STRINGSTRING
TNIP2 TNIP2 MAP2K4 MAP2K4 ENSPPYP00000023562 ENSPPYP00000023562 ENSPPYP00000023500 ENSPPYP00000023500 IKBKG IKBKG ENSPPYP00000022319 ENSPPYP00000022319 IKBKB IKBKB CUL1 CUL1 CR201_G0036702 CR201_G0036702 FBXW11 FBXW11 SKP1 SKP1 NFKB1 NFKB1 CR201_G0003353 CR201_G0003353 MAP2K1 MAP2K1 UBC UBC MAP3K8 MAP3K8 BTRC BTRC CHUK CHUK
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TNIP2TNIP2 isoform 1. (337 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (410 aa)
ENSPPYP00000023562annotation not available (156 aa)
ENSPPYP00000023500annotation not available (140 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (487 aa)
ENSPPYP00000022319annotation not available (162 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (697 aa)
CUL1Cullin-1; Core component of multiple cullin-RING-based SCF (SKP1-CUL1- F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SCF complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the [...] (776 aa)
CR201_G0036702CCDC71L isoform 2. (316 aa)
FBXW11FBXW11 isoform 1. (489 aa)
SKP1S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] (163 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
CR201_G0003353RPS27A isoform 1. (155 aa)
MAP2K1MAP2K1 isoform 1; Belongs to the protein kinase superfamily. (395 aa)
UBCUBC isoform 2. (625 aa)
MAP3K8Mitogen-activated protein kinase kinase kinase 8. (384 aa)
BTRCBTRC isoform 2. (605 aa)
CHUKCHUK isoform 1. (746 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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