Your Input: | |
| | PSMB4 | Proteasome subunit beta; Belongs to the peptidase T1B family. (264 aa) |
| | AHCYL1 | Adenosylhomocysteinase like 1; Belongs to the adenosylhomocysteinase family. (530 aa) |
| | BCL10 | BCL10 isoform 1. (263 aa) |
| | PSMB2 | Proteasome subunit beta. (201 aa) |
| | CR201_G0053435 | UBB isoform 1. (128 aa) |
| | PPP3CB | Serine/threonine-protein phosphatase. (438 aa) |
| | CHUK | CHUK isoform 1. (746 aa) |
| | BTRC | BTRC isoform 2. (605 aa) |
| | NFKB2 | NFKB2 isoform 4. (868 aa) |
| | ENSPPYP00000003414 | annotation not available (440 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (551 aa) |
| | PSMC3 | Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (439 aa) |
| | TRAF6 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (604 aa) |
| | PSMA1 | Proteasome subunit alpha type-1; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pr [...] (263 aa) |
| | CLEC7A | CLEC7A isoform 1. (247 aa) |
| | ITPR2 | Inositol 1,4,5-trisphosphate receptor type 2. (2701 aa) |
| | UBE2N | Ubiquitin-conjugating enzyme E2 N; The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly- ubiquitination of [...] (152 aa) |
| | PSMD9 | PSMD9 isoform 1. (223 aa) |
| | UBC | UBC isoform 2. (625 aa) |
| | PSMB5 | Proteasome subunit beta type-5; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pro [...] (263 aa) |
| | PSMB11 | Proteasome subunit beta. (300 aa) |
| | PSME1 | Proteasome activator subunit 1. (249 aa) |
| | PSME2 | Proteasome activator subunit 2. (239 aa) |
| | NFKBIA | NFKBIA isoform 1. (317 aa) |
| | PSMC6 | Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (403 aa) |
| | PSMA3 | Proteasome subunit alpha type. (255 aa) |
| | CALM1 | Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases (By similarity). Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity). (149 aa) |
| | PSMA4 | Proteasome subunit alpha type. (261 aa) |
| | CR201_G0003353 | RPS27A isoform 1. (155 aa) |
| | PDPK1 | PDPK1 isoform 1. (495 aa) |
| | PYCARD | PYD and CARD domain containing. (195 aa) |
| | PSMB10 | Proteasome subunit beta. (256 aa) |
| | NFATC3 | Nuclear factor of activated T cells 3. (1068 aa) |
| | NFAT5 | Nuclear factor of activated T cells 5. (1529 aa) |
| | PLCG2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1230 aa) |
| | PSMB6 | Proteasome subunit beta. (239 aa) |
| | ENSPPYP00000008980 | annotation not available (158 aa) |
| | PSMD11 | Proteasome 26S subunit, non-ATPase 11. (422 aa) |
| | MAP3K14 | Mitogen-activated protein kinase kinase kinase 14. (947 aa) |
| | PSME3 | Proteasome activator complex subunit 3; Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regul [...] (254 aa) |
| | PSMB3 | Proteasome subunit beta. (218 aa) |
| | PSMC5 | PSMC5 isoform 2; Belongs to the AAA ATPase family. (406 aa) |
| | PSMD12 | 26S proteasome non-ATPase regulatory subunit 12; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit p55 family. (456 aa) |
| | ENSPPYP00000009931 | annotation not available (76 aa) |
| | PSMA8 | Proteasome subunit alpha type. (256 aa) |
| | MALT1 | MALT1 isoform 1. (774 aa) |
| | NFATC1 | NFATC1 isoform 10. (766 aa) |
| | CDC34 | CDC34 isoform 1; Belongs to the ubiquitin-conjugating enzyme family. (217 aa) |
| | UBA52 | UBA52 isoform 10. (128 aa) |
| | PSMD8 | 26S proteasome non-ATPase regulatory subunit 8; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S14 family. (350 aa) |
| | PSMC4 | Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa) |
| | RELB | RELB isoform 1. (581 aa) |
| | UBE2M | Ubiquitin conjugating enzyme E2 M; Belongs to the ubiquitin-conjugating enzyme family. (183 aa) |
| | ENSPPYP00000012086 | annotation not available (110 aa) |
| | PSMF1 | Proteasome inhibitor PI31 subunit; Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28 (By similarity). (271 aa) |
| | SRC | Tyrosine-protein kinase. (553 aa) |
| | TMEM189-UBE2V1 | Ubiquitin-conjugating enzyme E2 variant 1; Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly- ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF- kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repa [...] (329 aa) |
