STRINGSTRING
MAP2K4 MAP2K4 PTPN5 PTPN5 SAA2 SAA2 PSMA1 PSMA1 IL18BP IL18BP CR201_G0025521 CR201_G0025521 S100B S100B IL36G IL36G IL36A IL36A IL36B IL36B IL36RN IL36RN IL1F10 IL1F10 IL1RN IL1RN PELI1 PELI1 PSME4 PSME4 MAP3K2 MAP3K2 PTPN4 PTPN4 PSMD14 PSMD14 MAP3K20 MAP3K20 CASP8 CASP8 PSMD1 PSMD1 PTPN18 PTPN18 IRAK2 IRAK2 PSMD6 PSMD6 PTPN23 PTPN23 MYD88 MYD88 NKIRAS1 NKIRAS1 MFSD1 MFSD1 LRRC34 LRRC34 LRRC31 LRRC31 PSMD2 PSMD2 ENSPPYP00000016196 ENSPPYP00000016196 TNIP2 TNIP2 MAPK10 MAPK10 PTPN13 PTPN13 NFKB1 NFKB1 TIFA TIFA ALPK1 ALPK1 IL13 IL13 IL4 IL4 SKP1 SKP1 FBXW11 FBXW11 SQSTM1 SQSTM1 AGER AGER MAP3K7 MAP3K7 TAB2 TAB2 PSMB1 PSMB1 PSMB8 PSMB8 PSMB9 PSMB9 VWC2 VWC2 PSMA2 PSMA2 CASP1 CASP1 IL18 IL18 NLRX1 NLRX1 PTPN6 PTPN6 IRAK4 IRAK4 TBK1 TBK1 IRAK3 IRAK3 UBE2N UBE2N PTPN11 PTPN11 PSMD9 PSMD9 UBC UBC HMGB1 HMGB1 PSMB5 PSMB5 PSMB11 PSMB11 PSME1 PSME1 PSME2 PSME2 KHNYN KHNYN CTSG CTSG NFKBIA NFKBIA PSMC6 PSMC6 PELI2 PELI2 PSMA3 PSMA3 LRRC74A LRRC74A PTPN21 PTPN21 MAP2K1 MAP2K1 SMAD3 SMAD3 PTPN9 PTPN9 PSMA4 PSMA4 CR201_G0003353 CR201_G0003353 N4BP1 N4BP1 NOD2 NOD2 NLRC5 NLRC5 PSMB10 PSMB10 PSMB6 PSMB6 TP53 TP53 ENSPPYP00000008980 ENSPPYP00000008980 PSMD11 PSMD11 PSME3 PSME3 STAT3 STAT3 NKIRAS2 NKIRAS2 PSMB3 PSMB3 MAP3K3 MAP3K3 PSMC5 PSMC5 PSMD12 PSMD12 MAP2K6 MAP2K6 LRRC45 LRRC45 ENSPPYP00000009931 ENSPPYP00000009931 PTPN2 PTPN2 USP14 USP14 PSMA8 PSMA8 UBA52 UBA52 PSMD8 PSMD8 NFKBIB NFKBIB PSMC4 PSMC4 NLRP9 NLRP9 NLRP13 NLRP13 ENSPPYP00000012086 ENSPPYP00000012086 PSMF1 PSMF1 TMEM189-UBE2V1 TMEM189-UBE2V1 PSMA7 PSMA7 APP APP NOD1 NOD1 ENSPPYP00000019816 ENSPPYP00000019816 PTPN12 PTPN12 PSMC2 PSMC2 CR201_G0036702 CR201_G0036702 CUL1 CUL1 IKBKB IKBKB RIPK2 RIPK2 TONSL TONSL LRRC14 LRRC14 IL33 IL33 PSMD5 PSMD5 PSMB7 PSMB7 TRAF2 TRAF2 ENSPPYP00000022319 ENSPPYP00000022319 PSMD13 PSMD13 ENSPPYP00000022487 ENSPPYP00000022487 IL1RAPL1 IL1RAPL1 TAB3 TAB3 ENSPPYP00000022638 ENSPPYP00000022638 PSMD10 PSMD10 UBE2NL UBE2NL IRAK1 IRAK1 IKBKG IKBKG ENSPPYP00000023500 ENSPPYP00000023500 PSMB1-2 PSMB1-2 ENSPPYP00000023537 ENSPPYP00000023537 PSMD7 PSMD7 ENSPPYP00000023561 ENSPPYP00000023561 ENSPPYP00000023562 ENSPPYP00000023562 ENSPPYP00000023569 ENSPPYP00000023569 TRAF6 TRAF6 LOC100457600 LOC100457600 CR201_G0050806 CR201_G0050806 PSMC1 PSMC1 GSDMD GSDMD PSMA6 PSMA6 PSMD4 PSMD4 PSMD3 PSMD3 PSMA5 PSMA5 ENSPPYP00000013015 ENSPPYP00000013015 SYNGR1 SYNGR1 RBX1 RBX1 LRRC74B LRRC74B IL1R2 IL1R2 IL1R1 IL1R1 IL1RL2 IL1RL2 IL1RL1 IL1RL1 IL18R1 IL18R1 IL18RAP IL18RAP IL1A IL1A IL1B IL1B IL37 IL37 PTPN14 PTPN14 PTPN7 PTPN7 LRRC71 LRRC71 S100A12 S100A12 PSMB4 PSMB4 PSMB2 PSMB2 CR201_G0053435 CR201_G0053435 ALOX5 ALOX5 PTPN20 PTPN20 MAPK8 MAPK8 CHUK CHUK BTRC BTRC NFKB2 NFKB2 MAP3K8 MAP3K8 NLRP6 NLRP6 SIGIRR SIGIRR TOLLIP TOLLIP ENSPPYP00000003414 ENSPPYP00000003414 PELI3 PELI3 RELA RELA PSMC3 PSMC3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (410 aa)
PTPN5Protein tyrosine phosphatase non-receptor type 5. (565 aa)
SAA2Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (122 aa)
PSMA1Proteasome subunit alpha type-1; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pr [...] (263 aa)
IL18BPInterleukin 18 binding protein. (194 aa)
CR201_G0025521CASP12 isoform 3; Belongs to the peptidase C14A family. (408 aa)
S100BProtein S100; Belongs to the S-100 family. (92 aa)
IL36GInterleukin-1. (151 aa)
IL36AInterleukin-1. (155 aa)
IL36BInterleukin-1. (157 aa)
IL36RNInterleukin-1. (155 aa)
IL1F10Interleukin-1. (152 aa)
