STRINGSTRING
CR201_G0053587 CR201_G0053587 PSMD3 PSMD3 CR201_G0053547 CR201_G0053547 CR201_G0053557 CR201_G0053557 ENSPPYP00000024580 ENSPPYP00000024580 ENSPPYP00000024524 ENSPPYP00000024524 ENSPPYP00000024486 ENSPPYP00000024486 PSMD4 PSMD4 ENSPPYP00000024373 ENSPPYP00000024373 ENSPPYP00000024351 ENSPPYP00000024351 PSMA6 PSMA6 ENSPPYP00000024254 ENSPPYP00000024254 CR201_G0055127 CR201_G0055127 PSMC1 PSMC1 ENSPPYP00000024185 ENSPPYP00000024185 CR201_G0053581 CR201_G0053581 ENSPPYP00000024082 ENSPPYP00000024082 CR201_G0053930 CR201_G0053930 CR201_G0053570 CR201_G0053570 ENSPPYP00000024003 ENSPPYP00000024003 CR201_G0052687 CR201_G0052687 CR201_G0055132 CR201_G0055132 IGKV1-27 IGKV1-27 ENSPPYP00000023887 ENSPPYP00000023887 LOC100457600 LOC100457600 ENSPPYP00000023791 ENSPPYP00000023791 IGKV1-5 IGKV1-5 ENSPPYP00000023724 ENSPPYP00000023724 CR201_G0047521 CR201_G0047521 ENSPPYP00000023706 ENSPPYP00000023706 CR201_G0052770 CR201_G0052770 CR201_G0052695 CR201_G0052695 MAPK1 MAPK1 CR201_G0052786 CR201_G0052786 MAP2K4 MAP2K4 CR201_G0052690 CR201_G0052690 CR201_G0053589 CR201_G0053589 ENSPPYP00000023577 ENSPPYP00000023577 ENSPPYP00000023573 ENSPPYP00000023573 ENSPPYP00000023569 ENSPPYP00000023569 ENSPPYP00000023562 ENSPPYP00000023562 ENSPPYP00000023561 ENSPPYP00000023561 PSMD7 PSMD7 PIK3CA PIK3CA PSMB1-2 PSMB1-2 ENSPPYP00000023500 ENSPPYP00000023500 IKBKG IKBKG UBE2NL UBE2NL PSMD10 PSMD10 BTK BTK ERAS ERAS TAB3 TAB3 RASGRP2 RASGRP2 CALM1 CALM1 FOS FOS PSMA3 PSMA3 PSMC6 PSMC6 NFKBIA NFKBIA PSME2 PSME2 PSME1 PSME1 PSMB11 PSMB11 PSMB5 PSMB5 TRDV3 TRDV3 CR201_G0032822 CR201_G0032822 TRAV26-2 TRAV26-2 TRAV16 TRAV16 TRAV17 TRAV17 TRAV18 TRAV18 TRAV22 TRAV22 CR201_G0032834 CR201_G0032834 TRAV30 TRAV30 FCER1G FCER1G TXK TXK TEC TEC MAPK10 MAPK10 PPP3CA PPP3CA NFKB1 NFKB1 CLNK CLNK PAK2 PAK2 PSMD2 PSMD2 PIK3CB PIK3CB PSMD6 PSMD6 ITPR1 ITPR1 PSMD1 PSMD1 MAP3K20 MAP3K20 PSMD14 PSMD14 CR201_G0053563 CR201_G0053563 CR201_G0053539 CR201_G0053539 ENSPPYP00000014184 ENSPPYP00000014184 CR201_G0053575 CR201_G0053575 FOSL2 FOSL2 SOS1 SOS1 CALM1-2 CALM1-2 PSME4 PSME4 WDR92 WDR92 IGKC IGKC CR201_G0053595 CR201_G0053595 IGKV5-2 IGKV5-2 ENSPPYP00000013596 ENSPPYP00000013596 CR201_G0053579 CR201_G0053579 CR201_G0053572 CR201_G0053572 CR201_G0053558 CR201_G0053558 ENSPPYP00000013590 ENSPPYP00000013590 CR201_G0053532 CR201_G0053532 ENSPPYP00000013588 ENSPPYP00000013588 ENSPPYP00000013587 ENSPPYP00000013587 CR201_G0055839 CR201_G0055839 ENSPPYP00000013398 ENSPPYP00000013398 CR201_G0054834 CR201_G0054834 GRAP2 GRAP2 SYNGR1 SYNGR1 CR201_G0047442 CR201_G0047442 CR201_G0047507 CR201_G0047507 CR201_G0047525 CR201_G0047525 IGLV6-57 IGLV6-57 PSMA7 PSMA7 NFATC2 NFATC2 TMEM189-UBE2V1 TMEM189-UBE2V1 PLCG1 PLCG1 PSMF1 PSMF1 ENSPPYP00000012086 ENSPPYP00000012086 PSMC4 PSMC4 RASGRP4 RASGRP4 PSMD8 PSMD8 UBA52 UBA52 CR201_G0037390 CR201_G0037390 MAP2K7 MAP2K7 VAV1 VAV1 CDC34 CDC34 NFATC1 NFATC1 MALT1 MALT1 PSMA8 PSMA8 ENSPPYP00000009931 ENSPPYP00000009931 GRB2 GRB2 PSMD12 PSMD12 PSMC5 PSMC5 PSMB3 PSMB3 PSME3 PSME3 PSMD11 PSMD11 ENSPPYP00000008980 ENSPPYP00000008980 PSMB6 PSMB6 MAP3K1 MAP3K1 PIK3R1 PIK3R1 SKP1 SKP1 ANKHD1 ANKHD1 ITK ITK LCP2 LCP2 FBXW11 FBXW11 MAPK9 MAPK9 ITPR3 ITPR3 MAP3K7 MAP3K7 FYN FYN TAB2 TAB2 PSMB1 PSMB1 PSMB8 PSMB8 