STRINGSTRING
MAN1A2 MAN1A2 SMIM10L2A SMIM10L2A ENSPPYP00000023221 ENSPPYP00000023221 BET1L BET1L RIC1 RIC1 RGP1 RGP1 COG5 COG5 YKT6 YKT6 CYTH3 CYTH3 MAN1A1 MAN1A1 MAN2A1 MAN2A1 FBXO8 FBXO8 RAB33B RAB33B GOLIM4 GOLIM4 SNAP29 SNAP29 CYTH4 CYTH4 RAB36 RAB36 STX16 STX16 NAPB NAPB CYTH2 CYTH2 NAPA NAPA SMIM7 SMIM7 NAPG NAPG CYTH1 CYTH1 COG1 COG1 NSF NSF GOSR2 GOSR2 GOSR1 GOSR1 COG4 COG4 COG8 COG8 COG7 COG7 MAN2A2 MAN2A2 GOLGA5 GOLGA5 TRIP11 TRIP11 VIPAS39 VIPAS39 COG3 COG3 COG6 COG6 RAB39A RAB39A RAB30 RAB30 STX5 STX5 VTI1A VTI1A MAN1C1 MAN1C1 VPS45 VPS45 STX6 STX6 ARF1 ARF1 COG2 COG2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAN1A2alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (641 aa)
SMIM10L2ASmall integral membrane protein 10 like 2A. (78 aa)
ENSPPYP00000023221annotation not available (52 aa)
BET1LBET1-like protein; Vesicle SNARE required for targeting and fusion of retrograde transport vesicles with the Golgi complex. Required for the integrity of the Golgi complex (By similarity). (111 aa)
RIC1RIC1 isoform 3. (1344 aa)
RGP1RGP1 homolog, RAB6A GEF complex partner 1. (391 aa)
COG5COG5 isoform 5. (859 aa)
YKT6YKT6 v-SNARE homolog; Belongs to the synaptobrevin family. (198 aa)
CYTH3CYTH3 isoform 1. (399 aa)
MAN1A1alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (813 aa)
MAN2A1Alpha-mannosidase. (1144 aa)
FBXO8F-box protein 8. (319 aa)
RAB33BRas-related protein Rab-33B; Protein transport. Acts, in coordination with RAB6A, to regulate intra-Golgi retrograde trafficking (By similarity). It is involved in autophagy, acting as a modulator of autophagosome formation (By similarity); Belongs to the small GTPase superfamily. Rab family. (229 aa)
GOLIM4GOLIM4 isoform 3. (638 aa)
SNAP29Synaptosomal-associated protein 29; SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. SNAP29 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane. Plays also a role in ciliogenesis by regulating membrane fusions. (258 aa)
CYTH4CYTH4 isoform 2. (394 aa)
RAB36RAB36, member RAS oncogene family. (333 aa)
STX16STX16-NPEPL1 isoform 1; Belongs to the syntaxin family. (308 aa)
NAPBNAPB isoform 4. (298 aa)
CYTH2T0102787 isoform 1. (399 aa)
NAPANAPA isoform 1. (276 aa)
SMIM7T0132324 isoform 5. (75 aa)
NAPGNAPG isoform 3. (312 aa)
CYTH1CYTH1 isoform 4. (399 aa)
COG1COG1 isoform 2. (980 aa)
NSFVesicle-fusing ATPase; Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin. Interaction with AMPAR subunit GRIA2 leads to influence GRIA2 membrane cycling (By similarity); Belongs to the AAA ATPase family. (816 aa)
GOSR2T0082108 isoform 1; Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network. (212 aa)
GOSR1Golgi SNAP receptor complex member 1; Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an import [...] (248 aa)
COG4Conserved oligomeric Golgi complex subunit 4; Required for normal Golgi function. Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with SCFD1. (785 aa)
COG8Conserved oligomeric Golgi complex subunit 8. (559 aa)
COG7COG7 isoform 1. (771 aa)
MAN2A2Alpha-mannosidase. (1081 aa)
GOLGA5GOLGA5 isoform 1. (731 aa)
TRIP11TRIP11 isoform 2. (1979 aa)
VIPAS39VIPAS39 isoform 6. (433 aa)
COG3COG3 isoform 1. (742 aa)
COG6Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function. (657 aa)
RAB39ARAB39A, member RAS oncogene family. (217 aa)
RAB30RAB30, member RAS oncogene family. (203 aa)
STX5STX5 isoform 1; Belongs to the syntaxin family. (355 aa)
VTI1AVesicle transport through interaction with t-SNAREs 1A. (217 aa)
MAN1C1alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (630 aa)
VPS45Vacuolar protein sorting 45 homolog; Belongs to the STXBP/unc-18/SEC1 family. (570 aa)
STX6Syntaxin-6; Involved in intracellular vesicle trafficking. (255 aa)
ARF1ADP ribosylation factor 1; Belongs to the small GTPase superfamily. Arf family. (181 aa)
COG2COG2 isoform 1. (738 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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