STRINGSTRING
FLOT1 FLOT1 GSDMD GSDMD CR201_G0050806 CR201_G0050806 ENSPPYP00000023562 ENSPPYP00000023562 ENSPPYP00000023500 ENSPPYP00000023500 XIAP XIAP OGT OGT ENSPPYP00000022638 ENSPPYP00000022638 ENSPPYP00000022487 ENSPPYP00000022487 TRAF2 TRAF2 ENSPPYP00000021735 ENSPPYP00000021735 CHMP4C CHMP4C SDCBP SDCBP CHMP7 CHMP7 TNFRSF10A TNFRSF10A TNFRSF10B TNFRSF10B GSDME GSDME CYCS CYCS NPVF NPVF ENSPPYP00000018466 ENSPPYP00000018466 CR201_G0016264 CR201_G0016264 RIPK1 RIPK1 IRF1 IRF1 NAIP NAIP ENSPPYP00000017062 ENSPPYP00000017062 ENSPPYP00000017056 ENSPPYP00000017056 CASP3 CASP3 IRF2 IRF2 ENSPPYP00000016980 ENSPPYP00000016980 TP63 TP63 TNFSF10 TNFSF10 PDCD6IP PDCD6IP CHMP2B CHMP2B CASP8 CASP8 CFLAR CFLAR ENSPPYP00000014206 ENSPPYP00000014206 PELI1 PELI1 ENSPPYP00000013663 ENSPPYP00000013663 CHMP3 CHMP3 IL1B IL1B IL1A IL1A ENSPPYP00000013015 ENSPPYP00000013015 UBE2L3 UBE2L3 BIRC7 BIRC7 ITCH ITCH CHMP4B CHMP4B CHMP2A CHMP2A CR201_G0029582 CR201_G0029582 ENSPPYP00000011173 ENSPPYP00000011173 UBA52 UBA52 CDC37 CDC37 ELANE ELANE ENSPPYP00000009931 ENSPPYP00000009931 CHMP6 CHMP6 GSDMB GSDMB FLOT2 FLOT2 ENSPPYP00000008980 ENSPPYP00000008980 TP53 TP53 MLKL MLKL CR201_G0015089 CR201_G0015089 ENSPPYP00000008172 ENSPPYP00000008172 STUB1 STUB1 CR201_G0003353 CR201_G0003353 HSP90AA1 HSP90AA1 TTC6 TTC6 GZMB GZMB RIPK3 RIPK3 CHMP4A CHMP4A HMGB1 HMGB1 BAK1 BAK1 UBE2L5 UBE2L5 UBC UBC IL18 IL18 CARD18 CARD18 CASP1 CASP1 CASP5 CASP5 CASP4 CASP4 CR201_G0025521 CR201_G0025521 BIRC2 BIRC2 ENSPPYP00000003894 ENSPPYP00000003894 FADD FADD FAS FAS CR201_G0053435 CR201_G0053435 FASLG FASLG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FLOT1Flotillin-1; May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. (427 aa)
GSDMDGSDMD isoform 1. (314 aa)
CR201_G0050806GSDMD isoform 17. (123 aa)
ENSPPYP00000023562annotation not available (156 aa)
ENSPPYP00000023500annotation not available (140 aa)
XIAPXIAP isoform 2. (513 aa)
OGTOGT isoform 1. (1045 aa)
ENSPPYP00000022638annotation not available (210 aa)
ENSPPYP00000022487annotation not available (153 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa)
ENSPPYP00000021735Cytochrome c-like. (38 aa)
CHMP4CCharged multivesicular body protein 4C. (233 aa)
SDCBPSDCBP isoform 3. (297 aa)
CHMP7Charged multivesicular body protein 7; ESCRT-III-like protein required to recruit the ESCRT-III complex to the nuclear envelope during late anaphase. Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase. Plays a role in the endosomal sorting pathway. (453 aa)
TNFRSF10ATNFRSF10A isoform 1. (468 aa)
TNFRSF10BTNFRSF10B isoform 3. (410 aa)
GSDMEDFNA5 isoform 1. (498 aa)
CYCSCytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity). (105 aa)
NPVFNeuropeptide VF precursor. (196 aa)
ENSPPYP00000018466Cytochrome c-like. (105 aa)
CR201_G0016264BAK1 isoform 3. (172 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (671 aa)
IRF1Interferon regulatory factor. (325 aa)
NAIPNAIP isoform 3. (1403 aa)
ENSPPYP00000017062annotation not available (62 aa)
ENSPPYP00000017056annotation not available (412 aa)
CASP3CASP3 isoform 1; Belongs to the peptidase C14A family. (277 aa)
IRF2Interferon regulatory factor. (349 aa)
ENSPPYP00000016980annotation not available (100 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
TNFSF10Tumor necrosis factor ligand superfamily member. (290 aa)
PDCD6IPPDCD6IP isoform 2. (945 aa)
CHMP2BCharged multivesicular body protein 2b; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential functio [...] (213 aa)
