STRINGSTRING
CR201_G0054189-2 CR201_G0054189-2 KIF4A KIF4A CXorf38 CXorf38 ENSPPYP00000022418 ENSPPYP00000022418 DCTN3 DCTN3 LOC100434822 LOC100434822 TUBB4B TUBB4B SURF4 SURF4 CR201_G0007992 CR201_G0007992 BICD2 BICD2 ENSPPYP00000021665 ENSPPYP00000021665 KIF27 KIF27 KIFC2 KIFC2 DCTN6 DCTN6 KIF13B KIF13B COPG2 COPG2 ENSPPYP00000020203 ENSPPYP00000020203 ARF5 ARF5 CAPZA2 CAPZA2 RINT1 RINT1 DYNC1I1 DYNC1I1 TMED4 TMED4 ZCWPW1 ZCWPW1 KDELR2 KDELR2 KIF25 KIF25 TUBE1 TUBE1 KLC4 KLC4 KIF6 KIF6 KIFC1 KIFC1 TUBB2B TUBB2B FAM193B FAM193B BNIP1 BNIP1 DCTN4 DCTN4 KIF20A KIF20A KIF3A KIF3A KIF2A KIF2A CFAP97 CFAP97 CR201_G0000620 CR201_G0000620 STX18 STX18 ENSPPYP00000016227 ENSPPYP00000016227 ARL14 ARL14 COPB2 COPB2 RAB6B RAB6B ZCWPW2 ZCWPW2 DYNC1LI1 DYNC1LI1 KIF15 KIF15 KIF9 KIF9 ARF4 ARF4 COPG1 COPG1 ENSPPYP00000014962 ENSPPYP00000014962 KIF1A KIF1A TUBA4A TUBA4A DYNC1I2 DYNC1I2 ARL5A ARL5A RAB3GAP1 RAB3GAP1 NBAS NBAS KIF3C KIF3C AFTPH AFTPH RAB1A RAB1A CR201_G0003005 CR201_G0003005 ENSPPYP00000013420 ENSPPYP00000013420 ARFGAP3 ARFGAP3 KDELR3 KDELR3 PLA2G6 PLA2G6 AGPAT3 AGPAT3 CR201_G0052180 CR201_G0052180 TUBB1 TUBB1 KIF3B KIF3B ATRN ATRN NAPB NAPB CR201_G0019710 CR201_G0019710 ENSPPYP00000011873 ENSPPYP00000011873 KDELR1 KDELR1 NAPA NAPA KLC3 KLC3 TMEM145 TMEM145 PAFAH1B3 PAFAH1B3 IGFLR1 IGFLR1 COPE COPE USE1 USE1 GALNT1 GALNT1 NAPG NAPG ENSPPYP00000010091 ENSPPYP00000010091 TUBB6 TUBB6 COPZ2 COPZ2 PRR15L PRR15L KIF19 KIF19 APPBP2 APPBP2 KIF18B KIF18B ENSPPYP00000009346 ENSPPYP00000009346 ENSPPYP00000009320 ENSPPYP00000009320 NSF NSF KIF2B KIF2B DYNLL2 DYNLL2 CR201_G0053422 CR201_G0053422 KIF1C KIF1C PAFAH1B1 PAFAH1B1 KIF22 KIF22 TUBB3 TUBB3 DYNC1LI2 DYNC1LI2 DCTN5 DCTN5 CR201_G0054880 CR201_G0054880 KIF7 KIF7 TMED3 TMED3 KIF23 KIF23 KIF26A KIF26A KLC1 KLC1 ACTR10 ACTR10 ENSPPYP00000005898 ENSPPYP00000005898 DYNLL1 DYNLL1 KIF5A KIF5A DCTN2 DCTN2 COPZ1 COPZ1 RACGAP1 RACGAP1 ARF3 ARF3 KIF21A KIF21A BICD1 BICD1 CAPZA3 CAPZA3 ARCN1 ARCN1 ZW10 ZW10 ENSPPYP00000004309 ENSPPYP00000004309 RAB6A RAB6A COPB1 COPB1 KIF18A KIF18A ARFGAP2 ARFGAP2 KLC2 KLC2 RAB1B RAB1B ATRNL1 ATRNL1 ACTR1A ACTR1A GBF1 GBF1 KIF11 KIF11 KIF20B KIF20B KIF5B KIF5B RAB18 RAB18 ARL5B ARL5B TUBAL3 TUBAL3 CR201_G0054189 CR201_G0054189 KIF1B KIF1B CAPZB CAPZB KIF2C KIF2C CAPZA1 CAPZA1 SEC22B SEC22B COPA COPA KIFAP3 KIFAP3 PLA2G4A PLA2G4A RAB3GAP2 RAB3GAP2 ENSPPYP00000000154 ENSPPYP00000000154 ARF1 ARF1 LOC100452886 LOC100452886 ENSPPYP00000000046 ENSPPYP00000000046 KIF26B KIF26B TUBA1B TUBA1B TMED10 TMED10 TMED2 TMED2 TUBA1C TUBA1C TUBA8 TUBA8 ENSPPYP00000023866 ENSPPYP00000023866 KIF21B KIF21B PAFAH1B2 PAFAH1B2 TMED9 TMED9
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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CR201_G0054189-2Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (444 aa)
KIF4AKIF4A isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (974 aa)
CXorf38Chromosome X open reading frame 38. (319 aa)
ENSPPYP00000022418annotation not available (435 aa)
DCTN3DCTN3 isoform 3. (186 aa)
LOC100434822TUBA3C isoform 1. (450 aa)
TUBB4BTubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family. (388 aa)
SURF4Surfeit locus protein 4; May play a role in the maintenance of the architecture of the endoplasmic reticulum-Golgi intermediate compartment and of the Golgi. Belongs to the SURF4 family. (254 aa)
CR201_G0007992Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (615 aa)
BICD2BICD cargo adaptor 2. (824 aa)
ENSPPYP00000021665annotation not available (330 aa)
KIF27LOW QUALITY PROTEIN: kinesin-like protein KIF27. (1308 aa)
KIFC2Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (831 aa)
DCTN6Dynactin subunit 6. (359 aa)
KIF13BKIF13B isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1825 aa)
COPG2Coatomer subunit gamma; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. (726 aa)
ENSPPYP00000020203annotation not available (122 aa)
ARF5ADP-ribosylation factor 5. (130 aa)
CAPZA2F-actin-capping protein subunit alpha-2; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity). (286 aa)
RINT1RINT1 isoform 1. (790 aa)
DYNC1I1Dynein cytoplasmic 1 intermediate chain 1. (645 aa)
TMED4Transmembrane p24 trafficking protein 4. (227 aa)
ZCWPW1ZCWPW1 isoform 2. (608 aa)
KDELR2ER lumen protein-retaining receptor. (212 aa)
