STRINGSTRING
XIAP XIAP MAPKAPK2 MAPKAPK2 IKBKE IKBKE USP21 USP21 OTUD7B OTUD7B CR201_G0053435 CR201_G0053435 CR201_G0053298 CR201_G0053298 CR201_G0044109 CR201_G0044109 OPTN OPTN UBE2D1 UBE2D1 CHUK CHUK FADD FADD MADD MADD BIRC2 BIRC2 USP2 USP2 TNFRSF1A TNFRSF1A TBK1 TBK1 UBC UBC ULK1 ULK1 UBE2L5 UBE2L5 RNF31 RNF31 NFATC4 NFATC4 SPPL2A SPPL2A CR201_G0003353 CR201_G0003353 STUB1 STUB1 CYLD CYLD CR201_G0015089 CR201_G0015089 ENSPPYP00000008980 ENSPPYP00000008980 SPPL2C SPPL2C ULK2 ULK2 ENSPPYP00000009931 ENSPPYP00000009931 SPPL2B SPPL2B UBA52 UBA52 CLIP3 CLIP3 RBCK1 RBCK1 SPATA2 SPATA2 BIRC7 BIRC7 UBE2L3 UBE2L3 CLIP4 CLIP4 CFLAR CFLAR CASP8 CASP8 TMEM198 TMEM198 USP4 USP4 UBE2D3 UBE2D3 OTULINL OTULINL OTULIN OTULIN NAIP NAIP UBE2D2 UBE2D2 RIPK1 RIPK1 TNF TNF TNFAIP3 TNFAIP3 TAX1BP1 TAX1BP1 ENSPPYP00000020022 ENSPPYP00000020022 IKBKB IKBKB SHARPIN SHARPIN WDR31 WDR31 TRAF1 TRAF1 TRAF2 TRAF2 RACK1 RACK1 ENSPPYP00000022487 ENSPPYP00000022487 CR201_G0044109-2 CR201_G0044109-2 ENSPPYP00000023562 ENSPPYP00000023562 ENSPPYP00000023500 ENSPPYP00000023500 OTUD1 OTUD1 IKBKG IKBKG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
XIAPXIAP isoform 2. (513 aa)
MAPKAPK2MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (401 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (716 aa)
USP21Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (565 aa)
OTUD7BOTU deubiquitinase 7B. (843 aa)
CR201_G0053435UBB isoform 1. (128 aa)
CR201_G0053298MIB2 isoform 16. (744 aa)
CR201_G0044109RACK1 isoform 5. (346 aa)
OPTNOptineurin; Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex th [...] (532 aa)
UBE2D1Ubiquitin conjugating enzyme E2 D1; Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
CHUKCHUK isoform 1. (746 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
MADDMADD isoform 6. (1579 aa)
BIRC2Baculoviral IAP repeat containing 2. (597 aa)
USP2Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (564 aa)
TNFRSF1ATNFRSF1A isoform 2. (454 aa)
TBK1TANK binding kinase 1. (729 aa)
UBCUBC isoform 2. (625 aa)
ULK1Serine/threonine-protein kinase; Serine/threonine-protein kinase involved in autophagy in response to starvation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. (924 aa)
UBE2L5Ubiquitin conjugating enzyme E2 L5; Belongs to the ubiquitin-conjugating enzyme family. (154 aa)
RNF31T0114761 isoform 1. (1053 aa)
NFATC4NFATC4 isoform 21. (868 aa)
SPPL2ASignal peptide peptidase like 2A. (520 aa)
CR201_G0003353RPS27A isoform 1. (155 aa)
STUB1STIP1 homology and U-box containing protein 1. (303 aa)
CYLDUbiquitin carboxyl-terminal hydrolase CYLD; Deubiquitinase that specifically cleaves 'Lys-63'- and linear 'Met-1'-linked polyubiquitin chains and is involved in NF-kappa-B activation and TNF-alpha-induced necroptosis. Plays an important role in the regulation of pathways leading to NF-kappa-B activation. Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation. Negative regulator of Wnt signaling. Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules. Plays a role in the regul [...] (956 aa)
CR201_G0015089TRADD isoform 2. (234 aa)
ENSPPYP00000008980annotation not available (158 aa)
SPPL2CSPPL2C isoform 1. (682 aa)
ULK2Serine/threonine-protein kinase; Serine/threonine-protein kinase involved in autophagy in response to starvation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. (1028 aa)
ENSPPYP00000009931annotation not available (76 aa)
