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FGD3 | FYVE, RhoGEF and PH domain-containing protein 3; Promotes the formation of filopodia. May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape (By similarity). (737 aa) | ||||
WDR31 | WDR31 isoform 2. (345 aa) | ||||
TRAF1 | TNF receptor-associated factor. (416 aa) | ||||
CR201_G0027422 | VAV2 isoform 3. (772 aa) | ||||
TRAF2 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa) | ||||
RACK1 | RACK1 isoform 13. (372 aa) | ||||
ENSPPYP00000022487 | annotation not available (153 aa) | ||||
TAB3 | TAB3 isoform 2. (670 aa) | ||||
MAGED1 | MAGE family member D1. (778 aa) | ||||
FGD1 | FGD1 isoform 1. (961 aa) | ||||
ARHGEF9 | Rho guanine nucleotide exchange factor 9; Acts as guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters (By similarity). (523 aa) | ||||
BEX3 | Brain expressed X-linked 3. (101 aa) | ||||
XIAP | XIAP isoform 2. (513 aa) | ||||
ARHGEF6 | Rac/Cdc42 guanine nucleotide exchange factor 6. (776 aa) | ||||
MCF2 | MCF2 isoform 9. (941 aa) | ||||
IRAK1 | Interleukin 1 receptor associated kinase 1. (682 aa) | ||||
IKBKG | Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (487 aa) | ||||
OTUD1 | OTUD1 isoform 1. (171 aa) | ||||
ENSPPYP00000023500 | annotation not available (140 aa) | ||||
ENSPPYP00000023562 | annotation not available (156 aa) | ||||
ARHGEF11 | ARHGEF11 isoform 1. (1578 aa) | ||||
CR201_G0023353 | ARHGEF17 isoform 1. (1097 aa) | ||||
ENSPPYP00000024179 | 14-3-3 protein epsilon-like isoform X1. (173 aa) | ||||
CR201_G0044109-2 | RACK1 isoform 22. (230 aa) | ||||
ARHGEF40 | ARHGEF40 isoform 4. (322 aa) | ||||
UBE2D1 | Ubiquitin conjugating enzyme E2 D1; Belongs to the ubiquitin-conjugating enzyme family. (147 aa) | ||||
FAS | FAS isoform 1. (336 aa) | ||||
CHUK | CHUK isoform 1. (746 aa) | ||||
FADD | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa) | ||||
RELA | RELA proto-oncogene, NF-kB subunit. (551 aa) | ||||
BAD | BCL2 associated agonist of cell death. (168 aa) | ||||
MADD | MADD isoform 6. (1579 aa) | ||||
TRAF6 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (604 aa) | ||||
BIRC2 | Baculoviral IAP repeat containing 2. (597 aa) | ||||
USP2 | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (564 aa) | ||||
ARHGEF12 | Rho guanine nucleotide exchange factor 12. (1544 aa) | ||||
TNFRSF1A | TNFRSF1A isoform 2. (454 aa) | ||||
FGD4 | FYVE, RhoGEF and PH domain containing 4. (766 aa) | ||||
TBK1 | TANK binding kinase 1. (729 aa) | ||||
PRDM4 | PR domain zinc finger protein 4; May function as a transcription factor involved in cell differentiation; Belongs to the class V-like SAM-binding methyltransferase superfamily. (801 aa) | ||||
UBC | UBC isoform 2. (625 aa) | ||||
ULK1 | Serine/threonine-protein kinase; Serine/threonine-protein kinase involved in autophagy in response to starvation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. (924 aa) | ||||
UBE2L5 | Ubiquitin conjugating enzyme E2 L5; Belongs to the ubiquitin-conjugating enzyme family. (154 aa) | ||||
ARHGEF7 | ARHGEF7 isoform 7. (803 aa) | ||||
MCF2L | MCF2L isoform 10. (1211 aa) | ||||
CR201_G0032908 | ARHGEF40 isoform 1. (757 aa) | ||||
RNF31 | T0114761 isoform 1. (1053 aa) | ||||
NFATC4 | NFATC4 isoform 21. (868 aa) | ||||
NFKBIA | NFKBIA isoform 1. (317 aa) | ||||
SOS2 | SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa) | ||||
PSEN1 | Presenilin-1 CTF subunit; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. Stimulates cell-cell adhesion via its interaction with CDH1; this stabili [...] (463 aa) | ||||
SPPL2A | Signal peptide peptidase like 2A. (520 aa) | ||||