PSMB9 PSMB9 CARD11 CARD11 RAC1 RAC1 LAT2 LAT2 PSMA2 PSMA2 CR201_G0026396 CR201_G0026396 CR201_G0026413 CR201_G0026413 ENSPPYP00000019816 ENSPPYP00000019816 PSMC2 PSMC2 CR201_G0036702 CR201_G0036702 CUL1 CUL1 IKBKB IKBKB ENSPPYP00000020826 ENSPPYP00000020826 LYN LYN SYK SYK PSMD5 PSMD5 PSMB7 PSMB7 CR201_G0027422 CR201_G0027422 ENSPPYP00000022296 ENSPPYP00000022296 ENSPPYP00000022297 ENSPPYP00000022297 GAB4 GAB4 ENSPPYP00000022319 ENSPPYP00000022319 CR201_G0053922 CR201_G0053922 CR201_G0055129 CR201_G0055129 PSMD13 PSMD13 ENSPPYP00000022487 ENSPPYP00000022487 TRAV8-1 TRAV8-1 TRAV9-1 TRAV9-1 TRAV10 TRAV10 ENSPPYP00000006385 ENSPPYP00000006385 TRAV13-1 TRAV13-1 TRAV12-3 TRAV12-3 TRAV13-2 TRAV13-2 SPNS3 SPNS3 PLCG2 PLCG2 NFAT5 NFAT5 NFATC3 NFATC3 PSMB10 PSMB10 MAPK3 MAPK3 SPNS1 SPNS1 LAT LAT PDPK1 PDPK1 CR201_G0003353 CR201_G0003353 PSMA4 PSMA4 RASGRP1 RASGRP1 ENSPPYP00000007094 ENSPPYP00000007094 IGHV1-3 IGHV1-3 CR201_G0052796 CR201_G0052796 CR201_G0052689 CR201_G0052689 ENSPPYP00000007081 ENSPPYP00000007081 ENSPPYP00000007074 ENSPPYP00000007074 CR201_G0032841 CR201_G0032841 CR201_G0055131 CR201_G0055131 CR201_G0055135 CR201_G0055135 CR201_G0052734 CR201_G0052734 IGHV2-26 IGHV2-26 CR201_G0052737 CR201_G0052737 CHUK CHUK PPP3CB PPP3CB MAPK8 MAPK8 PRKCQ PRKCQ CR201_G0053435 CR201_G0053435 PSMB2 PSMB2 TRAV5 TRAV5 TRAV4 TRAV4 UBC UBC PSMD9 PSMD9 UBE2N UBE2N ITPR2 ITPR2 KRAS KRAS CR201_G0041659 CR201_G0041659 MS4A15 MS4A15 GAB2 GAB2 PAK1 PAK1 PSMA1 PSMA1 TRAF6 TRAF6 HARBI1 HARBI1 PSMC3 PSMC3 MS4A2 MS4A2 CR201_G0041655 CR201_G0041655 MS4A4A MS4A4A MS4A1 MS4A1 MS4A12 MS4A12 CR201_G0041644 CR201_G0041644 MS4A10 MS4A10 RELA RELA ENSPPYP00000003414 ENSPPYP00000003414 HRAS HRAS BTRC BTRC JUN JUN BCL10 BCL10 VAV3 VAV3 AHCYL1 AHCYL1 NRAS NRAS CSDE1 CSDE1 PSMB4 PSMB4 SHC1 SHC1 FCRL5 FCRL5 FCRL4 FCRL4 FCRL3 FCRL3 FCRL2 FCRL2 FCER1A FCER1A ENSPPYP00000024777 ENSPPYP00000024777 CR201_G0052772 CR201_G0052772 IGLV2-11 IGLV2-11 CR201_G0053588 CR201_G0053588 ENSPPYP00000024705 ENSPPYP00000024705 PSMA5 PSMA5 CR201_G0047465 CR201_G0047465 CR201_G0053582 CR201_G0053582
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CR201_G0053587IGKV1-5 isoform 1. (133 aa)
PSMD3PSMD3 isoform 1. (536 aa)
CR201_G0053547IGKV2-24 isoform 1. (126 aa)
CR201_G0053557IGKV6-21 isoform 1. (127 aa)
ENSPPYP00000024580annotation not available (200 aa)
ENSPPYP00000024524annotation not available (131 aa)
ENSPPYP00000024486annotation not available (138 aa)
PSMD4PSMD4 isoform 1. (384 aa)
ENSPPYP00000024373annotation not available (131 aa)
ENSPPYP00000024351annotation not available (131 aa)
PSMA6Proteasome endopeptidase complex. (167 aa)
ENSPPYP00000024254annotation not available (158 aa)
CR201_G0055127IGHV2-70 isoform 1. (126 aa)
PSMC1Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family. (440 aa)
ENSPPYP00000024185annotation not available (152 aa)
CR201_G0053581IGKV1D-8 isoform 1. (125 aa)
ENSPPYP00000024082annotation not available (137 aa)
CR201_G0053930IGHV4-28 isoform 1. (117 aa)
CR201_G0053570IGKV1D-13 isoform 1. (125 aa)
ENSPPYP00000024003annotation not available (139 aa)
CR201_G0052687IGHV4-59 isoform 1. (138 aa)
CR201_G0055132IGHV3-15 isoform 1. (133 aa)
IGKV1-27Immunoglobulin kappa variable 1-27. (125 aa)
