STRINGSTRING
PSMD3 PSMD3 TUBA1B TUBA1B PSMD11 PSMD11 ENSPPYP00000008980 ENSPPYP00000008980 PSMB6 PSMB6 TUBB3 TUBB3 PSMB10 PSMB10 RPGRIP1L RPGRIP1L ADCY7 ADCY7 FOPNL FOPNL ADCY9 ADCY9 IFT140 IFT140 CR201_G0003353 CR201_G0003353 PSMA4 PSMA4 NUMB NUMB PSMA3 PSMA3 PSMC6 PSMC6 ADCY4 ADCY4 PSME2 PSME2 PSME1 PSME1 PSMB11 PSMB11 PSMB5 PSMB5 CSNK1A1L CSNK1A1L IFT88 IFT88 UBC UBC PSMD9 PSMD9 GLI1 GLI1 ADCY6 ADCY6 TULP3 TULP3 TEX52 TEX52 CR201_G0025506 CR201_G0025506 ENSPPYP00000004367 ENSPPYP00000004367 DYNC2H1 DYNC2H1 ENSPPYP00000004309 ENSPPYP00000004309 TUB TUB PSMA1 PSMA1 PSMC3 PSMC3 ENSPPYP00000003414 ENSPPYP00000003414 SUFU SUFU BTRC BTRC CR201_G0053435 CR201_G0053435 PSMB2 PSMB2 GLIS1 GLIS1 PRKACB PRKACB PSMB4 PSMB4 ADCY10 ADCY10 GPR161 GPR161 PSME3 PSME3 PSMB3 PSMB3 PSMC5 PSMC5 PSMD12 PSMD12 ENSPPYP00000009931 ENSPPYP00000009931 MKS1 MKS1 PRKAR1A PRKAR1A TUBB6 TUBB6 PSMA8 PSMA8 PRKACA PRKACA UBA52 UBA52 PDCD2L PDCD2L PSMD8 PSMD8 PSMC4 PSMC4 NUMBL NUMBL TULP2 TULP2 FUZ FUZ PSMF1 PSMF1 ITCH ITCH CNBD2 CNBD2 IFT52 IFT52 GNAS GNAS TUBB1 TUBB1 PSMA7 PSMA7 RBX1 RBX1 THAP7 THAP7 PSME4 PSME4 IFT172 IFT172 ADCY3 ADCY3 PTRHD1 PTRHD1 WDR35 WDR35 GLI2 GLI2 PSMD14 PSMD14 TTC21B TTC21B TUBA4A TUBA4A PSMD1 PSMD1 IFT122 IFT122 ADCY5 ADCY5 GSK3B GSK3B IFT57 IFT57 PSMD6 PSMD6 PRKAR2A PRKAR2A TTC21A TTC21A PSMD2 PSMD2 WDR19 WDR19 THAP6 THAP6 INTU INTU ADCY2 ADCY2 LOC100437628 LOC100437628 KIF3A KIF3A SKP1 SKP1 CSNK1A1 CSNK1A1 TULP1 TULP1 PSMB1 PSMB1 PDCD2 PDCD2 PSMB8 PSMB8 PSMB9 PSMB9 ADCY1 ADCY1 PSMA2 PSMA2 GLI3 GLI3 ENSPPYP00000019816 ENSPPYP00000019816 PSMC2 PSMC2 PRKAR2B PRKAR2B SMO SMO CUL1 CUL1 ENSPPYP00000020490 ENSPPYP00000020490 ADCY8 ADCY8 GLIS3 GLIS3 PRKACG PRKACG PTCH1 PTCH1 PSMD5 PSMD5 PSMB7 PSMB7 ENSPPYP00000022319 ENSPPYP00000022319 PSMD13 PSMD13 CR201_G0038668 CR201_G0038668 ENSPPYP00000022487 ENSPPYP00000022487 OFD1 OFD1 PSMD10 PSMD10 ENSPPYP00000023500 ENSPPYP00000023500 PSMB1-2 PSMB1-2 PSMD7 PSMD7 ENSPPYP00000023561 ENSPPYP00000023561 ENSPPYP00000023562 ENSPPYP00000023562 ENSPPYP00000023569 ENSPPYP00000023569 ENSPPYP00000023733 ENSPPYP00000023733 LOC100457600 LOC100457600 TUBA1C TUBA1C PSMC1 PSMC1 PSMA6 PSMA6 PSMD4 PSMD4 PSMA5 PSMA5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PSMD3PSMD3 isoform 1. (536 aa)
TUBA1BTubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (451 aa)
PSMD11Proteasome 26S subunit, non-ATPase 11. (422 aa)
ENSPPYP00000008980annotation not available (158 aa)
PSMB6Proteasome subunit beta. (239 aa)
TUBB3T0170152 isoform 1; Belongs to the tubulin family. (450 aa)
PSMB10Proteasome subunit beta. (256 aa)
RPGRIP1LRPGRIP1L isoform 3. (1315 aa)
ADCY7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa)
FOPNLFOPNL isoform 6. (107 aa)
ADCY9ADCY9 isoform 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (570 aa)
IFT140Intraflagellar transport 140. (1462 aa)
CR201_G0003353RPS27A isoform 1. (155 aa)
PSMA4Proteasome subunit alpha type. (261 aa)
NUMBNUMB endocytic adaptor protein. (651 aa)
PSMA3Proteasome subunit alpha type. (255 aa)
PSMC6Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (403 aa)
ADCY4Adenylate cyclase type 4 isoform X1. (1077 aa)
PSME2Proteasome activator subunit 2. (239 aa)
PSME1Proteasome activator subunit 1. (249 aa)
PSMB11Proteasome subunit beta. (300 aa)
PSMB5Proteasome subunit beta type-5; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pro [...] (263 aa)
CSNK1A1LCasein kinase 1 alpha 1 like; Belongs to the protein kinase superfamily. (337 aa)
IFT88IFT88 isoform 2. (768 aa)
UBCUBC isoform 2. (625 aa)
PSMD9PSMD9 isoform 1. (223 aa)
GLI1GLI family zinc finger 1. (1106 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1165 aa)