APH1B | Gamma-secretase subunit APH-1B; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (amyloid-beta precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Probably present in a minority of gamma-secretase complexes compared to APH1A (By similarity). (257 aa) | ||||
AKAP13 | AKAP13 isoform 5. (2833 aa) | ||||
CR201_G0003353 | RPS27A isoform 1. (155 aa) | ||||
STUB1 | STIP1 homology and U-box containing protein 1. (303 aa) | ||||
CYLD | Ubiquitin carboxyl-terminal hydrolase CYLD; Deubiquitinase that specifically cleaves 'Lys-63'- and linear 'Met-1'-linked polyubiquitin chains and is involved in NF-kappa-B activation and TNF-alpha-induced necroptosis. Plays an important role in the regulation of pathways leading to NF-kappa-B activation. Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation. Negative regulator of Wnt signaling. Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules. Plays a role in the regul [...] (956 aa) | ||||
CR201_G0015089 | TRADD isoform 2. (234 aa) | ||||
MAPK8 | Mitogen-activated protein kinase. (384 aa) | ||||
SMPD3 | SMPD3 isoform 1. (629 aa) | ||||
ABR | ABR isoform 1. (818 aa) | ||||
YWHAE | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (255 aa) | ||||
ARHGEF15 | ARHGEF15 isoform 1. (839 aa) | ||||
ENSPPYP00000008980 | annotation not available (158 aa) | ||||
OMG | OMG isoform 2. (440 aa) | ||||
AATF | AATF isoform 2. (560 aa) | ||||
SPPL2C | SPPL2C isoform 1. (682 aa) | ||||
GNA13 | G protein subunit alpha 13. (377 aa) | ||||
ULK2 | Serine/threonine-protein kinase; Serine/threonine-protein kinase involved in autophagy in response to starvation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. (1028 aa) | ||||
ENSPPYP00000009931 | annotation not available (76 aa) | ||||
NGFR | NGFR isoform 1. (407 aa) | ||||
SPPL2B | Signal peptide peptidase like 2B. (542 aa) | ||||
VAV1 | VAV1 isoform 2. (829 aa) | ||||
ENSPPYP00000010620 | Uncharacterized protein LOC103893029. (358 aa) | ||||
CR201_G0051707 | T0183294 isoform 1. (932 aa) | ||||
UBA52 | UBA52 isoform 10. (128 aa) | ||||
ARHGEF37 | ARHGEF37 isoform 2. (685 aa) | ||||
HDAC3 | Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys-27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activi [...] (428 aa) | ||||
UBE2D2 | Ubiquitin conjugating enzyme E2 D2; Belongs to the ubiquitin-conjugating enzyme family. (147 aa) | ||||
RASGRF2 | RASGRF2 isoform 1. (1227 aa) | ||||
NAIP | NAIP isoform 3. (1403 aa) | ||||
OTULIN | OTU deubiquitinase with linear linkage specificity. (352 aa) | ||||
OTULINL | FAM105A isoform 1. (360 aa) | ||||
TRIO | TRIO isoform 3. (3011 aa) | ||||
CASP3 | CASP3 isoform 1; Belongs to the peptidase C14A family. (277 aa) | ||||
ARHGEF38 | ARHGEF38 isoform 4. (219 aa) | ||||
UBE2D3 | Ubiquitin-conjugating enzyme E2 D3; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'-linked polyubiquitination. Cooperates with the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains from the UBE2D3-primed [...] (149 aa) | ||||
NFKB1 | Nuclear factor kappa B subunit 1. (969 aa) | ||||
MAPK10 | Mitogen-activated protein kinase. (384 aa) | ||||
MCF2L2 | MCF2L2 isoform 1. (1114 aa) | ||||
ECT2 | ECT2 isoform 4. (913 aa) | ||||
TNFSF10 | Tumor necrosis factor ligand superfamily member. (290 aa) | ||||
PRKCI | Protein kinase C iota type; Calcium- and diacylglycerol-independent serine/ threonine- protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis. In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell death process [...] (690 aa) | ||||
ARHGEF26 | ARHGEF26 isoform 4. (870 aa) | ||||
MYD88 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa) | ||||
