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| | HLA-DPB1 | Major histocompatibility complex, class II, DP beta 1. (258 aa) |
| | CD247 | CD247 isoform 2. (165 aa) |
| | PSMB4 | Proteasome subunit beta; Belongs to the peptidase T1B family. (264 aa) |
| | BCL10 | BCL10 isoform 1. (263 aa) |
| | PSMB2 | Proteasome subunit beta. (201 aa) |
| | LCK | Tyrosine-protein kinase. (487 aa) |
| | CR201_G0053435 | UBB isoform 1. (128 aa) |
| | PRKCQ | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa) |
| | PTEN | Pongo abelii phosphatase and tensin homolog (PTEN), mRNA; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa) |
| | CHUK | CHUK isoform 1. (746 aa) |
| | BTRC | BTRC isoform 2. (605 aa) |
| | ENSPPYP00000003414 | annotation not available (440 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (551 aa) |
| | PSMC3 | Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (439 aa) |
| | TRAF6 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (604 aa) |
| | PSMA1 | Proteasome subunit alpha type-1; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pr [...] (263 aa) |
| | CD3E | CD3E isoform 2. (198 aa) |
| | CD3D | CD3D isoform 1. (171 aa) |
| | CD3G | CD3G isoform 1. (182 aa) |
| | CD4 | CD4 isoform 2. (414 aa) |
| | UBE2N | Ubiquitin-conjugating enzyme E2 N; The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly- ubiquitination of [...] (152 aa) |
| | PSMD9 | PSMD9 isoform 1. (223 aa) |
| | UBC | UBC isoform 2. (625 aa) |
| | TRAV14DV4 | T cell receptor alpha variable 14/delta variable 4. (117 aa) |
| | TRAV19 | T cell receptor alpha variable 19. (117 aa) |
| | TRAV23DV6 | T cell receptor alpha variable 23/delta variable 6. (121 aa) |
| | TRAV38-1 | T cell receptor alpha variable 38-1. (116 aa) |
| | TRAV38-2DV8 | T cell receptor alpha variable 38-2/delta variable 8. (116 aa) |
| | CR201_G0032742 | TRAC isoform 1. (177 aa) |
| | PSMB5 | Proteasome subunit beta type-5; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pro [...] (263 aa) |
| | PSMB11 | Proteasome subunit beta. (300 aa) |
| | PSME1 | Proteasome activator subunit 1. (249 aa) |
| | PSME2 | Proteasome activator subunit 2. (239 aa) |
| | NFKBIA | NFKBIA isoform 1. (317 aa) |
| | PSMC6 | Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (403 aa) |
| | PSMA3 | Proteasome subunit alpha type. (255 aa) |
| | PGBD4 | PiggyBac transposable element derived 4. (585 aa) |
| | PSMA4 | Proteasome subunit alpha type. (261 aa) |
| | CR201_G0003353 | RPS27A isoform 1. (155 aa) |
| | PDPK1 | PDPK1 isoform 1. (495 aa) |
| | PSMB10 | Proteasome subunit beta. (256 aa) |
| | PSMB6 | Proteasome subunit beta. (239 aa) |
| | ENSPPYP00000008980 | annotation not available (158 aa) |
| | PSMD11 | Proteasome 26S subunit, non-ATPase 11. (422 aa) |
| | PSME3 | Proteasome activator complex subunit 3; Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regul [...] (254 aa) |
| | PSMB3 | Proteasome subunit beta. (218 aa) |
| | PSMC5 | PSMC5 isoform 2; Belongs to the AAA ATPase family. (406 aa) |
| | PSMD12 | 26S proteasome non-ATPase regulatory subunit 12; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit p55 family. (456 aa) |
| | ENSPPYP00000009931 | annotation not available (76 aa) |
| | PSMA8 | Proteasome subunit alpha type. (256 aa) |
| | MALT1 | MALT1 isoform 1. (774 aa) |
