STRINGSTRING
PSMA5 PSMA5 PSMD3 PSMD3 PSMD4 PSMD4 PSMA6 PSMA6 PSMC1 PSMC1 LOC100457600 LOC100457600 ENSPPYP00000023569 ENSPPYP00000023569 ENSPPYP00000023562 ENSPPYP00000023562 ENSPPYP00000023561 ENSPPYP00000023561 PSMD7 PSMD7 PSMB1-2 PSMB1-2 ENSPPYP00000023500 ENSPPYP00000023500 PSMD10 PSMD10 ENSPPYP00000022487 ENSPPYP00000022487 PSMD13 PSMD13 ENSPPYP00000022319 ENSPPYP00000022319 PSMB7 PSMB7 PSMD5 PSMD5 CUL1 CUL1 PSMC2 PSMC2 ENSPPYP00000019816 ENSPPYP00000019816 PSMA2 PSMA2 FBXL18 FBXL18 PSMB9 PSMB9 PSMB8 PSMB8 PSMB1 PSMB1 SKP1 SKP1 FBXL7 FBXL7 PSMD2 PSMD2 PSMD6 PSMD6 PSMD1 PSMD1 PSMD14 PSMD14 PSME4 PSME4 RBX1 RBX1 PSMA7 PSMA7 AURKA AURKA PSMF1 PSMF1 PSMC4 PSMC4 PSMD8 PSMD8 UBA52 UBA52 PSMA8 PSMA8 MPPE1 MPPE1 ENSPPYP00000009931 ENSPPYP00000009931 PSMD12 PSMD12 PSMC6 PSMC6 PSMA3 PSMA3 PSMA4 PSMA4 CR201_G0003353 CR201_G0003353 PSMB10 PSMB10 PSMB6 PSMB6 ENSPPYP00000008980 ENSPPYP00000008980 PSMD11 PSMD11 PSME3 PSME3 PSMB3 PSMB3 PSMC5 PSMC5 PSMB5 PSMB5 PSMB11 PSMB11 PSME1 PSME1 PSME2 PSME2 PSMD9 PSMD9 PSMA1 PSMA1 PSMC3 PSMC3 ENSPPYP00000003414 ENSPPYP00000003414 CR201_G0053435 CR201_G0053435 PSMB2 PSMB2 PSMB4 PSMB4 UBC UBC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PSMA5Proteasome subunit alpha type. (278 aa)
PSMD3PSMD3 isoform 1. (536 aa)
PSMD4PSMD4 isoform 1. (384 aa)
PSMA6Proteasome endopeptidase complex. (167 aa)
PSMC1Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family. (440 aa)
LOC100457600Proteasome subunit beta type-5-like. (263 aa)
ENSPPYP00000023569annotation not available (247 aa)
ENSPPYP00000023562annotation not available (156 aa)
ENSPPYP00000023561annotation not available (122 aa)
PSMD7PSMD7 isoform 1. (324 aa)
PSMB1-2Proteasome subunit beta type-1. (241 aa)
ENSPPYP00000023500annotation not available (140 aa)
PSMD10Proteasome 26S subunit, non-ATPase 10. (226 aa)
ENSPPYP00000022487annotation not available (153 aa)
PSMD13PSMD13 isoform 6. (376 aa)
ENSPPYP00000022319annotation not available (162 aa)
PSMB7Proteasome subunit beta. (277 aa)
PSMD5PSMD5 isoform 8. (97 aa)
CUL1Cullin-1; Core component of multiple cullin-RING-based SCF (SKP1-CUL1- F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SCF complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the [...] (776 aa)
PSMC226S proteasome regulatory subunit 7; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with [...] (433 aa)
ENSPPYP00000019816annotation not available (197 aa)
PSMA2Proteasome subunit alpha type. (234 aa)
FBXL18F-box and leucine rich repeat protein 18. (718 aa)
PSMB9Proteasome subunit beta. (218 aa)
PSMB8Proteasome subunit beta. (272 aa)
PSMB1Proteasome subunit beta. (241 aa)
SKP1S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] (163 aa)
FBXL7F-box and leucine rich repeat protein 7. (444 aa)
PSMD226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. (909 aa)
PSMD6Proteasome 26S subunit, non-ATPase 6. (389 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa)
PSMD14Proteasome 26S subunit, non-ATPase 14. (310 aa)
PSME4Proteasome activator subunit 4. (1843 aa)
RBX1RBX1 isoform 1. (108 aa)
PSMA7Proteasome subunit alpha type-7; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pr [...] (248 aa)
AURKAAURKA isoform 10; Belongs to the protein kinase superfamily. (404 aa)
PSMF1Proteasome inhibitor PI31 subunit; Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28 (By similarity). (271 aa)
PSMC4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa)
PSMD826S proteasome non-ATPase regulatory subunit 8; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S14 family. (350 aa)
UBA52UBA52 isoform 10. (128 aa)
PSMA8Proteasome subunit alpha type. (256 aa)
MPPE1Metallophosphoesterase 1; Metallophosphoesterase required for transport of GPI-anchor proteins from the endoplasmic reticulum to the Golgi. Acts in lipid remodeling steps of GPI-anchor maturation by mediating the removal of a side-chain ethanolamine-phosphate (EtNP) from the second Man (Man2) of the GPI intermediate, an essential step for efficient transport of GPI- anchor proteins (By similarity); Belongs to the metallophosphoesterase superfamily. MPPE1 family. (396 aa)
ENSPPYP00000009931annotation not available (76 aa)
PSMD1226S proteasome non-ATPase regulatory subunit 12; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit p55 family. (456 aa)
PSMC6Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (403 aa)
PSMA3Proteasome subunit alpha type. (255 aa)
PSMA4Proteasome subunit alpha type. (261 aa)
CR201_G0003353RPS27A isoform 1. (155 aa)
PSMB10Proteasome subunit beta. (256 aa)
PSMB6Proteasome subunit beta. (239 aa)
ENSPPYP00000008980annotation not available (158 aa)
PSMD11Proteasome 26S subunit, non-ATPase 11. (422 aa)
PSME3Proteasome activator complex subunit 3; Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regul [...] (254 aa)
PSMB3Proteasome subunit beta. (218 aa)
PSMC5PSMC5 isoform 2; Belongs to the AAA ATPase family. (406 aa)
PSMB5Proteasome subunit beta type-5; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pro [...] (263 aa)
PSMB11Proteasome subunit beta. (300 aa)
PSME1Proteasome activator subunit 1. (249 aa)
PSME2Proteasome activator subunit 2. (239 aa)
PSMD9PSMD9 isoform 1. (223 aa)
PSMA1Proteasome subunit alpha type-1; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pr [...] (263 aa)
PSMC3Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (439 aa)
ENSPPYP00000003414annotation not available (440 aa)
CR201_G0053435UBB isoform 1. (128 aa)
PSMB2Proteasome subunit beta. (201 aa)
PSMB4Proteasome subunit beta; Belongs to the peptidase T1B family. (264 aa)
UBCUBC isoform 2. (625 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.