(34 nodes) SUMOylation of transcription factors network (Pongo abelii)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

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Your Input:
	PIAS2	Protein inhibitor of activated STAT 2. (621 aa)
	ENSPPYP00000009997	annotation not available (95 aa)
	CR201_G0021349	KCTD2 isoform 7. (185 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
	HIC1	HIC1 isoform 6. (648 aa)
	TFAP2A	Transcription factor AP-2 alpha. (439 aa)
	NFATC2IP	Nuclear factor of activated T cells 2 interacting protein. (419 aa)
	UBE2I	Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. (158 aa)
	PIAS1	PIAS1 isoform 1. (683 aa)
	TP53BP1	TP53BP1 isoform 3. (1976 aa)
	MTA1	MTA1 isoform 4. (697 aa)
	ZMIZ1	ZMIZ1 isoform 2. (1002 aa)
	FOXD2	FOXD2 isoform 1. (493 aa)
	TFAP2C	TFAP2C isoform 1. (449 aa)
	SUMO3	Small ubiquitin-related modifier. (96 aa)
	HIC2	Hypermethylated in cancer 2 protein. (615 aa)
	SP5	Sp5 transcription factor. (398 aa)
	SP3	SP3 isoform 2. (689 aa)
	SUMO1	Small ubiquitin-related modifier 1; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post- translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for insta [...] (218 aa)
	MITF	Melanocyte inducing transcription factor. (520 aa)
	FOXL2	FOXL2 isoform 1. (376 aa)
	CR201_G0007169	SUMO1 isoform 5. (143 aa)
	VTCN1	VTCN1 isoform 1. (191 aa)
	TFEB	TFEB isoform 3. (581 aa)
	TFAP2B	TFAP2B isoform 1. (442 aa)
	ZMIZ2	Zinc finger MIZ-type containing 2. (920 aa)
	SP4	Sp4 transcription factor. (784 aa)
	CR201_G0021362	SUMO2 isoform 4. (95 aa)
	ENSPPYP00000021580	Forkhead box protein D4-like 1. (444 aa)
	PIAS4	PIAS4 isoform 1. (381 aa)
	CR201_G0021362-2	SUMO2 isoform 2. (71 aa)
	PIAS3	PIAS3 isoform 3. (619 aa)
	SUMO2	Small ubiquitin-related modifier. (95 aa)
	TFE3	TFE3 isoform 1. (297 aa)

Your Current Organism:

Pongo abelii

NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CR201_G0007169	CR201_G0021349	ENSPPYP00000000742	ENSPPYP00000009676	SUMO1 isoform 5.	KCTD2 isoform 7.	0.831
CR201_G0007169	CR201_G0021362	ENSPPYP00000000742	ENSPPYP00000020349	SUMO1 isoform 5.	SUMO2 isoform 4.	0.530
CR201_G0007169	CR201_G0021362-2	ENSPPYP00000000742	ENSPPYP00000023118	SUMO1 isoform 5.	SUMO2 isoform 2.	0.516
CR201_G0007169	ENSPPYP00000009997	ENSPPYP00000000742	ENSPPYP00000009997	SUMO1 isoform 5.	annotation not available	0.530
CR201_G0007169	PIAS1	ENSPPYP00000000742	ENSPPYP00000007471	SUMO1 isoform 5.	PIAS1 isoform 1.	0.749
CR201_G0007169	PIAS2	ENSPPYP00000000742	ENSPPYP00000010266	SUMO1 isoform 5.	Protein inhibitor of activated STAT 2.	0.877
CR201_G0007169	PIAS3	ENSPPYP00000000742	ENSPPYP00000001087	SUMO1 isoform 5.	PIAS3 isoform 3.	0.723
CR201_G0007169	PIAS4	ENSPPYP00000000742	ENSPPYP00000010535	SUMO1 isoform 5.	PIAS4 isoform 1.	0.733
CR201_G0007169	SUMO2	ENSPPYP00000000742	ENSPPYP00000023768	SUMO1 isoform 5.	Small ubiquitin-related modifier.	0.530
CR201_G0007169	SUMO3	ENSPPYP00000000742	ENSPPYP00000012841	SUMO1 isoform 5.	Small ubiquitin-related modifier.	0.530
CR201_G0007169	TP53	ENSPPYP00000000742	ENSPPYP00000008923	SUMO1 isoform 5.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.572
CR201_G0007169	TP53BP1	ENSPPYP00000000742	ENSPPYP00000007267	SUMO1 isoform 5.	TP53BP1 isoform 3.	0.621
CR201_G0007169	UBE2I	ENSPPYP00000000742	ENSPPYP00000007864	SUMO1 isoform 5.	Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family.	0.928
CR201_G0007169	ZMIZ1	ENSPPYP00000000742	ENSPPYP00000002676	SUMO1 isoform 5.	ZMIZ1 isoform 2.	0.580
CR201_G0007169	ZMIZ2	ENSPPYP00000000742	ENSPPYP00000019711	SUMO1 isoform 5.	Zinc finger MIZ-type containing 2.	0.580
CR201_G0021349	CR201_G0007169	ENSPPYP00000009676	ENSPPYP00000000742	KCTD2 isoform 7.	SUMO1 isoform 5.	0.831
CR201_G0021349	CR201_G0021362	ENSPPYP00000009676	ENSPPYP00000020349	KCTD2 isoform 7.	SUMO2 isoform 4.	0.722
CR201_G0021349	CR201_G0021362-2	ENSPPYP00000009676	ENSPPYP00000023118	KCTD2 isoform 7.	SUMO2 isoform 2.	0.722
CR201_G0021349	ENSPPYP00000009997	ENSPPYP00000009676	ENSPPYP00000009997	KCTD2 isoform 7.	annotation not available	0.722
CR201_G0021349	NFATC2IP	ENSPPYP00000009676	ENSPPYP00000008165	KCTD2 isoform 7.	Nuclear factor of activated T cells 2 interacting protein.	0.675