IL1RNInterleukin-1. (159 aa)
PELI1E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa)
PSME4Proteasome activator subunit 4. (1843 aa)
MAP3K2MAP3K2 isoform 1. (635 aa)
PTPN4Tyrosine-protein phosphatase non-receptor type; May act at junctions between the membrane and the cytoskeleton. (925 aa)
PSMD14Proteasome 26S subunit, non-ATPase 14. (310 aa)
MAP3K20MAP3K20 isoform 1. (457 aa)
CASP8CASP8 isoform 1; Belongs to the peptidase C14A family. (496 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa)
PTPN18PTPN18 isoform 2. (460 aa)
IRAK2Interleukin-1 receptor-associated kinase-like 2; Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. (625 aa)
PSMD6Proteasome 26S subunit, non-ATPase 6. (389 aa)
PTPN23PTPN23 isoform 3. (1636 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa)
NKIRAS1NFKB inhibitor interacting Ras like 1. (192 aa)
MFSD1Major facilitator superfamily domain-containing protein 1. (360 aa)
LRRC34Leucine rich repeat containing 34. (432 aa)
LRRC31LRRC31 isoform 1. (547 aa)
PSMD226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. (909 aa)
ENSPPYP00000016196annotation not available (248 aa)
TNIP2TNIP2 isoform 1. (337 aa)
MAPK10Mitogen-activated protein kinase. (384 aa)
PTPN13PTPN13 isoform 2. (2426 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
TIFATIFA isoform 1. (185 aa)
ALPK1ALPK1 isoform 3. (1181 aa)
IL13IL13 isoform 1. (146 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (153 aa)
SKP1S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] (163 aa)
FBXW11FBXW11 isoform 1. (489 aa)
SQSTM1Sequestosome-1; Autophagy receptor required for selective macroautophagy (aggrephagy). Functions as a bridge between polyubiquitinated cargo and autophagosomes. Interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. Required both for the formation and autophagic degradation of polyubiquitin- containing bodies, called ALIS (aggresome-like induced structures) and links ALIS to the autophagic machinery. Involved in midbody ring degradation (By similarity). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and [...] (436 aa)
AGERAGER isoform 1. (352 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as a [...] (606 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
PSMB1Proteasome subunit beta. (241 aa)
PSMB8Proteasome subunit beta. (272 aa)
PSMB9Proteasome subunit beta. (218 aa)
VWC2Von Willebrand factor C domain containing 2. (325 aa)
PSMA2Proteasome subunit alpha type. (234 aa)
CASP1CASP1 isoform 4; Belongs to the peptidase C14A family. (404 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
NLRX1NLRX1 isoform 1. (974 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (595 aa)
IRAK4IRAK4 isoform 6. (438 aa)
TBK1TANK binding kinase 1. (729 aa)
IRAK3IRAK3 isoform 1. (560 aa)
UBE2NUbiquitin-conjugating enzyme E2 N; The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly- ubiquitination of [...] (152 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (592 aa)
PSMD9PSMD9 isoform 1. (223 aa)
UBCUBC isoform 2. (625 aa)
HMGB1High mobility group box 1. (215 aa)
PSMB5Proteasome subunit beta type-5; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pro [...] (263 aa)
PSMB11Proteasome subunit beta. (300 aa)
PSME1Proteasome activator subunit 1. (249 aa)
PSME2Proteasome activator subunit 2. (239 aa)
KHNYNKHNYN isoform 1. (608 aa)
CTSGCTSG isoform 1; Belongs to the peptidase S1 family. (227 aa)
NFKBIANFKBIA isoform 1. (317 aa)
