Your Input: | |
| | ENSPPYP00000024179 | 14-3-3 protein epsilon-like isoform X1. (173 aa) |
| | SDCCAG8 | Serologically defined colon cancer antigen 8. (713 aa) |
| | NEK2 | NIMA related kinase 2. (445 aa) |
| | PPP1R12B | Protein phosphatase 1 regulatory subunit. (1038 aa) |
| | PDE4DIP-2 | Myomegalin. (1386 aa) |
| | PDE4DIP | PDE4DIP isoform 7. (2553 aa) |
| | CR201_G0042150 | ODF2L isoform 6. (759 aa) |
| | CROCC | CROCC isoform 3. (1866 aa) |
| | ENSPPYP00000002111 | LOW QUALITY PROTEIN: rootletin-like. (210 aa) |
| | CR201_G0053435 | UBB isoform 1. (128 aa) |
| | OPTN | Optineurin; Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex th [...] (532 aa) |
| | CDK1 | Cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins. Required in higher cells for entry into S-phase and mitosis. Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl-xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CENPA, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, G [...] (297 aa) |
| | BTRC | BTRC isoform 2. (605 aa) |
| | ACTR1A | Actin related protein 1A. (376 aa) |
| | CKAP5 | CKAP5 isoform 3. (2022 aa) |
| | DEUP1 | Deuterosome assembly protein 1. (604 aa) |
| | CEP57 | Centrosomal protein 57. (499 aa) |
| | CEP164 | CEP164 isoform 1. (1457 aa) |
| | DCTN2 | DCTN2 isoform 1. (401 aa) |
| | PPP1R12A | Protein phosphatase 1 regulatory subunit. (957 aa) |
| | CEP290 | CEP290 isoform 4. (2481 aa) |
| | NEDD1 | NEDD1 isoform 1. (659 aa) |
| | DYNLL1 | Dynein light chain. (89 aa) |
| | UBC | UBC isoform 2. (625 aa) |
| | CENPJ | CENPJ isoform 2. (1290 aa) |
| | BORA | BORA aurora kinase A activator. (619 aa) |
| | HAUS4 | T0115198 isoform 1. (436 aa) |
| | AJUBA | LIM domain-containing protein ajuba isoform X1. (538 aa) |
| | NIN | NIN isoform 1. (2132 aa) |
| | HSP90AA1 | HSP90AA1 isoform 6. (615 aa) |
| | HAUS2 | HAUS augmin-like complex subunit 2; Belongs to the HAUS2 family. (235 aa) |
| | CEP152 | CEP152 isoform 2. (1679 aa) |
| | CCNB2 | CCNB2 isoform 1; Belongs to the cyclin family. (398 aa) |
| | MYO1E | MYO1E isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1109 aa) |
| | CR201_G0003353 | RPS27A isoform 1. (155 aa) |
| | NDE1 | NDE1 isoform 1. (349 aa) |
| | FOPNL | FOPNL isoform 6. (107 aa) |
| | CCP110 | Centriolar coiled-coil protein 110. (1012 aa) |
| | PLK1 | Serine/threonine-protein kinase PLK. (603 aa) |
| | YWHAE | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (255 aa) |
| | PAFAH1B1 | Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...] (410 aa) |
| | ENSPPYP00000008980 | annotation not available (158 aa) |
| | CR201_G0021599 | CEP131 isoform 2. (894 aa) |
| | PPP1R27 | PPP1R27 isoform 1. (122 aa) |
| | CSNK1D | Casein kinase I isoform delta; Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, dete [...] (404 aa) |
| | ENSPPYP00000009931 | annotation not available (76 aa) |
| | CEP76 | Centrosomal protein of 76 kDa; Centrosomal protein involved in regulation of centriole duplication. Required to limit centriole duplication to once per cell cycle by preventing centriole reduplication (By similarity). (659 aa) |
| | MAPRE2 | Microtubule-associated protein RP/EB family member 2; May be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration (By similarity); Belongs to the MAPRE family. (327 aa) |
| | HAUS1 | HAUS augmin like complex subunit 1. (278 aa) |
| | MYO1F | MYO1F isoform 2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1013 aa) |
| | RAB8A | Ras-related protein Rab-8A; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes t [...] (207 aa) |
| | HAUS8 | HAUS8 isoform 2. (410 aa) |
| | UBA52 | UBA52 isoform 10. (128 aa) |
| | HAUS5 | HAUS5 isoform 5. (584 aa) |
| | PPP2R1A | PPP2R1A isoform 7. (558 aa) |
| | ENSPPYP00000011659 | annotation not available (548 aa) |
| | ENSPPYP00000011927 | annotation not available (116 aa) |
| | ENSPPYP00000011942 | annotation not available (117 aa) |
| | NINL | NINL isoform 2. (1382 aa) |
| | MAPRE1 | Microtubule-associated protein RP/EB family member 1; Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes cytoplasmic microtubule nucleation and elongation. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, a [...] (314 aa) |
| | CEP250 | CEP250 isoform 4. (2389 aa) |
| | PPP1R16B | PPP1R16B isoform 1. (519 aa) |
| | AURKA | AURKA isoform 10; Belongs to the protein kinase superfamily. (404 aa) |
| | NPEPL1 | Probable aminopeptidase NPEPL1; Probably catalyzes the removal of unsubstituted N-terminal amino acids from various peptides; Belongs to the peptidase M17 family. (411 aa) |
| | TCP10L | T-complex protein 10A homolog 2 isoform X1. (214 aa) |
| | PCNT | PCNT isoform 1. (3265 aa) |
| | SFI1 | SFI1 isoform 9. (1202 aa) |
