STRINGSTRING
ENSPPYP00000017056 ENSPPYP00000017056 TRIB3 TRIB3 AKT2 AKT2 VAV1 VAV1 JUP JUP VAV3 VAV3 CDH5 CDH5 PDPK1 PDPK1 MLST8 MLST8 AKT1 AKT1 HSP90AA1 HSP90AA1 CALM1 CALM1 PAK1 PAK1 CTNND1 CTNND1 STX12 STX12 PAK3 PAK3 CR201_G0027422 CR201_G0027422 MAPKAP1 MAPKAP1 NOS3 NOS3 CAV1 CAV1 RAC1 RAC1 STX7 STX7 CTNNA1 CTNNA1 RICTOR RICTOR ENSPPYP00000017062 ENSPPYP00000017062 AKT3 AKT3 THEM4 THEM4 ARVCF ARVCF CALM1-2 CALM1-2 CTNNB1 CTNNB1 PAK2 PAK2 ENSPPYP00000016980 ENSPPYP00000016980
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSPPYP00000017056annotation not available (412 aa)
TRIB3TRIB3 isoform 1. (358 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
VAV1VAV1 isoform 2. (829 aa)
JUPJUP isoform 1. (670 aa)
VAV3VAV3 isoform 1. (824 aa)
CDH5CDH5 isoform 2; Cadherins are calcium-dependent cell adhesion proteins. (781 aa)
PDPK1PDPK1 isoform 1. (495 aa)
MLST8MTOR associated protein, LST8 homolog. (326 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (413 aa)
HSP90AA1HSP90AA1 isoform 6. (615 aa)
CALM1Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases (By similarity). Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity). (149 aa)
PAK1Non-specific serine/threonine protein kinase. (546 aa)
CTNND1CTNND1 isoform 19. (968 aa)
STX12Syntaxin-12; SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. The SNARE complex containing STX6, STX12, VAMP4 and VTI1A mediates vesicle fusion (in vitro) (By similarity). Through complex formation with GRIP1, GRIA2 and NSG1 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity). (274 aa)
PAK3Non-specific serine/threonine protein kinase. (559 aa)
CR201_G0027422VAV2 isoform 3. (772 aa)
MAPKAP1Target of rapamycin complex 2 subunit MAPKAP1; Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the [...] (522 aa)
NOS3NOS3 isoform 2. (833 aa)
CAV1Caveolin-1; Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt [...] (178 aa)
RAC1Rac family small GTPase 1. (211 aa)
STX7Syntaxin-7; May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes (By similarity). (261 aa)
CTNNA1CTNNA1 isoform 1. (905 aa)
RICTORRICTOR isoform 1. (1690 aa)
ENSPPYP00000017062annotation not available (62 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
THEM4Thioesterase superfamily member 4. (240 aa)
ARVCFARVCF isoform 1. (877 aa)
CALM1-2Calmodulin 2. (149 aa)
CTNNB1CTNNB1 isoform 2. (781 aa)
PAK2Non-specific serine/threonine protein kinase. (502 aa)
ENSPPYP00000016980annotation not available (100 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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