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PARP1 | Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (972 aa) | ||||
CR201_G0007169 | SUMO1 isoform 5. (143 aa) | ||||
PIAS3 | PIAS3 isoform 3. (619 aa) | ||||
CHD1L | CHD1L isoform 6. (900 aa) | ||||
VTCN1 | VTCN1 isoform 1. (191 aa) | ||||
TCEANC2 | TCEANC2 isoform 3. (280 aa) | ||||
PPIE | Peptidyl-prolyl cis-trans isomerase E; Involved in pre-mRNA splicing as component of the spliceosome. Combines RNA-binding and PPIase activities. Binds mRNA and has a preference for single-stranded RNA molecules with poly-A and poly-U stretches, suggesting it binds to the poly(A)-region in the 3'- UTR of mRNA molecules. Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins. Inhibits KMT2A activity; this requires proline isomerase activity. (301 aa) | ||||
SPOCD1 | SPOCD1 isoform 1. (1095 aa) | ||||
TCEA3 | TCEA3 isoform 1. (327 aa) | ||||
CR201_G0053435 | UBB isoform 1. (128 aa) | ||||
ERCC6 | ERCC6 isoform 1. (1484 aa) | ||||
ENSPPYP00000003182 | annotation not available (90 aa) | ||||
POLD4 | POLD4 isoform 5. (107 aa) | ||||
POLR2G | POLR2G isoform 1. (174 aa) | ||||
DDB1 | DNA damage-binding protein 1; Required for DNA repair. Binds to DDB2 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiqui [...] (1135 aa) | ||||
PRPF19 | PRPF19 isoform 1. (523 aa) | ||||
DDB2 | Damage specific DNA binding protein 2. (427 aa) | ||||
GTF2H1 | General transcription factor IIH subunit 1. (548 aa) | ||||
POLD3 | DNA polymerase delta 3, accessory subunit. (466 aa) | ||||
VWA5A | VWA5A isoform 1. (821 aa) | ||||
NFRKB | NFRKB isoform 10. (1311 aa) | ||||
COPS7A | COP9 signalosome complex subunit 7a; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF- type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-de [...] (275 aa) | ||||
RPAP3 | RPAP3 isoform 1. (613 aa) | ||||
MCRS1 | MCRS1 isoform 1. (463 aa) | ||||
UBE2N | Ubiquitin-conjugating enzyme E2 N; The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly- ubiquitination of [...] (152 aa) | ||||
RFC5 | Replication factor C subunit 5. (340 aa) | ||||
GTF2H3 | GTF2H3 isoform 1. (272 aa) | ||||
UBC | UBC isoform 2. (625 aa) | ||||
POLE | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2039 aa) | ||||
RFC3 | Replication factor C subunit 3. (356 aa) | ||||
RCBTB2 | RCC1 and BTB domain-containing protein 2. (551 aa) | ||||
RCBTB1 | RCC1 and BTB domain containing protein 1. (531 aa) | ||||
ENSPPYP00000006252 | annotation not available (477 aa) | ||||
CUL4A | CUL4A isoform 5; Belongs to the cullin family. (759 aa) | ||||
PARP2 | Poly [ADP-ribose] polymerase. (570 aa) | ||||
POLE2 | DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (372 aa) | ||||
MNAT1 | CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (288 aa) | ||||
NRDE2 | NRDE2 isoform 5. (948 aa) | ||||
AQR | RNA helicase aquarius; Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre- mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing. (1484 aa) | ||||
INO80 | INO80 isoform 1. (1526 aa) | ||||
WDR76 | WD repeat-containing protein 76; Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. Belongs to the WD repeat DDB2/WDR76 family. (627 aa) | ||||
COPS2 | COP9 signalosome subunit 2. (443 aa) | ||||
RNF111 | E3 ubiquitin-protein ligase Arkadia; E3 ubiquitin-protein ligase (By similarity). Required for mesoderm patterning during embryonic development (By similarity). Acts as an enhancer of the transcriptional responses of the SMAD2/SMAD3 effectors, which are activated downstream of BMP. Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD7, inducing their proteasomal degradation and thereby enhancing the transcriptional activity of TGF-beta and BMP (By similarity). In addition to enhance transcription of SMAD2/SMAD3 effectors, also regulates their turnover by med [...] (984 aa) | ||||
PIAS1 | PIAS1 isoform 1. (683 aa) | ||||
CR201_G0003353 | RPS27A isoform 1. (155 aa) | ||||
