STRINGSTRING
TCEANC2 TCEANC2 PPIE PPIE SPOCD1 SPOCD1 TCEA3 TCEA3 CR201_G0053435 CR201_G0053435 ERCC6 ERCC6 ENSPPYP00000003182 ENSPPYP00000003182 POLD4 POLD4 POLR2G POLR2G DDB1 DDB1 PRPF19 PRPF19 GTF2H1 GTF2H1 POLD3 POLD3 RFC5 RFC5 GTF2H3 GTF2H3 UBC UBC POLE POLE RFC3 RFC3 RCBTB2 RCBTB2 RCBTB1 RCBTB1 CUL4A CUL4A POLE2 POLE2 MNAT1 MNAT1 NRDE2 NRDE2 AQR AQR CR201_G0003353 CR201_G0003353 MEIOB MEIOB USP7 USP7 POLR2C POLR2C POLR2A POLR2A ENSPPYP00000008980 ENSPPYP00000008980 ZNF830 ZNF830 LIG3 LIG3 ENSPPYP00000009931 ENSPPYP00000009931 ENSPPYP00000010315 ENSPPYP00000010315 ENSPPYP00000010327 ENSPPYP00000010327 POLR2E POLR2E XAB2 XAB2 UBA52 UBA52 POLR2I POLR2I XRCC1 XRCC1 ERCC2 ERCC2 LIG1 LIG1 POLD1 POLD1 PCNA PCNA TCEA2 TCEA2 HMGN1 HMGN1 POLR2F POLR2F CR201_G0024728 CR201_G0024728 RBX1 RBX1 EP300 EP300 POLE4 POLE4 POLR2D POLR2D ERCC3 ERCC3 USP40 USP40 ISY1 ISY1 ENSPPYP00000015798 ENSPPYP00000015798 POLR2H POLR2H RFC4 RFC4 UVSSA UVSSA RFC1 RFC1 POLR2B POLR2B ENSPPYP00000017061 ENSPPYP00000017061 ERCC8 ERCC8 CDK7 CDK7 LOC100456237 LOC100456237 POLK POLK CCNH CCNH GTF2H4 GTF2H4 PHF3 PHF3 GTF2H5 GTF2H5 RFC2 RFC2 POLD2 POLD2 RPA3 RPA3 TCEA1 TCEA1 POLR2K POLR2K POLE3 POLE3 ENSPPYP00000022487 ENSPPYP00000022487 TCEANC TCEANC CUL4B CUL4B ENSPPYP00000023500 ENSPPYP00000023500 ENSPPYP00000023562 ENSPPYP00000023562 POLR2L POLR2L
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TCEANC2TCEANC2 isoform 3. (280 aa)
PPIEPeptidyl-prolyl cis-trans isomerase E; Involved in pre-mRNA splicing as component of the spliceosome. Combines RNA-binding and PPIase activities. Binds mRNA and has a preference for single-stranded RNA molecules with poly-A and poly-U stretches, suggesting it binds to the poly(A)-region in the 3'- UTR of mRNA molecules. Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins. Inhibits KMT2A activity; this requires proline isomerase activity. (301 aa)
SPOCD1SPOCD1 isoform 1. (1095 aa)
TCEA3TCEA3 isoform 1. (327 aa)
CR201_G0053435UBB isoform 1. (128 aa)
ERCC6ERCC6 isoform 1. (1484 aa)
ENSPPYP00000003182annotation not available (90 aa)
POLD4POLD4 isoform 5. (107 aa)
POLR2GPOLR2G isoform 1. (174 aa)
DDB1DNA damage-binding protein 1; Required for DNA repair. Binds to DDB2 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiqui [...] (1135 aa)
PRPF19PRPF19 isoform 1. (523 aa)
GTF2H1General transcription factor IIH subunit 1. (548 aa)
POLD3DNA polymerase delta 3, accessory subunit. (466 aa)
RFC5Replication factor C subunit 5. (340 aa)
GTF2H3GTF2H3 isoform 1. (272 aa)
UBCUBC isoform 2. (625 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2039 aa)
RFC3Replication factor C subunit 3. (356 aa)
RCBTB2RCC1 and BTB domain-containing protein 2. (551 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (531 aa)
CUL4ACUL4A isoform 5; Belongs to the cullin family. (759 aa)
POLE2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (372 aa)
MNAT1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (288 aa)
NRDE2NRDE2 isoform 5. (948 aa)
AQRRNA helicase aquarius; Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre- mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing. (1484 aa)
CR201_G0003353RPS27A isoform 1. (155 aa)
MEIOBMEIOB isoform 4. (441 aa)
USP7USP7 isoform 8; Belongs to the peptidase C19 family. (1082 aa)
POLR2CRNA polymerase II subunit C. (275 aa)
POLR2ADNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1956 aa)
