STRINGSTRING
CR201_G0053435 CR201_G0053435 MAPK8 MAPK8 TRAF6 TRAF6 UBE2N UBE2N UBC UBC CR201_G0003353 CR201_G0003353 NOD2 NOD2 ENSPPYP00000008980 ENSPPYP00000008980 ENSPPYP00000009931 ENSPPYP00000009931 MAP2K7 MAP2K7 UBA52 UBA52 ENSPPYP00000012086 ENSPPYP00000012086 TMEM189-UBE2V1 TMEM189-UBE2V1 SYNGR1 SYNGR1 MAP3K20 MAP3K20 IRAK2 IRAK2 MAPK10 MAPK10 MAPK9 MAPK9 MAP3K7 MAP3K7 TAB2 TAB2 NOD1 NOD1 RIPK2 RIPK2 ENSPPYP00000022487 ENSPPYP00000022487 TAB3 TAB3 UBE2NL UBE2NL IRAK1 IRAK1 IKBKG IKBKG ENSPPYP00000023500 ENSPPYP00000023500 ENSPPYP00000023562 ENSPPYP00000023562 MAP2K4 MAP2K4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CR201_G0053435UBB isoform 1. (128 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (604 aa)
UBE2NUbiquitin-conjugating enzyme E2 N; The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly- ubiquitination of [...] (152 aa)
UBCUBC isoform 2. (625 aa)
CR201_G0003353RPS27A isoform 1. (155 aa)
NOD2NOD2 isoform 4. (1040 aa)
ENSPPYP00000008980annotation not available (158 aa)
ENSPPYP00000009931annotation not available (76 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (435 aa)
UBA52UBA52 isoform 10. (128 aa)
ENSPPYP00000012086annotation not available (110 aa)
TMEM189-UBE2V1Ubiquitin-conjugating enzyme E2 variant 1; Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly- ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF- kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repa [...] (329 aa)
SYNGR1Synaptogyrin-1; May play a role in regulated exocytosis. Modulates the localization of synaptophysin/SYP into synaptic-like microvesicles and may therefore play a role in synaptic-like microvesicle formation and/or maturation (By similarity). Involved in the regulation of short- term and long-term synaptic plasticity (By similarity). Belongs to the synaptogyrin family. (654 aa)
MAP3K20MAP3K20 isoform 1. (457 aa)
IRAK2Interleukin-1 receptor-associated kinase-like 2; Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. (625 aa)
MAPK10Mitogen-activated protein kinase. (384 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as a [...] (606 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
NOD1NOD1 isoform 4. (953 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa)
ENSPPYP00000022487annotation not available (153 aa)
TAB3TAB3 isoform 2. (670 aa)
UBE2NLUbiquitin conjugating enzyme E2 N like (gene/pseudogene). (152 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (682 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (487 aa)
ENSPPYP00000023500annotation not available (140 aa)
ENSPPYP00000023562annotation not available (156 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (410 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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