STRINGSTRING
RPA3 RPA3 CR201_G0021362 CR201_G0021362 UBE2V2 UBE2V2 COPS5 COPS5 ENSPPYP00000022487 ENSPPYP00000022487 POLE3 POLE3 RAD23B RAD23B UBE2I UBE2I MEIOB MEIOB ERCC4 ERCC4 NFATC2IP NFATC2IP INO80E INO80E ENSPPYP00000008980 ENSPPYP00000008980 COPS3 COPS3 LIG3 LIG3 CR201_G0021349 CR201_G0021349 GPS1 GPS1 ENSPPYP00000009931 ENSPPYP00000009931 ENSPPYP00000009997 ENSPPYP00000009997 INO80C INO80C COPS8 COPS8 COPS7B COPS7B CR201_G0007103 CR201_G0007103 SUMO1 SUMO1 ERCC3 ERCC3 WBP1 WBP1 POLE4 POLE4 RBX1 RBX1 SUMO3 SUMO3 ACTR5 ACTR5 PCNA PCNA LOC100456237 LOC100456237 CDK7 CDK7 ZFP42 ZFP42 XPA XPA COPS4 COPS4 RFC1 RFC1 RFC4 RFC4 POLD2 POLD2 PARP1 PARP1 CR201_G0007169 CR201_G0007169 PIAS3 PIAS3 CHD1L CHD1L VTCN1 VTCN1 CR201_G0053435 CR201_G0053435 POLD4 POLD4 RFC2 RFC2 COPS6 COPS6 ACTB ACTB GTF2H5 GTF2H5 DDB1 DDB1 DDB2 DDB2 GTF2H1 GTF2H1 VWA5B2 VWA5B2 ENSPPYP00000016046 ENSPPYP00000016046 ACTL6A ACTL6A PARP3 PARP3 ACTR8 ACTR8 ENSPPYP00000015360 ENSPPYP00000015360 RUVBL1 RUVBL1 XPC XPC USP45 USP45 GTF2H4 GTF2H4 CETN3 CETN3 CCNH CCNH POLK POLK SUMO2 SUMO2 ERCC5 ERCC5 YY1 YY1 ENSPPYP00000023562 ENSPPYP00000023562 ENSPPYP00000023500 ENSPPYP00000023500 CETN2 CETN2 UBE2NL UBE2NL CUL4B CUL4B CR201_G0021362-2 CR201_G0021362-2 POLD3 POLD3 VWA5A VWA5A NFRKB NFRKB COPS7A COPS7A RPAP3 RPAP3 MCRS1 MCRS1 UBE2N UBE2N RFC5 RFC5 GTF2H3 GTF2H3 UBC UBC POLE POLE VWA5B1 VWA5B1 TFPT TFPT POLD1 POLD1 LIG1 LIG1 ERCC1 ERCC1 ERCC2 ERCC2 XRCC1 XRCC1 UBA52 UBA52 RAD23A RAD23A ENSPPYP00000010327 ENSPPYP00000010327 RFC3 RFC3 RCBTB2 RCBTB2 RCBTB1 RCBTB1 ENSPPYP00000006252 ENSPPYP00000006252 CUL4A CUL4A PARP2 PARP2 POLE2 POLE2 MNAT1 MNAT1 INO80 INO80 WDR76 WDR76 COPS2 COPS2 RNF111 RNF111 PIAS1 PIAS1 CR201_G0003353 CR201_G0003353
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RPA3Replication protein A3. (121 aa)
CR201_G0021362SUMO2 isoform 4. (95 aa)
UBE2V2Ubiquitin-conjugating enzyme E2 variant 2; Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly- ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage (By similarity); Belongs to the ubiquitin-c [...] (145 aa)
COPS5COP9 signalosome subunit 5. (334 aa)
ENSPPYP00000022487annotation not available (153 aa)
POLE3DNA polymerase epsilon subunit 3; Accessory component of the DNA polymerase epsilon complex (By similarity). Participates in DNA repair and in chromosomal DNA replication (By similarity). Forms a complex with CHRAC1 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome-remodeling activity of ISWI/SNF2H and ACF1 (By similarity). (147 aa)
RAD23BRAD23 homolog B, nucleotide excision repair protein. (337 aa)
UBE2IUbiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. (158 aa)
MEIOBMEIOB isoform 4. (441 aa)
ERCC4ERCC4 isoform 2. (916 aa)
NFATC2IPNuclear factor of activated T cells 2 interacting protein. (419 aa)
INO80EINO80E isoform 1. (163 aa)
ENSPPYP00000008980annotation not available (158 aa)
COPS3COP9 signalosome complex subunit 3; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2 (By similarity). The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association [...] (423 aa)
LIG3DNA ligase. (1009 aa)
CR201_G0021349KCTD2 isoform 7. (185 aa)
GPS1GPS1 isoform 6. (514 aa)
ENSPPYP00000009931annotation not available (76 aa)
ENSPPYP00000009997annotation not available (95 aa)
INO80CINO80 complex subunit C. (192 aa)
COPS8COP9 signalosome complex subunit 8; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF- type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN- [...] (209 aa)
COPS7BCOPS7B isoform 14. (264 aa)
CR201_G0007103INO80D isoform 2. (652 aa)
SUMO1Small ubiquitin-related modifier 1; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post- translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for insta [...] (218 aa)
ERCC3General transcription and DNA repair factor IIH helicase subunit XPB; ATP-dependent 3'-5' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATPase activity of XPB/ERCC3, but not its helicase activity, is required fo [...] (782 aa)
WBP1WW domain binding protein 1. (264 aa)
POLE4DNA polymerase epsilon 4, accessory subunit. (117 aa)
RBX1RBX1 isoform 1. (108 aa)
SUMO3Small ubiquitin-related modifier. (96 aa)
ACTR5Actin related protein 5; Belongs to the actin family. (607 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
LOC100456237General transcription factor IIH subunit. (395 aa)
CDK7CDK7 isoform 1; Belongs to the protein kinase superfamily. (346 aa)
ZFP42ZFP42 zinc finger protein. (311 aa)
XPAXPA, DNA damage recognition and repair factor. (273 aa)
COPS4COP9 signalosome complex subunit 4; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2 (By similarity). Also involved in the deneddylation of non-cullin subunits such as STON2 (By similarity). The complex is also involved in phosphorylation of p53 [...] (406 aa)
