 1. (249 aa)
PSME2Proteasome activator subunit 2. (239 aa)
NFKBIANFKBIA isoform 1. (317 aa)
PSMC6Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (403 aa)
PSMA3Proteasome subunit alpha type. (255 aa)
PGBD4PiggyBac transposable element derived 4. (585 aa)
PSMA4Proteasome subunit alpha type. (261 aa)
CR201_G0003353RPS27A isoform 1. (155 aa)
PDPK1PDPK1 isoform 1. (495 aa)
PSMB10Proteasome subunit beta. (256 aa)
PSMB6Proteasome subunit beta. (239 aa)
ENSPPYP00000008980annotation not available (158 aa)
PSMD11Proteasome 26S subunit, non-ATPase 11. (422 aa)
PSME3Proteasome activator complex subunit 3; Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regul [...] (254 aa)
PSMB3Proteasome subunit beta. (218 aa)
PSMC5PSMC5 isoform 2; Belongs to the AAA ATPase family. (406 aa)
PSMD1226S proteasome non-ATPase regulatory subunit 12; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit p55 family. (456 aa)
ENSPPYP00000009931annotation not available (76 aa)
PSMA8Proteasome subunit alpha type. (256 aa)
MALT1MALT1 isoform 1. (774 aa)
CDC34CDC34 isoform 1; Belongs to the ubiquitin-conjugating enzyme family. (217 aa)
CR201_G0037390PIK3R2 isoform 1. (641 aa)
UBA52UBA52 isoform 10. (128 aa)
PSMD826S proteasome non-ATPase regulatory subunit 8; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S14 family. (350 aa)
PSMC4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa)
ENSPPYP00000012086annotation not available (110 aa)
PSMF1Proteasome inhibitor PI31 subunit; Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28 (By similarity). (271 aa)
TMEM189-UBE2V1Ubiquitin-conjugating enzyme E2 variant 1; Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly- ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF- kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repa [...] (329 aa)
PSMA7Proteasome subunit alpha type-7; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pr [...] (248 aa)
PSME4Proteasome activator subunit 4. (1843 aa)
PSMD14Proteasome 26S subunit, non-ATPase 14. (310 aa)
MAP3K20MAP3K20 isoform 1. (457 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa)
INPP5DINPP5D isoform 3. (1144 aa)
TRAT1T cell receptor associated transmembrane adaptor 1. (185 aa)
PSMD6Proteasome 26S subunit, non-ATPase 6. (389 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
PSMD226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. (909 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha; Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling. Modulates the cellular response to ER stress by promoting nuclear translocation [...] (723 aa)
SKP1S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] (163 aa)
FBXW11FBXW11 isoform 1. (489 aa)
HLA-DRB5Ig-like domain-containing protein. (266 aa)
CR201_G0016196HLA-DQB1 isoform 5. (304 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as a [...] (606 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
PSMB1Proteasome subunit beta. (241 aa)
CR201_G0016191HLA-DRB5 isoform 1. (290 aa)
ENSPPYP00000019293HLA class II histocompatibility antigen, DRB1-11 beta chain isoform X1. (266 aa)
HLA-DQB2Major histocompatibility complex, class II, DQ beta 2. (264 aa)
PSMB8Proteasome subunit beta. (272 aa)
PSMB9Proteasome subunit beta. (218 aa)
CR201_G0016218HLA-DPA1 isoform 1; Belongs to the MHC class II family. (260 aa)
CR201_G0016219HLA-DPB1 isoform 1. (283 aa)
LOC100460187MHC class II protein; Belongs to the MHC class II family. (254 aa)
ENSPPYP00000019322annotation not available (157 aa)
CR201_G0016218-2HLA-DPA1 isoform 3. (239 aa)
CARD11CARD11 isoform 1. (1155 aa)
PSMA2Proteasome subunit alpha type. (234 aa)
ENSPPYP00000019816annotation not available (197 aa)
PSMC226S proteasome regulatory subunit 7; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with [...] (433 aa)
CR201_G0036702CCDC71L isoform 2. (316 aa)
TRBV4-1TRBV4-1 isoform 1. (114 aa)
TRBV5-1TRBV5-1 isoform 1. (114 aa)
TRBV7-2T0078417 isoform 1. (116 aa)
TRBV6-7TRBV6-6 isoform 1. (115 aa)
TRBV5-3T cell receptor beta variable 5-3 (non-functional). (114 aa)
TRBV9T cell receptor beta variable 9. (114 aa)
TRBV10-1TRBV10-3 isoform 1. (114 aa)
TRBV10-2TRBV10-2 isoform 1. (115 aa)
CR201_G0022781TRBV5-5 isoform 1. (114 aa)
TRBV11-3T0078391 isoform 1. (115 aa)
TRBV12-5T cell receptor beta variable 12-5. (116 aa)
TRBV15T cell receptor beta variable 15. (114 aa)
TRBV17T0078384 isoform 1. (115 aa)
TRBV18T cell receptor beta variable 18. (116 aa)
TRBV19TRBV19 isoform 1. (116 aa)
TRBV20-1TRBV20-1 isoform 1. (126 aa)
TRBV23-1TRBV23-1 isoform 1. (116 aa)
TRBV24-1T cell receptor beta variable 24-1. (115 aa)
TRBV25-1TRBV25-1 isoform 1. (114 aa)
TRBV29-1TRBV29-1 isoform 1. (111 aa)
TRBV30T cell receptor beta variable 30 (gene/pseudogene). (112 aa)
CUL1Cullin-1; Core component of multiple cullin-RING-based SCF (SKP1-CUL1- F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SCF complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the [...] (776 aa)
CR201_G0022785TRBV7-4 isoform 1. (116 aa)
ENSPPYP00000020459annotation not available (115 aa)
ENSPPYP00000020461annotation not available (114 aa)
CR201_G0022737T0078345 isoform 1. (199 aa)
CR201_G0022753TRBV27 isoform 1. (115 aa)
CR201_G0022752TRBV28 isoform 1. (114 aa)
CR201_G0022776TRBV7-9 isoform 1. (114 aa)
TRBV13T0078393 isoform 1. (125 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (697 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa)
PSMD5PSMD5 isoform 8. (97 aa)
PSMB7Proteasome subunit beta. (277 aa)
ENSPPYP00000022259annotation not available (120 aa)
CR201_G0039019TRBV20OR9-2 isoform 1. (124 aa)
ENSPPYP00000022319annotation not available (162 aa)
PSMD13PSMD13 isoform 6. (376 aa)
ENSPPYP00000022407annotation not available (129 aa)
ENSPPYP00000022487annotation not available (153 aa)
PSMD10Proteasome 26S subunit, non-ATPase 10. (226 aa)
UBE2NLUbiquitin conjugating enzyme E2 N like (gene/pseudogene). (152 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (487 aa)
ENSPPYP00000023500annotation not available (140 aa)
PSMB1-2Proteasome subunit beta type-1. (241 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (832 aa)
PSMD7PSMD7 isoform 1. (324 aa)
ENSPPYP00000023561annotation not available (122 aa)
ENSPPYP00000023562annotation not available (156 aa)
ENSPPYP00000023569annotation not available (247 aa)
CR201_G0022801T0078419 isoform 1. (137 aa)
LOC100457600Proteasome subunit beta type-5-like. (263 aa)
PSMC1Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family. (440 aa)
PSMA6Proteasome endopeptidase complex. (167 aa)
PSMD4PSMD4 isoform 1. (384 aa)
ENSPPYP00000024608annotation not available (157 aa)
PSMD3PSMD3 isoform 1. (536 aa)
PSMA5Proteasome subunit alpha type. (278 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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