| | LOC100447547 | T0085674 isoform 1; Belongs to the protein kinase superfamily. (416 aa) |
| | TSGA10 | TSGA10 isoform 2. (698 aa) |
| | CR201_G0003005 | T0009947 isoform 1. (1278 aa) |
| | ALMS1 | ALMS1 isoform 2. (4160 aa) |
| | PPP1CB | Serine/threonine-protein phosphatase PP1-beta catalytic subunit; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progressi [...] (327 aa) |
| | MAPRE3 | Microtubule associated protein RP/EB family member 3. (281 aa) |
| | CLASP1 | CLASP1 isoform 3. (1537 aa) |
| | DYNC1I2 | Cytoplasmic dynein 1 intermediate chain 2; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and help dynein bind to dynactin 150 kDa component (By similarity). organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCNT1. Involved in membrane-transport, such a [...] (638 aa) |
| | TUBA4A | Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (448 aa) |
| | SPATA3 | SPATA3 isoform 1. (183 aa) |
| | CEP63 | Centrosomal protein of 63 kDa; Required for normal spindle assembly. Plays a key role in mother-centriole-dependent centriole duplication; the function seems also to involve CEP152, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication. Also recruits CDK1 to centrosomes (By similarity). Plays a role in DNA damage response. Following DNA damage, such as double- strand breaks (DSBs), is removed from centrosomes; this leads to the inactivation of spindle assembly and delay in mitotic progression (By similarity). (541 aa) |
| | CEP70 | Centrosomal protein of 70 kDa; Plays a role in the organization of both preexisting and nascent microtubules in interphase cells. During mitosis, required for the organization and orientation of the mitotic spindle (By similarity). (597 aa) |
| | HAUS3 | HAUS3 isoform 1. (428 aa) |
| | LAP3 | Leucine aminopeptidase 3. (519 aa) |
| | CEP135 | CEP135 isoform 2. (1140 aa) |
| | PLK4 | Serine/threonine-protein kinase PLK4; Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit [...] (970 aa) |
| | ENSPPYP00000016980 | annotation not available (100 aa) |
| | ENSPPYP00000017056 | annotation not available (412 aa) |
| | ENSPPYP00000017062 | annotation not available (62 aa) |
| | CEP72 | CEP72 isoform 1. (641 aa) |
| | LOC100437628 | Oral-facial-digital syndrome 1 protein-like isoform X1. (1012 aa) |
| | CCNB1 | CCNB1 isoform 1; Belongs to the cyclin family. (433 aa) |
| | SKP1 | S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] (163 aa) |
| | FBXW11 | FBXW11 isoform 1. (489 aa) |
| | FAM193B | FAM193B isoform 1. (814 aa) |
| | TUBB | Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). Belongs to the tubulin family. (444 aa) |
| | CR201_G0044827 | TCP10L2 isoform 1. (353 aa) |
| | YWHAG | 14-3-3 protein gamma, N-terminally processed; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner; Belongs to the 14-3-3 family. (247 aa) |
| | ENSPPYP00000019656 | annotation not available (239 aa) |
| | AKAP9 | AKAP9 isoform 1. (3770 aa) |
| | PRKAR2B | PRKAR2B isoform 1. (390 aa) |
| | CEP41 | CEP41 isoform 2. (372 aa) |
| | CUL1 | Cullin-1; Core component of multiple cullin-RING-based SCF (SKP1-CUL1- F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SCF complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the [...] (776 aa) |
| | PCM1 | PCM1 isoform 1. (2042 aa) |
| | PPP1R16A | PPP1R16A isoform 5. (485 aa) |
| | CEP78 | CEP78 isoform 1. (678 aa) |
| | CDK5RAP2 | CDK5RAP2 isoform 3. (1893 aa) |
| | CNTRL | CNTRL isoform 3. (2183 aa) |
| | ODF2 | Outer dense fiber protein 2; Seems to be a major component of sperm tail outer dense fibers (ODF). ODFs are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail. May have a modulating influence on sperm motility. Functions as a general scaffold protein that is specifically localized at the distal/subdistal appendages of mother centrioles. Component of the centrosome matrix required for the localization of PLK1 and NIN to th [...] (824 aa) |
| | SSNA1 | SSNA1 isoform 2. (119 aa) |
| | ENSPPYP00000022319 | annotation not available (162 aa) |
| | DCTN3 | DCTN3 isoform 3. (186 aa) |
| | CR201_G0038668 | FOPNL isoform 7. (72 aa) |
| | ENSPPYP00000022487 | annotation not available (153 aa) |
| | OFD1 | OFD1 isoform 3. (959 aa) |
| | CCNB3 | CCNB3 isoform 3; Belongs to the cyclin family. (1394 aa) |
| | ENSPPYP00000023230 | annotation not available (111 aa) |
| | CETN2 | CETN2 isoform 1. (172 aa) |
| | HAUS7 | HAUS augmin-like complex subunit 7 isoform X1. (394 aa) |
| | ENSPPYP00000023500 | annotation not available (140 aa) |
| | ENSPPYP00000023562 | annotation not available (156 aa) |
| | CNTD2 | CNTD2 isoform 5; Belongs to the cyclin family. (201 aa) |
| | CEP192 | CEP192 isoform 7. (1925 aa) |
| | WDR41 | WDR41 isoform 3. (419 aa) |