USP4 | Ubiquitin carboxyl-terminal hydrolase 4; Deubiquitinating enzyme that removes conjugated ubiquitin from target proteins. Deubiquitinates PDPK1. Deubiquitinates TRIM21. Deubiquitinates receptor ADORA2A which increases the amount of functional receptor at the cell surface. May regulate mRNA splicing through deubiquitination of the U4 spliceosomal protein PRPF3. This may prevent its recognition by the U5 component PRPF8 thereby destabilizing interactions within the U4/U6.U5 snRNP. May also play a role in the regulation of quality control in the ER. (735 aa) | ||||
RHOA | Transforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essent [...] (196 aa) | ||||
ARHGEF3 | Rho guanine nucleotide exchange factor 3; Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases. (526 aa) | ||||
KALRN | KALRN isoform 1. (2858 aa) | ||||
NGEF | Ephexin-1; Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity). (708 aa) | ||||
TMEM198 | Transmembrane protein 198. (360 aa) | ||||
SOS1 | SOS1 isoform 2. (1290 aa) | ||||
ARHGEF33 | ARHGEF33 isoform 1. (720 aa) | ||||
CLIP4 | CLIP4 isoform 4. (659 aa) | ||||
ADAM17 | ADAM17 isoform 1. (725 aa) | ||||
ARHGEF4 | ARHGEF4 isoform 1. (1000 aa) | ||||
MAG | MAG isoform 1. (627 aa) | ||||
MAP3K20 | MAP3K20 isoform 1. (457 aa) | ||||
SESTD1 | SESTD1 isoform 1. (661 aa) | ||||
CFLAR | CASP8 and FADD-like apoptosis regulator subunit p12; Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity (By similarity). Belongs to [...] (480 aa) | ||||
CASP10 | CASP10 isoform 3; Belongs to the peptidase C14A family. (521 aa) | ||||
CASP8 | CASP8 isoform 1; Belongs to the peptidase C14A family. (496 aa) | ||||
CLIP3 | CAP-Gly domain-containing linker protein 3; Functions as a cytoplasmic linker protein. Involved in TGN- endosome dynamics. May modulate the cellular compartmentalization of AKT kinase family and promote its cell membrane localization, thereby playing a role in glucose transport in adipocytes (By similarity). (547 aa) | ||||
PLEKHG2 | PLEKHG2 isoform 5. (577 aa) | ||||
CR201_G0044078 | ARHGEF1 isoform 7. (764 aa) | ||||
TGM6 | Transglutaminase 6. (706 aa) | ||||
TGM3 | TGM3 isoform 1. (693 aa) | ||||
RBCK1 | RBCK1 isoform 5. (509 aa) | ||||
PREX1 | PREX1 isoform 2. (1457 aa) | ||||
SPATA2 | SPATA2 isoform 1. (520 aa) | ||||
BIRC7 | Baculoviral IAP repeat containing 7. (280 aa) | ||||
TIAM1 | TIAM1 isoform 1. (1591 aa) | ||||
ITSN1 | ITSN1 isoform 4. (1610 aa) | ||||
RTN4R | RTN4R isoform 1. (535 aa) | ||||
UBE2L3 | Ubiquitin-conjugating enzyme E2 L3; Ubiquitin-conjugating enzyme E2 that specifically acts with HECT-type and RBR family E3 ubiquitin-protein ligases. Does not function with most RING-containing E3 ubiquitin-protein ligases because it lacks intrinsic E3-independent reactivity with lysine: in contrast, it has activity with the RBR family E3 enzymes, such as PRKN and ARIH1, that function like function like RING-HECT hybrids. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-linked polyubiquitination. Involved in the [...] (154 aa) | ||||
SYNGR1 | Synaptogyrin-1; May play a role in regulated exocytosis. Modulates the localization of synaptophysin/SYP into synaptic-like microvesicles and may therefore play a role in synaptic-like microvesicle formation and/or maturation (By similarity). Involved in the regulation of short- term and long-term synaptic plasticity (By similarity). Belongs to the synaptogyrin family. (654 aa) | ||||
BCL2L11 | BCL2L11 isoform 4. (138 aa) | ||||
RTN4 | Reticulon. (1192 aa) | ||||
OBSCN | OBSCN isoform 2. (7677 aa) | ||||
PSEN2 | Presenilin-2 CTF subunit; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the other members of the gamma- secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. The holoprotein functions as a calcium-leak channel that allows the passive movement o [...] (448 aa) | ||||
MAPKAPK2 | MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (401 aa) | ||||