TULP3TULP3 isoform 2. (439 aa)
TEX52T0163828 isoform 1. (306 aa)
CR201_G0025506DYNC2H1 isoform 3. (1794 aa)
ENSPPYP00000004367annotation not available (644 aa)
DYNC2H1DYNC2H1 isoform 2. (987 aa)
ENSPPYP00000004309annotation not available (437 aa)
TUBTubby-like protein; Belongs to the TUB family. (561 aa)
PSMA1Proteasome subunit alpha type-1; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pr [...] (263 aa)
PSMC3Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (439 aa)
ENSPPYP00000003414annotation not available (440 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (484 aa)
BTRCBTRC isoform 2. (605 aa)
CR201_G0053435UBB isoform 1. (128 aa)
PSMB2Proteasome subunit beta. (201 aa)
GLIS1GLIS1 isoform 2. (740 aa)
PRKACBPRKACB isoform 9; Belongs to the protein kinase superfamily. (354 aa)
PSMB4Proteasome subunit beta; Belongs to the peptidase T1B family. (264 aa)
ADCY10Adenylate cyclase type 10; Catalyzes the formation of the signaling molecule cAMP. May function as sensor that mediates responses to changes in cellular bicarbonate and CO(2) levels. Has a critical role in mammalian spermatogenesis by producing the cAMP which regulates cAMP-responsive nuclear factors indispensable for sperm maturation in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization. Involved in ciliary beat regulation. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1394 aa)
GPR161G protein-coupled receptor 161; Belongs to the G-protein coupled receptor 1 family. (549 aa)
PSME3Proteasome activator complex subunit 3; Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regul [...] (254 aa)
PSMB3Proteasome subunit beta. (218 aa)
PSMC5PSMC5 isoform 2; Belongs to the AAA ATPase family. (406 aa)
PSMD1226S proteasome non-ATPase regulatory subunit 12; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit p55 family. (456 aa)
ENSPPYP00000009931annotation not available (76 aa)
MKS1MKS1 isoform 7. (343 aa)
PRKAR1AcAMP-dependent protein kinase type I-alpha regulatory subunit; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. (381 aa)
TUBB6Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (446 aa)
PSMA8Proteasome subunit alpha type. (256 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha. (299 aa)
UBA52UBA52 isoform 10. (128 aa)
PDCD2LProgrammed cell death protein 2-like. (358 aa)
PSMD826S proteasome non-ATPase regulatory subunit 8; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S14 family. (350 aa)
PSMC4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa)
NUMBLNUMBL isoform 1. (418 aa)
TULP2TULP2 isoform 2; Belongs to the TUB family. (308 aa)
FUZFuzzy planar cell polarity protein. (418 aa)
PSMF1Proteasome inhibitor PI31 subunit; Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28 (By similarity). (271 aa)
ITCHE3 ubiquitin-protein ligase. (849 aa)
CNBD2Cyclic nucleotide binding domain containing 2. (572 aa)
IFT52IFT52 isoform 1. (448 aa)
GNASGNAS isoform 2. (1037 aa)
TUBB1Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (452 aa)
PSMA7Proteasome subunit alpha type-7; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pr [...] (248 aa)
RBX1RBX1 isoform 1. (108 aa)
THAP7THAP domain containing 7. (309 aa)
PSME4Proteasome activator subunit 4. (1843 aa)
IFT172IFT172 isoform 1. (1728 aa)
ADCY3Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1084 aa)
PTRHD1Peptidyl-tRNA hydrolase domain containing 1. (140 aa)
WDR35WD repeat-containing protein 35; As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in ciliogenesis and ciliary protein trafficking. (1181 aa)
GLI2GLI2 isoform 1. (1521 aa)
PSMD14Proteasome 26S subunit, non-ATPase 14. (310 aa)
