STRINGSTRING
FGD3 FGD3 WDR31 WDR31 TRAF1 TRAF1 CR201_G0027422 CR201_G0027422 TRAF2 TRAF2 RACK1 RACK1 ENSPPYP00000022487 ENSPPYP00000022487 TAB3 TAB3 MAGED1 MAGED1 FGD1 FGD1 ARHGEF9 ARHGEF9 BEX3 BEX3 XIAP XIAP ARHGEF6 ARHGEF6 MCF2 MCF2 IRAK1 IRAK1 IKBKG IKBKG OTUD1 OTUD1 ENSPPYP00000023500 ENSPPYP00000023500 ENSPPYP00000023562 ENSPPYP00000023562 ARHGEF11 ARHGEF11 CR201_G0023353 CR201_G0023353 ENSPPYP00000024179 ENSPPYP00000024179 CR201_G0044109-2 CR201_G0044109-2 ARHGEF40 ARHGEF40 UBE2D1 UBE2D1 FAS FAS CHUK CHUK FADD FADD RELA RELA BAD BAD MADD MADD TRAF6 TRAF6 BIRC2 BIRC2 USP2 USP2 ARHGEF12 ARHGEF12 TNFRSF1A TNFRSF1A FGD4 FGD4 TBK1 TBK1 PRDM4 PRDM4 UBC UBC ULK1 ULK1 UBE2L5 UBE2L5 ARHGEF7 ARHGEF7 MCF2L MCF2L CR201_G0032908 CR201_G0032908 RNF31 RNF31 NFATC4 NFATC4 NFKBIA NFKBIA SOS2 SOS2 PSEN1 PSEN1 SPPL2A SPPL2A APH1B APH1B AKAP13 AKAP13 CR201_G0003353 CR201_G0003353 STUB1 STUB1 CYLD CYLD CR201_G0015089 CR201_G0015089 MAPK8 MAPK8 SMPD3 SMPD3 ABR ABR YWHAE YWHAE ARHGEF15 ARHGEF15 ENSPPYP00000008980 ENSPPYP00000008980 OMG OMG AATF AATF SPPL2C SPPL2C GNA13 GNA13 ULK2 ULK2 ENSPPYP00000009931 ENSPPYP00000009931 NGFR NGFR SPPL2B SPPL2B VAV1 VAV1 ENSPPYP00000010620 ENSPPYP00000010620 CR201_G0051707 CR201_G0051707 UBA52 UBA52 ARHGEF37 ARHGEF37 HDAC3 HDAC3 UBE2D2 UBE2D2 RASGRF2 RASGRF2 NAIP NAIP OTULIN OTULIN OTULINL OTULINL TRIO TRIO CASP3 CASP3 ARHGEF38 ARHGEF38 UBE2D3 UBE2D3 NFKB1 NFKB1 MAPK10 MAPK10 MCF2L2 MCF2L2 ECT2 ECT2 TNFSF10 TNFSF10 PRKCI PRKCI ARHGEF26 ARHGEF26 MYD88 MYD88 USP4 USP4 RHOA RHOA ARHGEF3 ARHGEF3 KALRN KALRN NGEF NGEF TMEM198 TMEM198 SOS1 SOS1 ARHGEF33 ARHGEF33 CLIP4 CLIP4 ADAM17 ADAM17 ARHGEF4 ARHGEF4 MAG MAG MAP3K20 MAP3K20 SESTD1 SESTD1 CFLAR CFLAR CASP10 CASP10 CASP8 CASP8 CLIP3 CLIP3 PLEKHG2 PLEKHG2 CR201_G0044078 CR201_G0044078 TGM6 TGM6 TGM3 TGM3 RBCK1 RBCK1 PREX1 PREX1 SPATA2 SPATA2 BIRC7 BIRC7 TIAM1 TIAM1 ITSN1 ITSN1 RTN4R RTN4R UBE2L3 UBE2L3 SYNGR1 SYNGR1 BCL2L11 BCL2L11 RTN4 RTN4 OBSCN OBSCN PSEN2 PSEN2 MAPKAPK2 MAPKAPK2 IKBKE IKBKE FASLG FASLG USP21 USP21 NCSTN NCSTN ARHGEF2 ARHGEF2 APH1A APH1A OTUD7B OTUD7B NGF NGF VAV3 VAV3 ITGB3BP ITGB3BP HDAC1 HDAC1 ARHGEF10L ARHGEF10L ARHGEF19 ARHGEF19 CR201_G0053435 CR201_G0053435 PLEKHG5 PLEKHG5 ARHGEF16 ARHGEF16 CR201_G0053298 CR201_G0053298 NET1 NET1 CR201_G0044109 CR201_G0044109 OPTN OPTN LINGO2 LINGO2 ARHGEF39 ARHGEF39 SHARPIN SHARPIN RIPK2 RIPK2 NSMAF NSMAF IKBKB IKBKB BAG4 BAG4 TNFRSF10A TNFRSF10A TNFRSF10D TNFRSF10D TNFRSF10B TNFRSF10B ARHGEF10 ARHGEF10 ARHGEF5 ARHGEF5 CASP2 CASP2 CR201_G0036702 CR201_G0036702 ENSPPYP00000020022 ENSPPYP00000020022 TAX1BP1 TAX1BP1 ENSPPYP00000019656 ENSPPYP00000019656 RAC1 RAC1 TIAM2 TIAM2 TAB2 TAB2 ECT2L ECT2L TNFAIP3 TNFAIP3 HDAC2 HDAC2 SMPD2 SMPD2 MAP3K7 MAP3K7 FGD2 FGD2 TNF TNF RIPK1 RIPK1 SQSTM1 SQSTM1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FGD3FYVE, RhoGEF and PH domain-containing protein 3; Promotes the formation of filopodia. May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape (By similarity). (737 aa)
WDR31WDR31 isoform 2. (345 aa)
TRAF1TNF receptor-associated factor. (416 aa)
CR201_G0027422VAV2 isoform 3. (772 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa)