UBE2I | Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. (158 aa) | ||||
MEIOB | MEIOB isoform 4. (441 aa) | ||||
USP7 | USP7 isoform 8; Belongs to the peptidase C19 family. (1082 aa) | ||||
ERCC4 | ERCC4 isoform 2. (916 aa) | ||||
NFATC2IP | Nuclear factor of activated T cells 2 interacting protein. (419 aa) | ||||
INO80E | INO80E isoform 1. (163 aa) | ||||
POLR2C | RNA polymerase II subunit C. (275 aa) | ||||
POLR2A | DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1956 aa) | ||||
ENSPPYP00000008980 | annotation not available (158 aa) | ||||
COPS3 | COP9 signalosome complex subunit 3; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2 (By similarity). The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association [...] (423 aa) | ||||
ZNF830 | Zinc finger protein 830. (372 aa) | ||||
LIG3 | DNA ligase. (1009 aa) | ||||
CR201_G0021349 | KCTD2 isoform 7. (185 aa) | ||||
GPS1 | GPS1 isoform 6. (514 aa) | ||||
ENSPPYP00000009931 | annotation not available (76 aa) | ||||
ENSPPYP00000009997 | annotation not available (95 aa) | ||||
INO80C | INO80 complex subunit C. (192 aa) | ||||
ENSPPYP00000010315 | annotation not available (90 aa) | ||||
ENSPPYP00000010327 | annotation not available (526 aa) | ||||
POLR2E | DNA-directed RNA polymerases I, II, and III subunit RPABC1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2E/RPB5 is part of the [...] (211 aa) | ||||
XAB2 | XAB2 isoform 1. (795 aa) | ||||
RAD23A | RAD23A isoform 1. (350 aa) | ||||
UBA52 | UBA52 isoform 10. (128 aa) | ||||
POLR2I | DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (125 aa) | ||||
XRCC1 | DNA repair protein XRCC1. (633 aa) | ||||
ERCC2 | ERCC2 isoform 1. (729 aa) | ||||
ERCC1 | ERCC excision repair 1, endonuclease non-catalytic subunit. (297 aa) | ||||
LIG1 | DNA ligase. (919 aa) | ||||
POLD1 | DNA polymerase delta catalytic subunit. (1121 aa) | ||||
TFPT | TCF3 fusion partner. (253 aa) | ||||
VWA5B1 | VWA5B1 isoform 1. (343 aa) | ||||
PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa) | ||||
ACTR5 | Actin related protein 5; Belongs to the actin family. (607 aa) | ||||
TCEA2 | Transcription elongation factor A2. (299 aa) | ||||
HMGN1 | High mobility group nucleosome binding domain 1. (100 aa) | ||||
SUMO3 | Small ubiquitin-related modifier. (96 aa) | ||||
POLR2F | DNA-directed RNA polymerases I, II, and III subunit RPABC2; DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2F/RPB6 is part of the [...] (127 aa) | ||||
CR201_G0024728 | POLR2F isoform 12. (141 aa) | ||||
RBX1 | RBX1 isoform 1. (108 aa) | ||||
EP300 | EP300 isoform 1. (2380 aa) | ||||
POLE4 | DNA polymerase epsilon 4, accessory subunit. (117 aa) | ||||
WBP1 | WW domain binding protein 1. (264 aa) | ||||
POLR2D | RNA polymerase II subunit D. (142 aa) | ||||
ERCC3 | General transcription and DNA repair factor IIH helicase subunit XPB; ATP-dependent 3'-5' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATPase activity of XPB/ERCC3, but not its helicase activity, is required fo [...] (782 aa) | ||||
SUMO1 | Small ubiquitin-related modifier 1; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post- translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for insta [...] (218 aa) | ||||
CR201_G0007103 | INO80D isoform 2. (652 aa) | ||||
COPS7B | COPS7B isoform 14. (264 aa) | ||||
USP40 | USP40 isoform 5; Belongs to the peptidase C19 family. (1164 aa) | ||||
COPS8 | COP9 signalosome complex subunit 8; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF- type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN- [...] (209 aa) | ||||
XPC | XPC complex subunit, DNA damage recognition and repair factor. (943 aa) | ||||
ISY1 | ISY1 isoform 1. (285 aa) | ||||
RUVBL1 | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa) | ||||
ENSPPYP00000015360 | annotation not available (174 aa) | ||||