TTC21BTTC21B isoform 1. (1211 aa)
TUBA4ATubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (448 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa)
IFT122IFT122 isoform 10. (1102 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1100 aa)
GSK3BGSK3B isoform 2; Belongs to the protein kinase superfamily. (380 aa)
IFT57Intraflagellar transport 57. (429 aa)
PSMD6Proteasome 26S subunit, non-ATPase 6. (389 aa)
PRKAR2AProtein kinase cAMP-dependent type II regulatory subunit alpha. (382 aa)
TTC21ATTC21A isoform 3. (1317 aa)
PSMD226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. (909 aa)
WDR19WDR19 isoform 1. (1273 aa)
THAP6THAP domain containing 6. (222 aa)
INTUINTU isoform 1. (942 aa)
ADCY2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1013 aa)
LOC100437628Oral-facial-digital syndrome 1 protein-like isoform X1. (1012 aa)
KIF3AKinesin-like protein KIF3A; Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro. Plays a role in primary cilia formation. Plays a role in centriole cohesion and subdistal appendage organization and function. Regulates the formation of the subdistal appendage via recruitment of DCTN1 to the centriole. Also required for ciliary basal feet formation and microtubule anchoring to mother centriole. (696 aa)
SKP1S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] (163 aa)
CSNK1A1CSNK1A1 isoform 6; Belongs to the protein kinase superfamily. (365 aa)
TULP1Tubby-like protein; Belongs to the TUB family. (542 aa)
PSMB1Proteasome subunit beta. (241 aa)
PDCD2Programmed cell death 2. (344 aa)
PSMB8Proteasome subunit beta. (272 aa)
PSMB9Proteasome subunit beta. (218 aa)
ADCY1Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (636 aa)
PSMA2Proteasome subunit alpha type. (234 aa)
GLI3GLI3 isoform 3. (1580 aa)
ENSPPYP00000019816annotation not available (197 aa)
PSMC226S proteasome regulatory subunit 7; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with [...] (433 aa)
PRKAR2BPRKAR2B isoform 1. (390 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (789 aa)
CUL1Cullin-1; Core component of multiple cullin-RING-based SCF (SKP1-CUL1- F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SCF complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the [...] (776 aa)
ENSPPYP00000020490annotation not available (78 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa)
GLIS3GLIS family zinc finger 3. (930 aa)
PRKACGProtein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. (351 aa)
PTCH1PTCH1 isoform 7. (1429 aa)
PSMD5PSMD5 isoform 8. (97 aa)
PSMB7Proteasome subunit beta. (277 aa)
ENSPPYP00000022319annotation not available (162 aa)
PSMD13PSMD13 isoform 6. (376 aa)
CR201_G0038668FOPNL isoform 7. (72 aa)
ENSPPYP00000022487annotation not available (153 aa)
OFD1OFD1 isoform 3. (959 aa)
PSMD10Proteasome 26S subunit, non-ATPase 10. (226 aa)
ENSPPYP00000023500annotation not available (140 aa)
PSMB1-2Proteasome subunit beta type-1. (241 aa)
PSMD7PSMD7 isoform 1. (324 aa)
ENSPPYP00000023561annotation not available (122 aa)
ENSPPYP00000023562annotation not available (156 aa)
ENSPPYP00000023569annotation not available (247 aa)
ENSPPYP00000023733annotation not available (177 aa)
LOC100457600Proteasome subunit beta type-5-like. (263 aa)
TUBA1CTubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (476 aa)
PSMC1Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family. (440 aa)
PSMA6Proteasome endopeptidase complex. (167 aa)
PSMD4PSMD4 isoform 1. (384 aa)
PSMA5Proteasome subunit alpha type. (278 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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