RACK1RACK1 isoform 13. (372 aa)
ENSPPYP00000022487annotation not available (153 aa)
TAB3TAB3 isoform 2. (670 aa)
MAGED1MAGE family member D1. (778 aa)
FGD1FGD1 isoform 1. (961 aa)
ARHGEF9Rho guanine nucleotide exchange factor 9; Acts as guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters (By similarity). (523 aa)
BEX3Brain expressed X-linked 3. (101 aa)
XIAPXIAP isoform 2. (513 aa)
ARHGEF6Rac/Cdc42 guanine nucleotide exchange factor 6. (776 aa)
MCF2MCF2 isoform 9. (941 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (682 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (487 aa)
OTUD1OTUD1 isoform 1. (171 aa)
ENSPPYP00000023500annotation not available (140 aa)
ENSPPYP00000023562annotation not available (156 aa)
ARHGEF11ARHGEF11 isoform 1. (1578 aa)
CR201_G0023353ARHGEF17 isoform 1. (1097 aa)
ENSPPYP0000002417914-3-3 protein epsilon-like isoform X1. (173 aa)
CR201_G0044109-2RACK1 isoform 22. (230 aa)
ARHGEF40ARHGEF40 isoform 4. (322 aa)
UBE2D1Ubiquitin conjugating enzyme E2 D1; Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
FASFAS isoform 1. (336 aa)
CHUKCHUK isoform 1. (746 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
BADBCL2 associated agonist of cell death. (168 aa)
MADDMADD isoform 6. (1579 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (604 aa)
BIRC2Baculoviral IAP repeat containing 2. (597 aa)
USP2Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (564 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12. (1544 aa)
TNFRSF1ATNFRSF1A isoform 2. (454 aa)
FGD4FYVE, RhoGEF and PH domain containing 4. (766 aa)
TBK1TANK binding kinase 1. (729 aa)
PRDM4PR domain zinc finger protein 4; May function as a transcription factor involved in cell differentiation; Belongs to the class V-like SAM-binding methyltransferase superfamily. (801 aa)
UBCUBC isoform 2. (625 aa)
ULK1Serine/threonine-protein kinase; Serine/threonine-protein kinase involved in autophagy in response to starvation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. (924 aa)
UBE2L5Ubiquitin conjugating enzyme E2 L5; Belongs to the ubiquitin-conjugating enzyme family. (154 aa)
ARHGEF7ARHGEF7 isoform 7. (803 aa)
MCF2LMCF2L isoform 10. (1211 aa)
CR201_G0032908ARHGEF40 isoform 1. (757 aa)
RNF31T0114761 isoform 1. (1053 aa)
NFATC4NFATC4 isoform 21. (868 aa)
NFKBIANFKBIA isoform 1. (317 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa)
PSEN1Presenilin-1 CTF subunit; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. Stimulates cell-cell adhesion via its interaction with CDH1; this stabili [...] (463 aa)
SPPL2ASignal peptide peptidase like 2A. (520 aa)
APH1BGamma-secretase subunit APH-1B; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (amyloid-beta precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Probably present in a minority of gamma-secretase complexes compared to APH1A (By similarity). (257 aa)
AKAP13AKAP13 isoform 5. (2833 aa)
CR201_G0003353RPS27A isoform 1. (155 aa)
STUB1STIP1 homology and U-box containing protein 1. (303 aa)