PSMC6Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (403 aa)
PELI2E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (420 aa)
PSMA3Proteasome subunit alpha type. (255 aa)
LRRC74ALeucine rich repeat containing 74A. (488 aa)
PTPN21Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. (1153 aa)
MAP2K1MAP2K1 isoform 1; Belongs to the protein kinase superfamily. (395 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
PTPN9PTPN9 isoform 1. (619 aa)
PSMA4Proteasome subunit alpha type. (261 aa)
CR201_G0003353RPS27A isoform 1. (155 aa)
N4BP1N4BP1 isoform 1. (894 aa)
NOD2NOD2 isoform 4. (1040 aa)
NLRC5NLRC5 isoform 2. (1632 aa)
PSMB10Proteasome subunit beta. (256 aa)
PSMB6Proteasome subunit beta. (239 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
ENSPPYP00000008980annotation not available (158 aa)
PSMD11Proteasome 26S subunit, non-ATPase 11. (422 aa)
PSME3Proteasome activator complex subunit 3; Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regul [...] (254 aa)
STAT3Signal transducer and activator of transcription. (772 aa)
NKIRAS2NFKB inhibitor interacting Ras like 2. (191 aa)
PSMB3Proteasome subunit beta. (218 aa)
MAP3K3Mitogen-activated protein kinase kinase kinase 3. (657 aa)
PSMC5PSMC5 isoform 2; Belongs to the AAA ATPase family. (406 aa)
PSMD1226S proteasome non-ATPase regulatory subunit 12; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit p55 family. (456 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
LRRC45LRRC45 isoform 1. (674 aa)
ENSPPYP00000009931annotation not available (76 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (387 aa)
USP14Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (435 aa)
PSMA8Proteasome subunit alpha type. (256 aa)
UBA52UBA52 isoform 10. (128 aa)
PSMD826S proteasome non-ATPase regulatory subunit 8; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S14 family. (350 aa)
NFKBIBNFKBIB isoform 6. (354 aa)
PSMC4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa)
NLRP9NLRP9 isoform 1. (937 aa)
NLRP13NLRP13 isoform 2. (1044 aa)
ENSPPYP00000012086annotation not available (110 aa)
PSMF1Proteasome inhibitor PI31 subunit; Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28 (By similarity). (271 aa)
TMEM189-UBE2V1Ubiquitin-conjugating enzyme E2 variant 1; Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly- ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF- kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repa [...] (329 aa)
PSMA7Proteasome subunit alpha type-7; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pr [...] (248 aa)
APPAPP isoform 3. (736 aa)
NOD1NOD1 isoform 4. (953 aa)
ENSPPYP00000019816annotation not available (197 aa)
PTPN12Tyrosine-protein phosphatase non-receptor type 12; Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades. (750 aa)
PSMC226S proteasome regulatory subunit 7; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with [...] (433 aa)
CR201_G0036702CCDC71L isoform 2. (316 aa)
CUL1Cullin-1; Core component of multiple cullin-RING-based SCF (SKP1-CUL1- F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SCF complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the [...] (776 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (697 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa)
TONSLTONSL isoform 2. (1217 aa)
LRRC14Leucine rich repeat containing 14. (493 aa)