ENSPPYP00000023887annotation not available (133 aa)
LOC100457600Proteasome subunit beta type-5-like. (263 aa)
ENSPPYP00000023791annotation not available (130 aa)
IGKV1-5IGKV1D-16 isoform 1. (125 aa)
ENSPPYP00000023724Uncharacterized protein LOC100937427. (176 aa)
CR201_G0047521IGLV4-69 isoform 1. (135 aa)
ENSPPYP00000023706annotation not available (130 aa)
CR201_G0052770T0186910 isoform 1. (131 aa)
CR201_G0052695T0186831 isoform 1. (138 aa)
MAPK1Mitogen-activated protein kinase 1 isoform X1. (158 aa)
CR201_G0052786IGHV2-5 isoform 1. (143 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (410 aa)
CR201_G0052690IGHV4-61 isoform 1. (91 aa)
CR201_G0053589IGKV3-7 isoform 1. (130 aa)
ENSPPYP00000023577annotation not available (172 aa)
ENSPPYP00000023573annotation not available (118 aa)
ENSPPYP00000023569annotation not available (247 aa)
ENSPPYP00000023562annotation not available (156 aa)
ENSPPYP00000023561annotation not available (122 aa)
PSMD7PSMD7 isoform 1. (324 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (832 aa)
PSMB1-2Proteasome subunit beta type-1. (241 aa)
ENSPPYP00000023500annotation not available (140 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (487 aa)
UBE2NLUbiquitin conjugating enzyme E2 N like (gene/pseudogene). (152 aa)
PSMD10Proteasome 26S subunit, non-ATPase 10. (226 aa)
BTKTyrosine-protein kinase. (659 aa)
ERASES cell expressed Ras. (233 aa)
TAB3TAB3 isoform 2. (670 aa)
RASGRP2RASGRP2 isoform 1. (302 aa)
CALM1Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases (By similarity). Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity). (149 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
PSMA3Proteasome subunit alpha type. (255 aa)
PSMC6Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (403 aa)
NFKBIANFKBIA isoform 1. (317 aa)
PSME2Proteasome activator subunit 2. (239 aa)
PSME1Proteasome activator subunit 1. (249 aa)
PSMB11Proteasome subunit beta. (300 aa)
PSMB5Proteasome subunit beta type-5; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pro [...] (263 aa)
TRDV3T cell receptor delta variable 3. (113 aa)
CR201_G0032822TRAV36DV7 isoform 1. (134 aa)
TRAV26-2TRAV26-2 isoform 1. (109 aa)
TRAV16TRAV16 isoform 1. (110 aa)
TRAV17T cell receptor alpha variable 17. (112 aa)
TRAV18TRAV18 isoform 1. (111 aa)
TRAV22T cell receptor alpha variable 22. (110 aa)
CR201_G0032834TRAV26-1 isoform 1. (109 aa)
TRAV30T cell receptor alpha variable 30. (111 aa)
FCER1GFc fragment of IgE receptor Ig. (86 aa)
TXKTyrosine-protein kinase. (527 aa)
TECTyrosine-protein kinase. (515 aa)
MAPK10Mitogen-activated protein kinase. (384 aa)
PPP3CASerine/threonine-protein phosphatase. (514 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
CLNKCLNK isoform 1. (412 aa)
PAK2Non-specific serine/threonine protein kinase. (502 aa)
PSMD226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. (909 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
PSMD6Proteasome 26S subunit, non-ATPase 6. (389 aa)
ITPR1ITPR1 isoform 3. (2769 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa)
MAP3K20MAP3K20 isoform 1. (457 aa)
PSMD14Proteasome 26S subunit, non-ATPase 14. (310 aa)
CR201_G0053563IGKV1-16 isoform 1. (125 aa)
CR201_G0053539IGKV1-33 isoform 1. (118 aa)
ENSPPYP00000014184annotation not available (120 aa)
