STRINGSTRING
PARP1 PARP1 CR201_G0007169 CR201_G0007169 PIAS3 PIAS3 CHD1L CHD1L VTCN1 VTCN1 CR201_G0053435 CR201_G0053435 DDB1 DDB1 DDB2 DDB2 GTF2H1 GTF2H1 VWA5A VWA5A UBE2N UBE2N GTF2H3 GTF2H3 UBC UBC ENSPPYP00000006252 ENSPPYP00000006252 CUL4A CUL4A PARP2 PARP2 MNAT1 MNAT1 WDR76 WDR76 RNF111 RNF111 PIAS1 PIAS1 CR201_G0003353 CR201_G0003353 UBE2I UBE2I MEIOB MEIOB ERCC4 ERCC4 NFATC2IP NFATC2IP ENSPPYP00000008980 ENSPPYP00000008980 CR201_G0021349 CR201_G0021349 ENSPPYP00000009931 ENSPPYP00000009931 ENSPPYP00000009997 ENSPPYP00000009997 ENSPPYP00000010327 ENSPPYP00000010327 RAD23A RAD23A UBA52 UBA52 ERCC2 ERCC2 ERCC1 ERCC1 VWA5B1 VWA5B1 SUMO3 SUMO3 RBX1 RBX1 ERCC3 ERCC3 SUMO1 SUMO1 XPC XPC PARP3 PARP3 ENSPPYP00000016046 ENSPPYP00000016046 VWA5B2 VWA5B2 CDK7 CDK7 LOC100456237 LOC100456237 CCNH CCNH CETN3 CETN3 GTF2H4 GTF2H4 USP45 USP45 GTF2H5 GTF2H5 RPA3 RPA3 CR201_G0021362 CR201_G0021362 UBE2V2 UBE2V2 XPA XPA RAD23B RAD23B ENSPPYP00000022487 ENSPPYP00000022487 CR201_G0021362-2 CR201_G0021362-2 CUL4B CUL4B UBE2NL UBE2NL CETN2 CETN2 ENSPPYP00000023500 ENSPPYP00000023500 ENSPPYP00000023562 ENSPPYP00000023562 ERCC5 ERCC5 SUMO2 SUMO2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (972 aa)
CR201_G0007169SUMO1 isoform 5. (143 aa)
PIAS3PIAS3 isoform 3. (619 aa)
CHD1LCHD1L isoform 6. (900 aa)
VTCN1VTCN1 isoform 1. (191 aa)
CR201_G0053435UBB isoform 1. (128 aa)
DDB1DNA damage-binding protein 1; Required for DNA repair. Binds to DDB2 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiqui [...] (1135 aa)
DDB2Damage specific DNA binding protein 2. (427 aa)
GTF2H1General transcription factor IIH subunit 1. (548 aa)
VWA5AVWA5A isoform 1. (821 aa)
UBE2NUbiquitin-conjugating enzyme E2 N; The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly- ubiquitination of [...] (152 aa)
GTF2H3GTF2H3 isoform 1. (272 aa)
UBCUBC isoform 2. (625 aa)
ENSPPYP00000006252annotation not available (477 aa)
CUL4ACUL4A isoform 5; Belongs to the cullin family. (759 aa)
PARP2Poly [ADP-ribose] polymerase. (570 aa)
MNAT1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (288 aa)
WDR76WD repeat-containing protein 76; Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. Belongs to the WD repeat DDB2/WDR76 family. (627 aa)
RNF111E3 ubiquitin-protein ligase Arkadia; E3 ubiquitin-protein ligase (By similarity). Required for mesoderm patterning during embryonic development (By similarity). Acts as an enhancer of the transcriptional responses of the SMAD2/SMAD3 effectors, which are activated downstream of BMP. Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD7, inducing their proteasomal degradation and thereby enhancing the transcriptional activity of TGF-beta and BMP (By similarity). In addition to enhance transcription of SMAD2/SMAD3 effectors, also regulates their turnover by med [...] (984 aa)
PIAS1PIAS1 isoform 1. (683 aa)
CR201_G0003353RPS27A isoform 1. (155 aa)
UBE2IUbiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. (158 aa)
MEIOBMEIOB isoform 4. (441 aa)
ERCC4ERCC4 isoform 2. (916 aa)
NFATC2IPNuclear factor of activated T cells 2 interacting protein. (419 aa)
ENSPPYP00000008980annotation not available (158 aa)
CR201_G0021349KCTD2 isoform 7. (185 aa)
ENSPPYP00000009931annotation not available (76 aa)
ENSPPYP00000009997annotation not available (95 aa)
ENSPPYP00000010327annotation not available (526 aa)
RAD23ARAD23A isoform 1. (350 aa)
UBA52UBA52 isoform 10. (128 aa)
ERCC2ERCC2 isoform 1. (729 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (297 aa)
VWA5B1VWA5B1 isoform 1. (343 aa)
SUMO3Small ubiquitin-related modifier. (96 aa)
RBX1RBX1 isoform 1. (108 aa)
ERCC3General transcription and DNA repair factor IIH helicase subunit XPB; ATP-dependent 3'-5' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATPase activity of XPB/ERCC3, but not its helicase activity, is required fo [...] (782 aa)
SUMO1Small ubiquitin-related modifier 1; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post- translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for insta [...] (218 aa)
XPCXPC complex subunit, DNA damage recognition and repair factor. (943 aa)
PARP3Poly [ADP-ribose] polymerase. (531 aa)
ENSPPYP00000016046annotation not available (124 aa)
VWA5B2VWA5B2 isoform 1. (1000 aa)
CDK7CDK7 isoform 1; Belongs to the protein kinase superfamily. (346 aa)
LOC100456237General transcription factor IIH subunit. (395 aa)
CCNHCCNH isoform 4; Belongs to the cyclin family. (323 aa)
CETN3CETN3 isoform 1. (167 aa)
GTF2H4General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (462 aa)
USP45Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (815 aa)
GTF2H5General transcription factor IIH subunit 5. (71 aa)
RPA3Replication protein A3. (121 aa)
CR201_G0021362SUMO2 isoform 4. (95 aa)
UBE2V2Ubiquitin-conjugating enzyme E2 variant 2; Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly- ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage (By similarity); Belongs to the ubiquitin-c [...] (145 aa)
XPAXPA, DNA damage recognition and repair factor. (273 aa)
RAD23BRAD23 homolog B, nucleotide excision repair protein. (337 aa)
ENSPPYP00000022487annotation not available (153 aa)
CR201_G0021362-2SUMO2 isoform 2. (71 aa)
CUL4BCUL4B isoform 4; Belongs to the cullin family. (843 aa)
UBE2NLUbiquitin conjugating enzyme E2 N like (gene/pseudogene). (152 aa)
CETN2CETN2 isoform 1. (172 aa)
ENSPPYP00000023500annotation not available (140 aa)
ENSPPYP00000023562annotation not available (156 aa)
ERCC5ERCC5 isoform 1. (1131 aa)
SUMO2Small ubiquitin-related modifier. (95 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.