STRINGSTRING
RBX1 RBX1 CR201_G0028599 CR201_G0028599 NPLOC4 NPLOC4 ENSPPYP00000023562 ENSPPYP00000023562 ENSPPYP00000023500 ENSPPYP00000023500 CUL4B CUL4B ENSPPYP00000022487 ENSPPYP00000022487 POLE3 POLE3 VCP VCP RPA3 RPA3 POLD2 POLD2 RFC2 RFC2 POLH POLH REV3L REV3L POLK POLK SPATA5 SPATA5 RCHY1 RCHY1 RFC1 RFC1 RFC4 RFC4 WDR48 WDR48 UBA7 UBA7 RAD18 RAD18 POLE4 POLE4 REV1 REV1 UFD1 UFD1 PCNA PCNA SPRTN SPRTN POLD1 POLD1 UBA52 UBA52 POLI POLI ENSPPYP00000009931 ENSPPYP00000009931 TRIM65 TRIM65 TRIM47 TRIM47 TRIM25 TRIM25 ENSPPYP00000008980 ENSPPYP00000008980 USP43 USP43 USP10 USP10 USP31 USP31 MEIOB MEIOB CR201_G0003353 CR201_G0003353 PCLAF PCLAF SPATA5L1 SPATA5L1 POLE2 POLE2 CUL4A CUL4A RCBTB1 RCBTB1 RCBTB2 RCBTB2 RFC3 RFC3 POLE POLE UBC UBC RFC5 RFC5 POLD3 POLD3 UBE2L6 UBE2L6 DDB1 DDB1 POLD4 POLD4 ISG15 ISG15 CR201_G0053435 CR201_G0053435 MAD2L2 MAD2L2 USP1 USP1 DTL DTL
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RBX1RBX1 isoform 1. (108 aa)
CR201_G0028599SPRTN isoform 5. (111 aa)
NPLOC4NPLOC4 isoform 1. (609 aa)
ENSPPYP00000023562annotation not available (156 aa)
ENSPPYP00000023500annotation not available (140 aa)
CUL4BCUL4B isoform 4; Belongs to the cullin family. (843 aa)
ENSPPYP00000022487annotation not available (153 aa)
POLE3DNA polymerase epsilon subunit 3; Accessory component of the DNA polymerase epsilon complex (By similarity). Participates in DNA repair and in chromosomal DNA replication (By similarity). Forms a complex with CHRAC1 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome-remodeling activity of ISWI/SNF2H and ACF1 (By similarity). (147 aa)
VCPTransitional endoplasmic reticulum ATPase isoform X1. (806 aa)
RPA3Replication protein A3. (121 aa)
POLD2DNA polymerase delta 2, accessory subunit. (504 aa)
RFC2RFC2 isoform 5. (306 aa)
POLHPOLH isoform 1. (516 aa)
REV3LREV3L isoform 3. (3117 aa)
POLKPOLK isoform 1. (892 aa)
SPATA5SPATA5 isoform 1. (892 aa)
RCHY1Ring finger and CHY zinc finger domain containing 1. (261 aa)
RFC1Replication factor C subunit 1. (1020 aa)
RFC4Replication factor C subunit 4. (363 aa)
WDR48WD repeat-containing protein 48; Regulator of deubiquitinating complexes. Acts as a strong activator of USP1 and USP46. Enhances the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself. Also activates deubiquitinating activity of complexes containing USP12. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. May play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes; Belongs to the WD repeat WDR48 family. (677 aa)
UBA7UBA7 isoform 1; Belongs to the ubiquitin-activating E1 family. (956 aa)
RAD18RAD18 isoform 2. (495 aa)
POLE4DNA polymerase epsilon 4, accessory subunit. (117 aa)
REV1DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents (By similarity); Belongs to the DNA polymerase type-Y family. (1251 aa)
UFD1Ubiquitin recognition factor in ER associated degradation 1. (307 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
SPRTNSPRTN isoform 1. (385 aa)
POLD1DNA polymerase delta catalytic subunit. (1121 aa)
UBA52UBA52 isoform 10. (128 aa)
POLIPOLI isoform 1. (660 aa)
ENSPPYP00000009931annotation not available (76 aa)
TRIM65TRIM65 isoform 3. (475 aa)
TRIM47TRIM47 isoform 1. (640 aa)
TRIM25Tripartite motif containing 25. (630 aa)
ENSPPYP00000008980annotation not available (158 aa)
USP43USP43 isoform 1; Belongs to the peptidase C19 family. (1105 aa)
USP10Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (798 aa)
USP31USP domain-containing protein; Belongs to the peptidase C19 family. (1318 aa)
MEIOBMEIOB isoform 4. (441 aa)
CR201_G0003353RPS27A isoform 1. (155 aa)
PCLAFPCLAF isoform 3. (111 aa)
SPATA5L1SPATA5L1 isoform 1. (753 aa)
POLE2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (372 aa)
CUL4ACUL4A isoform 5; Belongs to the cullin family. (759 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (531 aa)
RCBTB2RCC1 and BTB domain-containing protein 2. (551 aa)
RFC3Replication factor C subunit 3. (356 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2039 aa)
UBCUBC isoform 2. (625 aa)
RFC5Replication factor C subunit 5. (340 aa)
POLD3DNA polymerase delta 3, accessory subunit. (466 aa)
UBE2L6Ubiquitin conjugating enzyme E2 L6; Belongs to the ubiquitin-conjugating enzyme family. (153 aa)
DDB1DNA damage-binding protein 1; Required for DNA repair. Binds to DDB2 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiqui [...] (1135 aa)
POLD4POLD4 isoform 5. (107 aa)
ISG15ISG15 ubiquitin like modifier. (165 aa)
CR201_G0053435UBB isoform 1. (128 aa)
MAD2L2Mitotic arrest deficient 2 like 2. (211 aa)
USP1Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (785 aa)
DTLDTL isoform 2. (659 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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