CYLDUbiquitin carboxyl-terminal hydrolase CYLD; Deubiquitinase that specifically cleaves 'Lys-63'- and linear 'Met-1'-linked polyubiquitin chains and is involved in NF-kappa-B activation and TNF-alpha-induced necroptosis. Plays an important role in the regulation of pathways leading to NF-kappa-B activation. Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation. Negative regulator of Wnt signaling. Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules. Plays a role in the regul [...] (956 aa)
CR201_G0015089TRADD isoform 2. (234 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
SMPD3SMPD3 isoform 1. (629 aa)
ABRABR isoform 1. (818 aa)
YWHAETyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (255 aa)
ARHGEF15ARHGEF15 isoform 1. (839 aa)
ENSPPYP00000008980annotation not available (158 aa)
OMGOMG isoform 2. (440 aa)
AATFAATF isoform 2. (560 aa)
SPPL2CSPPL2C isoform 1. (682 aa)
GNA13G protein subunit alpha 13. (377 aa)
ULK2Serine/threonine-protein kinase; Serine/threonine-protein kinase involved in autophagy in response to starvation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. (1028 aa)
ENSPPYP00000009931annotation not available (76 aa)
NGFRNGFR isoform 1. (407 aa)
SPPL2BSignal peptide peptidase like 2B. (542 aa)
VAV1VAV1 isoform 2. (829 aa)
ENSPPYP00000010620Uncharacterized protein LOC103893029. (358 aa)
CR201_G0051707T0183294 isoform 1. (932 aa)
UBA52UBA52 isoform 10. (128 aa)
ARHGEF37ARHGEF37 isoform 2. (685 aa)
HDAC3Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys-27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activi [...] (428 aa)
UBE2D2Ubiquitin conjugating enzyme E2 D2; Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
RASGRF2RASGRF2 isoform 1. (1227 aa)
NAIPNAIP isoform 3. (1403 aa)
OTULINOTU deubiquitinase with linear linkage specificity. (352 aa)
OTULINLFAM105A isoform 1. (360 aa)
TRIOTRIO isoform 3. (3011 aa)
CASP3CASP3 isoform 1; Belongs to the peptidase C14A family. (277 aa)
ARHGEF38ARHGEF38 isoform 4. (219 aa)
UBE2D3Ubiquitin-conjugating enzyme E2 D3; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'-linked polyubiquitination. Cooperates with the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains from the UBE2D3-primed [...] (149 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
MAPK10Mitogen-activated protein kinase. (384 aa)
MCF2L2MCF2L2 isoform 1. (1114 aa)
ECT2ECT2 isoform 4. (913 aa)
TNFSF10Tumor necrosis factor ligand superfamily member. (290 aa)
PRKCIProtein kinase C iota type; Calcium- and diacylglycerol-independent serine/ threonine- protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis. In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell death process [...] (690 aa)
ARHGEF26ARHGEF26 isoform 4. (870 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa)
USP4Ubiquitin carboxyl-terminal hydrolase 4; Deubiquitinating enzyme that removes conjugated ubiquitin from target proteins. Deubiquitinates PDPK1. Deubiquitinates TRIM21. Deubiquitinates receptor ADORA2A which increases the amount of functional receptor at the cell surface. May regulate mRNA splicing through deubiquitination of the U4 spliceosomal protein PRPF3. This may prevent its recognition by the U5 component PRPF8 thereby destabilizing interactions within the U4/U6.U5 snRNP. May also play a role in the regulation of quality control in the ER. (735 aa)
RHOATransforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essent [...] (196 aa)
ARHGEF3Rho guanine nucleotide exchange factor 3; Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases. (526 aa)
KALRNKALRN isoform 1. (2858 aa)
NGEFEphexin-1; Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity). (708 aa)
TMEM198Transmembrane protein 198. (360 aa)
SOS1SOS1 isoform 2. (1290 aa)
ARHGEF33ARHGEF33 isoform 1. (720 aa)
CLIP4CLIP4 isoform 4. (659 aa)
ADAM17ADAM17 isoform 1. (725 aa)
ARHGEF4ARHGEF4 isoform 1. (1000 aa)
MAGMAG isoform 1. (627 aa)
MAP3K20MAP3K20 isoform 1. (457 aa)
SESTD1SESTD1 isoform 1. (661 aa)
CFLARCASP8 and FADD-like apoptosis regulator subunit p12; Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity (By similarity). Belongs to [...] (480 aa)
CASP10CASP10 isoform 3; Belongs to the peptidase C14A family. (521 aa)
CASP8CASP8 isoform 1; Belongs to the peptidase C14A family. (496 aa)
CLIP3CAP-Gly domain-containing linker protein 3; Functions as a cytoplasmic linker protein. Involved in TGN- endosome dynamics. May modulate the cellular compartmentalization of AKT kinase family and promote its cell membrane localization, thereby playing a role in glucose transport in adipocytes (By similarity). (547 aa)
PLEKHG2PLEKHG2 isoform 5. (577 aa)
CR201_G0044078ARHGEF1 isoform 7. (764 aa)
TGM6Transglutaminase 6. (706 aa)
TGM3TGM3 isoform 1. (693 aa)
RBCK1RBCK1 isoform 5. (509 aa)
PREX1PREX1 isoform 2. (1457 aa)
SPATA2SPATA2 isoform 1. (520 aa)
BIRC7Baculoviral IAP repeat containing 7. (280 aa)
TIAM1TIAM1 isoform 1. (1591 aa)
ITSN1ITSN1 isoform 4. (1610 aa)
RTN4RRTN4R isoform 1. (535 aa)
UBE2L3Ubiquitin-conjugating enzyme E2 L3; Ubiquitin-conjugating enzyme E2 that specifically acts with HECT-type and RBR family E3 ubiquitin-protein ligases. Does not function with most RING-containing E3 ubiquitin-protein ligases because it lacks intrinsic E3-independent reactivity with lysine: in contrast, it has activity with the RBR family E3 enzymes, such as PRKN and ARIH1, that function like function like RING-HECT hybrids. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-linked polyubiquitination. Involved in the [...] (154 aa)
SYNGR1Synaptogyrin-1; May play a role in regulated exocytosis. Modulates the localization of synaptophysin/SYP into synaptic-like microvesicles and may therefore play a role in synaptic-like microvesicle formation and/or maturation (By similarity). Involved in the regulation of short- term and long-term synaptic plasticity (By similarity). Belongs to the synaptogyrin family. (654 aa)
BCL2L11BCL2L11 isoform 4. (138 aa)
RTN4Reticulon. (1192 aa)
OBSCNOBSCN isoform 2. (7677 aa)
PSEN2Presenilin-2 CTF subunit; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the other members of the gamma- secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. The holoprotein functions as a calcium-leak channel that allows the passive movement o [...] (448 aa)
MAPKAPK2MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (401 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (716 aa)