| | CDC34 | CDC34 isoform 1; Belongs to the ubiquitin-conjugating enzyme family. (217 aa) |
| | CR201_G0037390 | PIK3R2 isoform 1. (641 aa) |
| | UBA52 | UBA52 isoform 10. (128 aa) |
| | PSMD8 | 26S proteasome non-ATPase regulatory subunit 8; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S14 family. (350 aa) |
| | PSMC4 | Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa) |
| | ENSPPYP00000012086 | annotation not available (110 aa) |
| | PSMF1 | Proteasome inhibitor PI31 subunit; Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28 (By similarity). (271 aa) |
| | TMEM189-UBE2V1 | Ubiquitin-conjugating enzyme E2 variant 1; Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly- ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF- kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repa [...] (329 aa) |
| | PSMA7 | Proteasome subunit alpha type-7; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pr [...] (248 aa) |
| | PSME4 | Proteasome activator subunit 4. (1843 aa) |
| | PSMD14 | Proteasome 26S subunit, non-ATPase 14. (310 aa) |
| | MAP3K20 | MAP3K20 isoform 1. (457 aa) |
| | PSMD1 | 26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa) |
| | INPP5D | INPP5D isoform 3. (1144 aa) |
| | TRAT1 | T cell receptor associated transmembrane adaptor 1. (185 aa) |
| | PSMD6 | Proteasome 26S subunit, non-ATPase 6. (389 aa) |
| | PIK3CB | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa) |
| | PSMD2 | 26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. (909 aa) |
| | NFKB1 | Nuclear factor kappa B subunit 1. (969 aa) |
| | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha; Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling. Modulates the cellular response to ER stress by promoting nuclear translocation [...] (723 aa) |
| | SKP1 | S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] (163 aa) |
| | FBXW11 | FBXW11 isoform 1. (489 aa) |
| | HLA-DRB5 | Ig-like domain-containing protein. (266 aa) |
| | CR201_G0016196 | HLA-DQB1 isoform 5. (304 aa) |
| | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as a [...] (606 aa) |
| | TAB2 | TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa) |
| | PSMB1 | Proteasome subunit beta. (241 aa) |
| | CR201_G0016191 | HLA-DRB5 isoform 1. (290 aa) |
| | ENSPPYP00000019293 | HLA class II histocompatibility antigen, DRB1-11 beta chain isoform X1. (266 aa) |
| | HLA-DQB2 | Major histocompatibility complex, class II, DQ beta 2. (264 aa) |
| | PSMB8 | Proteasome subunit beta. (272 aa) |
| | PSMB9 | Proteasome subunit beta. (218 aa) |
| | CR201_G0016218 | HLA-DPA1 isoform 1; Belongs to the MHC class II family. (260 aa) |
| | CR201_G0016219 | HLA-DPB1 isoform 1. (283 aa) |
| | LOC100460187 | MHC class II protein; Belongs to the MHC class II family. (254 aa) |
| | ENSPPYP00000019322 | annotation not available (157 aa) |
| | CR201_G0016218-2 | HLA-DPA1 isoform 3. (239 aa) |
| | CARD11 | CARD11 isoform 1. (1155 aa) |
| | PSMA2 | Proteasome subunit alpha type. (234 aa) |
| | ENSPPYP00000019816 | annotation not available (197 aa) |
| | PSMC2 | 26S proteasome regulatory subunit 7; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with [...] (433 aa) |
| | CR201_G0036702 | CCDC71L isoform 2. (316 aa) |
| | TRBV4-1 | TRBV4-1 isoform 1. (114 aa) |
| | TRBV5-1 | TRBV5-1 isoform 1. (114 aa) |