| | NFATC2 | Nuclear factor of activated T cells 2. (925 aa) |
| | PSMA7 | Proteasome subunit alpha type-7; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pr [...] (248 aa) |
| | SYNGR1 | Synaptogyrin-1; May play a role in regulated exocytosis. Modulates the localization of synaptophysin/SYP into synaptic-like microvesicles and may therefore play a role in synaptic-like microvesicle formation and/or maturation (By similarity). Involved in the regulation of short- term and long-term synaptic plasticity (By similarity). Belongs to the synaptogyrin family. (654 aa) |
| | IL1B | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (268 aa) |
| | WDR92 | WDR92 isoform 1. (765 aa) |
| | PSME4 | Proteasome activator subunit 4. (1843 aa) |
| | CALM1-2 | Calmodulin 2. (149 aa) |
| | PSMD14 | Proteasome 26S subunit, non-ATPase 14. (310 aa) |
| | MAP3K20 | MAP3K20 isoform 1. (457 aa) |
| | CASP8 | CASP8 isoform 1; Belongs to the peptidase C14A family. (496 aa) |
| | PSMD1 | 26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa) |
| | ITPR1 | ITPR1 isoform 3. (2769 aa) |
| | UBA3 | NEDD8-activating enzyme E1 catalytic subunit; Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down- regulates steroid receptor activity. Necessary for cell cycle progression (By similarity). (484 aa) |
| | PSMD6 | Proteasome 26S subunit, non-ATPase 6. (389 aa) |
| | PRKCD | Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa) |
| | PSMD2 | 26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. (909 aa) |
| | PPP3CA | Serine/threonine-protein phosphatase. (514 aa) |
| | NFKB1 | Nuclear factor kappa B subunit 1. (969 aa) |
| | SKP1 | S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] (163 aa) |
| | FBXW11 | FBXW11 isoform 1. (489 aa) |
| | ITPR3 | ITPR3 isoform 1. (2641 aa) |
| | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as a [...] (606 aa) |
| | TAB2 | TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa) |
| | PSMB1 | Proteasome subunit beta. (241 aa) |
| | PSMB8 | Proteasome subunit beta. (272 aa) |
| | PSMB9 | Proteasome subunit beta. (218 aa) |
| | CARD11 | CARD11 isoform 1. (1155 aa) |
| | PSMA2 | Proteasome subunit alpha type. (234 aa) |
| | ENSPPYP00000019816 | annotation not available (197 aa) |
| | PSMC2 | 26S proteasome regulatory subunit 7; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with [...] (433 aa) |
| | CR201_G0036702 | CCDC71L isoform 2. (316 aa) |
| | CUL1 | Cullin-1; Core component of multiple cullin-RING-based SCF (SKP1-CUL1- F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SCF complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the [...] (776 aa) |
| | IKBKB | Inhibitor of nuclear factor kappa B kinase subunit beta. (697 aa) |
| | SYK | Tyrosine-protein kinase. (588 aa) |
| | PSMD5 | PSMD5 isoform 8. (97 aa) |
| | PSMB7 | Proteasome subunit beta. (277 aa) |
| | CARD9 | CARD9 isoform 1. (434 aa) |
| | ENSPPYP00000022319 | annotation not available (162 aa) |
| | PSMD13 | PSMD13 isoform 6. (376 aa) |
| | ENSPPYP00000022487 | annotation not available (153 aa) |
| | TAB3 | TAB3 isoform 2. (670 aa) |
| | PSMD10 | Proteasome 26S subunit, non-ATPase 10. (226 aa) |
| | UBE2NL | Ubiquitin conjugating enzyme E2 N like (gene/pseudogene). (152 aa) |
| | IKBKG | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (487 aa) |
| | ENSPPYP00000023500 | annotation not available (140 aa) |
| | PSMB1-2 | Proteasome subunit beta type-1. (241 aa) |
| | PSMD7 | PSMD7 isoform 1. (324 aa) |
| | ENSPPYP00000023561 | annotation not available (122 aa) |
| | ENSPPYP00000023562 | annotation not available (156 aa) |
| | ENSPPYP00000023569 | annotation not available (247 aa) |
| | LOC100457600 | Proteasome subunit beta type-5-like. (263 aa) |
| | PSMC1 | Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family. (440 aa) |
| | PSMA6 | Proteasome endopeptidase complex. (167 aa) |
| | PSMD4 | PSMD4 isoform 1. (384 aa) |
| | PSMD3 | PSMD3 isoform 1. (536 aa) |
| | PSMA5 | Proteasome subunit alpha type. (278 aa) |