CR201_G0053575IGKV3-11 isoform 1. (126 aa)
FOSL2FOS like 2, AP-1 transcription factor subunit. (318 aa)
SOS1SOS1 isoform 2. (1290 aa)
CALM1-2Calmodulin 2. (149 aa)
PSME4Proteasome activator subunit 4. (1843 aa)
WDR92WDR92 isoform 1. (765 aa)
IGKCImmunoglobulin kappa constant. (106 aa)
CR201_G0053595IGKV4-1 isoform 1. (177 aa)
IGKV5-2IGKV5-2 isoform 1. (137 aa)
ENSPPYP00000013596annotation not available (120 aa)
CR201_G0053579IGKV1-8 isoform 1. (125 aa)
CR201_G0053572IGKV1D-12 isoform 1. (118 aa)
CR201_G0053558IGKV3D-20 isoform 1. (123 aa)
ENSPPYP00000013590annotation not available (135 aa)
CR201_G0053532IGKV2-30 isoform 1. (93 aa)
ENSPPYP00000013588annotation not available (133 aa)
ENSPPYP00000013587annotation not available (97 aa)
CR201_G0055839IGLL1 isoform 2. (190 aa)
ENSPPYP00000013398annotation not available (195 aa)
CR201_G0054834IGLV5-52 isoform 1. (123 aa)
GRAP2GRB2 related adaptor protein 2. (330 aa)
SYNGR1Synaptogyrin-1; May play a role in regulated exocytosis. Modulates the localization of synaptophysin/SYP into synaptic-like microvesicles and may therefore play a role in synaptic-like microvesicle formation and/or maturation (By similarity). Involved in the regulation of short- term and long-term synaptic plasticity (By similarity). Belongs to the synaptogyrin family. (654 aa)
CR201_G0047442IGLC2 isoform 1. (121 aa)
CR201_G0047507IGLV1-50 isoform 1. (167 aa)
CR201_G0047525IGLV10-54 isoform 1. (128 aa)
IGLV6-57Immunoglobulin lambda variable 6-57. (117 aa)
PSMA7Proteasome subunit alpha type-7; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pr [...] (248 aa)
NFATC2Nuclear factor of activated T cells 2. (925 aa)
TMEM189-UBE2V1Ubiquitin-conjugating enzyme E2 variant 1; Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly- ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF- kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repa [...] (329 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1257 aa)
PSMF1Proteasome inhibitor PI31 subunit; Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28 (By similarity). (271 aa)
ENSPPYP00000012086annotation not available (110 aa)
PSMC4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa)
RASGRP4RASGRP4 isoform 13. (674 aa)
PSMD826S proteasome non-ATPase regulatory subunit 8; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S14 family. (350 aa)
UBA52UBA52 isoform 10. (128 aa)
CR201_G0037390PIK3R2 isoform 1. (641 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (435 aa)
VAV1VAV1 isoform 2. (829 aa)
CDC34CDC34 isoform 1; Belongs to the ubiquitin-conjugating enzyme family. (217 aa)
NFATC1NFATC1 isoform 10. (766 aa)
MALT1MALT1 isoform 1. (774 aa)
PSMA8Proteasome subunit alpha type. (256 aa)
ENSPPYP00000009931annotation not available (76 aa)
GRB2Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Belongs to the GRB2/sem-5/DRK family. (217 aa)
PSMD1226S proteasome non-ATPase regulatory subunit 12; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit p55 family. (456 aa)
PSMC5PSMC5 isoform 2; Belongs to the AAA ATPase family. (406 aa)
PSMB3Proteasome subunit beta. (218 aa)
PSME3Proteasome activator complex subunit 3; Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regul [...] (254 aa)