SPPL2BSignal peptide peptidase like 2B. (542 aa)
UBA52UBA52 isoform 10. (128 aa)
CLIP3CAP-Gly domain-containing linker protein 3; Functions as a cytoplasmic linker protein. Involved in TGN- endosome dynamics. May modulate the cellular compartmentalization of AKT kinase family and promote its cell membrane localization, thereby playing a role in glucose transport in adipocytes (By similarity). (547 aa)
RBCK1RBCK1 isoform 5. (509 aa)
SPATA2SPATA2 isoform 1. (520 aa)
BIRC7Baculoviral IAP repeat containing 7. (280 aa)
UBE2L3Ubiquitin-conjugating enzyme E2 L3; Ubiquitin-conjugating enzyme E2 that specifically acts with HECT-type and RBR family E3 ubiquitin-protein ligases. Does not function with most RING-containing E3 ubiquitin-protein ligases because it lacks intrinsic E3-independent reactivity with lysine: in contrast, it has activity with the RBR family E3 enzymes, such as PRKN and ARIH1, that function like function like RING-HECT hybrids. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-linked polyubiquitination. Involved in the [...] (154 aa)
CLIP4CLIP4 isoform 4. (659 aa)
CFLARCASP8 and FADD-like apoptosis regulator subunit p12; Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity (By similarity). Belongs to [...] (480 aa)
CASP8CASP8 isoform 1; Belongs to the peptidase C14A family. (496 aa)
TMEM198Transmembrane protein 198. (360 aa)
USP4Ubiquitin carboxyl-terminal hydrolase 4; Deubiquitinating enzyme that removes conjugated ubiquitin from target proteins. Deubiquitinates PDPK1. Deubiquitinates TRIM21. Deubiquitinates receptor ADORA2A which increases the amount of functional receptor at the cell surface. May regulate mRNA splicing through deubiquitination of the U4 spliceosomal protein PRPF3. This may prevent its recognition by the U5 component PRPF8 thereby destabilizing interactions within the U4/U6.U5 snRNP. May also play a role in the regulation of quality control in the ER. (735 aa)
UBE2D3Ubiquitin-conjugating enzyme E2 D3; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'-linked polyubiquitination. Cooperates with the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains from the UBE2D3-primed [...] (149 aa)
OTULINLFAM105A isoform 1. (360 aa)
OTULINOTU deubiquitinase with linear linkage specificity. (352 aa)
NAIPNAIP isoform 3. (1403 aa)
UBE2D2Ubiquitin conjugating enzyme E2 D2; Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (671 aa)
TNFTumor necrosis factor ligand 1F; Belongs to the tumor necrosis factor family. (233 aa)
TNFAIP3TNFAIP3 isoform 1. (790 aa)
TAX1BP1Tax1-binding protein 1 homolog; Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti- apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade (By similarity). (771 aa)
ENSPPYP00000020022annotation not available (99 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (697 aa)
SHARPINSHARPIN isoform 2. (410 aa)
WDR31WDR31 isoform 2. (345 aa)
TRAF1TNF receptor-associated factor. (416 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa)
RACK1RACK1 isoform 13. (372 aa)
ENSPPYP00000022487annotation not available (153 aa)
CR201_G0044109-2RACK1 isoform 22. (230 aa)
ENSPPYP00000023562annotation not available (156 aa)
ENSPPYP00000023500annotation not available (140 aa)
OTUD1OTUD1 isoform 1. (171 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (487 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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