STRINGSTRING
CASP8 CASP8 TONSL TONSL RIPK2 RIPK2 IKBKB IKBKB CR201_G0036702 CR201_G0036702 NOD1 NOD1 VWC2 VWC2 TAB2 TAB2 MAP3K7 MAP3K7 AGER AGER ALPK1 ALPK1 TIFA TIFA LRRC14 LRRC14 TRAF2 TRAF2 ENSPPYP00000022487 ENSPPYP00000022487 TAB3 TAB3 ENSPPYP00000022638 ENSPPYP00000022638 UBE2NL UBE2NL IRAK1 IRAK1 IKBKG IKBKG ENSPPYP00000023500 ENSPPYP00000023500 ENSPPYP00000023537 ENSPPYP00000023537 ENSPPYP00000023562 ENSPPYP00000023562 NFKB1 NFKB1 LRRC31 LRRC31 LRRC34 LRRC34 NKIRAS1 NKIRAS1 IRAK2 IRAK2 MAP3K20 MAP3K20 LRRC74B LRRC74B SYNGR1 SYNGR1 ENSPPYP00000013015 ENSPPYP00000013015 S100B S100B APP APP TMEM189-UBE2V1 TMEM189-UBE2V1 ENSPPYP00000012086 ENSPPYP00000012086 NLRP13 NLRP13 NLRP9 NLRP9 NFKBIB NFKBIB UBA52 UBA52 USP14 USP14 ENSPPYP00000009931 ENSPPYP00000009931 LRRC45 LRRC45 NKIRAS2 NKIRAS2 ENSPPYP00000008980 ENSPPYP00000008980 TP53 TP53 NLRC5 NLRC5 NOD2 NOD2 N4BP1 N4BP1 CR201_G0003353 CR201_G0003353 LRRC74A LRRC74A NFKBIA NFKBIA KHNYN KHNYN HMGB1 HMGB1 UBC UBC UBE2N UBE2N NLRX1 NLRX1 SAA2 SAA2 TRAF6 TRAF6 RELA RELA NLRP6 NLRP6 NFKB2 NFKB2 CHUK CHUK CR201_G0053435 CR201_G0053435 S100A12 S100A12 LRRC71 LRRC71
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CASP8CASP8 isoform 1; Belongs to the peptidase C14A family. (496 aa)
TONSLTONSL isoform 2. (1217 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (697 aa)
CR201_G0036702CCDC71L isoform 2. (316 aa)
NOD1NOD1 isoform 4. (953 aa)
VWC2Von Willebrand factor C domain containing 2. (325 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as a [...] (606 aa)
AGERAGER isoform 1. (352 aa)
ALPK1ALPK1 isoform 3. (1181 aa)
TIFATIFA isoform 1. (185 aa)
LRRC14Leucine rich repeat containing 14. (493 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa)
ENSPPYP00000022487annotation not available (153 aa)
TAB3TAB3 isoform 2. (670 aa)
ENSPPYP00000022638annotation not available (210 aa)
UBE2NLUbiquitin conjugating enzyme E2 N like (gene/pseudogene). (152 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (682 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (487 aa)
ENSPPYP00000023500annotation not available (140 aa)
ENSPPYP00000023537annotation not available (121 aa)
ENSPPYP00000023562annotation not available (156 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
LRRC31LRRC31 isoform 1. (547 aa)
LRRC34Leucine rich repeat containing 34. (432 aa)
NKIRAS1NFKB inhibitor interacting Ras like 1. (192 aa)
IRAK2Interleukin-1 receptor-associated kinase-like 2; Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. (625 aa)
MAP3K20MAP3K20 isoform 1. (457 aa)
LRRC74BLRRC74B isoform 4. (161 aa)
SYNGR1Synaptogyrin-1; May play a role in regulated exocytosis. Modulates the localization of synaptophysin/SYP into synaptic-like microvesicles and may therefore play a role in synaptic-like microvesicle formation and/or maturation (By similarity). Involved in the regulation of short- term and long-term synaptic plasticity (By similarity). Belongs to the synaptogyrin family. (654 aa)
ENSPPYP00000013015annotation not available (211 aa)
S100BProtein S100; Belongs to the S-100 family. (92 aa)
APPAPP isoform 3. (736 aa)
TMEM189-UBE2V1Ubiquitin-conjugating enzyme E2 variant 1; Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly- ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF- kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repa [...] (329 aa)
ENSPPYP00000012086annotation not available (110 aa)
NLRP13NLRP13 isoform 2. (1044 aa)
NLRP9NLRP9 isoform 1. (937 aa)
NFKBIBNFKBIB isoform 6. (354 aa)
UBA52UBA52 isoform 10. (128 aa)
USP14Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (435 aa)
ENSPPYP00000009931annotation not available (76 aa)
LRRC45LRRC45 isoform 1. (674 aa)
NKIRAS2NFKB inhibitor interacting Ras like 2. (191 aa)
ENSPPYP00000008980annotation not available (158 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
NLRC5NLRC5 isoform 2. (1632 aa)
NOD2NOD2 isoform 4. (1040 aa)
N4BP1N4BP1 isoform 1. (894 aa)
CR201_G0003353RPS27A isoform 1. (155 aa)
LRRC74ALeucine rich repeat containing 74A. (488 aa)
NFKBIANFKBIA isoform 1. (317 aa)
KHNYNKHNYN isoform 1. (608 aa)
HMGB1High mobility group box 1. (215 aa)
UBCUBC isoform 2. (625 aa)
UBE2NUbiquitin-conjugating enzyme E2 N; The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly- ubiquitination of [...] (152 aa)
NLRX1NLRX1 isoform 1. (974 aa)
SAA2Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (122 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (604 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
NLRP6NLRP6 isoform 2. (812 aa)
NFKB2NFKB2 isoform 4. (868 aa)
CHUKCHUK isoform 1. (746 aa)
CR201_G0053435UBB isoform 1. (128 aa)
S100A12S100 calcium binding protein A12; Belongs to the S-100 family. (92 aa)
LRRC71LRRC71 isoform 1. (559 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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