ENSPPYP00000008980annotation not available (158 aa)
ZNF830Zinc finger protein 830. (372 aa)
LIG3DNA ligase. (1009 aa)
ENSPPYP00000009931annotation not available (76 aa)
ENSPPYP00000010315annotation not available (90 aa)
ENSPPYP00000010327annotation not available (526 aa)
POLR2EDNA-directed RNA polymerases I, II, and III subunit RPABC1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2E/RPB5 is part of the [...] (211 aa)
XAB2XAB2 isoform 1. (795 aa)
UBA52UBA52 isoform 10. (128 aa)
POLR2IDNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (125 aa)
XRCC1DNA repair protein XRCC1. (633 aa)
ERCC2ERCC2 isoform 1. (729 aa)
LIG1DNA ligase. (919 aa)
POLD1DNA polymerase delta catalytic subunit. (1121 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
TCEA2Transcription elongation factor A2. (299 aa)
HMGN1High mobility group nucleosome binding domain 1. (100 aa)
POLR2FDNA-directed RNA polymerases I, II, and III subunit RPABC2; DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2F/RPB6 is part of the [...] (127 aa)
CR201_G0024728POLR2F isoform 12. (141 aa)
RBX1RBX1 isoform 1. (108 aa)
EP300EP300 isoform 1. (2380 aa)
POLE4DNA polymerase epsilon 4, accessory subunit. (117 aa)
POLR2DRNA polymerase II subunit D. (142 aa)
ERCC3General transcription and DNA repair factor IIH helicase subunit XPB; ATP-dependent 3'-5' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATPase activity of XPB/ERCC3, but not its helicase activity, is required fo [...] (782 aa)
USP40USP40 isoform 5; Belongs to the peptidase C19 family. (1164 aa)
ISY1ISY1 isoform 1. (285 aa)
ENSPPYP00000015798annotation not available (85 aa)
POLR2HDNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (150 aa)
RFC4Replication factor C subunit 4. (363 aa)
UVSSAUVSSA isoform 4. (699 aa)
RFC1Replication factor C subunit 1. (1020 aa)
POLR2BDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1174 aa)
ENSPPYP00000017061annotation not available (383 aa)
ERCC8ERCC excision repair 8, CSA ubiquitin ligase complex subunit. (396 aa)
CDK7CDK7 isoform 1; Belongs to the protein kinase superfamily. (346 aa)
LOC100456237General transcription factor IIH subunit. (395 aa)
POLKPOLK isoform 1. (892 aa)
CCNHCCNH isoform 4; Belongs to the cyclin family. (323 aa)
GTF2H4General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (462 aa)
PHF3PHF3 isoform 4. (2013 aa)
GTF2H5General transcription factor IIH subunit 5. (71 aa)
RFC2RFC2 isoform 5. (306 aa)
POLD2DNA polymerase delta 2, accessory subunit. (504 aa)
RPA3Replication protein A3. (121 aa)
TCEA1Transcription elongation factor A1. (301 aa)
POLR2KRNA polymerase II subunit K. (58 aa)
POLE3DNA polymerase epsilon subunit 3; Accessory component of the DNA polymerase epsilon complex (By similarity). Participates in DNA repair and in chromosomal DNA replication (By similarity). Forms a complex with CHRAC1 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome-remodeling activity of ISWI/SNF2H and ACF1 (By similarity). (147 aa)
ENSPPYP00000022487annotation not available (153 aa)
TCEANCTranscription elongation factor A N-terminal and central domain containing. (351 aa)
CUL4BCUL4B isoform 4; Belongs to the cullin family. (843 aa)
ENSPPYP00000023500annotation not available (140 aa)
ENSPPYP00000023562annotation not available (156 aa)
POLR2LPOLR2L isoform 1. (67 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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