PSMD11Proteasome 26S subunit, non-ATPase 11. (422 aa)
ENSPPYP00000008980annotation not available (158 aa)
PSMB6Proteasome subunit beta. (239 aa)
MAP3K1MAP3K1 isoform 1. (1505 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha; Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling. Modulates the cellular response to ER stress by promoting nuclear translocation [...] (723 aa)
SKP1S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] (163 aa)
ANKHD1ANKHD1 isoform 1. (2505 aa)
ITKTyrosine-protein kinase. (620 aa)
LCP2LCP2 isoform 3. (534 aa)
FBXW11FBXW11 isoform 1. (489 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
ITPR3ITPR3 isoform 1. (2641 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as a [...] (606 aa)
FYNTyrosine-protein kinase. (537 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
PSMB1Proteasome subunit beta. (241 aa)
PSMB8Proteasome subunit beta. (272 aa)
PSMB9Proteasome subunit beta. (218 aa)
CARD11CARD11 isoform 1. (1155 aa)
RAC1Rac family small GTPase 1. (211 aa)
LAT2Linker for activation of T cells family member 2. (244 aa)
PSMA2Proteasome subunit alpha type. (234 aa)
CR201_G0026396TRGV2 isoform 1. (128 aa)
CR201_G0026413TRGC2 isoform 1. (188 aa)
ENSPPYP00000019816annotation not available (197 aa)
PSMC226S proteasome regulatory subunit 7; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with [...] (433 aa)
CR201_G0036702CCDC71L isoform 2. (316 aa)
CUL1Cullin-1; Core component of multiple cullin-RING-based SCF (SKP1-CUL1- F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SCF complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the [...] (776 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (697 aa)
ENSPPYP00000020826annotation not available (100 aa)
LYNTyrosine-protein kinase. (512 aa)
SYKTyrosine-protein kinase. (588 aa)
PSMD5PSMD5 isoform 8. (97 aa)
PSMB7Proteasome subunit beta. (277 aa)
CR201_G0027422VAV2 isoform 3. (772 aa)
ENSPPYP00000022296annotation not available (128 aa)
ENSPPYP00000022297annotation not available (107 aa)
GAB4GAB4 isoform 1. (442 aa)
ENSPPYP00000022319annotation not available (162 aa)
CR201_G0053922IGHV2OR16-5 isoform 1. (133 aa)
CR201_G0055129IGHV1OR15-9 isoform 1. (120 aa)
PSMD13PSMD13 isoform 6. (376 aa)
ENSPPYP00000022487annotation not available (153 aa)
TRAV8-1T cell receptor alpha variable 8-1. (114 aa)
TRAV9-1T cell receptor alpha variable 9-1. (112 aa)
TRAV10T cell receptor alpha variable 10. (114 aa)
ENSPPYP00000006385annotation not available (127 aa)
TRAV13-1T cell receptor alpha variable 13-1. (112 aa)
TRAV12-3TRAV12-3 isoform 1. (116 aa)
TRAV13-2T cell receptor alpha variable 13-2. (113 aa)
SPNS3SPNS3 isoform 1. (446 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1230 aa)
NFAT5Nuclear factor of activated T cells 5. (1529 aa)
NFATC3Nuclear factor of activated T cells 3. (1068 aa)
PSMB10Proteasome subunit beta. (256 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (381 aa)
SPNS1Sphingolipid transporter 1 (putative). (528 aa)
LATLAT isoform 2. (233 aa)
PDPK1PDPK1 isoform 1. (495 aa)
CR201_G0003353RPS27A isoform 1. (155 aa)
PSMA4Proteasome subunit alpha type. (261 aa)
RASGRP1RASGRP1 isoform 2. (787 aa)
ENSPPYP00000007094annotation not available (139 aa)
IGHV1-3Immunoglobulin heavy variable 1-3. (117 aa)