RFC1Replication factor C subunit 1. (1020 aa)
RFC4Replication factor C subunit 4. (363 aa)
POLD2DNA polymerase delta 2, accessory subunit. (504 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (972 aa)
CR201_G0007169SUMO1 isoform 5. (143 aa)
PIAS3PIAS3 isoform 3. (619 aa)
CHD1LCHD1L isoform 6. (900 aa)
VTCN1VTCN1 isoform 1. (191 aa)
CR201_G0053435UBB isoform 1. (128 aa)
POLD4POLD4 isoform 5. (107 aa)
RFC2RFC2 isoform 5. (306 aa)
COPS6COP9 signalosome complex subunit 6; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2 (By similarity). The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with [...] (327 aa)
ACTBActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa)
GTF2H5General transcription factor IIH subunit 5. (71 aa)
DDB1DNA damage-binding protein 1; Required for DNA repair. Binds to DDB2 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiqui [...] (1135 aa)
DDB2Damage specific DNA binding protein 2. (427 aa)
GTF2H1General transcription factor IIH subunit 1. (548 aa)
VWA5B2VWA5B2 isoform 1. (1000 aa)
ENSPPYP00000016046annotation not available (124 aa)
ACTL6AACTL6A isoform 2; Belongs to the actin family. (387 aa)
PARP3Poly [ADP-ribose] polymerase. (531 aa)
ACTR8Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize (By similarity); Belongs to the actin family. ARP8 subfamily. (618 aa)
ENSPPYP00000015360annotation not available (174 aa)
RUVBL1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa)
XPCXPC complex subunit, DNA damage recognition and repair factor. (943 aa)
USP45Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (815 aa)
GTF2H4General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (462 aa)
CETN3CETN3 isoform 1. (167 aa)
CCNHCCNH isoform 4; Belongs to the cyclin family. (323 aa)
POLKPOLK isoform 1. (892 aa)
SUMO2Small ubiquitin-related modifier. (95 aa)
ERCC5ERCC5 isoform 1. (1131 aa)
YY1YY1 isoform 1. (189 aa)
ENSPPYP00000023562annotation not available (156 aa)
ENSPPYP00000023500annotation not available (140 aa)
CETN2CETN2 isoform 1. (172 aa)
UBE2NLUbiquitin conjugating enzyme E2 N like (gene/pseudogene). (152 aa)
CUL4BCUL4B isoform 4; Belongs to the cullin family. (843 aa)
CR201_G0021362-2SUMO2 isoform 2. (71 aa)
POLD3DNA polymerase delta 3, accessory subunit. (466 aa)
VWA5AVWA5A isoform 1. (821 aa)
NFRKBNFRKB isoform 10. (1311 aa)
COPS7ACOP9 signalosome complex subunit 7a; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF- type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-de [...] (275 aa)
RPAP3RPAP3 isoform 1. (613 aa)
MCRS1MCRS1 isoform 1. (463 aa)
UBE2NUbiquitin-conjugating enzyme E2 N; The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly- ubiquitination of [...] (152 aa)
RFC5Replication factor C subunit 5. (340 aa)
GTF2H3GTF2H3 isoform 1. (272 aa)
UBCUBC isoform 2. (625 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2039 aa)
VWA5B1VWA5B1 isoform 1. (343 aa)
TFPTTCF3 fusion partner. (253 aa)
POLD1DNA polymerase delta catalytic subunit. (1121 aa)
LIG1DNA ligase. (919 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (297 aa)
ERCC2ERCC2 isoform 1. (729 aa)
XRCC1DNA repair protein XRCC1. (633 aa)
UBA52UBA52 isoform 10. (128 aa)
RAD23ARAD23A isoform 1. (350 aa)
ENSPPYP00000010327annotation not available (526 aa)
RFC3Replication factor C subunit 3. (356 aa)
RCBTB2RCC1 and BTB domain-containing protein 2. (551 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (531 aa)
ENSPPYP00000006252annotation not available (477 aa)
CUL4ACUL4A isoform 5; Belongs to the cullin family. (759 aa)
PARP2Poly [ADP-ribose] polymerase. (570 aa)
POLE2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (372 aa)
MNAT1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (288 aa)
INO80INO80 isoform 1. (1526 aa)
WDR76WD repeat-containing protein 76; Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. Belongs to the WD repeat DDB2/WDR76 family. (627 aa)
COPS2COP9 signalosome subunit 2. (443 aa)
RNF111E3 ubiquitin-protein ligase Arkadia; E3 ubiquitin-protein ligase (By similarity). Required for mesoderm patterning during embryonic development (By similarity). Acts as an enhancer of the transcriptional responses of the SMAD2/SMAD3 effectors, which are activated downstream of BMP. Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD7, inducing their proteasomal degradation and thereby enhancing the transcriptional activity of TGF-beta and BMP (By similarity). In addition to enhance transcription of SMAD2/SMAD3 effectors, also regulates their turnover by med [...] (984 aa)
PIAS1PIAS1 isoform 1. (683 aa)
CR201_G0003353RPS27A isoform 1. (155 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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