ACTR8 | Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize (By similarity); Belongs to the actin family. ARP8 subfamily. (618 aa) | ||||
PARP3 | Poly [ADP-ribose] polymerase. (531 aa) | ||||
ENSPPYP00000015798 | annotation not available (85 aa) | ||||
ACTL6A | ACTL6A isoform 2; Belongs to the actin family. (387 aa) | ||||
ENSPPYP00000016046 | annotation not available (124 aa) | ||||
VWA5B2 | VWA5B2 isoform 1. (1000 aa) | ||||
POLR2H | DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (150 aa) | ||||
RFC4 | Replication factor C subunit 4. (363 aa) | ||||
UVSSA | UVSSA isoform 4. (699 aa) | ||||
RFC1 | Replication factor C subunit 1. (1020 aa) | ||||
POLR2B | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1174 aa) | ||||
COPS4 | COP9 signalosome complex subunit 4; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2 (By similarity). Also involved in the deneddylation of non-cullin subunits such as STON2 (By similarity). The complex is also involved in phosphorylation of p53 [...] (406 aa) | ||||
ZFP42 | ZFP42 zinc finger protein. (311 aa) | ||||
ENSPPYP00000017061 | annotation not available (383 aa) | ||||
ERCC8 | ERCC excision repair 8, CSA ubiquitin ligase complex subunit. (396 aa) | ||||
CDK7 | CDK7 isoform 1; Belongs to the protein kinase superfamily. (346 aa) | ||||
LOC100456237 | General transcription factor IIH subunit. (395 aa) | ||||
POLK | POLK isoform 1. (892 aa) | ||||
CCNH | CCNH isoform 4; Belongs to the cyclin family. (323 aa) | ||||
CETN3 | CETN3 isoform 1. (167 aa) | ||||
GTF2H4 | General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (462 aa) | ||||
PHF3 | PHF3 isoform 4. (2013 aa) | ||||
USP45 | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (815 aa) | ||||
GTF2H5 | General transcription factor IIH subunit 5. (71 aa) | ||||
ACTB | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa) | ||||
COPS6 | COP9 signalosome complex subunit 6; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2 (By similarity). The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with [...] (327 aa) | ||||
RFC2 | RFC2 isoform 5. (306 aa) | ||||
POLD2 | DNA polymerase delta 2, accessory subunit. (504 aa) | ||||
RPA3 | Replication protein A3. (121 aa) | ||||
CR201_G0021362 | SUMO2 isoform 4. (95 aa) | ||||
UBE2V2 | Ubiquitin-conjugating enzyme E2 variant 2; Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly- ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage (By similarity); Belongs to the ubiquitin-c [...] (145 aa) | ||||
TCEA1 | Transcription elongation factor A1. (301 aa) | ||||
PPP1R42 | Protein phosphatase 1 regulatory subunit 42. (228 aa) | ||||
COPS5 | COP9 signalosome subunit 5. (334 aa) | ||||
POLR2K | RNA polymerase II subunit K. (58 aa) | ||||
XPA | XPA, DNA damage recognition and repair factor. (273 aa) | ||||
RAD23B | RAD23 homolog B, nucleotide excision repair protein. (337 aa) | ||||
POLE3 | DNA polymerase epsilon subunit 3; Accessory component of the DNA polymerase epsilon complex (By similarity). Participates in DNA repair and in chromosomal DNA replication (By similarity). Forms a complex with CHRAC1 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome-remodeling activity of ISWI/SNF2H and ACF1 (By similarity). (147 aa) | ||||
ENSPPYP00000022487 | annotation not available (153 aa) | ||||
TCEANC | Transcription elongation factor A N-terminal and central domain containing. (351 aa) | ||||
CR201_G0021362-2 | SUMO2 isoform 2. (71 aa) | ||||
CUL4B | CUL4B isoform 4; Belongs to the cullin family. (843 aa) | ||||
UBE2NL | Ubiquitin conjugating enzyme E2 N like (gene/pseudogene). (152 aa) | ||||
CETN2 | CETN2 isoform 1. (172 aa) | ||||
ENSPPYP00000023500 | annotation not available (140 aa) | ||||
ENSPPYP00000023562 | annotation not available (156 aa) | ||||
YY1 | YY1 isoform 1. (189 aa) | ||||
ERCC5 | ERCC5 isoform 1. (1131 aa) | ||||
SUMO2 | Small ubiquitin-related modifier. (95 aa) | ||||
POLR2L | POLR2L isoform 1. (67 aa) |