KIF25Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (359 aa)
TUBE1Tubulin epsilon 1; Belongs to the tubulin family. (475 aa)
KLC4KLC4 isoform 7. (636 aa)
KIF6Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (813 aa)
KIFC1Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (672 aa)
TUBB2BTubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (445 aa)
FAM193BFAM193B isoform 1. (814 aa)
BNIP1BCL2 interacting protein 1. (271 aa)
DCTN4Dynactin subunit 4; Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton (By similarity). (460 aa)
KIF20AKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (817 aa)
KIF3AKinesin-like protein KIF3A; Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro. Plays a role in primary cilia formation. Plays a role in centriole cohesion and subdistal appendage organization and function. Regulates the formation of the subdistal appendage via recruitment of DCTN1 to the centriole. Also required for ciliary basal feet formation and microtubule anchoring to mother centriole. (696 aa)
KIF2AKinesin-like protein KIF2A; Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity (By similarity). (660 aa)
CFAP97Cilia- and flagella-associated protein 97; Belongs to the CFAP97 family. (530 aa)
CR201_G0000620CENPE isoform 4; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1770 aa)
STX18Syntaxin-18; Syntaxin that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER. (338 aa)
ENSPPYP00000016227annotation not available (190 aa)
ARL14ADP ribosylation factor like GTPase 14; Belongs to the small GTPase superfamily. Arf family. (192 aa)
COPB2Coatomer subunit beta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also infl [...] (900 aa)
RAB6BRAB6B, member RAS oncogene family. (208 aa)
ZCWPW2Zinc finger CW-type and PWWP domain containing 2. (356 aa)
DYNC1LI1Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (523 aa)
KIF15Kinesin family member 15; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1388 aa)
KIF9Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (790 aa)
ARF4ADP-ribosylation factor 4; GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus (By similarity); Belongs to the small GTPase superfamily. Arf family. (180 aa)
COPG1Coatomer subunit gamma; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. (964 aa)
ENSPPYP00000014962annotation not available (447 aa)
KIF1AKIF1A isoform 2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1554 aa)
TUBA4ATubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (448 aa)
DYNC1I2Cytoplasmic dynein 1 intermediate chain 2; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and help dynein bind to dynactin 150 kDa component (By similarity). organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCNT1. Involved in membrane-transport, such a [...] (638 aa)
ARL5AADP ribosylation factor like GTPase 5A; Belongs to the small GTPase superfamily. Arf family. (179 aa)
RAB3GAP1RAB3GAP1 isoform 3. (975 aa)
NBASNBAS isoform 1. (2330 aa)
KIF3CKinesin-like protein KIF3C; Microtubule-based anterograde translocator for membranous organelles. (754 aa)
AFTPHAFTPH isoform 3. (919 aa)
RAB1ARAB1A isoform 1. (205 aa)
CR201_G0003005T0009947 isoform 1. (1278 aa)
ENSPPYP00000013420annotation not available (154 aa)
ARFGAP3ADP-ribosylation factor GTPase-activating protein 3; GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes (By similarity). (516 aa)
KDELR3ER lumen protein-retaining receptor. (214 aa)
PLA2G6PLA2G6 isoform 1. (805 aa)
AGPAT31-acyl-sn-glycerol-3-phosphate acyltransferase gamma; Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (By similarity). Acts on LPA containing saturated or unsaturated fatty acids C16:0-C20:4 at the sn-1 position using C18:1, C20:4 or C18:2-CoA as the acyl donor (By similarity). Also acts on lysophosphatidylcholine, lysophosphatidylinositol and lysophosphatidylserine using C18:1 or C20:4-CoA. Has a preference for arachidon [...] (376 aa)
CR201_G0052180ARFGAP1 isoform 10. (324 aa)
TUBB1Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (452 aa)
KIF3BKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (695 aa)
ATRNATRN isoform 2. (1378 aa)
NAPBNAPB isoform 4. (298 aa)
CR201_G0019710KIF16B isoform 2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1102 aa)