IL33Interleukin-33; Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an 'alarmin', that amplifies immune responses during tissue injury (By similarity); Belongs to the IL-1 family. Highly divergent. (270 aa)
PSMD5PSMD5 isoform 8. (97 aa)
PSMB7Proteasome subunit beta. (277 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa)
ENSPPYP00000022319annotation not available (162 aa)
PSMD13PSMD13 isoform 6. (376 aa)
ENSPPYP00000022487annotation not available (153 aa)
IL1RAPL1IL1RAPL1 isoform 1. (695 aa)
TAB3TAB3 isoform 2. (670 aa)
ENSPPYP00000022638annotation not available (210 aa)
PSMD10Proteasome 26S subunit, non-ATPase 10. (226 aa)
UBE2NLUbiquitin conjugating enzyme E2 N like (gene/pseudogene). (152 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (682 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (487 aa)
ENSPPYP00000023500annotation not available (140 aa)
PSMB1-2Proteasome subunit beta type-1. (241 aa)
ENSPPYP00000023537annotation not available (121 aa)
PSMD7PSMD7 isoform 1. (324 aa)
ENSPPYP00000023561annotation not available (122 aa)
ENSPPYP00000023562annotation not available (156 aa)
ENSPPYP00000023569annotation not available (247 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (604 aa)
LOC100457600Proteasome subunit beta type-5-like. (263 aa)
CR201_G0050806GSDMD isoform 17. (123 aa)
PSMC1Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family. (440 aa)
GSDMDGSDMD isoform 1. (314 aa)
PSMA6Proteasome endopeptidase complex. (167 aa)
PSMD4PSMD4 isoform 1. (384 aa)
PSMD3PSMD3 isoform 1. (536 aa)
PSMA5Proteasome subunit alpha type. (278 aa)
ENSPPYP00000013015annotation not available (211 aa)
SYNGR1Synaptogyrin-1; May play a role in regulated exocytosis. Modulates the localization of synaptophysin/SYP into synaptic-like microvesicles and may therefore play a role in synaptic-like microvesicle formation and/or maturation (By similarity). Involved in the regulation of short- term and long-term synaptic plasticity (By similarity). Belongs to the synaptogyrin family. (654 aa)
RBX1RBX1 isoform 1. (108 aa)
LRRC74BLRRC74B isoform 4. (161 aa)
IL1R2IL1R2 isoform 2. (390 aa)
IL1R1Interleukin 1 receptor type 1. (569 aa)
IL1RL2IL1RL2 isoform 1. (617 aa)
IL1RL1IL1RL1 isoform 3. (328 aa)
IL18R1Interleukin 18 receptor 1. (541 aa)
IL18RAPIL18RAP isoform 1. (599 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (273 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (268 aa)
IL37Interleukin-1. (217 aa)
PTPN14Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. (1187 aa)
PTPN7PTPN7 isoform 3. (425 aa)
LRRC71LRRC71 isoform 1. (559 aa)
S100A12S100 calcium binding protein A12; Belongs to the S-100 family. (92 aa)
PSMB4Proteasome subunit beta; Belongs to the peptidase T1B family. (264 aa)
PSMB2Proteasome subunit beta. (201 aa)
CR201_G0053435UBB isoform 1. (128 aa)
ALOX5ALOX5 isoform 2. (623 aa)
PTPN20PTPN20 isoform 13. (390 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
CHUKCHUK isoform 1. (746 aa)
BTRCBTRC isoform 2. (605 aa)
NFKB2NFKB2 isoform 4. (868 aa)
MAP3K8Mitogen-activated protein kinase kinase kinase 8. (384 aa)
NLRP6NLRP6 isoform 2. (812 aa)
SIGIRRSIGIRR isoform 11. (351 aa)
TOLLIPToll interacting protein. (274 aa)
ENSPPYP00000003414annotation not available (440 aa)
PELI3E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (445 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
PSMC3Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (439 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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