FASLGFASLG isoform 1; Belongs to the tumor necrosis factor family. (280 aa)
USP21Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (565 aa)
NCSTNNCSTN isoform 1. (639 aa)
ARHGEF2Rho/Rac guanine nucleotide exchange factor 2. (986 aa)
APH1AAph-1 homolog A, gamma-secretase subunit. (265 aa)
OTUD7BOTU deubiquitinase 7B. (843 aa)
NGFNGF isoform 1; Belongs to the NGF-beta family. (294 aa)
VAV3VAV3 isoform 1. (824 aa)
ITGB3BPCentromere protein R; Transcription coregulator that can have both coactivator and corepressor functions. (177 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium st [...] (482 aa)
ARHGEF10LRho guanine nucleotide exchange factor 10-like protein; Acts as guanine nucleotide exchange factor (GEF) for RHOA, RHOB and RHOC. (1034 aa)
ARHGEF19ARHGEF19 isoform 2. (701 aa)
CR201_G0053435UBB isoform 1. (128 aa)
PLEKHG5PLEKHG5 isoform 5. (905 aa)
ARHGEF16ARHGEF16 isoform 1. (683 aa)
CR201_G0053298MIB2 isoform 16. (744 aa)
NET1NET1 isoform 1. (596 aa)
CR201_G0044109RACK1 isoform 5. (346 aa)
OPTNOptineurin; Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex th [...] (532 aa)
LINGO2Leucine rich repeat and Ig domain containing 2. (606 aa)
ARHGEF39ARHGEF39 isoform 2. (335 aa)
SHARPINSHARPIN isoform 2. (410 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa)
NSMAFNSMAF isoform 1. (901 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (697 aa)
BAG4BAG4 isoform 1. (542 aa)
TNFRSF10ATNFRSF10A isoform 1. (468 aa)
TNFRSF10DUncharacterized protein. (388 aa)
TNFRSF10BTNFRSF10B isoform 3. (410 aa)
ARHGEF10CLN8 isoform 7. (1541 aa)
ARHGEF5ARHGEF35 isoform 1. (1585 aa)
CASP2CASP2 isoform 1; Belongs to the peptidase C14A family. (452 aa)
CR201_G0036702CCDC71L isoform 2. (316 aa)
ENSPPYP00000020022annotation not available (99 aa)
TAX1BP1Tax1-binding protein 1 homolog; Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti- apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade (By similarity). (771 aa)
ENSPPYP00000019656annotation not available (239 aa)
RAC1Rac family small GTPase 1. (211 aa)
TIAM2TIAM2 isoform 10. (1675 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
ECT2LEpithelial cell transforming 2 like. (904 aa)
TNFAIP3TNFAIP3 isoform 1. (790 aa)
HDAC2Histone deacetylase 2. (580 aa)
SMPD2SMPD2 isoform 1. (577 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as a [...] (606 aa)
FGD2FGD2 isoform 2. (655 aa)
TNFTumor necrosis factor ligand 1F; Belongs to the tumor necrosis factor family. (233 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (671 aa)
SQSTM1Sequestosome-1; Autophagy receptor required for selective macroautophagy (aggrephagy). Functions as a bridge between polyubiquitinated cargo and autophagosomes. Interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. Required both for the formation and autophagic degradation of polyubiquitin- containing bodies, called ALIS (aggresome-like induced structures) and links ALIS to the autophagic machinery. Involved in midbody ring degradation (By similarity). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and [...] (436 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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