ENSPPYP00000011873annotation not available (417 aa)
KDELR1ER lumen protein-retaining receptor. (212 aa)
NAPANAPA isoform 1. (276 aa)
KLC3Kinesin light chain 3; Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport; Belongs to the kinesin light chain family. (504 aa)
TMEM145TMEM145 isoform 3. (565 aa)
PAFAH1B3Platelet-activating factor acetylhydrolase IB subunit gamma; Inactivates paf by removing the acetyl group at the sn-2 position. This is a catalytic subunit. Plays an important role during the development of brain (By similarity); Belongs to the 'GDSL' lipolytic enzyme family. Platelet- activating factor acetylhydrolase IB beta/gamma subunits subfamily. (231 aa)
IGFLR1IGFLR1 isoform 1. (359 aa)
COPECoatomer subunit epsilon; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated with ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex [...] (308 aa)
USE1Unconventional SNARE in the endoplasmic reticulum protein 1. (259 aa)
GALNT1Polypeptide N-acetylgalactosaminyltransferase. (559 aa)
NAPGNAPG isoform 3. (312 aa)
ENSPPYP00000010091annotation not available (152 aa)
TUBB6Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (446 aa)
COPZ2Coatomer subunit zeta; The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex. (175 aa)
PRR15LProline rich 15 like. (103 aa)
KIF19Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (829 aa)
APPBP2Amyloid beta precursor protein binding protein 2. (585 aa)
KIF18BKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (409 aa)
ENSPPYP00000009346annotation not available (387 aa)
ENSPPYP00000009320ADP-ribosylation factor 2-like. (48 aa)
NSFVesicle-fusing ATPase; Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin. Interaction with AMPAR subunit GRIA2 leads to influence GRIA2 membrane cycling (By similarity); Belongs to the AAA ATPase family. (816 aa)
KIF2BKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (674 aa)
DYNLL2Dynein light chain. (89 aa)
CR201_G0053422TTC19 isoform 1. (434 aa)
KIF1CKIF1C isoform 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1070 aa)
PAFAH1B1Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...] (410 aa)
KIF22Kinesin-like protein KIF22; Kinesin family member that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA. Plays a role in congression of laterally attached chromosomes in NDC80-depleted cells. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (665 aa)
TUBB3T0170152 isoform 1; Belongs to the tubulin family. (450 aa)
DYNC1LI2Cytoplasmic dynein 1 light intermediate chain 2; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (465 aa)
DCTN5Dynactin subunit 5; Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily. (182 aa)
CR201_G0054880CCDC78 isoform 5. (376 aa)
KIF7KIF7 isoform 2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (875 aa)
TMED3Transmembrane p24 trafficking protein 3. (217 aa)
KIF23Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (950 aa)
KIF26AKIF26A isoform 2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1090 aa)
KLC1Kinesin light chain 1; Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By similarity). (551 aa)
ACTR10Actin related protein 10; Belongs to the actin family. (417 aa)
ENSPPYP00000005898annotation not available (382 aa)
DYNLL1Dynein light chain. (89 aa)
KIF5AKinesin heavy chain isoform 5A; Microtubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL). Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner. The ZFYVE27-KIF5A complex contributes to the vesicular transport of VAPA, VAPB, SURF4, RAB11A, RAB11B and RTN3 proteins in neurons. Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. [...] (1030 aa)
DCTN2DCTN2 isoform 1. (401 aa)
COPZ1Coatomer subunit zeta-1; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity). The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-disso [...] (177 aa)
RACGAP1Rac GTPase activating protein 1. (632 aa)
ARF3ADP-ribosylation factor 3; GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus (By similarity). (181 aa)
KIF21AKIF21A isoform 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1674 aa)
BICD1BICD1 isoform 4. (975 aa)
CAPZA3F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (299 aa)
ARCN1Coatomer subunit delta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also inf [...] (423 aa)