CR201_G0052796IGHV1-2 isoform 1. (129 aa)
CR201_G0052689IGHV4-39 isoform 1. (138 aa)
ENSPPYP00000007081Immunoglobulin delta heavy chain-like. (117 aa)
ENSPPYP00000007074annotation not available (140 aa)
CR201_G0032841TRAV21 isoform 1. (112 aa)
CR201_G0055131IGHV3-21 isoform 1. (132 aa)
CR201_G0055135IGHV3-73 isoform 1. (98 aa)
CR201_G0052734IGHV3-16 isoform 1. (118 aa)
IGHV2-26Immunoglobulin heavy variable 2-26. (118 aa)
CR201_G0052737IGHV4-4 isoform 1. (138 aa)
CHUKCHUK isoform 1. (746 aa)
PPP3CBSerine/threonine-protein phosphatase. (438 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
CR201_G0053435UBB isoform 1. (128 aa)
PSMB2Proteasome subunit beta. (201 aa)
TRAV5TRAV5 isoform 1. (112 aa)
TRAV4T cell receptor alpha variable 4. (109 aa)
UBCUBC isoform 2. (625 aa)
PSMD9PSMD9 isoform 1. (223 aa)
UBE2NUbiquitin-conjugating enzyme E2 N; The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly- ubiquitination of [...] (152 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa)
KRASKRAS proto-oncogene, GTPase. (188 aa)
CR201_G0041659MS4A2 isoform 4. (211 aa)
MS4A15MS4A15 isoform 4. (124 aa)
GAB2GRB2 associated binding protein 2. (638 aa)
PAK1Non-specific serine/threonine protein kinase. (546 aa)
PSMA1Proteasome subunit alpha type-1; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pr [...] (263 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (604 aa)
HARBI1Harbinger transposase derived 1. (349 aa)
PSMC3Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (439 aa)
MS4A2MS4A2 isoform 2. (213 aa)
CR201_G0041655MS4A4E isoform 2. (144 aa)
MS4A4AMS4A4A isoform 1. (182 aa)
MS4A1Membrane spanning 4-domains A1. (297 aa)
MS4A12Membrane spanning 4-domains A12. (267 aa)
CR201_G0041644MS4A8 isoform 1. (177 aa)
MS4A10Membrane-spanning 4-domains subfamily A member 10; May be involved in signal transduction as a component of a multimeric receptor complex; Belongs to the MS4A family. (265 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
ENSPPYP00000003414annotation not available (440 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
BTRCBTRC isoform 2. (605 aa)
JUNJUN isoform 1; Belongs to the bZIP family. (334 aa)
BCL10BCL10 isoform 1. (263 aa)
VAV3VAV3 isoform 1. (824 aa)
AHCYL1Adenosylhomocysteinase like 1; Belongs to the adenosylhomocysteinase family. (530 aa)
NRASGTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa)
CSDE1Cold shock domain containing E1. (798 aa)
PSMB4Proteasome subunit beta; Belongs to the peptidase T1B family. (264 aa)
SHC1SHC-transforming protein 1; Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis (By similarity). (583 aa)
FCRL5FCRL5 isoform 1. (972 aa)
FCRL4FCRL4 isoform 2. (520 aa)
FCRL3Fc receptor like 3. (742 aa)
FCRL2FCRL2 isoform 2. (497 aa)
FCER1AFCER1A isoform 1. (260 aa)
ENSPPYP00000024777annotation not available (164 aa)
CR201_G0052772IGHV3-23 isoform 1. (125 aa)
IGLV2-11Immunoglobulin lambda variable 2-11. (129 aa)
CR201_G0053588IGKV1D-17 isoform 1. (123 aa)
ENSPPYP00000024705annotation not available (130 aa)
PSMA5Proteasome subunit alpha type. (278 aa)
CR201_G0047465IGLV2-14 isoform 1. (139 aa)
CR201_G0053582IGKV3D-7 isoform 1. (130 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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