| | TRBV7-2 | T0078417 isoform 1. (116 aa) |
| | TRBV6-7 | TRBV6-6 isoform 1. (115 aa) |
| | TRBV5-3 | T cell receptor beta variable 5-3 (non-functional). (114 aa) |
| | TRBV9 | T cell receptor beta variable 9. (114 aa) |
| | TRBV10-1 | TRBV10-3 isoform 1. (114 aa) |
| | TRBV10-2 | TRBV10-2 isoform 1. (115 aa) |
| | CR201_G0022781 | TRBV5-5 isoform 1. (114 aa) |
| | TRBV11-3 | T0078391 isoform 1. (115 aa) |
| | TRBV12-5 | T cell receptor beta variable 12-5. (116 aa) |
| | TRBV15 | T cell receptor beta variable 15. (114 aa) |
| | TRBV17 | T0078384 isoform 1. (115 aa) |
| | TRBV18 | T cell receptor beta variable 18. (116 aa) |
| | TRBV19 | TRBV19 isoform 1. (116 aa) |
| | TRBV20-1 | TRBV20-1 isoform 1. (126 aa) |
| | TRBV23-1 | TRBV23-1 isoform 1. (116 aa) |
| | TRBV24-1 | T cell receptor beta variable 24-1. (115 aa) |
| | TRBV25-1 | TRBV25-1 isoform 1. (114 aa) |
| | TRBV29-1 | TRBV29-1 isoform 1. (111 aa) |
| | TRBV30 | T cell receptor beta variable 30 (gene/pseudogene). (112 aa) |
| | CUL1 | Cullin-1; Core component of multiple cullin-RING-based SCF (SKP1-CUL1- F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SCF complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the [...] (776 aa) |
| | CR201_G0022785 | TRBV7-4 isoform 1. (116 aa) |
| | ENSPPYP00000020459 | annotation not available (115 aa) |
| | ENSPPYP00000020461 | annotation not available (114 aa) |
| | CR201_G0022737 | T0078345 isoform 1. (199 aa) |
| | CR201_G0022753 | TRBV27 isoform 1. (115 aa) |
| | CR201_G0022752 | TRBV28 isoform 1. (114 aa) |
| | CR201_G0022776 | TRBV7-9 isoform 1. (114 aa) |
| | TRBV13 | T0078393 isoform 1. (125 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa B kinase subunit beta. (697 aa) |
| | RIPK2 | Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa) |
| | PSMD5 | PSMD5 isoform 8. (97 aa) |
| | PSMB7 | Proteasome subunit beta. (277 aa) |
| | ENSPPYP00000022259 | annotation not available (120 aa) |
| | CR201_G0039019 | TRBV20OR9-2 isoform 1. (124 aa) |
| | ENSPPYP00000022319 | annotation not available (162 aa) |
| | PSMD13 | PSMD13 isoform 6. (376 aa) |
| | ENSPPYP00000022407 | annotation not available (129 aa) |
| | ENSPPYP00000022487 | annotation not available (153 aa) |
| | PSMD10 | Proteasome 26S subunit, non-ATPase 10. (226 aa) |
| | UBE2NL | Ubiquitin conjugating enzyme E2 N like (gene/pseudogene). (152 aa) |
| | IKBKG | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (487 aa) |
| | ENSPPYP00000023500 | annotation not available (140 aa) |
| | PSMB1-2 | Proteasome subunit beta type-1. (241 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (832 aa) |
| | PSMD7 | PSMD7 isoform 1. (324 aa) |
| | ENSPPYP00000023561 | annotation not available (122 aa) |
| | ENSPPYP00000023562 | annotation not available (156 aa) |
| | ENSPPYP00000023569 | annotation not available (247 aa) |
| | CR201_G0022801 | T0078419 isoform 1. (137 aa) |
| | LOC100457600 | Proteasome subunit beta type-5-like. (263 aa) |
| | PSMC1 | Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family. (440 aa) |
| | PSMA6 | Proteasome endopeptidase complex. (167 aa) |
| | PSMD4 | PSMD4 isoform 1. (384 aa) |
| | ENSPPYP00000024608 | annotation not available (157 aa) |
| | PSMD3 | PSMD3 isoform 1. (536 aa) |
| | PSMA5 | Proteasome subunit alpha type. (278 aa) |