ZW10Centromere/kinetochore protein zw10 homolog; Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (By similarity). (779 aa)
ENSPPYP00000004309annotation not available (437 aa)
RAB6ARas-related protein Rab-6A; Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Involved in COPI-independent retrograde transport from the Golgi to the ER (By similarity); Belongs to the small GTPase superfamily. Rab family. (208 aa)
COPB1Coatomer subunit beta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also infl [...] (953 aa)
KIF18AKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (880 aa)
ARFGAP2ADP-ribosylation factor GTPase-activating protein 2; GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Implicated in coatomer-mediated protein transport between the Golgi complex and the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes (By similarity). (521 aa)
KLC2KLC2 isoform 1. (622 aa)
RAB1BRas-related protein Rab-1B; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). Plays a role in the initial events of the autophagic vacuole development which take place at specialized regions of the endoplasmic reticulum (By similarity). Regulates [...] (199 aa)
ATRNL1ATRNL1 isoform 1. (1334 aa)
ACTR1AActin related protein 1A. (376 aa)
GBF1GBF1 isoform 1. (1855 aa)
KIF11Kinesin family member 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1056 aa)
KIF20BKIF20B isoform 2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1734 aa)
KIF5BKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (964 aa)
RAB18Ras-related protein Rab-18; Plays a role in apical endocytosis/recycling. May be implicated in transport between the plasma membrane and early endosomes. Plays a key role in eye and brain development and neurodegeneration (By similarity). (206 aa)
ARL5BADP ribosylation factor like GTPase 5B. (151 aa)
TUBAL3Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (446 aa)
CR201_G0054189Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (442 aa)
KIF1BKIF1B isoform 3; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1790 aa)
CAPZBF-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization (By similarity). (277 aa)
KIF2CKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (706 aa)
CAPZA1F-actin-capping protein subunit alpha-1; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the formation of epithelial cell junctions. (286 aa)
SEC22BVesicle-trafficking protein SEC22b; SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER. (215 aa)
COPACoatomer subunit alpha; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. (1224 aa)
KIFAP3KIFAP3 isoform 2. (787 aa)
PLA2G4ACytosolic phospholipase A2; Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response (By similarity). (749 aa)
RAB3GAP2RAB3GAP2 isoform 1. (1393 aa)
ENSPPYP00000000154annotation not available (424 aa)
ARF1ADP ribosylation factor 1; Belongs to the small GTPase superfamily. Arf family. (181 aa)
LOC100452886TUBB8 isoform 7. (440 aa)
ENSPPYP00000000046annotation not available (160 aa)
KIF26BKIF26B isoform 3; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1702 aa)
TUBA1BTubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (451 aa)
TMED10Transmembrane emp24 domain-containing protein 10; Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED2 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft [...] (216 aa)
TMED2Transmembrane p24 trafficking protein 2. (208 aa)
TUBA1CTubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (476 aa)
TUBA8Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (454 aa)
ENSPPYP00000023866annotation not available (88 aa)
KIF21BKIF21B isoform 2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1637 aa)
PAFAH1B2Platelet-activating factor acetylhydrolase IB subunit beta; Inactivates PAF by removing the acetyl group at the sn-2 position. This is a catalytic subunit (By similarity); Belongs to the 'GDSL' lipolytic enzyme family. Platelet- activating factor acetylhydrolase IB beta/gamma subunits subfamily. (241 aa)
TMED9Transmembrane p24 trafficking protein 9. (235 aa)
Your Current Organism:
Pongo abelii
NCBI taxonomy Id: 9601
Other names: Orang-utan, Orangutan, P. abelii, Pongo pygmaeus abeli, Pongo pygmaeus abelii, Sumatran orangutan, orang utan
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