IKBKE | Inhibitor of nuclear factor kappa B kinase subunit epsilon. (716 aa) | ||||
FASLG | FASLG isoform 1; Belongs to the tumor necrosis factor family. (280 aa) | ||||
USP21 | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (565 aa) | ||||
NCSTN | NCSTN isoform 1. (639 aa) | ||||
ARHGEF2 | Rho/Rac guanine nucleotide exchange factor 2. (986 aa) | ||||
APH1A | Aph-1 homolog A, gamma-secretase subunit. (265 aa) | ||||
OTUD7B | OTU deubiquitinase 7B. (843 aa) | ||||
NGF | NGF isoform 1; Belongs to the NGF-beta family. (294 aa) | ||||
VAV3 | VAV3 isoform 1. (824 aa) | ||||
ITGB3BP | Centromere protein R; Transcription coregulator that can have both coactivator and corepressor functions. (177 aa) | ||||
HDAC1 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium st [...] (482 aa) | ||||
ARHGEF10L | Rho guanine nucleotide exchange factor 10-like protein; Acts as guanine nucleotide exchange factor (GEF) for RHOA, RHOB and RHOC. (1034 aa) | ||||
ARHGEF19 | ARHGEF19 isoform 2. (701 aa) | ||||
CR201_G0053435 | UBB isoform 1. (128 aa) | ||||
PLEKHG5 | PLEKHG5 isoform 5. (905 aa) | ||||
ARHGEF16 | ARHGEF16 isoform 1. (683 aa) | ||||
CR201_G0053298 | MIB2 isoform 16. (744 aa) | ||||
NET1 | NET1 isoform 1. (596 aa) | ||||
CR201_G0044109 | RACK1 isoform 5. (346 aa) | ||||
OPTN | Optineurin; Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex th [...] (532 aa) | ||||
LINGO2 | Leucine rich repeat and Ig domain containing 2. (606 aa) | ||||
ARHGEF39 | ARHGEF39 isoform 2. (335 aa) | ||||
SHARPIN | SHARPIN isoform 2. (410 aa) | ||||
RIPK2 | Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa) | ||||
NSMAF | NSMAF isoform 1. (901 aa) | ||||
IKBKB | Inhibitor of nuclear factor kappa B kinase subunit beta. (697 aa) | ||||
BAG4 | BAG4 isoform 1. (542 aa) | ||||
TNFRSF10A | TNFRSF10A isoform 1. (468 aa) | ||||
TNFRSF10D | Uncharacterized protein. (388 aa) | ||||
TNFRSF10B | TNFRSF10B isoform 3. (410 aa) | ||||
ARHGEF10 | CLN8 isoform 7. (1541 aa) | ||||
ARHGEF5 | ARHGEF35 isoform 1. (1585 aa) | ||||
CASP2 | CASP2 isoform 1; Belongs to the peptidase C14A family. (452 aa) | ||||
CR201_G0036702 | CCDC71L isoform 2. (316 aa) | ||||
ENSPPYP00000020022 | annotation not available (99 aa) | ||||
TAX1BP1 | Tax1-binding protein 1 homolog; Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti- apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade (By similarity). (771 aa) | ||||
ENSPPYP00000019656 | annotation not available (239 aa) | ||||
RAC1 | Rac family small GTPase 1. (211 aa) | ||||
TIAM2 | TIAM2 isoform 10. (1675 aa) | ||||
TAB2 | TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa) | ||||
ECT2L | Epithelial cell transforming 2 like. (904 aa) | ||||
TNFAIP3 | TNFAIP3 isoform 1. (790 aa) | ||||
HDAC2 | Histone deacetylase 2. (580 aa) | ||||
SMPD2 | SMPD2 isoform 1. (577 aa) | ||||
MAP3K7 | Mitogen-activated protein kinase kinase kinase 7; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as a [...] (606 aa) | ||||
FGD2 | FGD2 isoform 2. (655 aa) | ||||
TNF | Tumor necrosis factor ligand 1F; Belongs to the tumor necrosis factor family. (233 aa) | ||||
RIPK1 | Receptor interacting serine/threonine kinase 1. (671 aa) | ||||
SQSTM1 | Sequestosome-1; Autophagy receptor required for selective macroautophagy (aggrephagy). Functions as a bridge between polyubiquitinated cargo and autophagosomes. Interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. Required both for the formation and autophagic degradation of polyubiquitin- containing bodies, called ALIS (aggresome-like induced structures) and links ALIS to the autophagic machinery. Involved in midbody ring degradation (By similarity). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and [...] (436 aa) |