CASP8CASP8 isoform 1; Belongs to the peptidase C14A family. (496 aa)
CFLARCASP8 and FADD-like apoptosis regulator subunit p12; Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity (By similarity). Belongs to [...] (480 aa)
ENSPPYP00000014206annotation not available (100 aa)
PELI1E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa)
ENSPPYP00000013663annotation not available (38 aa)
CHMP3Charged multivesicular body protein 3; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function [...] (222 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (268 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (273 aa)
ENSPPYP00000013015annotation not available (211 aa)
UBE2L3Ubiquitin-conjugating enzyme E2 L3; Ubiquitin-conjugating enzyme E2 that specifically acts with HECT-type and RBR family E3 ubiquitin-protein ligases. Does not function with most RING-containing E3 ubiquitin-protein ligases because it lacks intrinsic E3-independent reactivity with lysine: in contrast, it has activity with the RBR family E3 enzymes, such as PRKN and ARIH1, that function like function like RING-HECT hybrids. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-linked polyubiquitination. Involved in the [...] (154 aa)
BIRC7Baculoviral IAP repeat containing 7. (280 aa)
ITCHE3 ubiquitin-protein ligase. (849 aa)
CHMP4BCHMP4B isoform 1. (210 aa)
CHMP2ACHMP2A isoform 1. (222 aa)
CR201_G0029582BAX isoform 2. (246 aa)
ENSPPYP00000011173annotation not available (222 aa)
UBA52UBA52 isoform 10. (128 aa)
CDC37CDC37 isoform 2. (338 aa)
ELANEELANE isoform 1; Belongs to the peptidase S1 family. (267 aa)
ENSPPYP00000009931annotation not available (76 aa)
CHMP6Charged multivesicular body protein 6; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function [...] (178 aa)
GSDMBGSDMB isoform 1. (395 aa)
FLOT2Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (428 aa)
ENSPPYP00000008980annotation not available (158 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
MLKLMLKL isoform 4. (356 aa)
CR201_G0015089TRADD isoform 2. (234 aa)
ENSPPYP00000008172annotation not available (229 aa)
STUB1STIP1 homology and U-box containing protein 1. (303 aa)
CR201_G0003353RPS27A isoform 1. (155 aa)
HSP90AA1HSP90AA1 isoform 6. (615 aa)
TTC6TTC6 isoform 3. (617 aa)
GZMBGZMB isoform 1; Belongs to the peptidase S1 family. (281 aa)
RIPK3Receptor interacting serine/threonine kinase 3. (518 aa)
CHMP4ACHMP4A isoform 4. (258 aa)
HMGB1High mobility group box 1. (215 aa)
BAK1Bcl-2 homologous antagonist/killer. (147 aa)
UBE2L5Ubiquitin conjugating enzyme E2 L5; Belongs to the ubiquitin-conjugating enzyme family. (154 aa)
UBCUBC isoform 2. (625 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
CARD18CARD18 isoform 1. (89 aa)
CASP1CASP1 isoform 4; Belongs to the peptidase C14A family. (404 aa)
CASP5CASP5 isoform 2; Belongs to the peptidase C14A family. (444 aa)
CASP4CASP4 isoform 2; Belongs to the peptidase C14A family. (377 aa)
CR201_G0025521CASP12 isoform 3; Belongs to the peptidase C14A family. (408 aa)
BIRC2Baculoviral IAP repeat containing 2. (597 aa)
ENSPPYP00000003894annotation not available (104 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
FASFAS isoform 1. (336 aa)
CR201_G0053435UBB isoform 1. (128 aa)
FASLGFASLG isoform 1; Belongs to the tumor necrosis factor family. (280 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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